Published in Annu Rev Nutr on January 01, 1999
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A (2002) 4.22
Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study. Circ Cardiovasc Genet (2009) 1.71
A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. Eur J Epidemiol (2006) 1.68
Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J Nutr Biochem (2012) 1.65
Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism. J Neural Transm (Vienna) (2006) 1.43
The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism. Am J Hum Genet (2007) 1.42
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet (2009) 1.33
H2S protects against methionine-induced oxidative stress in brain endothelial cells. Antioxid Redox Signal (2009) 1.30
Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina. Toxicol Appl Pharmacol (2010) 1.30
Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res A Clin Mol Teratol (2009) 1.29
The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate. Brain Res Mol Brain Res (2004) 1.23
Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. Am J Clin Nutr (2009) 1.20
Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res (2009) 1.20
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proc Natl Acad Sci U S A (2003) 1.17
Mechanisms of cardiovascular remodeling in hyperhomocysteinemia. Antioxid Redox Signal (2011) 1.16
Glycine rectifies vascular dysfunction induced by dietary protein imbalance during pregnancy. J Physiol (2003) 1.16
Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution. Epidemiology (2010) 1.14
The annexin A2 system and vascular homeostasis. Vascul Pharmacol (2011) 1.14
One-carbon metabolism biomarkers and risk of colon and rectal cancers. Cancer Epidemiol Biomarkers Prev (2008) 1.14
Thiol reactive probes and chemosensors. Sensors (Basel) (2012) 1.12
Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. PLoS One (2011) 1.11
Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr (2009) 1.09
Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis. J Clin Invest (2009) 1.04
Nutri-epigenetics ameliorates blood-brain barrier damage and neurodegeneration in hyperhomocysteinemia: role of folic acid. J Mol Neurosci (2014) 1.03
Methionine metabolism in human pregnancy. Am J Clin Nutr (2009) 1.01
Hyperhomocysteinemia and neurologic disorders: a review. J Clin Neurol (2014) 1.00
Homocysteine, system b0,+ and the renal epithelial transport and toxicity of inorganic mercury. Am J Pathol (2004) 1.00
Gender differences in cardiovascular disease: hormonal and biochemical influences. Reprod Sci (2010) 0.99
Hydrogen sulfide mitigates matrix metalloproteinase-9 activity and neurovascular permeability in hyperhomocysteinemic mice. Neurochem Int (2009) 0.98
Low micronutrient levels as a predictor of incident disability in older women. Arch Intern Med (2006) 0.97
The use of orthologous sequences to predict the impact of amino acid substitutions on protein function. PLoS Genet (2010) 0.97
Homocysteine transport by systems L, A and y+L across the microvillous plasma membrane of human placenta. J Physiol (2009) 0.97
Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway. Acta Pharmacol Sin (2014) 0.97
The annexin A2/S100A10 system in health and disease: emerging paradigms. J Biomed Biotechnol (2012) 0.96
Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutr Res (2010) 0.95
Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection. Chem Biol Interact (2012) 0.95
Current understanding of lifestyle and environmental factors and risk of non-hodgkin lymphoma: an epidemiological update. J Cancer Epidemiol (2012) 0.95
DNA Methylation Variants at HIF3A Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts. Diabetes (2015) 0.93
Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients. Springerplus (2013) 0.92
Annexin A2 system in human biology: cell surface and beyond. Semin Thromb Hemost (2013) 0.92
Folic acid supplementation promotes mammary tumor progression in a rat model. PLoS One (2014) 0.92
Folate and vitamin B12 status of adolescent girls in northern Nigeria. J Natl Med Assoc (2000) 0.92
Homocysteine is associated with the progression of non-culprit coronary lesions in elderly acute coronary syndrome patients after percutaneous coronary intervention. J Geriatr Cardiol (2016) 0.90
Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c mediated autophagy in hyperhomocysteinemia mice after cerebral ischemia. J Mol Neurosci (2012) 0.90
Genetic and epigenetic factors: Role in male infertility. Indian J Urol (2011) 0.89
Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India. Eur J Clin Nutr (2010) 0.89
Mathematical model insights into arsenic detoxification. Theor Biol Med Model (2011) 0.89
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol (2014) 0.89
Epigenetic regulation of aortic remodeling in hyperhomocysteinemia. FASEB J (2014) 0.87
Mthfs is an Essential Gene in Mice and a Component of the Purinosome. Front Genet (2011) 0.87
Homocysteine induces apoptosis of rat hippocampal neurons by inhibiting 14-3-3ε expression and activating calcineurin. PLoS One (2012) 0.87
Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis. Graefes Arch Clin Exp Ophthalmol (2011) 0.86
Hyperhomocysteinemia decreases bone blood flow. Vasc Health Risk Manag (2011) 0.86
Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans. J Nutr (2011) 0.86
Nutrient intake values for folate during pregnancy and lactation vary widely around the world. Nutrients (2013) 0.85
Nutritional interventions in depression and perinatal depression. Yale J Biol Med (2013) 0.85
Creatine metabolism and safety profiles after six-week oral guanidinoacetic acid administration in healthy humans. Int J Med Sci (2013) 0.85
The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model. Mol Nutr Food Res (2012) 0.85
Peculiarities of one-carbon metabolism in the strict carnivorous cat and the role in feline hepatic lipidosis. Nutrients (2013) 0.85
Are dietary choline and betaine intakes determinants of total homocysteine concentration? Am J Clin Nutr (2010) 0.85
Prothrombotic States that Predispose to Stroke. Curr Treat Options Neurol (2002) 0.84
Association between intake of B vitamins and cognitive function in elderly Koreans with cognitive impairment. Nutr J (2014) 0.84
Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects. Int J Med Sci (2004) 0.84
Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. Nutr J (2012) 0.84
DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase. PLoS One (2009) 0.83
Inhibition of cystathionine β-synthase is associated with glucocorticoids over-secretion in psychological stress-induced hyperhomocystinemia rat liver. Cell Stress Chaperones (2013) 0.83
Plasma homocysteine and lipoprotein (a) levels in Turkish patients with metabolic syndrome. Heart Vessels (2005) 0.83
Betaine supplement enhances skeletal muscle differentiation in murine myoblasts via IGF-1 signaling activation. J Transl Med (2013) 0.83
Relation of resistin levels with C-reactve protein, homocysteine and uric acid in smokers and non-smokers. J Res Med Sci (2011) 0.83
Dietary fiber and fiber-rich food intake in relation to risk of stroke in male smokers. Eur J Clin Nutr (2009) 0.83
Dietary intake of folate, B-vitamins and methionine and breast cancer risk among Hispanic and non-Hispanic white women. PLoS One (2013) 0.83
Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia. Proc Natl Acad Sci U S A (2013) 0.82
Effects of heparin on the production of homocysteine-induced extracellular matrix metalloproteinase-2 in cultured rat vascular smooth muscle cells. Can J Cardiol (2007) 0.82
Notable epigenetic role of hyperhomocysteinemia in atherogenesis. Lipids Health Dis (2014) 0.82
Homocystinuria: Diagnosis and Neuroimaging Findings of Iranian Pediatric patients. Iran J Child Neurol (2015) 0.81
Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis. J Neurol (2007) 0.81
Plasma vitamin B(6) and risk of myocardial infarction in women. Circulation (2009) 0.81
Short-term creatine supplementation does not reduce increased homocysteine concentration induced by acute exercise in humans. Eur J Nutr (2013) 0.81
Dose-response effects of oral guanidinoacetic acid on serum creatine, homocysteine and B vitamins levels. Eur J Nutr (2014) 0.81
Assessment of lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1, interleukin-6, homocysteine, and uric acid levels in patients with psoriasis. Dis Markers (2014) 0.80
Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: a review. World J Gastroenterol (2015) 0.80
Homocysteine and asymmetric dimethylarginine in relation to B vitamins in elderly people. Wien Klin Wochenschr (2011) 0.80
High homocysteine induces betaine depletion. Biosci Rep (2015) 0.80
Daily rhythms in plasma levels of homocysteine. J Circadian Rhythms (2004) 0.80
Homocysteine in renovascular complications: hydrogen sulfide is a modulator and plausible anaerobic ATP generator. Nitric Oxide (2014) 0.80
Effect of vitamin B(6) deficiency on antioxidative status in rats with exercise-induced oxidative stress. Nutr Res Pract (2009) 0.80
Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice. Eur J Nutr (2012) 0.80
Effect of entacapone on plasma homocysteine levels in Parkinson's disease patients. Neurol Sci (2010) 0.80
Vitamin status and cognitive function in a long-term care population. BMC Geriatr (2005) 0.80
Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus. J Cell Mol Med (2008) 0.80
High levels of homocysteine results in cerebral amyloid angiopathy in mice. J Alzheimers Dis (2015) 0.79
Increased plasma homocysteine levels in shift working bus drivers. Occup Environ Med (2003) 0.79
Hydrogen sulfide deactivates common nitrobenzofurazan-based fluorescent thiol labeling reagents. Anal Chem (2014) 0.79
Association of homocysteine level with biopsy-proven non-alcoholic fatty liver disease: a meta-analysis. J Clin Biochem Nutr (2015) 0.79
Role of Oxytocin in deceleration of early atherosclerotic inflammatory processes in adult male rats. Int J Clin Exp Med (2011) 0.79
Oxidative stress impairs learning and memory in apoE knockout mice. Pharmacol Biochem Behav (2010) 0.79