Published in J Mol Biol on August 13, 1999
A large conformational change of the translocation ATPase SecA. Proc Natl Acad Sci U S A (2004) 1.86
A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S. PLoS Genet (2016) 1.43
In Silico Generation of Peptides by Replica Exchange Monte Carlo: Docking-Based Optimization of Maltose-Binding-Protein Ligands. PLoS One (2015) 1.40
Combinatorial peptide libraries reveal the ligand-binding mechanism of the oligopeptide receptor OppA of Lactococcus lactis. Proc Natl Acad Sci U S A (2000) 1.18
On the binding mechanism of the peptide receptor of the oligopeptide transport system of Lactococcus lactis. EMBO J (2000) 1.14
Thermodynamic consequences of disrupting a water-mediated hydrogen bond network in a protein:pheromone complex. Protein Sci (2005) 1.06
Analysis of differences in the functional properties of the substrate binding proteins of the Borrelia burgdorferi oligopeptide permease (Opp) operon. J Bacteriol (2004) 1.05
Conserved oligopeptide permeases modulate sporulation initiation in Clostridium difficile. Infect Immun (2014) 1.03
Rapid and accurate prediction and scoring of water molecules in protein binding sites. PLoS One (2012) 1.02
Water and proteins: a love-hate relationship. Proc Natl Acad Sci U S A (2004) 1.01
MALISAM: a database of structurally analogous motifs in proteins. Nucleic Acids Res (2007) 0.96
Prediction of antibiotic resistance by gene expression profiles. Nat Commun (2014) 0.91
Specific metal recognition in nickel trafficking. Biochemistry (2012) 0.90
Systematic placement of structural water molecules for improved scoring of protein-ligand interactions. Protein Eng Des Sel (2011) 0.82
Evaluation of the relative stability of liganded versus ligand-free protein conformations using Simplicial Neighborhood Analysis of Protein Packing (SNAPP) method. Proteins (2004) 0.82
Compensating stereochemical changes allow murein tripeptide to be accommodated in a conventional peptide-binding protein. J Biol Chem (2011) 0.81
A Pyranose-2-Phosphate Motif Is Responsible for Both Antibiotic Import and Quorum-Sensing Regulation in Agrobacterium tumefaciens. PLoS Pathog (2015) 0.81
Influence of Glu-376 --> Gln mutation on enthalpy and heat capacity changes for the binding of slightly altered ligands to medium chain acyl-CoA dehydrogenase. Protein Sci (2001) 0.81
Plasticity in protein-peptide recognition: crystal structures of two different peptides bound to concanavalin A. Biophys J (2001) 0.79
Dipole Moment and Binding Energy of Water in Proteins from Crystallographic Analysis. J Chem Theory Comput (2014) 0.78
Trapping of peptide-based surrogates in an artificially created channel of cytochrome c peroxidase. Protein Sci (2003) 0.77
Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing the Length of an Alkyl Chain. ACS Med Chem Lett (2013) 0.76
Dowser++, a new method of hydrating protein structures. Proteins (2016) 0.76
Free-energy calculations of residue mutations in a tripeptide using various methods to overcome inefficient sampling. J Comput Chem (2016) 0.75
Evidence that bacterial ABC-type transporter imports free EDTA for metabolism. J Bacteriol (2007) 0.75
Thermodynamic aspects of hydrophobicity and biological QSAR. J Comput Aided Mol Des (2001) 0.75
Hydrogen bonding and biological specificity analysed by protein engineering. Nature (1985) 6.20
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell (1997) 6.12
AAA+ superfamily ATPases: common structure--diverse function. Genes Cells (2001) 5.83
The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus). Cell (1984) 4.75
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO J (1998) 4.46
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem (1999) 4.02
The stereochemical mechanism of the cooperative effects in hemoglobin revisited. Annu Rev Biophys Biomol Struct (1998) 3.47
The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains. EMBO J (2000) 3.00
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. EMBO J (1999) 2.71
Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding. Nature (1982) 2.63
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell (1994) 2.61
TCR binding to peptide-MHC stabilizes a flexible recognition interface. Immunity (1999) 2.33
Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation. Biochemistry (1983) 2.31
Two EGF molecules contribute additively to stabilization of the EGFR dimer. EMBO J (1997) 2.16
The structural basis of sequence-independent peptide binding by OppA protein. Science (1994) 2.05
Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases. Site-directed mutagenesis of the ATP-dependent protease FtsH. J Biol Chem (1999) 1.97
The solution structure of human epidermal growth factor. Nature (1987) 1.94
Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure (1999) 1.74
The mechanism of autooxidation of myoglobin. J Biol Chem (1993) 1.71
Phosphorylated aspartate in the structure of a response regulator protein. J Mol Biol (1999) 1.66
Crystal structure of GerE, the ultimate transcriptional regulator of spore formation in Bacillus subtilis. J Mol Biol (2001) 1.62
The structure of the cofactor-binding fragment of the LysR family member, CysB: a familiar fold with a surprising subunit arrangement. Structure (1997) 1.50
Oligomerization of the chromatin-structuring protein H-NS. Mol Microbiol (2000) 1.50
Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies. J Mol Biol (1997) 1.48
An evolutionary link between sporulation and prophage induction in the structure of a repressor:anti-repressor complex. J Mol Biol (1998) 1.47
A large increase in enzyme-substrate affinity by protein engineering. Nature (1984) 1.46
Oligomeric structure of the Bacillus subtilis cell division protein DivIVA determined by transmission electron microscopy. Mol Microbiol (2004) 1.45
RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef. Biochemistry (1998) 1.43
Heller's myotomy with partial fundoplication. Br J Surg (1989) 1.41
The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin. Proteins (1997) 1.40
Injuries incurred at "roller discos". Br Med J (Clin Res Ed) (1982) 1.33
Structural factors governing azide and cyanide binding to mammalian metmyoglobins. J Biol Chem (1994) 1.31
The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form). J Mol Biol (1996) 1.30
The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands. Structure (1995) 1.28
Crystallisation of the Bacillus subtilis sporulation inhibitor SinR, complexed with its antagonist, SinI. FEBS Lett (1996) 1.26
Stability of myoglobin: a model for the folding of heme proteins. Biochemistry (1994) 1.23
Effects of cigarette smoking upon clinical outcomes of assisted reproduction: a meta-analysis. Hum Reprod Update (2008) 1.23
The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases. J Biol Chem (2001) 1.21
Ezetimibe monotherapy for cholesterol lowering in 2,722 people: systematic review and meta-analysis of randomized controlled trials. J Intern Med (2008) 1.20
The role of water in sequence-independent ligand binding by an oligopeptide transporter protein. Nat Struct Biol (1996) 1.15
Water-mediated protein-DNA interactions: the relationship of thermodynamics to structural detail. Protein Sci (1996) 1.13
Thermodynamic studies of tyrosyl-phosphopeptide binding to the SH2 domain of p56lck. Biochemistry (1994) 1.13
Reduction in CD4 binding affinity associated with removal of a single glycosylation site in the external glycoprotein of HIV-2. Virology (1991) 1.12
Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis. Acta Crystallogr D Biol Crystallogr (2006) 1.11
Proteolytic analysis of the FliH/FliI complex, the ATPase component of the type III flagellar export apparatus of Salmonella. J Mol Biol (2001) 1.10
Structural factors governing hemin dissociation from metmyoglobin. Biochemistry (1996) 1.10
The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon. J Mol Biol (1998) 1.09
A retrospective analysis of conservative versus active management in severe open myelomeningocele. Z Kinderchir Grenzgeb (1979) 1.08
The trans-activation domain of the sporulation response regulator Spo0A revealed by X-ray crystallography. Mol Microbiol (2000) 1.07
Structure and molecular model refinement of Aspergillus oryzae (TAKA) alpha-amylase: an application of the simulated-annealing method. Acta Crystallogr B (1991) 1.06
Alternative modes of binding of proteins with tandem SH2 domains. Protein Sci (2000) 1.05
Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: a thermodynamic study. Biochemistry (1998) 1.05
Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2. J Biol Chem (1994) 1.03
Domain swapping in the sporulation response regulator Spo0A. J Mol Biol (2000) 1.03
Probing histidine-substrate interactions in tyrosyl-tRNA synthetase using asparagine and glutamine replacements. Biochemistry (1985) 1.02
Peptide binding in OppA, the crystal structures of the periplasmic oligopeptide binding protein in the unliganded form and in complex with lysyllysine. Biochemistry (1997) 1.01
Expression of HIV-1 gp120 and human soluble CD4 by recombinant baculoviruses and their interaction in vitro. AIDS Res Hum Retroviruses (1990) 1.00
