Published in Infect Immun on September 01, 1999
Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc Natl Acad Sci U S A (2000) 3.07
ESAT-6 subunit vaccination against Mycobacterium tuberculosis. Infect Immun (2000) 2.87
Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6. Infect Immun (2001) 2.62
Comparative immune response to PE and PE_PGRS antigens of Mycobacterium tuberculosis. Infect Immun (2001) 2.26
DNA vaccination against tuberculosis: expression of a ubiquitin-conjugated tuberculosis protein enhances antimycobacterial immunity. Infect Immun (2000) 1.33
Functional domains present in the mycobacterial hemagglutinin, HBHA. J Bacteriol (1999) 1.32
responses of mycobacterium tuberculosis to growth in the mouse lung. Infect Immun (2005) 1.31
DNA vaccine combinations expressing either tissue plasminogen activator signal sequence fusion proteins or ubiquitin-conjugated antigens induce sustained protective immunity in a mouse model of pulmonary tuberculosis. Infect Immun (2002) 1.19
The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis. Infect Immun (2004) 1.17
Immunization with a DNA vaccine cocktail protects mice lacking CD4 cells against an aerogenic infection with Mycobacterium tuberculosis. Infect Immun (2004) 1.13
Plasmid DNA vaccine vector design: impact on efficacy, safety and upstream production. Biotechnol Adv (2009) 1.12
Vaccine-induced immune responses in rodents and nonhuman primates by use of a humanized human immunodeficiency virus type 1 pol gene. J Virol (2002) 1.07
Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation. Immunology (2001) 1.05
On the use of DNA vaccines for the prophylaxis of mycobacterial diseases. Infect Immun (2003) 1.02
Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis bacillus Calmette-Guérin strains expressing the antigen ESAT-6 from Mycobacterium tuberculosis. Infect Immun (2003) 1.01
DNA immunization in a mouse model of latent tuberculosis: effect of DNA vaccination on reactivation of disease and on reinfection with a secondary challenge. Infect Immun (2002) 0.98
DNA-Salmonella enterica serovar Typhimurium primer-booster vaccination biases towards T helper 1 responses and enhances protection against Leishmania major infection in mice. Infect Immun (2004) 0.92
Vaccination with a Sindbis virus-based DNA vaccine expressing antigen 85B induces protective immunity against Mycobacterium tuberculosis. Infect Immun (2005) 0.92
Role of signal sequence in vaccine-induced protection against experimental coccidioidomycosis. Infect Immun (2002) 0.90
Surface expression of MPT64 as a fusion with the PE domain of PE_PGRS33 enhances Mycobacterium bovis BCG protective activity against Mycobacterium tuberculosis in mice. Infect Immun (2010) 0.89
Analysis of known bacterial protein vaccine antigens reveals biased physical properties and amino acid composition. Comp Funct Genomics (2003) 0.89
Vector Design for Improved DNA Vaccine Efficacy, Safety and Production. Vaccines (Basel) (2013) 0.88
Protection against virulent Mycobacterium avium infection following DNA vaccination with the 35-kilodalton antigen is accompanied by induction of gamma interferon-secreting CD4(+) T cells. Infect Immun (2000) 0.87
Protective and therapeutic efficacy of Mycobacterium smegmatis expressing HBHA-hIL12 fusion protein against Mycobacterium tuberculosis in mice. PLoS One (2012) 0.81
Bioinformatics in new generation flavivirus vaccines. J Biomed Biotechnol (2010) 0.81
The PPE domain of PPE17 is responsible for its surface localization and can be used to express heterologous proteins on the mycobacterial surface. PLoS One (2013) 0.80
Multivalent TB vaccines targeting the esx gene family generate potent and broad cell-mediated immune responses superior to BCG. Hum Vaccin Immunother (2014) 0.79
Design, Construction and Cloning of Truncated ORF2 and tPAsp-PADRE-Truncated ORF2 Gene Cassette From Hepatitis E Virus in the pVAX1 Expression Vector. Jundishapur J Microbiol (2015) 0.78
Manipulation of BCG vaccine: a double-edged sword. Eur J Clin Microbiol Infect Dis (2016) 0.77
Expression library immunization: a road map for discovery of vaccines against infectious diseases. Infect Immun (2005) 0.76
Construction and evaluation of the novel DNA vaccine harboring the inhibin α (1-32) and the RF-amide related peptide-3 genes for improving fertility in mice. Exp Anim (2015) 0.75
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med (1993) 18.56
Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med (1993) 17.01
Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. JAMA (1994) 14.96
Global surveillance for antituberculosis-drug resistance, 1994-1997. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance. N Engl J Med (1998) 10.78
Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity (1995) 10.65
A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. N Engl J Med (1996) 7.66
Global tuberculosis incidence and mortality during 1990-2000. Bull World Health Organ (1994) 6.11
Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature (1988) 5.56
Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat Med (1996) 5.38
DNA vaccines. Annu Rev Immunol (1997) 5.05
An antimicrobial activity of cytolytic T cells mediated by granulysin. Science (1998) 5.02
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J Exp Med (1995) 4.21
Multidrug-resistant tuberculosis. Ann Intern Med (1992) 4.06
Vaccination against tuberculosis by DNA injection. Nat Med (1996) 3.76
A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science (1995) 3.58
Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis. Infect Immun (1998) 3.14
Key epitopes on the ESAT-6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis. J Immunol (1996) 2.80
Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. Infect Immun (1999) 2.57
T-cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect Immun (1995) 2.57
Expression of katG in Mycobacterium tuberculosis is associated with its growth and persistence in mice and guinea pigs. J Infect Dis (1998) 2.07
CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity. Eur J Immunol (1994) 2.00
Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis. Tuber Lung Dis (1997) 1.76
Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin. Proc Natl Acad Sci U S A (1998) 1.76
Functions and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection. J Immunol (1997) 1.76
DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction. J Virol (1997) 1.69
Protection to mice afforded by BCG vaccines against an aerogenic challenge by three mycobacteria of decreasing virulence. Tubercle (1985) 1.60
DNA immunization against herpes simplex virus: enhanced efficacy using a Sindbis virus-based vector. J Virol (1998) 1.57
Protection against tuberculosis by a plasmid DNA vaccine. Vaccine (1997) 1.48
A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung. Proc Natl Acad Sci U S A (1996) 1.44
Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys. J Virol (1996) 1.29
Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes. J Immunol (1996) 1.17
Clinical evaluation of MPT-64 and MPT-59, two proteins secreted from Mycobacterium tuberculosis, for skin test reagents. Tuber Lung Dis (1996) 1.10
Induction of neonatal tolerance by plasmid DNA vaccination of mice. J Clin Invest (1996) 1.08
Deoxyribonucleic acid vaccines encoding antigens with rapid proteasome-dependent degradation are highly efficient inducers of cytolytic T lymphocytes. J Immunol (1997) 1.06
Genetic immunization: a new era in vaccines and immune therapeutics. FASEB J (1997) 1.05
Induction of humoral and cellular immune responses by vaccination with M. tuberculosis antigen 85 DNA. Cell Mol Biol (Noisy-le-grand) (1997) 0.99
Comparative study of DNA-based immunization vectors: effect of secretion signals on the antibody responses in mice. FEMS Immunol Med Microbiol (1997) 0.94
DNA vaccines: application to tuberculosis. Int J Tuberc Lung Dis (1998) 0.94
Antibody response and protective capacity of plasmid vaccines expressing three different herpes simplex virus glycoproteins. J Infect Dis (1998) 0.87
Intranasal administration of HIV-DNA vaccine formulated with a polymer, carboxymethylcellulose, augments mucosal antibody production and cell-mediated immune response. Clin Immunol Immunopathol (1998) 0.83
Tuberculosis vaccines: how close to human testing? Tuber Lung Dis (1997) 0.81
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Effects of the obese gene product on body weight regulation in ob/ob mice. Science (1995) 13.57
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (1999) 13.19
Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell (1996) 10.40
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science (1993) 6.73
Risk of adverse birth outcomes in populations living near landfill sites. BMJ (2001) 4.96
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell (1990) 4.12
Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care (1998) 3.99
On the presence of a volatile organic chlorine compound in blood. Biochem J (1930) 3.85
Expectations and high school change: teacher-researcher collaboration to prevent school failure. Am J Community Psychol (1991) 3.62
Interpretation of electrocardiograms by doctors. BMJ (1994) 3.48
The laryngeal mask airway: its features, effects and role. Can J Anaesth (1994) 3.23
A human serum immunoglobulin with specificity for certain homologous target cells, which induces target cell damage by normal human lymphocytes. Immunology (1969) 3.12
Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells. Infect Immun (2001) 2.98
Evidence for a prostate cancer susceptibility locus on the X chromosome. Nat Genet (1998) 2.90
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. Science (1995) 2.87
The digestibility of dietary protein in the ruminant: Endogenous nitrogen excretion on a low nitrogen diet and in starvation. Biochem J (1936) 2.73
The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination. Nature (2001) 2.65
Functional recovery in parkinsonian monkeys treated with GDNF. Nature (1996) 2.35
Human cytomegalovirus-specific cytotoxic T lymphocytes: requirements for in vitro generation and specificity. Eur J Immunol (1983) 2.34
Appropriate size and inflation of the laryngeal mask airway. Br J Anaesth (1998) 2.33
Impact of vitamin A supplementation on childhood morbidity in northern Ghana. Lancet (1992) 2.31
Mutation in codon 713 of the beta amyloid precursor protein gene presenting with schizophrenia. Nat Genet (1992) 2.27
Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours. Nat Genet (2000) 2.26
Biochemical and genetic data suggest that InhA is not the primary target for activated isoniazid in Mycobacterium tuberculosis. J Infect Dis (1996) 2.13
Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results. J Biomed Opt (2000) 2.09
Purification and structural analysis of the fourth component of human complement. Biochemistry (1977) 2.08
Expression of katG in Mycobacterium tuberculosis is associated with its growth and persistence in mice and guinea pigs. J Infect Dis (1998) 2.07
The oxytocic property of the blood of the cow. J Physiol (1934) 2.06
Chronic widespread pain in the community: the influence of psychological symptoms and mental disorder on healthcare seeking behavior. J Rheumatol (1999) 1.90
A medium-density genetic linkage map of the bovine genome. Mamm Genome (1997) 1.85
Recruitment experience in the first phase of the African American Hereditary Prostate Cancer (AAHPC) study. Ann Epidemiol (2000) 1.79
Temperature, housing, deprivation and their relationship to excess winter mortality in Great Britain, 1986-1996. Int J Epidemiol (2001) 1.79
Quantitation of human cytomegalovirus DNA from peripheral blood cells of human immunodeficiency virus-infected patients could predict cytomegalovirus retinitis. J Infect Dis (1995) 1.77
Spectroscopic confirmation of a galaxy at redshift z = 8.6. Nature (2010) 1.72
Human cytomegalovirus (CMV) DNA in plasma reflects quantity of CMV DNA present in leukocytes. J Clin Microbiol (1995) 1.69
Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors. Antimicrob Agents Chemother (2000) 1.66
Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts. Oncogene (1993) 1.61
Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor. Science (1991) 1.58
Genetic information and the workplace: legislative approaches and policy changes. Science (1997) 1.56
Recurrent transverse myelitis associates with anti-Ro (SSA) autoantibodies. Neurology (2004) 1.55
Outcome following deep wound contamination in cemented arthroplasty. Int Orthop (2006) 1.54
The effect of respirator training on the ability of healthcare workers to pass a qualitative fit test. Infect Control Hosp Epidemiol (1996) 1.52
Induction of neurite outgrowth by a conditioned-medium factor bound to the culture substratum. Proc Natl Acad Sci U S A (1978) 1.52
Short- and long-term outcomes of children with complex regional pain syndrome type I treated with exercise therapy. Clin J Pain (1999) 1.50
Purification, cloning, and expression of ciliary neurotrophic factor (CNTF). Science (1989) 1.50
Comparison of morphine alone with morphine plus clonidine for postoperative patient-controlled analgesia. Br J Anaesth (2002) 1.50
Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments. Nucleic Acids Res (2001) 1.49
A simple effective clean practice protocol significantly improves hand decontamination and infection control measures in the acute surgical setting. Infection (2008) 1.49
In search of susceptibility genes for type 2 diabetes in West Africa: the design and results of the first phase of the AADM study. Ann Epidemiol (2001) 1.49
Evaluation of a nonradiometric system (BACTEC 9000 MB) for detection of mycobacteria in human clinical samples. J Clin Microbiol (1997) 1.48
Hospital-based needlestick use and injuries by Dublin interns in 2010. Ir J Med Sci (2011) 1.43
Underpowered and overbiased? Potentially unfair to the single-use bougie. Anaesthesia (2003) 1.42
Levonorgestrel-releasing (20 microgram/day) intrauterine systems (Mirena) compared with other methods of reversible contraceptives. BJOG (2000) 1.42
