Published in Dis Model Mech on April 05, 2012
Fellow travellers: emergent properties of collective cell migration. EMBO Rep (2012) 1.41
Computational models reveal a passive mechanism for cell migration in the crypt. PLoS One (2013) 0.88
APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane. Mol Biol Cell (2015) 0.83
Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts. Mol Biol Cell (2016) 0.81
Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound. Sci Rep (2016) 0.75
Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice. Oncotarget (2016) 0.75
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Basic local alignment search tool. J Mol Biol (1990) 659.07
Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J (1999) 10.82
Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci (2002) 4.92
The intestinal stem cell. Genes Dev (2008) 4.21
beta-catenin signaling and cancer. Bioessays (1999) 4.16
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell (2004) 4.05
Alleles of the APC gene: an attenuated form of familial polyposis. Cell (1993) 3.84
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65
The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis. Nat Med (1999) 2.76
The Yin-Yang of TCF/beta-catenin signaling. Adv Cancer Res (2000) 2.62
ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias. Proc Natl Acad Sci U S A (1993) 2.19
Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8. Dev Cell (2002) 2.19
Collective cell migration in development. J Cell Sci (2009) 2.10
Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions. Nature (2008) 1.98
The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium. Annu Rev Cell Dev Biol (2004) 1.90
Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. J Cell Biol (2010) 1.59
Regulated binding of adenomatous polyposis coli protein to actin. J Biol Chem (2007) 1.41
Maintenance of functional stem cells in isolated and cultured adult intestinal epithelium. Exp Cell Res (1999) 1.31
Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration. Cancer Res (1997) 1.29
APC and its modifiers in colon cancer. Adv Exp Med Biol (2009) 1.28
New perspectives on APC control of cell fate and proliferation in colorectal cancer. Cell Cycle (2009) 1.21
Paxillin is required for cell-substrate adhesion, cell sorting and slug migration during Dictyostelium development. J Cell Sci (2005) 1.17
Complete deletion of Apc results in severe polyposis in mice. Oncogene (2009) 1.16
Preparation of wholemount mouse intestine for high-resolution three-dimensional imaging using two-photon microscopy. J Microsc (2009) 1.09
Novel self-association of the APC molecule affects APC clusters and cell migration. J Cell Sci (2008) 1.00
Tumor-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains. Cancer Res (2005) 0.96
The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. EMBO Rep (2009) 0.96
Cell proliferation in gastrointestinal mucosa. J Clin Pathol (1999) 0.93
Inducible nuclear translocation of a STAT protein in Dictyostelium prespore cells: implications for morphogenesis and cell-type regulation. Development (2001) 0.91
Different phenotypic consequences of simultaneous versus stepwise Apc loss. Oncogene (2011) 0.91
Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res (2011) 0.87
Genetic and Chemical Models of Colorectal Cancer in Mice. Curr Colorectal Cancer Rep (2010) 0.85
Dictyostelium development: a prototypic Wnt pathway? Methods Mol Biol (2008) 0.84
Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89
Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Bioinformatics (2009) 31.84
The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48
Genome sequence and analysis of the tuber crop potato. Nature (2011) 7.77
ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins. Nucleic Acids Res (2003) 6.86
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Draft genome of the filarial nematode parasite Brugia malayi. Science (2007) 5.28
A randomized placebo-controlled clinical trial of 5 smoking cessation pharmacotherapies. Arch Gen Psychiatry (2009) 4.66
Identification of multiple distinct Snf2 subfamilies with conserved structural motifs. Nucleic Acids Res (2006) 4.64
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65
Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8. Dev Cell (2002) 2.19
TarO: a target optimisation system for structural biology. Nucleic Acids Res (2008) 1.89
Evaluating performance in three-dimensional fluorescence microscopy. J Microsc (2007) 1.89
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol (2007) 1.77
Signaling to cytoskeletal dynamics during chemotaxis. Dev Cell (2005) 1.73
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol (2007) 1.62
The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness. Mol Cell Proteomics (2009) 1.56
Cell regulation by the Apc protein Apc as master regulator of epithelia. Curr Opin Cell Biol (2008) 1.53
In vivo analysis of 3-phosphoinositide dynamics during Dictyostelium phagocytosis and chemotaxis. J Cell Sci (2004) 1.51
Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol Biol Cell (2006) 1.50
Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network. Bioessays (2014) 1.45
The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells. J Cell Biol (2002) 1.43
Simultaneous quantification of cell motility and protein-membrane-association using active contours. Cell Motil Cytoskeleton (2002) 1.42
Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol Biol Cell (2006) 1.42
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. Biochem J (2008) 1.38
Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine (2004) 1.31
The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium. Mol Biol Cell (2003) 1.30
Imaging of cell migration. EMBO J (2006) 1.26
