Published in Nat Med on September 01, 1999
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Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. J Cell Biol (2003) 2.13
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APC mutations are sufficient for the growth of early colorectal adenomas. Proc Natl Acad Sci U S A (2000) 1.41
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More than two decades of Apc modeling in rodents. Biochim Biophys Acta (2013) 0.91
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The in vivo rate of somatic adenomatous polyposis coli mutation. Am J Pathol (2008) 0.88
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Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients. PLoS One (2011) 0.87
The mini-driver model of polygenic cancer evolution. Nat Rev Cancer (2015) 0.87
Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant. Am J Hum Genet (2016) 0.87
Location in the large bowel influences the APC mutations observed in FAP adenomas. Fam Cancer (2010) 0.87
Age related shift in the mutation spectra of germline and somatic NF2 mutations: hypothetical role of DNA repair mechanisms. J Med Genet (2005) 0.85
A De Novo Germline APC Mutation (3927del5) in a Patient with Familial Adenomatous Polyposis: Case Report and Literature Review. Clin Med Insights Oncol (2012) 0.84
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Extra-abdominal desmoid tumors associated with familial adenomatous polyposis. Sarcoma (2012) 0.83
The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma. Semin Oncol (2006) 0.83
Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc(-/+) mice. BMC Cancer (2013) 0.83
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Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP. J Med Genet (2007) 0.80
Expression Profiles in Stage II Colon Cancer According to APC Gene Status. Transl Oncol (2012) 0.79
The C-terminus of Apc does not influence intestinal adenoma development or progression. J Pathol (2011) 0.79
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Two Chinese pedigrees for adenomatous polyposis coli: new mutations at codon 1309 and predisposition to phenotypic variations. Fam Cancer (2014) 0.78
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Germline and somatic mutations of the APC gene in papillary thyroid carcinoma associated with familial adenomatous polyposis: Analysis of three cases and a review of the literature. Oncol Lett (2015) 0.78
Three novel mutations of APC gene in Chinese patients with familial adenomatous polyposis. Tumour Biol (2016) 0.78
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Novel mutations of the APC gene and genetic consequences of splicing mutations in the Czech FAP families. Fam Cancer (2013) 0.76
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Gastric tumours in FAP. Fam Cancer (2017) 0.75
CD24 and APC Genetic Polymorphisms in Pancreatic Cancers as Potential Biomarkers for Clinical Outcome. PLoS One (2015) 0.75
Germline APC Mutation and Familial Barrett Esophagus: Causal or Coincidence? Gastroenterol Hepatol (N Y) (2011) 0.75
A Patient With Gardner's Syndrome and Familial Adenomatous Polyposis Presenting With Extra-abdominal Desmoid Tumors and Diffuse Intestinal Polyposis. ACG Case Rep J (2015) 0.75
The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells. BMC Cancer (2016) 0.75
Analysis of bacteria from intestinal tract of FAP patients for the presence of APC-like sequences. Med Sci Monit (2012) 0.75
Mutation analysis of 13 driver genes of colorectal cancer-related pathways in Taiwanese patients. World J Gastroenterol (2016) 0.75
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Deficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology. World J Gastroenterol (2006) 0.75
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Colorectal tumors from APC*I1307K carriers principally harbor somatic APC mutations outside the A8 tract. PLoS One (2014) 0.75
Suppression of intestinal tumorigenesis in Apc mutant mice by Musashi-1 deletion. J Cell Sci (2017) 0.75
Mutational Heterogeneity in APC and KRAS Arises at the Crypt level and Leads to Polyclonality in Early Colorectal Tumorigenesis. Clin Cancer Res (2017) 0.75
Profuse familial adenomatous polyposis with an adenomatous polyposis coli exon 3 mutation. Fam Cancer (2001) 0.75
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