Published in Circulation on September 14, 1999
ER chaperones in mammalian development and human diseases. FEBS Lett (2007) 4.40
Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest (2001) 2.45
Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice. Blood (2011) 1.77
Green tea catechins and cardiovascular health: an update. Curr Med Chem (2008) 1.58
Iron sucrose augments homocysteine-induced endothelial dysfunction in normal subjects. Kidney Int (2006) 1.50
Plasma total homocysteine and gallstone in middle-aged Japanese men. J Gastroenterol (2005) 1.46
Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview. J Inherit Metab Dis (2006) 1.42
H2S protects against methionine-induced oxidative stress in brain endothelial cells. Antioxid Redox Signal (2009) 1.30
Biomarkers of obesity and subsequent cardiovascular events. Epidemiol Rev (2007) 1.17
Homocysteine stimulates phosphorylation of NADPH oxidase p47phox and p67phox subunits in monocytes via protein kinase Cbeta activation. Biochem J (2006) 1.10
Plasma and aqueous humour levels of homocysteine in exfoliation syndrome. Graefes Arch Clin Exp Ophthalmol (2004) 1.06
Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc. Cardiovasc Res (2011) 1.04
Hydrogen sulfide attenuates neurodegeneration and neurovascular dysfunction induced by intracerebral-administered homocysteine in mice. Neuroscience (2013) 1.02
The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis. J Biomed Sci (2009) 0.97
Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation. Am J Pathol (2002) 0.93
Dissociation between sympathetic nerve traffic and sympathetically mediated vascular tone in normotensive human obesity. Hypertension (2008) 0.90
Correlation of serum homocysteine levels with the severity of coronary artery disease. Indian J Clin Biochem (2013) 0.89
Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women. Menopause (2010) 0.87
[Atherosclerosis and uremia: signifance of non-traditional risk factors]. Wien Klin Wochenschr (2003) 0.86
Serum uric Acid in smokers. Oman Med J (2008) 0.84
Homocysteine transport by human aortic endothelial cells: identification and properties of import systems. Arch Biochem Biophys (2006) 0.83
Statins in the treatment of polycystic ovary syndrome. Semin Reprod Med (2008) 0.80
Association Between Leukocyte Telomere Length and Plasma Homocysteine in a Singapore Chinese Population. Rejuvenation Res (2015) 0.80
Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus. J Cell Mol Med (2008) 0.80
The effects of oral methionine and homocysteine on endothelial function. Heart (2001) 0.79
Acute hyperhomocysteinaemia affects pulse pressure but not microvascular vasodilator function. Br J Clin Pharmacol (2001) 0.78
Autonomic cardiovascular responses in acclimatized lowlanders on prolonged stay at high altitude: a longitudinal follow up study. PLoS One (2014) 0.78
Genistein attenuates vascular endothelial impairment in ovariectomized hyperhomocysteinemic rats. J Biomed Biotechnol (2012) 0.78
The association of homocysteine with metabolic syndrome in a community-dwelling population: homocysteine might be concomitant with metabolic syndrome. PLoS One (2014) 0.77
Effect of methionine loading on pulse wave analysis in elderly volunteers. Postgrad Med J (2006) 0.77
Cardiovascular complications in inflammatory bowel disease. Curr Drug Targets (2015) 0.77
Gender differences in neuropsychological performance in individuals with atherosclerosis: impact of vascular function. J Clin Exp Neuropsychol (2010) 0.77
Homocysteine-induced attenuation of vascular endothelium-dependent hyperalgesia in the rat. Neuroscience (2014) 0.77
Converging evidence of mitochondrial dysfunction in a yeast model of homocysteine metabolism imbalance. J Biol Chem (2011) 0.77
Acute effect of folic acid, betaine, and serine supplements on flow-mediated dilation after methionine loading: a randomized trial. PLoS Clin Trials (2006) 0.77
Co-Administration of Metformin and N-Acetyl Cysteine Fails to Improve Clinical Manifestations in PCOS Individual Undergoing ICSI. Int J Fertil Steril (2014) 0.76
Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus. J Cell Mol Med (2008) 0.75
The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia. BMC Cardiovasc Disord (2001) 0.75
Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation. J Vet Sci (2006) 0.75
The impact of moderate to severe renal insufficiency on patients with acute myocardial infarction. Korean Circ J (2011) 0.75
Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress. Sci Rep (2017) 0.75
Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest (1991) 3.49
Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation (2000) 2.83
Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings. Hypertension (1989) 2.21
The endothelin family of peptides: local hormones with diverse roles in health and disease? Clin Sci (Lond) (1993) 2.18
Bactericidal effects of polyunsaturated fatty acids. J Infect Dis (1986) 1.96
Energy-dependent calcium sequestration activity in rat liver microsomes. J Biol Chem (1975) 1.91
Screening for human immunodeficiency virus: a survey of British clinical pharmacology units. Br J Clin Pharmacol (1993) 1.85
Ionophores stimulate prostaglandin and thromboxane biosynthesis. Proc Natl Acad Sci U S A (1977) 1.82
Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens (1999) 1.62
L-NMMA increases blood pressure in man. Lancet (1993) 1.60
Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans. Clin Sci (Lond) (2001) 1.59
Muscle sympathetic nerve activity is reduced in IDDM before overt autonomic neuropathy. Diabetes (1993) 1.45
Clinical implications of prostaglandin and thromboxane A2 formation (1). N Engl J Med (1988) 1.45
Effects of leptin on insulin sensitivity in normal rats. Endocrinology (1997) 1.42
Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens (1999) 1.42
14,15-Epoxyeicosatrienoic acid metabolism in endothelial cells. J Lipid Res (1993) 1.36
Biosynthesis of prostaglandin D2. 1. Formation of prostaglandin D2 by human platelets. Prostaglandins (1977) 1.36
In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis. N Engl J Med (1986) 1.36
Static light scattering studies of OmpF porin: implications for integral membrane protein crystallization. Protein Sci (2000) 1.34
Use of anorectal manometry during rectal infusion of saline to investigate sphincter function in incontinent patients. Gastroenterology (1983) 1.31
Ano-rectal activity in man during rectal infusion of saline: a dynamic assessment of the anal continence mechanism. J Physiol (1982) 1.29
Postexercise hypotension and sympathoinhibition in borderline hypertensive men. Hypertension (1989) 1.28
Clinical implications of prostaglandin and thromboxane A2 formation (2). N Engl J Med (1988) 1.19
Longitudinal follow-up comparison of educational interventions: multimedia textbook, traditional lecture, and printed textbook. Acad Radiol (1997) 1.16
Endogenous biosynthesis of prostacyclin during cardiac catheterization and angiography in man. Circulation (1985) 1.05
Mental stress increases sympathetic nerve activity during sustained baroreceptor stimulation in humans. Hypertension (1991) 1.05
Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans. Hypertension (1992) 1.01
Inhibition of neutral endopeptidase causes vasoconstriction of human resistance vessels in vivo. Circulation (1998) 0.99
State-of-the-art-lecture: Obesity-induced hypertension: new concepts from the emerging biology of obesity. Hypertension (1999) 0.98
Suppression of eicosanoid biosynthesis during coronary angioplasty by fish oil and aspirin. Circulation (1991) 0.97
Frequency response characteristics of sympathetically mediated vasomotor waves in humans. Am J Physiol (1998) 0.97
Calcium-dependent stimulation of thromboxane and prostaglandin biosynthesis by ionophores. Adv Prostaglandin Thromboxane Res (1978) 0.96
Arachidonic acid diols produced by cytochrome P-450 monooxygenases are incorporated into phospholipids of vascular endothelial cells. J Biol Chem (1996) 0.96
