Published in Proc Natl Acad Sci U S A on February 01, 1992
Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci U S A (1998) 6.82
Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice. Infect Immun (1993) 3.38
Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol (2005) 3.14
Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect Immun (1995) 2.80
Interleukin 1 signaling occurs exclusively via the type I receptor. Proc Natl Acad Sci U S A (1993) 2.67
The T-cell-independent role of gamma interferon and tumor necrosis factor alpha in macrophage activation during murine cytomegalovirus and herpes simplex virus infections. J Virol (1995) 2.45
Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone. J Exp Med (1996) 2.28
Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice. Proc Natl Acad Sci U S A (1996) 2.18
Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One (2009) 2.14
Susceptibility to secondary Francisella tularensis live vaccine strain infection in B-cell-deficient mice is associated with neutrophilia but not with defects in specific T-cell-mediated immunity. Infect Immun (2001) 1.91
Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection. Infect Immun (2004) 1.77
Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes. J Exp Med (2006) 1.69
Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75. J Exp Med (1995) 1.67
Interleukin-12 in infectious diseases. Clin Microbiol Rev (1997) 1.63
Precarious balance: Th17 cells in host defense. Infect Immun (2009) 1.60
Lymphocyte apoptosis during early phase of Listeria infection in mice. Am J Pathol (1997) 1.55
Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death. J Immunol (2010) 1.36
Interleukin 1: an important mediator of host resistance against Pneumocystis carinii. J Exp Med (1992) 1.36
Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice. Proc Natl Acad Sci U S A (1998) 1.27
Endogenous interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitis. Infect Immun (2001) 1.22
Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase. Cell Res (2010) 1.20
Immune complexes inhibit antimicrobial responses through interleukin-10 production. Effects in severe combined immunodeficient mice during Listeria infection. J Clin Invest (1995) 1.17
The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C. J Immunol (2012) 1.08
IL-1α signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo. J Immunol (2013) 1.08
Interleukin-1 is involved in mouse resistance to Mycobacterium avium. Infect Immun (1994) 1.03
Effects of interleukin-1 receptor antagonist overexpression on infection by Listeria monocytogenes. Infect Immun (1999) 0.93
Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1). J Immunol (2013) 0.88
Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes. Infect Immun (2010) 0.86
Lipophosphoglycan from Leishmania suppresses agonist-induced interleukin 1 beta gene expression in human monocytes via a unique promoter sequence. Proc Natl Acad Sci U S A (1996) 0.84
Clash of the Cytokine Titans: counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses. Cell Mol Immunol (2016) 0.83
Hemolytically active (acylated) alpha-hemolysin elicits interleukin-1beta (IL-1beta) but augments the lethality of Escherichia coli by an IL-1- and tumor necrosis factor-independent mechanism. Infect Immun (1998) 0.83
p47(phox) directs murine macrophage cell fate decisions. Am J Pathol (2012) 0.82
An anti-CD3 monoclonal antibody protects mice against a lethal infection with Listeria monocytogenes through induction of endogenous cytokines. Infect Immun (1993) 0.81
Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Nat Commun (2016) 0.79
Interaction of interleukin-6, tumour necrosis factor and interleukin-1 during Listeria infection. Immunology (1995) 0.79
Distinct contributions of interleukin-1α (IL-1α) and IL-1β to innate immune recognition of Pseudomonas aeruginosa in the lung. Infect Immun (2014) 0.78
Cytokine response in Balb/c mice infected with Francisella tularensis LVS and the Pohang isolate. J Vet Sci (2008) 0.77
Inflammatory cells of immunosuppressive phenotypes in oral lichen planus have a proinflammatory pattern of expression and are associated with clinical parameters. Clin Oral Investig (2012) 0.75
A severe combined immunodeficiency mutation in the mouse. Nature (1983) 13.99
Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu Rev Immunol (1991) 10.58
Antigen-presenting function of the macrophage. Annu Rev Immunol (1984) 7.83
Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection. Proc Natl Acad Sci U S A (1985) 7.15
Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors. J Immunol (1989) 5.39
Cytokines and endothelial cell biology. Physiol Rev (1990) 5.02
Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice. J Immunol (1989) 4.70
Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity. J Immunol (1985) 4.44
Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial stimuli. Infect Immun (1991) 4.18
Retracted Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice. J Immunol (1990) 3.76