The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts. Mol Biol Cell (2004) 1.25
Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. Cell Res (2011) 1.24
Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development. Curr Biol (2002) 1.21
PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression. Development (2008) 1.21
Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei. J Proteome Res (2013) 1.18
Cell movement during chick primitive streak formation. Dev Biol (2006) 1.17
Open microscopy environment and findspots: integrating image informatics with quantitative multidimensional image analysis. Biotechniques (2006) 1.17
Paxillin is required for cell-substrate adhesion, cell sorting and slug migration during Dictyostelium development. J Cell Sci (2005) 1.17
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet (2010) 1.16
Analysis of tissue flow patterns during primitive streak formation in the chick embryo. Dev Biol (2005) 1.15
Chemotactic cell movement during Dictyostelium development and gastrulation. Curr Opin Genet Dev (2006) 1.11
Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance. J Cell Sci (2013) 1.09
Chemotactic cell movement during development. Curr Opin Genet Dev (2003) 1.08
UK Food Standards Agency Workshop Report: an investigation of the relative contributions of diet and sunlight to vitamin D status. Br J Nutr (2010) 1.05
Redefining the subcellular location and transport of APC: new insights using a panel of antibodies. EMBO Rep (2005) 1.04
Wnt3a-mediated chemorepulsion controls movement patterns of cardiac progenitors and requires RhoA function. Development (2008) 1.03
Novel self-association of the APC molecule affects APC clusters and cell migration. J Cell Sci (2008) 1.00
The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J Cell Sci (2005) 0.98
Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection. Mol Biol Cell (2010) 0.97
Retrotransposon populations of Vicia species with varying genome size. Mol Genet Genomics (2005) 0.97
Postpartum pneumomediastinum: an uncommon cause for chest pain. Obstet Gynecol Int (2010) 0.96
Tumor-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains. Cancer Res (2005) 0.96
Modeling gastrulation in the chick embryo: formation of the primitive streak. PLoS One (2010) 0.95
The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr. Am J Physiol Gastrointest Liver Physiol (2009) 0.94
A two-dimensional model of the colonic crypt accounting for the role of the basement membrane and pericryptal fibroblast sheath. PLoS Comput Biol (2012) 0.94
Expanding the three Rs to meet new challenges in humane animal experimentation. Altern Lab Anim (2004) 0.94
The interpretation and application of the three Rs by animal ethics committee members. Altern Lab Anim (2005) 0.94
The mechanisms underlying primitive streak formation in the chick embryo. Curr Top Dev Biol (2008) 0.92
Modelling of Dictyostelium discoideum slug migration. J Theor Biol (2003) 0.91
Epidemiological investigation into the re-emergence and control of an outbreak of infectious salmon anaemia in the Shetland Islands, Scotland. Dis Aquat Organ (2010) 0.91
Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost. Philos Trans R Soc Lond B Biol Sci (2013) 0.90
Correlating cell behavior with tissue topology in embryonic epithelia. PLoS One (2011) 0.90
Rapid habituation of ventral striatal response to reward receipt in postpartum depression. Biol Psychiatry (2011) 0.89
Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP. J Cell Sci (2010) 0.88
Computational models reveal a passive mechanism for cell migration in the crypt. PLoS One (2013) 0.88
Collective epithelial and mesenchymal cell migration during gastrulation. Curr Genomics (2012) 0.87
Andrographolide inhibits melanoma tumor growth by inactivating the TLR4/NF-κB signaling pathway. Melanoma Res (2014) 0.87
Autophagy functions on EMT in gastrulation of avian embryo. Cell Cycle (2014) 0.86
The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment. Dev Cell (2012) 0.85
A new oxidative stress model, 2,2-azobis(2-amidinopropane) dihydrochloride induces cardiovascular damages in chicken embryo. PLoS One (2013) 0.85
Dual mode of paraxial mesoderm formation during chick gastrulation. Proc Natl Acad Sci U S A (2007) 0.85
Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1. Inflamm Bowel Dis (2004) 0.85
High-energy particle-induced tumorigenesis throughout the gastrointestinal tract. Radiat Res (2014) 0.84
Silencing BRE expression in human umbilical cord perivascular (HUCPV) progenitor cells accelerates osteogenic and chondrogenic differentiation. PLoS One (2013) 0.84
Exploring the caffeine-induced teratogenicity on neurodevelopment using early chick embryo. PLoS One (2012) 0.84
Enhanced beta-catenin expression and inflammation are associated with human ectopic tubal pregnancy. Hum Reprod (2013) 0.84
Visualizing signaling and cell movement during the multicellular stages of dictyostelium development. Methods Mol Biol (2006) 0.83
Exposure to 2,5-hexanedione can induce neural malformations in chick embryos. Neurotoxicology (2012) 0.82
Animal control measures and their relationship to the reported incidence of dog bites in urban Canadian municipalities. Can Vet J (2013) 0.81
ConfocalCheck--a software tool for the automated monitoring of confocal microscope performance. PLoS One (2013) 0.81
The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin. PLoS One (2012) 0.80
The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively. J Cell Sci (2012) 0.80
Autophagy is involved in high glucose-induced heart tube malformation. Cell Cycle (2015) 0.80
Caffeine interferes embryonic development through over-stimulating serotonergic system in chicken embryo. Food Chem Toxicol (2012) 0.80