Published in Immunity on August 01, 1999
Transcriptional analysis of the B cell germinal center reaction. Proc Natl Acad Sci U S A (2003) 3.45
Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. J Exp Med (2004) 2.42
Mechanisms promoting translocations in editing and switching peripheral B cells. Nature (2009) 2.27
Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells. J Clin Invest (2004) 2.21
Microbial colonization influences early B-lineage development in the gut lamina propria. Nature (2013) 1.96
The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol (2010) 1.77
A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome. J Clin Invest (2007) 1.67
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nat Immunol (2009) 1.61
T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. J Immunol (2007) 1.60
Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production. J Exp Med (2000) 1.57
B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors. J Exp Med (2004) 1.53
Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers. Am J Pathol (2001) 1.52
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med (2008) 1.47
Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J Exp Med (2003) 1.43
Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice. J Exp Med (2004) 1.34
Enhanced antitumor immunity in mice deficient in CD69. J Exp Med (2003) 1.29
Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation. EMBO J (2001) 1.25
Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. J Exp Med (2011) 1.24
Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. J Immunol (2009) 1.22
Mechanisms controlling expression of the RAG locus during lymphocyte development. Curr Opin Immunol (2009) 1.13
Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice. J Exp Med (2000) 1.12
Receptor editing in peripheral B cell tolerance. Proc Natl Acad Sci U S A (2005) 1.08
Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection. J Exp Med (2003) 1.07
RAG-dependent peripheral T cell receptor diversification in CD8+ T lymphocytes. Proc Natl Acad Sci U S A (2002) 1.06
B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice. J Clin Invest (2008) 1.01
Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells. J Exp Med (2007) 1.00
Deletion of immunoglobulin beta in developing B cells leads to cell death. Proc Natl Acad Sci U S A (2002) 0.98
RAG2 is regulated differentially in B and T cells by elements 5' of the promoter. Proc Natl Acad Sci U S A (1999) 0.97
Developmental separation of V(D)J recombinase expression and initiation of IgH recombination in B lineage progenitors in vivo. J Exp Med (2004) 0.94
Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites. J Immunol (2011) 0.92
Spontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3. Lupus (2009) 0.85
Bidirectional activity of the NWC promoter is responsible for RAG-2 transcription in non-lymphoid cells. PLoS One (2012) 0.81
Differential expression patterns of recombination-activating genes in individual mature B cells in juvenile idiopathic arthritis. Ann Rheum Dis (2006) 0.80
Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. J Exp Med (2016) 0.79
Antibody repertoire development in fetal and neonatal piglets. XXII. λ Rearrangement precedes κ rearrangement during B-cell lymphogenesis in swine. Immunology (2012) 0.79
Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity. Proc Natl Acad Sci U S A (2006) 0.78
Review article: role of the surrogate light chain and the pre-B-cell receptor in mouse B-cell development. Immunology (2000) 0.78
Recombination activating genes (RAG) induce secondary Ig gene rearrangement in and subsequent apoptosis of human peripheral blood circulating B lymphocytes. Clin Exp Immunol (2004) 0.78
Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis. Aging Cell (2016) 0.77
Patterns of receptor revision in the immunoglobulin heavy chains of a teleost fish. J Immunol (2009) 0.77
Transcript expression of two Iglambda rearrangements and RAG-1/RAG-2 in a mature human B cell producing IgMlambda islet cell autoantibody. J Clin Immunol (2003) 0.76
Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity. J Hematol Oncol (2016) 0.76
Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells. BMC Immunol (2009) 0.75
Generation of transgenic mouse fluorescent reporter lines for studying hematopoietic development. Methods Mol Biol (2014) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
The sequence of the human genome. Science (2001) 101.55
The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature (1997) 33.47
The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics (2003) 32.92
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature (2004) 16.76
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 16.03
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science (1992) 14.70
Essential Bacillus subtilis genes. Proc Natl Acad Sci U S A (2003) 14.01
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (1995) 13.15
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A (1996) 12.92
Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med (2001) 10.36
Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet (1994) 10.14
Avian flu: H5N1 virus outbreak in migratory waterfowl. Nature (2005) 10.04
Highly pathogenic H5N1 influenza virus infection in migratory birds. Science (2005) 9.64
Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc Natl Acad Sci U S A (2006) 9.26
Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem (1978) 9.13
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci U S A (1982) 8.53
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 8.38
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet (1998) 7.89
Intraclonal generation of antibody mutants in germinal centres. Nature (1991) 7.39
PSORTb v.2.0: expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis. Bioinformatics (2004) 7.15
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity (1995) 6.91
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet (1997) 6.83
Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell (2000) 6.70
Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell (1985) 6.21
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science (2001) 6.17
A global profile of germline gene expression in C. elegans. Mol Cell (2000) 5.97
Atomic structure of a thermostable subdomain of HIV-1 gp41. Proc Natl Acad Sci U S A (1997) 5.76
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature (1984) 5.75
Preoperative chemotherapy in patients with operable breast cancer: nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18. J Natl Cancer Inst Monogr (2001) 5.74
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell (1980) 5.59
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell (1995) 5.58
Structure of the replicating complex of a pol alpha family DNA polymerase. Cell (2001) 5.26
Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J (2000) 5.22
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell (2001) 5.19
Indium phosphide nanowires as building blocks for nanoscale electronic and optoelectronic devices. Nature (2001) 5.09
Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised phase III noninferiority trial. Ann Oncol (2009) 5.08
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science (1994) 4.99
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J Exp Med (1991) 4.98
Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. Annu Rev Immunol (1999) 4.97
A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature (1986) 4.95
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science (1999) 4.77
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature (2000) 4.75
Impairment of V(D)J recombination in double-strand break repair mutants. Science (1993) 4.72
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature (2010) 4.52
Emergence and predominance of an H5N1 influenza variant in China. Proc Natl Acad Sci U S A (2006) 4.49
The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome. Proc Natl Acad Sci U S A (2008) 4.45
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature (1998) 4.37
The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell (1996) 4.35
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell (1995) 4.35
Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol Cell Biol (1982) 4.26
Gene amplification and drug resistance in cultured murine cells. Science (1978) 4.25
Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions. J Comp Physiol A (1994) 4.24
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci U S A (2000) 4.22
Mechanisms and rates of decay of marine viruses in seawater. Appl Environ Microbiol (1992) 4.22
Defective B cell development and function in Btk-deficient mice. Immunity (1995) 4.20
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature (1984) 4.18
Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs. Science (2013) 4.17
Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell (1983) 4.13
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci U S A (1997) 4.13
Regulation of the assembly and expression of variable-region genes. Annu Rev Immunol (1986) 4.09
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity (2001) 4.09
Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol (1993) 4.08
Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Gastroenterology (2000) 3.97
Anthropogenic warming of Earth's climate system. Science (2001) 3.94
Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol. J Natl Cancer Inst (2001) 3.88
Detection of Norwalk virus in stool by polymerase chain reaction. J Clin Microbiol (1992) 3.82
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell (2000) 3.82
Quantum annealing with manufactured spins. Nature (2011) 3.81
SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome. Nat Genet (1998) 3.79
Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature (1987) 3.74
Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest (1996) 3.74
Phase III trial comparing whole-pelvic versus prostate-only radiotherapy and neoadjuvant versus adjuvant combined androgen suppression: Radiation Therapy Oncology Group 9413. J Clin Oncol (2003) 3.73
Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin. Science (1999) 3.71
The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia (2008) 3.69
Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int Immunol (1993) 3.67
Regulation of genome rearrangement events during lymphocyte differentiation. Immunol Rev (1986) 3.65
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc Natl Acad Sci U S A (1993) 3.65
Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev (2000) 3.62
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity (1998) 3.58