A T cell-independent mechanism of macrophage activation by interferon-gamma. J Immunol (1987) 3.55
Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas. J Immunol (1984) 3.41
Identification of a membrane-associated interleukin 1 in macrophages. Proc Natl Acad Sci U S A (1985) 3.39
The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical. Nature (1987) 2.68
Presentation of Listeria monocytogenes to CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth. J Immunol (1990) 2.54
Regulation of macrophage Ia expression in mice with severe combined immunodeficiency: induction of Ia expression by a T cell-independent mechanism. J Immunol (1986) 2.51
Molecular transductional mechanisms by which IFN gamma and other signals regulate macrophage development. Immunol Rev (1987) 2.37
Two high-affinity interleukin 1 receptors represent separate gene products. Proc Natl Acad Sci U S A (1989) 2.13
Evidence for different interleukin 1 receptors in murine B- and T-cell lines. Proc Natl Acad Sci U S A (1989) 1.90
Generation of monoclonal antibodies to murine IL-1 beta and demonstration of IL-1 in vivo. J Immunol (1991) 1.65
Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity. J Immunol (1988) 1.63
Molecules and structures involved in the adhesion of natural killer cells to vascular endothelium. J Exp Med (1991) 1.51
Demonstration and partial characterization of the interferon-gamma receptor on human mononuclear phagocytes. J Clin Invest (1985) 1.40
Retention of ligand binding activity by the extracellular domain of the IL-1 receptor. J Immunol (1989) 1.02
Indomethacin in vivo increases the sensitivity to Listeria infection in mice. A possible role for macrophage thromboxane A2 synthesis. J Clin Invest (1987) 1.01
How cells respond to interferons. Annu Rev Biochem (1998) 24.27
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (1990) 14.46
IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature (2001) 11.03
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell (1996) 10.49
Binding of immunogenic peptides to Ia histocompatibility molecules. Nature (1985) 8.39
Requirement of thymus (T) lymphocytes for resistance to listeriosis. J Exp Med (1972) 8.25
Immunoglobulins on the surface of lymphocytes. I. Distribution and quantitation. J Exp Med (1971) 8.22
Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science (1988) 7.96
Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. J Exp Med (1977) 7.89
Antigen-presenting function of the macrophage. Annu Rev Immunol (1984) 7.83
Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection. Proc Natl Acad Sci U S A (1985) 7.15
Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci U S A (1998) 6.82
Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor. J Exp Med (1982) 6.56
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci U S A (1993) 6.33
The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol (1993) 5.88
Immunoglobulins on the surface of lymphocytes. II. The bone marrow as the main source of lymphocytes with detectable surface-bound immunoglobulin. J Exp Med (1971) 5.43
Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors. J Immunol (1989) 5.39
Critical role of determinant presentation in the induction of specific responses in immunocompetent lymphocytes. J Exp Med (1973) 5.30
Ligand-induced movement of lymphocyte membrane macromolecules. I. Analysis by immunofluorescence and ultrastructural radioautography. J Exp Med (1972) 5.01
A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science (1990) 4.90
Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells. Proc Natl Acad Sci U S A (1982) 4.85
The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu Rev Immunol (1997) 4.76
The regulatory role of macrophages in antigenic stimulation. Part Two: symbiotic relationship between lymphocytes and macrophages. Adv Immunol (1981) 4.72
Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice. J Immunol (1989) 4.70
The regulatory role of macrophages in antigenic stimulation. Adv Immunol (1972) 4.69
Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature (1990) 4.59
The basis for the immunoregulatory role of macrophages and other accessory cells. Science (1987) 4.51
Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity. J Immunol (1985) 4.44
Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity (2001) 4.23
Membrane and cytoplasmic changes in B lymphocytes induced by ligand-surface immunoglobulin interaction. Adv Immunol (1976) 4.18
Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial stimuli. Infect Immun (1991) 4.18
Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell (1990) 4.15
Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity. J Exp Med (1984) 4.00
Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes. J Immunol (1981) 3.94
Prostaglandins modulate macrophage Ia expression. Nature (1982) 3.83
Experimental glomerulonephritis: immunological events and pathogenetic mechanisms. Adv Immunol (1967) 3.83
Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation. Cell (1985) 3.81
Activated macrophages induce vascular proliferation. Nature (1977) 3.74
