Published in Nutr Res on July 01, 2010
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
Homocysteine imbalance: a pathological metabolic marker. Adv Nutr (2012) 1.14
Plasma lipids and betaine are related in an acute coronary syndrome cohort. PLoS One (2011) 0.97
Betaine and secondary events in an acute coronary syndrome cohort. PLoS One (2012) 0.90
Homocysteinemia in mice with genetic betaine homocysteine S-methyltransferase deficiency is independent of dietary folate intake. J Nutr (2012) 0.84
Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study. Cardiovasc Diabetol (2012) 0.84
Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity. Nutr Res (2011) 0.77
The contrasting relationships between betaine and homocysteine in two clinical cohorts are associated with plasma lipids and drug treatments. PLoS One (2012) 0.77
Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis. Nutrients (2017) 0.75
G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods (2007) 50.83
AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr (1993) 16.37
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med (2002) 11.20
Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med (1991) 6.03
Physiological actions of taurine. Physiol Rev (1992) 4.63
Homocysteine metabolism. Annu Rev Nutr (1999) 3.75
Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet (1995) 3.70
Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci U S A (1995) 3.51
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A (2001) 2.93
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Hum Mol Genet (2001) 2.93
A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands. Biochem Biophys Res Commun (1999) 1.77
Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. J Biol Chem (1984) 1.75
Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem (2003) 1.70
Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice. Circ Res (2004) 1.68
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci U S A (2006) 1.66
Is it time to reevaluate methyl balance in humans? Am J Clin Nutr (2006) 1.61
Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum Mutat (2007) 1.59
Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Hum Mol Genet (2005) 1.52
Glycine N-methyltransferase is a folate binding protein of rat liver cytosol. Proc Natl Acad Sci U S A (1984) 1.49
Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Am J Physiol Regul Integr Comp Physiol (2004) 1.47
Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase. Proc Natl Acad Sci U S A (1997) 1.44
Biochemical and evolutionary significance of phospholipid methylation. J Biol Chem (1998) 1.37
A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice. J Biol Chem (2003) 1.27
The potential protective effects of taurine on coronary heart disease. Atherosclerosis (2009) 1.27
Total homocysteine and cardiovascular disease. J Intern Med (1999) 1.23
Neural-tube defects and derangement of homocysteine metabolism. N Engl J Med (1991) 1.21
Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis (2003) 1.17
Male cardiovascular mortality and dietary markers in 25 population samples of 16 countries. J Hypertens (2006) 1.17
Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries: results from the WHO-CARDIAC study. Hypertens Res (2001) 1.16
Phenotype of the taurine transporter knockout mouse. Methods Enzymol (2007) 1.16
Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene. J Biol Chem (1999) 1.15
Phosphatidylethanolamine N-methyltransferase from rat liver. Methods Enzymol (1992) 1.14
Plasma homocysteine is regulated by phospholipid methylation. J Biol Chem (2002) 1.14
Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat. Clin Sci (Lond) (1991) 1.11
Immunohistochemical detection of betaine-homocysteine S-methyltransferase in human, pig, and rat liver and kidney. Arch Biochem Biophys (2001) 1.09
CTP: phosphocholine cytidylyltransferase from rat liver. Methods Enzymol (1981) 1.09
Plasma homocysteine predicts progression of atherosclerosis. Atherosclerosis (2005) 1.07
Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J Nutr (2006) 1.07
Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. Am J Med Genet A (2003) 1.06
Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption. Mol Genet Metab (2007) 1.03
Betaine-homocysteine methyltransferase (BHMT): genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans. Mol Genet Metab (2000) 0.98
Homocysteine transport by systems L, A and y+L across the microvillous plasma membrane of human placenta. J Physiol (2009) 0.97
Regulation of hepatic betaine-homocysteine methyltransferase by dietary betaine. J Nutr (1983) 0.94
Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting, methyl-deficient diets. Cancer Res (1989) 0.93
Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. Thromb Haemost (2010) 0.90
Retinoic acid and glucocorticoid treatment induce hepatic glycine N-methyltransferase and lower plasma homocysteine concentrations in rats and rat hepatoma cells. J Nutr (2003) 0.89
Regulation of hepatic betaine-homocysteine methyltransferase by dietary methionine. Biochem Biophys Res Commun (1982) 0.87
S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem (2006) 0.84
Triiodothyronine treatment attenuates the induction of hepatic glycine N-methyltransferase by retinoic acid and elevates plasma homocysteine concentrations in rats. J Nutr (2004) 0.78
The L-methionine-sparing effect of dietary glutathione in rats. J Nutr (1982) 0.78
Relative contributions of sulfur atoms of dietary cysteine and methionine to rat liver glutathione and proteins. J Biochem (1981) 0.78
Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study. Am J Obstet Gynecol (2008) 2.82
Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line. Cancer Res (2002) 2.35
Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood (2011) 2.02
Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease. Circ Res (2006) 1.99
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. J Biol Chem (2004) 1.77
Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice. Blood (2011) 1.77
Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice. Circ Res (2004) 1.68
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. FASEB J (2003) 1.59
Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Hum Mol Genet (2005) 1.52
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe. J Biol Chem (2007) 1.34
Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. FASEB J (2008) 1.32
Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy. Clin Cancer Res (2003) 1.31
Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice. Circulation (2009) 1.30
Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci U S A (2002) 1.28
Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. J Biol Chem (2004) 1.28
