Published in N Engl J Med on September 15, 1988
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci U S A (1994) 4.15
Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor. J Clin Invest (1999) 1.66
Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. J Clin Invest (1998) 1.46
Primed stimulation of isolated perfused rabbit lung by endotoxin and platelet activating factor induces enhanced production of thromboxane and lung injury. J Clin Invest (1990) 1.19
The tyrosine kinase activity of the epidermal-growth-factor receptor is necessary for phospholipase A2 activation. Biochem J (1990) 1.04
The involvement of endothelium-derived relaxing factor in the regulation of renal cortical blood flow in the rat. Br J Pharmacol (1991) 1.02
Distinct structural specificities for functional coupling of the epidermal growth factor receptor to calcium-signalling versus phospholipase A2 responses. Biochem J (1991) 0.88
Prostanoids and blood pressure: which way is up? J Clin Invest (2004) 0.87
Thromboxane-insensitive dog platelets have impaired activation of phospholipase C due to receptor-linked G protein dysfunction. J Clin Invest (1993) 0.86
The interaction of vasoactive substances during exercise modulates platelet aggregation in hypertension and coronary artery disease. BMC Cardiovasc Disord (2008) 0.82
Association of thromboxane A2 receptor gene polymorphisms with cerebral infarction in a Chinese population. Neurol Sci (2013) 0.82
Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling. Biochim Biophys Acta (2007) 0.81
Stereoselective pharmacokinetics of ketoprofen and ketoprofen glucuronide in end-stage renal disease: evidence for a 'futile cycle' of elimination. Br J Clin Pharmacol (1999) 0.81
Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3. PPAR Res (2010) 0.80
Physical (in)activity and endothelium-derived constricting factors: overlooked adaptations. J Physiol (2007) 0.80
Prostaglandins, masculinization and its disorders: effects of fetal exposure of the rat to the cyclooxygenase inhibitor- indomethacin. PLoS One (2013) 0.80
Mefenamic Acid induced nephrotoxicity: an animal model. Adv Pharm Bull (2014) 0.80
Modulation of sensitivity to cis-diamminedichloroplatinum (II) by thromboxane A2 receptor antagonists in non-small-cell lung cancer cell lines. Br J Cancer (1996) 0.79
Lipid analogues as potential drugs for the regulation of mitochondrial cell death. Br J Pharmacol (2014) 0.77
The human platelet fibrinogen receptor: clinical and therapeutic significance. Br J Clin Pharmacol (1992) 0.77
Urinary Metabolites of Prostanoids and Risk of Recurrent Colorectal Adenomas in the Aspirin/Folate Polyp Prevention Study (AFPPS). Cancer Prev Res (Phila) (2015) 0.77
Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus. Cancer Prev Res (Phila) (2015) 0.76
Nonsteroidal anti-inflammatory drugs alter vasa recta diameter via pericytes. Am J Physiol Renal Physiol (2015) 0.75
Effect of cytoplasmic pH on Ca(2+)-stimulated eicosanoid biosynthesis in human platelets. Br J Pharmacol (1994) 0.75
Inhibition of tumor growth and metastasis by chronic intravenous infusion of prostaglandin E1. Ann Surg (1990) 0.75
Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease. Thromb Res (2015) 0.75
Effect of interleukin 2 on urinary excretion of degradation products of prostacyclin and thromboxane A2 in patients with ovarian cancer. Br J Cancer (1995) 0.75
The effect of aspirin on thrombin stimulated platelet adhesion receptor expression and the role of neutrophils. Br J Clin Pharmacol (1998) 0.75
Electrolyte and Acid-base disturbances associated with non-steroidal anti-inflammatory drugs. Electrolyte Blood Press (2007) 0.75
Incidence and clinical relevance of heterotopic ossification after internal fixation of acetabular fractures: retrospective cohort and case control study. J Orthop Surg Res (2015) 0.75
The antiphospholipid antibody dilemma. Clin Rheumatol (1990) 0.75
Neutrophil-Derived Cytosolic PLA2α Contributes to Bacterial-Induced Neutrophil Transepithelial Migration. J Immunol (2017) 0.75
The acetylene-ethylene assay for n(2) fixation: laboratory and field evaluation. Plant Physiol (1968) 28.49
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet (2013) 8.16
Incidence of uraemia and requirements for maintenance haemodialysis. Br Med J (1971) 7.17
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med (2001) 5.96
A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci U S A (1990) 5.31