Vasodilator effects of endothelin-converting enzyme inhibition and endothelin ETA receptor blockade in chronic heart failure patients treated with ACE inhibitors. Circulation (1996) 0.95
The effects of short-term passive smoke exposure on endothelium-dependent and independent vasodilation. J Hypertens (1999) 0.93
Role of corticotrophin-releasing factor in effects of leptin on sympathetic nerve activity and arterial pressure. Hypertension (2001) 0.93
Hemodialysis and L-arginine, but not D-arginine, correct renal failure-associated endothelial dysfunction. Kidney Int (1998) 0.93
A prospective study of the effect of haemorrhoidectomy on sphincter function and faecal continence. Br J Surg (1982) 0.92
Differences in anorectal manometry between patients with haemorrhoids and patients with descending perineum syndrome: implications for management. Br J Surg (1983) 0.92
Hyperglycemia without hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Diabetes Complications (1999) 0.91
Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure. Hypertension (2001) 0.91
Stimulation of prostaglandin biosynthesis in the renal papilla by hypertonic mediums. Am J Physiol (1978) 0.90
A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat. Acta Physiol Scand (2003) 0.89
The increase in human plasma immunoreactive endothelin but not big endothelin-1 or its C-terminal fragment induced by systemic administration of the endothelin antagonist TAK-044. Br J Pharmacol (1996) 0.89
A low temperature flotation method to rapidly isolate lipoproteins from plasma. J Lipid Res (1998) 0.89
Dissociation of sympathoexcitatory and vasodilator actions of modestly elevated plasma insulin levels. J Hypertens (1995) 0.89
Synthesis and metabolism of prostaglandins E2, F2alpha and D2 by the rat gastrointestinal tract. Stimulation by a hypertonic environment in vitro. Prostaglandins (1978) 0.88
Leukotriene B4 synthesis and neutrophil chemotaxis in chronic granulocytic leukaemia. J Clin Pathol (1988) 0.88
Endothelin receptor antagonism in patients with chronic heart failure. Cardiovasc Res (2000) 0.87
Effect of dietary potassium on blood pressure, renal function, muscle sympathetic nerve activity, and forearm vascular resistance and flow in normotensive and borderline hypertensive humans. Circulation (1990) 0.87
Endothelin production in sepsis and the adult respiratory distress syndrome. Intensive Care Med (1996) 0.87
A comparison of techniques to assess skin blanching following the topical application of glucocorticoids. Br J Dermatol (1996) 0.86
Local inhibition of nitric oxide generation in man reduces blood flow in finger pulp but not in hand dorsum skin. J Physiol (1996) 0.86
Contrasting autonomic and hemodynamic effects of insulin in healthy elderly versus young subjects. Hypertension (1997) 0.86
Acute myocardial infarctions, strokes and influenza: seasonal and pandemic effects. Epidemiol Infect (2013) 0.85
Anorectal contractility under basal conditions and during rectal infusion of saline in ulcerative colitis. Gut (1988) 0.84
The peptide endothelin receptor antagonist, TAK-044, produces sustained inhibition of endothelin-1 mediated arteriolar vasoconstriction. Br J Clin Pharmacol (1997) 0.84
Phosphoramidon inhibition of the in vivo conversion of big endothelin-1 to endothelin-1 in the human forearm. Br J Pharmacol (1995) 0.83
The effect of sex on certain properties of the very low density lipoprotein secreted by the liver. Biochem Biophys Res Commun (1974) 0.83
Does leptin stimulate nitric oxide to oppose the effects of sympathetic activation? Hypertension (2001) 0.83
Homocysteine as a novel risk factor for atherosclerosis. Curr Opin Cardiol (1999) 0.82
Effect of acute and antecedent hypoglycemia on sympathetic neural activity and catecholamine responsiveness in normal rats. Diabetes (2001) 0.82
Omega-3 fatty acids, endogenous prostaglandins, and blood pressure regulation in humans. Nutr Rev (1989) 0.82
Erythropoietin enhances vascular responsiveness to norepinephrine in renal failure. Kidney Int (1995) 0.82
