Published in Proc Natl Acad Sci U S A on September 01, 1998
Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet (2008) 13.95
Genetic susceptibility to non-polyposis colorectal cancer. J Med Genet (1999) 4.16
Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas. Proc Natl Acad Sci U S A (2004) 3.62
The empirical power of rare variant association methods: results from sanger sequencing in 1,998 individuals. PLoS Genet (2012) 2.86
Cancer genetics: colorectal cancer as a model. J Hum Genet (2006) 1.64
Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1. Proc Natl Acad Sci U S A (1999) 1.45
Evolution of the nomenclature for the hereditary colorectal cancer syndromes. Fam Cancer (2005) 1.40
Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism. Am J Hum Genet (1999) 1.26
Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells. Proc Natl Acad Sci U S A (1999) 1.23
Genetic and clinical characterisation of familial adenomatous polyposis: a population based study. Gut (2002) 1.16
Notable intrafamilial phenotypic variability in a kindred with familial adenomatous polyposis and an APC mutation in exon 9. Gut (1999) 1.10
Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes. Gut (2001) 1.05
Alkaline-mediated differential interaction (AMDI): a simple automatable single-nucleotide polymorphism assay. Proc Natl Acad Sci U S A (2001) 1.03
Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families. Mutat Res (2009) 1.00
A novel function of adenomatous polyposis coli (APC) in regulating DNA repair. Cancer Lett (2008) 0.99
The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea. Gut (2000) 0.98
Familial adenomatous polyposis: more evidence for disease diversity and genetic heterogeneity. Gut (2001) 0.97
A robust model-free approach for rare variants association studies incorporating gene-gene and gene-environmental interactions. PLoS One (2013) 0.96
Flavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapies. Int J Mol Sci (2014) 0.89
Germline Missense Changes in the APC Gene and Their Relationship to Disease. Hered Cancer Clin Pract (2004) 0.87
Increased variance in germline allele-specific expression of APC associates with colorectal cancer. Gastroenterology (2011) 0.87
SEQCHIP: a powerful method to integrate sequence and genotype data for the detection of rare variant associations. Bioinformatics (2012) 0.86
PATH-SCAN: a reporting tool for identifying clinically actionable variants. Pac Symp Biocomput (2014) 0.85
Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk. Dis Colon Rectum (2008) 0.83
Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer. J Hum Genet (2012) 0.83
Familial colorectal cancer type X syndrome: two distinct molecular entities? Fam Cancer (2011) 0.82
Polymorphisms in the adenomatous polyposis coli (APC) gene and advanced colorectal adenoma risk. Eur J Cancer (2010) 0.82
Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients. J Hum Genet (2010) 0.82
A novel approach for the simultaneous analysis of common and rare variants in complex traits. Bioinform Biol Insights (2012) 0.81
Single nucleotide polymorphisms of the APC gene and colorectal cancer risk: a case-control study in Taiwan. BMC Cancer (2006) 0.80
A single nucleotide primer extension assay to detect the APC I1307K gene variant. J Mol Diagn (2003) 0.80
Genetic factors and colorectal cancer in Ashkenazi Jews. Fam Cancer (2004) 0.80
Genetic analysis of the APC gene regions involved in attenuated APC phenotype in Israeli patients with early onset and familial colorectal cancer. Br J Cancer (2001) 0.80
A novel pathogenic germline mutation in the adenomatous polyposis coli gene in a Tunisian family with FAP. Fam Cancer (2011) 0.79
Association of polymorphisms in mitofusin-2 gene with type 2 diabetes in Han Chinese. J Biomed Biotechnol (2012) 0.79
Genetic testing for colon cancer: joint statement of the American College of Medical Genetics and American Society of Human Genetics. Joint Test and Technology Transfer Committee Working Group. Genet Med (2001) 0.78
N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer. Int J Colorectal Dis (2006) 0.78
Detecting low penetrance genes in cancer: the way ahead. J Med Genet (2000) 0.77
Reconstructed beta-catenin/TCF4 signaling in yeast applicable to functional evaluation of APC mutations. Am J Pathol (2003) 0.77
Analysis of candidate genes in occurrence and growth of colorectal adenomas. J Oncol (2009) 0.75
Application of computational methods in genetic study of inflammatory bowel disease. World J Gastroenterol (2016) 0.75
APC Yin-Yang haplotype associated with colorectal cancer risk. Exp Ther Med (2010) 0.75
Trans-ethnic follow-up of breast cancer GWAS hits using the preferential linkage disequilibrium approach. Oncotarget (2016) 0.75
Detection of a Tumor Suppressor Gene Variant Predisposing to Colorectal Cancer in an 18th Century Hungarian Mummy. PLoS One (2016) 0.75
Some aspects of molecular diagnostics in Lynch syndrome. Hered Cancer Clin Pract (2006) 0.75
Association of APC I1307K and E1317Q polymorphisms with colorectal cancer among Egyptian subjects. Fam Cancer (2016) 0.75