Disability income, cocaine use, and repeated hospitalization among schizophrenic cocaine abusers--a government-sponsored revolving door? N Engl J Med (1995) 4.77
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci U S A (1999) 4.16
Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med (1995) 3.91
Evidence that histamine is the causative toxin of scombroid-fish poisoning. N Engl J Med (1991) 3.65
Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J Biol Chem (1997) 3.42
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13
Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids. Anal Biochem (1990) 2.84
Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. J Immunol (1982) 2.69
Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin Pharmacol Ther (1985) 2.69
Methods for defining and determining the clinical significance of treatment effects: description, application, and alternatives. J Consult Clin Psychol (1999) 2.60
Platelet activation in unstable coronary disease. N Engl J Med (1986) 2.60
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell (2001) 2.59
Effects of vitamin E on lipid peroxidation in healthy persons. JAMA (2001) 2.58
Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Proc Natl Acad Sci U S A (1992) 2.51
Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress. Methods Enzymol (1999) 2.40
Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2. Science (1976) 2.39
The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. N Engl J Med (1989) 2.36
Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective study. JAMA (1999) 2.34
Platelet-active drugs : the relationships among dose, effectiveness, and side effects. Chest (2001) 2.25
Genetic and pharmacological analysis of prostanoid receptor function. J Clin Invest (2001) 2.19
Determinants of serum antipyrine half-lives in patients with liver disease. Gut (1973) 2.19
Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism. Clin Pharmacol Ther (1984) 2.19
Estimated rate of prostacyclin secretion into the circulation of normal man. J Clin Invest (1981) 2.18
Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology (1999) 2.16
Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest (1983) 2.13
Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. J Pharmacol Exp Ther (1999) 2.10
Release of prostaglandin D2 into human airways during acute antigen challenge. N Engl J Med (1986) 2.03
The isoprostanes: unique bioactive products of lipid peroxidation. Prog Lipid Res (1997) 2.02
Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. N Engl J Med (1984) 2.00
Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Nat Med (1998) 1.98
Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs. Blood (1987) 1.96
Bactericidal effects of polyunsaturated fatty acids. J Infect Dis (1986) 1.96
Measurement of lipid peroxidation. Free Radic Res (1998) 1.91
Energy-dependent calcium sequestration activity in rat liver microsomes. J Biol Chem (1975) 1.91
Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. J Clin Invest (1997) 1.90
Clinical evaluation of fibreoptic sigmoidoscopy employing the Olympus CF-SB colonoscope. Gut (1971) 1.90
Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester. J Clin Invest (1994) 1.89
Integrated regional haemodialysis and renal transplantation centre. Br Med J (1970) 1.89
The relationship between liver volume, antipyrine clearance and indocyanine green clearance before and after phenobarbitone administration in man. Br J Clin Pharmacol (1976) 1.88
A study of factors influencing drug disposition in chronic liver disease, using the model drug (+)-propranolol. Br J Clin Pharmacol (1976) 1.87
Ionophores stimulate prostaglandin and thromboxane biosynthesis. Proc Natl Acad Sci U S A (1977) 1.82
Increased formation of distinct F2 isoprostanes in hypercholesterolemia. Circulation (1999) 1.79
Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity. Ann Neurol (2000) 1.79
Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. J Clin Invest (2000) 1.78
Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors. J Clin Invest (1992) 1.77
Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. J Biol Chem (1994) 1.76
Increased clearance of antipyrine and d-propranolol after phenobarbital treatment in the monkey. Relative contributions of enzyme induction and increased hepatic blood flow. J Clin Invest (1974) 1.74
Combined administration of aspirin and a specific thrombin inhibitor in man. Circulation (1991) 1.74