Alteration of axial coordination by protein engineering in myoglobin. Bisimidazole ligation in the His64-->Val/Val68-->His double mutant. J Biol Chem (1995) 0.99
The solution structure of human transforming growth factor alpha. Eur J Biochem (1991) 0.99
Distal pocket polarity in ligand binding to myoglobin: structural and functional characterization of a threonine68(E11) mutant. Biochemistry (1991) 0.98
Rapid nondestructive analysis of threading dislocations in wurtzite materials using the scanning electron microscope. Phys Rev Lett (2012) 0.98
Structure of the Bacillus cell fate determinant SpoIIAA in phosphorylated and unphosphorylated forms. Structure (2001) 0.97
Quaternary re-arrangement analysed by spectral enhancement: the interaction of a sporulation repressor with its antagonist. J Mol Biol (1999) 0.96
Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase. Biochemistry (1996) 0.96
Dynamics of a monomeric insulin analogue: testing the molten-globule hypothesis. Biochemistry (1993) 0.95
Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides. Structure (1998) 0.95
Structural characterization of the N-terminal oligomerization domain of the bacterial chromatin-structuring protein, H-NS. J Mol Biol (2001) 0.95
The functional similarity and structural diversity of human and cartilaginous fish hemoglobins. J Mol Biol (2001) 0.94
Interactions among residues CD3, E7, E10, and E11 in myoglobins: attempts to simulate the ligand-binding properties of Aplysia myoglobin. Biochemistry (1995) 0.94
Walking speed in children and young adults with neuromuscular disease: comparison between two assessment methods. J Pediatr Orthop (2003) 0.94
Relating structure to thermodynamics: the crystal structures and binding affinity of eight OppA-peptide complexes. Protein Sci (1999) 0.94
Mechanism of hydrogen cyanide binding to myoglobin. Biochemistry (1996) 0.93
Seat belt injury to ileostomy. Br Med J (1978) 0.93
Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6. Structure (2000) 0.93
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens. Acta Crystallogr D Biol Crystallogr (2006) 0.93
Dimer-induced signal propagation in Spo0A. Mol Microbiol (2004) 0.92
An unusual case of left paraduodenal hernia. Int J Clin Pract (2001) 0.92
Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy. Biochemistry (1993) 0.92
A ribonuclease S-peptide antagonist discovered with a bacteriophage display library. Gene (1993) 0.92
Specificity and interactions of the protein OppA: partitioning solvent binding effects using mass spectrometry. J Mol Biol (2000) 0.91
Proximal gastric vagotomy: follow-up at 10-20 years. Br J Surg (1991) 0.91
Contributions of residue 45(CD3) and heme-6-propionate to the biomolecular and geminate recombination reactions of myoglobin. Biochemistry (1991) 0.90
Characterization of sequence-specific DNA binding by the transcription factor Oct-1. Biochemistry (2000) 0.90
Probing the mechanism of ATP hydrolysis and substrate translocation in the AAA protease FtsH by modelling and mutagenesis. Mol Microbiol (2001) 0.90
Site-specific cation binding mediates TATA binding protein-DNA interaction from a hyperthermophilic archaeon. Biochemistry (2001) 0.89
The dimerization interface of the metastasis-associated protein S100A4 (Mts1): in vivo and in vitro studies. J Biol Chem (2001) 0.88
Tension in haemoglobin revealed by Fe-His(F8) bond rupture in the fully liganded T-state. J Mol Biol (1997) 0.87
Halophilic adaptation of protein-DNA interactions. Biochem Soc Trans (2003) 0.87
A structural characterization of the interactions between titin Z-repeats and the alpha-actinin C-terminal domain. Biochemistry (2001) 0.87
High resolution electron backscatter diffraction measurements of elastic strain variations in the presence of larger lattice rotations. Ultramicroscopy (2012) 0.86
Characterization of the CysB protein of Klebsiella aerogenes: direct evidence that N-acetylserine rather than O-acetylserine serves as the inducer of the cysteine regulon. Biochem J (1994) 0.86
RNA cleavage without hydrolysis. Splitting the catalytic activities of binase with Asn101 and Thr101 mutations. Protein Eng (1997) 0.85
Structural basis for recognition of dipeptides by peptide transporters. Arch Biochem Biophys (2000) 0.85
Measurement of residual elastic strain and lattice rotations with high resolution electron backscatter diffraction. Ultramicroscopy (2011) 0.84
Serine92 (F7) contributes to the control of heme reactivity and stability in myoglobin. Biochemistry (1993) 0.84