Colorectal tumors from APC*I1307K carriers principally harbor somatic APC mutations outside the A8 tract. PLoS One (2014) 0.75
Colonic Adenomas Do Not Cosegregate with the I1307K APC Missense Mutation in an Israeli Non-Ashkenazi Family. Dig Dis Sci (2005) 0.75
Novel APC gene mutations associated with protein alteration in diffuse type gastric cancer. BMC Med Genet (2017) 0.75
Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS). Nucleic Acids Res (1989) 15.35
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet (1992) 5.14
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet (1997) 4.86
Alleles of the APC gene: an attenuated form of familial polyposis. Cell (1993) 3.84
Mutations of the APC (adenomatous polyposis coli) gene. Hum Mutat (1993) 2.63
APC gene: database of germline and somatic mutations in human tumors and cell lines. Nucleic Acids Res (1996) 2.26
Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli. Hum Genet (1996) 1.67
Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein. Hum Genet (1996) 1.55
Mixed epithelial polyps in association with hereditary non-polyposis colorectal cancer providing an alternative pathway of cancer histogenesis. Pathology (1997) 1.51
CA repeat polymorphism at the D5S82 locus, proximal to adenomatous polyposis coli (APC). Nucleic Acids Res (1991) 1.29
The HLA system and the analysis of multifactorial genetic disease. Trends Genet (1995) 1.28
A CA-repeat polymorphism close to the adenomatous polyposis coli (APC) gene offers improved diagnostic testing for familial APC. Am J Hum Genet (1993) 1.21
CA repeat polymorphism at the D5S299 locus linked to adenomatous polyposis coli (APC). Nucleic Acids Res (1991) 1.18
The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds. Cancer Res (1997) 1.12
Germline APC mutation (Gln1317) in a cancer-prone family that does not result in familial adenomatous polyposis. Genes Chromosomes Cancer (1996) 1.11
APC mutations in familial adenomatous polyposis families in the Northwest of England. Hum Mutat (1997) 1.10
Multiple polyps of esophagus, stomach, colon, and rectum accompanying rectal cancer in a patient with constitutional chromosomal inversion. Cancer (1993) 0.87
Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell (1978) 14.82
Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature (1987) 10.21
The number of balanced polymorphisms that can be maintained in a natural population. Genetics (1967) 8.80
Linkage and selection: theoretical analysis of the deterministic two locus random mating model. Genetics (1967) 7.12
Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science (1998) 7.08
Monoclonal antibodies for analysis of the HLA system. Immunol Rev (1979) 6.63
A prospective study of colonoscopy practice in the UK today: are we adequately prepared for national colorectal cancer screening tomorrow? Gut (2004) 5.97
HL-A, immune-response genes, and disease. Lancet (1974) 5.67
p53 mutations in colorectal cancer. Proc Natl Acad Sci U S A (1990) 5.43
Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C, antigens. J Immunol (1979) 5.06
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation. Hum Mol Genet (1998) 4.72
A migration matrix model for the study of random genetic drift. Genetics (1968) 4.59
Chromosome 5 allele loss in human colorectal carcinomas. Nature (1987) 4.46
HL-A antigens and disease. Statistical and genetical considerations. Tissue Antigens (1974) 4.41
Monoclonal antibody to cytokeratin for use in routine histopathology. J Clin Pathol (1984) 4.36
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci U S A (1999) 4.35
The ABC of APC. Hum Mol Genet (2001) 4.16
Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas. Proc Natl Acad Sci U S A (1995) 4.15
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet (2005) 4.12
Evolutionary significance of the HL-A system. Nature (1972) 4.06
Studies on Histoplasmosis in a Rural Community. Am J Public Health Nations Health (1947) 4.04
Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture. Int J Cancer (1981) 3.90
Upper gastrointestinal cancer in patients with familial adenomatous polyposis. Lancet (1989) 3.84
Beta-catenin mutations in cell lines established from human colorectal cancers. Proc Natl Acad Sci U S A (1997) 3.79
Factors affecting the outcome of endoscopic surveillance for cancer in ulcerative colitis. Gastroenterology (1994) 3.44
Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas. Lancet (1992) 3.44
Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. Int J Radiat Oncol Biol Phys (1996) 3.42
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits". Proc Natl Acad Sci U S A (2000) 3.41
The Eurasian heartland: a continental perspective on Y-chromosome diversity. Proc Natl Acad Sci U S A (2001) 3.38
Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens. Eur J Immunol (1979) 3.27
PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome. Hum Mol Genet (1999) 3.22
Nomenclature for factors of the HLA system, 2010. Tissue Antigens (2010) 3.22
Peutz-Jeghers syndrome: a systematic review and recommendations for management. Gut (2010) 3.22
Recombination and integration in Bacillus subtilis transformation: involvement of DNA synthesis. J Mol Biol (1965) 3.21