Amphotericin B nephrotoxicity. Drug Saf (1990) 1.74
Modulation of oxidant stress in vivo in chronic cigarette smokers. Circulation (1996) 1.74
Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease. Circulation (1983) 1.73
Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. N Engl J Med (1984) 1.73
Modulation of monocyte-endothelial cell interactions by platelet microparticles. J Clin Invest (1998) 1.73
Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA. J Am Coll Cardiol (2001) 1.71
A double blind placebo controlled crossover study of prostacyclin in man. Life Sci (1979) 1.67
Increased production of prostaglandin D2 in patients with systemic mastocytosis. N Engl J Med (1980) 1.63
Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2alpha). Clin Exp Allergy (2001) 1.62
Effects of age and cigarette smoking on propranolol disposition. Clin Pharmacol Ther (1979) 1.62
Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J Biol Chem (1993) 1.59
Interstitial brain adenosine and xanthine increase during jugular venous oxygen desaturations in humans after traumatic brain injury. Crit Care Med (2001) 1.59
Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans. Clin Sci (Lond) (2001) 1.59
Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin. N Engl J Med (1991) 1.58
Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs. Proc Natl Acad Sci U S A (1999) 1.57
Thromboxane A2 synthesis in pregnancy-induced hypertension. Lancet (1990) 1.56
Genetic polymorphism of S-mephenytoin hydroxylation. Pharmacol Ther (1989) 1.55
Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. Proc Natl Acad Sci U S A (1985) 1.55
Alcohol-induced generation of lipid peroxidation products in humans. J Clin Invest (1999) 1.55
Effect of aging and cigarette smoking on antipyrine and indocyanine green elimination. Clin Pharmacol Ther (1979) 1.55
Determinants of response to frusemide in normal subjects. Br J Clin Pharmacol (1977) 1.54
Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated. Circulation (1997) 1.54
Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production. Neuroscience (2006) 1.53
Isoprostanes: potential markers of oxidant stress in atherothrombotic disease. Arterioscler Thromb Vasc Biol (1997) 1.53
The isoprostanes. Current knowledge and directions for future research. Biochem Pharmacol (1996) 1.53
Isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo. J Biol Chem (1999) 1.53
Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children: association with severity of injury and excitotoxicity. Crit Care Med (2001) 1.52
Two polymorphisms in the human lipoprotein lipase (LPL) gene. Nucleic Acids Res (1987) 1.51
Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction. Circulation (1988) 1.49
Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins (1989) 1.49
Effect of age and parenchymal liver disease on the disposition and elimination of chlordiazepoxide (librium). Gastroenterology (1978) 1.48
Indices of lipid peroxidation in vivo: strengths and limitations. Free Radic Biol Med (2000) 1.48
Dipyridamole. N Engl J Med (1987) 1.48
Identification of extremely reactive gamma-ketoaldehydes (isolevuglandins) as products of the isoprostane pathway and characterization of their lysyl protein adducts. J Biol Chem (1999) 1.47
Are anaesthetists prone to suicide? A review of rates and risk factors. Anaesth Intensive Care (2003) 1.46
Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice. Circulation (2001) 1.46
Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F(2)-isoprostanes in human urine. Proc Natl Acad Sci U S A (1999) 1.45
Effects of celecoxib on major prostaglandins in asthma. Clin Exp Allergy (2010) 1.45
Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans. Circulation (1999) 1.44
Prevention of skin cancer in xeroderma pigmentosum: the physician as advocate. J Am Acad Dermatol (1993) 1.44
IPF2alpha-I: an index of lipid peroxidation in humans. Proc Natl Acad Sci U S A (1998) 1.43
Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radic Biol Med (2005) 1.42
8-epi PGF2 alpha generation during coronary reperfusion. A potential quantitative marker of oxidant stress in vivo. Circulation (1997) 1.41
The effects of alcohol on the marital interactions of aggressive and nonaggressive husbands and their wives. J Abnorm Psychol (1998) 1.41
Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. J Biol Chem (1985) 1.40