Extended spectrum beta-lactamases in Escherichia coli & Klebsiella pneumoniae & associated risk factors. Indian J Med Res (2009) 1.26
Betaine-homocysteine methyltransferase: zinc in a distorted barrel. Structure (2002) 1.26
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab (2007) 1.24
The role of cystathionine beta-synthase in homocysteine metabolism. Antioxid Redox Signal (2005) 1.20
Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice. Circ Res (2012) 1.18
Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis (2003) 1.17
Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. J Biol Chem (2003) 1.16
The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects. Hum Mutat (2009) 1.16
New insights into the regulation of methyl group and homocysteine metabolism. J Nutr (2007) 1.14
Vitamin A and its derivatives induce hepatic glycine N-methyltransferase and hypomethylation of DNA in rats. J Nutr (2002) 1.14
Chemical chaperone rescue of mutant human cystathionine beta-synthase. Mol Genet Metab (2007) 1.14
Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice. Am J Clin Nutr (2005) 1.11
Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype. Oncogene (2004) 1.11
Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A. J Biol Chem (2012) 1.09
Hepatitis B viremia is associated with increased risk of hepatocellular carcinoma in chronic carriers. J Med Virol (2004) 1.09
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Blood (2003) 1.09
Cystathionine beta-synthase p.S466L mutation causes hyperhomocysteinemia in mice. Hum Mutat (2008) 1.08
Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. FASEB J (2009) 1.07
Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J Nutr (2006) 1.07
Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. Am J Med Genet A (2003) 1.06
Spina bifida, folate metabolism, and dietary folate intake in a Northern Canadian aboriginal population. Int J Circumpolar Health (2002) 1.04
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma. Cancer Res (2009) 1.04
Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase. Proteins (2010) 1.03
Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone. J Biol Chem (2008) 1.03
Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Clin Cancer Res (2004) 1.02
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. J Biol Chem (2008) 1.02
Serum amino acid levels as a biomarker for renal cell carcinoma. J Urol (2011) 1.02
Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism. J Nutr (2010) 1.01
Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. Am J Physiol Endocrinol Metab (2005) 1.01
S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine beta-synthase. Mol Genet Metab (2002) 1.00
Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. Biochemistry (2004) 1.00
A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment. Mol Genet Metab (2010) 1.00
Type I diabetes leads to tissue-specific DNA hypomethylation in male rats. J Nutr (2008) 0.99
Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates. J Nutr (2004) 0.98
Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis (2003) 0.98
ApcMin/+ mouse model of colon cancer: gene expression profiling in tumors. J Cell Biochem (2004) 0.98
Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. Arterioscler Thromb Vasc Biol (2003) 0.98
Tissue-specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat. Diabetes Metab Res Rev (2012) 0.97
High intake of folic acid disrupts embryonic development in mice. Birth Defects Res A Clin Mol Teratol (2010) 0.97
Functional rescue of mutant human cystathionine beta-synthase by manipulation of Hsp26 and Hsp70 levels in Saccharomyces cerevisiae. J Biol Chem (2008) 0.96
Epigenetics in adipose tissue, obesity, weight loss, and diabetes. Adv Nutr (2014) 0.96
Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activated receptor gamma agonist in an in vivo mouse model of spontaneous breast cancer. Clin Cancer Res (2008) 0.95
Homocysteine metabolism and its relation to health and disease. Biofactors (2010) 0.95
Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c. Cancer Res (2006) 0.95
Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus. Mol Genet Metab (2012) 0.95
Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk. Mol Genet Metab (2003) 0.95
Oligomerization is required for betaine-homocysteine S-methyltransferase function. Arch Biochem Biophys (2004) 0.94
Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes. J Inherit Metab Dis (2010) 0.94
Chemoradiation with hyperthermia in the treatment of head and neck cancer. Int J Hyperthermia (2010) 0.94
Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice. Mol Genet Metab (2008) 0.94
Cystathionine beta-synthase deficiency causes fat loss in mice. PLoS One (2011) 0.93
High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney. Am J Physiol Regul Integr Comp Physiol (2004) 0.92
Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency. Biochem J (2004) 0.92
Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice. Am J Clin Nutr (2010) 0.91
Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells. Cancer Biol Ther (2012) 0.91
Effectiveness of an essential oil mouthrinse in improving oral health in orthodontic patients. Angle Orthod (2008) 0.91
SLC7A9 mutations in all three cystinuria subtypes. Kidney Int (2002) 0.90
Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer. J Biol Chem (2007) 0.90
Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid. Atherosclerosis (2003) 0.90
Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice. Birth Defects Res A Clin Mol Teratol (2009) 0.90
Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase. Int J Dev Neurosci (2005) 0.90
Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. J Biol Chem (2004) 0.90
Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption. Am J Obstet Gynecol (2007) 0.90
Retinoic acid and glucocorticoid treatment induce hepatic glycine N-methyltransferase and lower plasma homocysteine concentrations in rats and rat hepatoma cells. J Nutr (2003) 0.89
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice. Carcinogenesis (2003) 0.89
Primary pyomyositis in a child. Int J Infect Dis (2008) 0.89
Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70. PLoS Genet (2010) 0.89
All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats. J Nutr (2003) 0.89
Risk of congenital heart defects is influenced by genetic variation in folate metabolism. Cardiol Young (2012) 0.88
Methionine-deficient diet induces post-transcriptional downregulation of cystathionine β-synthase. Nutrition (2009) 0.88
Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation. Biol Reprod (2004) 0.88
Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice. Endocrinology (2010) 0.88