Red cell membrane fatty acids, cytosolic phospholipase-A2 and schizophrenia. Schizophr Res (1998) 1.42
Damage to the laryngeal mask by residual fluid in the cuff. Anaesthesia (1997) 1.39
Auscultation of the chest after tracheal intubation. Anaesthesia (2004) 1.38
Axon initiation by ciliary neurons in culture. Dev Biol (1978) 1.38
Teaching fibreoptic intubation. Effect of alfentanil on the haemodynamic response. Anaesthesia (1994) 1.38
The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis. Blood (1996) 1.37
Marfan syndrome: no evidence for heterogeneity in different populations, and more precise mapping of the gene. Am J Hum Genet (1991) 1.35
DNA vaccination against tuberculosis: expression of a ubiquitin-conjugated tuberculosis protein enhances antimycobacterial immunity. Infect Immun (2000) 1.33
Sequences of human repetitive DNA, non-alpha-globin genes, and major histocompatibility locus genes. Cold Spring Harb Symp Quant Biol (1983) 1.33
A survey of nosocomial respiratory viral infections in a children's hospital: occult respiratory infection in patients admitted during an epidemic season. Infect Control Hosp Epidemiol (1991) 1.33
The association between chronic widespread pain and mental disorder: a population-based study. Arthritis Rheum (2000) 1.32
Cytotoxicity of immune guinea-pig cells. II. The mechanism of macrophage cytotoxicity. Immunology (1973) 1.30
Lack of effect of codeine in the treatment of cough associated with acute upper respiratory tract infection. J Clin Pharm Ther (1992) 1.29
Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. Brain Res Bull (1995) 1.29
Effector activating determinants on IgG. I. The distribution and factors influencing the display of complement, neutrophil and cytotoxic B-cell determinants on human IgG sub-classes. Immunology (1973) 1.29
Surveillance of insecticide resistance in head lice using biochemical and molecular methods. Arch Dis Child (2006) 1.29
Clinical effects of clozapine in chronic schizophrenia: response to treatment and predictors of outcome. Am J Psychiatry (1994) 1.29
Voluntary suppression of cough induced by inhalation of capsaicin in healthy volunteers. Respir Med (1993) 1.28
Complement deficiency and nephritis. A report of a family. Lancet (1980) 1.27
Evidence for correlation between the antigenic specificity and charge of human IgG. A study of antibody-inducing lymphocyte mediated cell damage. Immunology (1972) 1.25
IgA deficiency in juvenile chronic polyarthritis. J Rheumatol (1979) 1.23
Pneumococcal carriage amongst Australian aborigines in Alice Springs, Northern Territory. J Hyg (Lond) (1985) 1.22
The presence of a magnocellular defect depends on the type of dyslexia. Vision Res (1996) 1.21
Microvascular pericyte contractility in vitro: comparison with other cells of the vascular wall. J Cell Biol (1987) 1.21
Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp Neurol (1993) 1.19
CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis. Infect Immun (2000) 1.19
Markers for monitoring overtraining and recovery. Med Sci Sports Exerc (1995) 1.18
Multiple congenital defects associated with maternal use of topical tretinoin. Lancet (1993) 1.18
Exposure of juvenile roach (Rutilus rutilus) to treated sewage effluent induces dose-dependent and persistent disruption in gonadal duct development. Environ Sci Technol (2001) 1.18
The immunogenicity of single and combination DNA vaccines against tuberculosis. Vaccine (2000) 1.17
Differences in expression of homeobox transcription factors in proximal and distal human small intestine. Gastroenterology (1997) 1.17
Invasive meningococcal disease in Canada, 1 January 1997 to 31 December 1998. Can Commun Dis Rep (2000) 1.17
fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children. Brain (2008) 1.14
Role for GDNF in biochemical and behavioral adaptations to drugs of abuse. Neuron (2000) 1.14
Multiple biological roles associated with the Rous sarcoma virus 5' untranslated RNA U5-IR stem and loop. J Virol (1997) 1.14
The DNA mismatch repair enzyme PMS1 is a myositis-specific autoantigen. Arthritis Rheum (2001) 1.14
Markers of low level arsenic exposure for evaluating human cancer risks in a US population. Int J Occup Med Environ Health (2001) 1.13
Associations between adverse events in childhood and chronic widespread pain in adulthood: are they explained by differential recall? J Rheumatol (2001) 1.13
Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ (2013) 1.13
A reevaluation of the fertilizin hypothesis of sperm agglutination and the description of a novel form of sperm adhesion. Dev Biol (1976) 1.13
Use of a behavioural programme in the first 3 months to prevent infant crying and sleeping problems. J Paediatr Child Health (2001) 1.13