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc Natl Acad Sci U S A (2000) 3.69
Antigen presentation: comments on its regulation and mechanism. J Immunol (1984) 3.68
Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science (1993) 3.62
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc Natl Acad Sci U S A (1996) 3.62
Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production. J Immunol (1982) 3.61
A T cell-independent mechanism of macrophage activation by interferon-gamma. J Immunol (1987) 3.55
Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma. J Immunol (1994) 3.50
Natural immunity: a T-cell-independent pathway of macrophage activation, defined in the scid mouse. Immunol Rev (1991) 3.49
Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria. Proc Natl Acad Sci U S A (1983) 3.47
Regulation of macrophage populations. I. Preferential induction of Ia-rich peritoneal exudates by immunologic stimuli. J Immunol (1980) 3.46
Regulation of Toll-like receptors in human monocytes and dendritic cells. J Immunol (2001) 3.45
Molecular biology and chemistry of the alternative pathway of complement. Adv Immunol (1980) 3.41
Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas. J Immunol (1984) 3.41
Identification of a membrane-associated interleukin 1 in macrophages. Proc Natl Acad Sci U S A (1985) 3.39
Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice. Infect Immun (1993) 3.38
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med (1995) 3.37
Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc Natl Acad Sci U S A (1994) 3.34
Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature (1994) 3.34
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell (1998) 3.25
Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFN gamma receptors. Immunity (1994) 3.24
Properdin- and nephritic factor-dependent C3 convertases: requirement of native C3 for enzyme formation and the function of bound C3b as properdin receptor. J Exp Med (1975) 3.12
A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. Nat Genet (1999) 3.12
Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science (2001) 3.11
Interleukin 1 is processed and released during apoptosis. Proc Natl Acad Sci U S A (1991) 3.09
Gamma interferon limits access of Listeria monocytogenes to the macrophage cytoplasm. J Exp Med (1989) 3.08
Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope. Nature (1987) 3.08
In vivo modulation of the murine immune response to Francisella tularensis LVS by administration of anticytokine antibodies. Infect Immun (1992) 3.07
Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis. J Exp Med (1993) 3.06
A mononuclear cell component in experimental immunological glomerulonephritis. J Exp Med (1978) 3.02
Detection and characterization of high affinity plasma membrane receptors for human interleukin 1. J Exp Med (1985) 3.00
Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA. Science (1989) 2.98
Fourth component of human complement: description of a three polypeptide chain structure. J Exp Med (1974) 2.93
Macrophage-T cell interactions involving Listeria monocytogenes--role of the H-2 gene complex. J Immunol (1979) 2.93
Persistence of immunogenicity of antigen after uptake by macrophages. J Exp Med (1968) 2.93
Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc Natl Acad Sci U S A (1997) 2.89
Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3. J Exp Med (1981) 2.88
Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). EMBO J (1994) 2.82
Eradication of established tumors by CD8+ T cell adoptive immunotherapy. Immunity (2000) 2.81
The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. J Biol Chem (1987) 2.78
Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. J Immunol (1993) 2.73
The costimulatory function of antigen-presenting cells. Immunol Today (1990) 2.71
The binding of clathrin triskelions to membranes from coated vesicles. Cell (1981) 2.70
The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical. Nature (1987) 2.68
Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J Immunol (1994) 2.68
The immune response of mice to antigen in macrophages. Immunology (1968) 2.67
An ultrastructural study of lymphocytes with surface-bound immunoglobulin. J Exp Med (1972) 2.65
Macrophage-activating factor produced by a T cell hybridoma: physiochemical and biosynthetic resemblance to gamma-interferon. J Immunol (1983) 2.61
CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma. Proc Natl Acad Sci U S A (1999) 2.60
Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. Blood (1995) 2.57
Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins. Proc Natl Acad Sci U S A (1978) 2.57
Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci U S A (2001) 2.56
Two distinct mechanisms for redistribution of lymphocyte surface macromolecules. I. Relationship to cytoplasmic myosin. J Cell Biol (1978) 2.54
The modulation of lymphocyte functions by molecules secreted by macrophages. I. Description and partial biochemical analysis. J Exp Med (1975) 2.54