Lack of effect of alpha- and beta-adrenergic inhibition on forearm glucose uptake despite differences in forearm blood flow in healthy humans. Metabolism (2002) 0.81
Hypoglycemia increases muscle sympathetic nerve activity in IDDM and control subjects. Diabetes Care (1994) 0.81
Endothelium-dependent modulation of venoconstriction to sarafotoxin S6c in human veins in vivo. J Cardiovasc Pharmacol (1995) 0.81
Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats. Am J Physiol (1999) 0.81
Nitric oxide in liver failure. Lancet (1992) 0.81
Endothelins come of age. Lancet (1993) 0.80
Venoconstriction to endothelin-1 in humans is attenuated by local generation of prostacyclin but not nitric oxide. J Cardiovasc Pharmacol (1993) 0.80
The effect of linoleic, arachidonic and eicosapentaenoic acid supplementation on prostacyclin production in rats. Lipids (1994) 0.80
Endothelins as regulators of growth and function in endocrine tissues. Clin Endocrinol (Oxf) (1993) 0.80
Prostaglandins and calcium. Ann N Y Acad Sci (1978) 0.79
Dietary salt produces abnormal renal vasoconstrictor responses to upright posture in borderline hypertensive subjects. Hypertension (1988) 0.79
Genetic characterization of the "new" Harlan Sprague Dawley Dahl salt-sensitive rats. Hypertension (1996) 0.79
Reduced endogenous endothelin-1-mediated vascular tone in chronic renal failure. Kidney Int (1999) 0.79
Dietary fish oil accelerates the response to coronary thrombolysis with tissue-type plasminogen activator. Evidence for a modest platelet inhibitory effect in vivo. Circulation (1990) 0.79
Effects of feeding ethyl-dihomo-gamma-linolenate on rabbit renomedullary lipid composition and prostaglandin production in vitro. Lipids (1978) 0.79
Sympathetic nerve activity and insulin sensitivity in normotensive offspring of hypertensive parents. Am J Hypertens (1998) 0.79
Lessons from Leptin's molecular biology: Potential therapeutic actions of recombinant leptin and leptin-related compounds. Mini Rev Med Chem (2007) 0.78
Hypoglycemic symptom variation is related to epinephrine and not peripheral muscle sympathetic nerve response. J Diabetes Complications (1997) 0.78
Effects of fludrocortisone on sympathetic nerve activity in humans. Hypertension (1994) 0.78
Monovalent cations and renomedullary prostaglandin release. Adv Prostaglandin Thromboxane Res (1980) 0.78
Measurement of C-terminal fragment of big endothelin-1: a novel method for assessing the generation of endothelin-1 in humans. J Cardiovasc Pharmacol (1995) 0.78
Resistance vessel endothelial function in healthy humans during transient postprandial hypertriglyceridemia. Am J Cardiol (2000) 0.78
Does leptin cause functional peripheral sympatholysis? Am J Hypertens (2001) 0.77
Nitric oxide and gall-bladder motor function. Aliment Pharmacol Ther (1998) 0.77
Venous endothelin receptor function in patients with chronic heart failure. Clin Sci (Lond) (2000) 0.77
Muscle sympathetic nerve activity is higher in intensively versus conventionally treated IDDM subjects. Diabetes Care (1995) 0.77
The role of endothelin-1 in cardiovascular physiology and pathophysiology. Scott Med J (1995) 0.76
An effect of estradiol and testosterone on the calcium pump activity and phospholipid fatty acid composition of rat liver microsomes. Endocrinology (1977) 0.76
Microneurographically determined muscle sympathetic nerve activity levels are reproducible in insulin-dependent diabetes mellitus. J Diabetes Complications (1999) 0.76
Hyperlipidemia and fatty acid composition in patients treated for type IA glycogen storage disease. J Pediatr (1991) 0.76
Raised plasma endothelin in unstable angina and non-Q wave myocardial infarction: relation to cardiovascular outcome. Br Heart J (1994) 0.76
Effects of feeding ethyl-dihomo-gamma-linolenate on prostaglandin biosynthesis and platelet aggregation in the rabbit. Biochim Biophys Acta (1976) 0.76
Bosentan in essential hypertension. N Engl J Med (1998) 0.75
Drug-nutrient interactions in medical training. J Am Coll Nutr (1995) 0.75