Evolution of sickle variant gene. Lancet (1979) 3.09
Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut (2004) 3.01
Monoclonal antibody to a human histocompatibility alloantigen, HLA-A2. Nature (1978) 2.93
Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis. Gut (2004) 2.92
Evolution and function of the HLA system. Br Med Bull (1978) 2.91
Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology (1994) 2.85
The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis. Nat Med (1999) 2.76
TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. Gut (2011) 2.75
The mutation rate and cancer. Proc Natl Acad Sci U S A (1996) 2.73
Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. Br J Surg (1993) 2.70
The clinical significance of invasion of veins by rectal cancer. Br J Surg (1980) 2.69
Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus. A possible genetic predisposition to disease. N Engl J Med (1971) 2.69
Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology (2002) 2.68
Cancer surveillance in ulcerative colitis. Experience over 15 years. Lancet (1983) 2.67
CpG island clones from a deletion encompassing the gene for adenomatous polyposis coli. Proc Natl Acad Sci U S A (1989) 2.66
Towards safer colonoscopy: a report on the complications of 5000 diagnostic or therapeutic colonoscopies. Gut (1983) 2.66
Protein clinical manifestations of primary tumors of the heart. Am J Med (1972) 2.61
Cancer in colitis: assessment of the individual risk by clinical and histological criteria. Gastroenterology (1977) 2.61
Human genetics: the molecular challenge. Cold Spring Harb Symp Quant Biol (1986) 2.54
Anal and cervical intraepithelial neoplasia: possible parallel. Lancet (1989) 2.52
cDNA clones coding for the heavy chain of human HLA-DR antigen. Proc Natl Acad Sci U S A (1982) 2.51
Targeting of iodine-123-labelled tumour-associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumours. Lancet (1982) 2.51
Juvenile polyposis--a precancerous condition. Histopathology (1988) 2.47
Site of pain from the irritable bowel. Lancet (1980) 2.44
The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin. Tissue Antigens (1978) 2.40
Neuroendocrine differentiation and prognosis in breast adenocarcinoma. Histopathology (2002) 2.35
Granulomatous mastitis: a report of seven cases. J Clin Pathol (1982) 2.35
Integration of deoxyribonuclease-treated DNA in bacillus subtilis transformation. J Gen Physiol (1966) 2.32
Chronic inflammatory bowel disease in childhood. Br Med J (Clin Res Ed) (1982) 2.29
The beta2-microglobulin gene is on chromosome 15 and not in the HL-A region. Nature (1975) 2.29
Depth of insertion at flexible sigmoidoscopy: implications for colorectal cancer screening and instrument design. Endoscopy (1999) 2.23
Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. Science (1996) 2.22
The electrocardiogram in general practice: its use and its interpretation. J R Soc Med (1990) 2.20
Use of colour duplex ultrasound as a first line surveillance tool following EVAR is associated with a reduction in cost without compromising accuracy. Eur J Vasc Endovasc Surg (2012) 2.20
Sequence of an HLA-DR alpha-chain cDNA clone and intron-exon organization of the corresponding gene. Nature (1982) 2.18
Screening and genetic counselling for relatives of patients with colorectal cancer in a family cancer clinic. BMJ (1990) 2.17
Usefulness of pediatric colonoscopes in adult colonoscopy. Gastrointest Endosc (1989) 2.11
Colonoscopic polypectomy in children. Br Med J (1980) 2.11
Colonoscopy for unexplained rectal bleeding. Br Med J (1978) 2.08
A new variable stiffness colonoscope makes colonoscopy easier: a randomised controlled trial. Gut (2000) 2.06
Radiological features of Meckel's diverticulum and its complications. Clin Radiol (2008) 2.05
Two cases of X/autosome translocation in females with incontinentia pigmenti. Hum Genet (1985) 2.05
Ultrasonographic appearance of Ascaris lumbricoides in the small bowel. J Ultrasound Med (2001) 2.05
Cellular distrubtion, purification, and molecular nature of human Ia antigens. Scand J Immunol (1977) 2.04
Chromosomal localisation of the human homologues to the oncogenes erbA and B. EMBO J (1984) 2.02
Colonic adenomas--a colonoscopy survey. Gut (1979) 2.01
A monoclonal antibody that detects HLA-D region antigen in routinely fixed, wax embedded sections of normal and neoplastic lymphoid tissues. J Clin Pathol (1985) 2.00
Assignment of the structural gene for the third component of human complement to chromosome 19. Proc Natl Acad Sci U S A (1982) 2.00
Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years. Gut (1990) 1.99
Rapid isolation of human chromosome-specific DNA probes from a somatic cell hybrid. Genomics (1990) 1.99
Why is colonoscopy more difficult in women? Gastrointest Endosc (1996) 1.99
Genetic factors in Hodgkin's disease: association with a disease-susceptibility locus (DSA) in the HL-A region. Natl Cancer Inst Monogr (1973) 1.98
Nomenclature for factors of the HLA system, 1990. Tissue Antigens (1991) 1.98
Absence of toxicity of oats in patients with dermatitis herpetiformis. N Engl J Med (1997) 1.98