PubRank

F W Alt

Author PubWeight™ 491.30‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 1996 12.92
2 Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem 1978 9.13
3 An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 1994 8.60
4 Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci U S A 1982 8.53
5 Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995 6.91
6 Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J 1984 6.67
7 Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell 1985 6.21
8 Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature 1984 5.75
9 Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell 1980 5.59
10 Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 1995 5.58
11 Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 1994 4.99
12 A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature 1986 4.95
13 A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 1998 4.78
14 Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science 1999 4.77
15 Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 2000 4.75
16 Impairment of V(D)J recombination in double-strand break repair mutants. Science 1993 4.72
17 Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 1998 4.37
18 The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell 1996 4.35
19 The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 1995 4.35
20 Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol Cell Biol 1982 4.26
21 Gene amplification and drug resistance in cultured murine cells. Science 1978 4.25
22 Defective B cell development and function in Btk-deficient mice. Immunity 1995 4.20
23 Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature 1984 4.18
24 Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell 1983 4.13
25 Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci U S A 1997 4.13
26 Regulation of the assembly and expression of variable-region genes. Annu Rev Immunol 1986 4.09
27 Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity 2001 4.09
28 Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol 1993 4.08
29 DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 2000 3.82
30 Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature 1987 3.74
31 Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int Immunol 1993 3.67
32 Regulation of genome rearrangement events during lymphocyte differentiation. Immunol Rev 1986 3.65
33 RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc Natl Acad Sci U S A 1993 3.65
34 N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev 2000 3.62
35 A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 1998 3.58
36 The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell 1996 3.55
37 Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell 1986 3.51
38 Human N-myc is closely related in organization and nucleotide sequence to c-myc. Nature 1986 3.40
39 Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J Exp Med 1998 3.37
40 Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity 1997 3.35
41 The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci U S A 2000 3.21
42 Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line. Nature 1982 3.05
43 Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 1993 2.93
44 Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity 1998 2.92
45 N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol 2001 2.91
46 Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells. Nature 1985 2.85
47 Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science 1993 2.80
48 Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching. Cell 1988 2.77
49 VDJ recombination. Immunol Today 1992 2.74
50 Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev 1992 2.72
51 The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell 1988 2.71
52 Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 1993 2.68
53 Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain. Cell 1980 2.68
54 Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. EMBO J 1986 2.62
55 Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 1998 2.62
56 Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J 1990 2.52
57 Function of the TCR alpha enhancer in alphabeta and gammadelta T cells. Immunity 1997 2.51
58 Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 1995 2.50
59 Activated expression of the N-myc gene in human neuroblastomas and related tumors. Science 1984 2.46
60 The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes. Immunity 1996 2.39
61 Structure and expression of the murine N-myc gene. Proc Natl Acad Sci U S A 1986 2.36
62 Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells. J Biol Chem 1976 2.36
63 Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet 2000 2.34
64 N-myc can cooperate with ras to transform normal cells in culture. Proc Natl Acad Sci U S A 1985 2.33
65 The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes Dev 1987 2.33
66 Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature 1995 2.33
67 Regulated progression of a cultured pre-B-cell line to the B-cell stage. Nature 1985 2.32
68 Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains. EMBO J 1987 2.31
69 Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr Biol 1998 2.30
70 RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proc Natl Acad Sci U S A 1997 2.23
71 Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements. Annu Rev Immunol 1996 2.19
72 Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol 2000 2.19
73 myc family oncogenes in the development of normal and neoplastic cells. Adv Cancer Res 1991 2.08
74 A class switch control region at the 3' end of the immunoglobulin heavy chain locus. Cell 1994 2.04
75 Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity 1998 2.00
76 Bclx regulates the survival of double-positive thymocytes. Proc Natl Acad Sci U S A 1995 2.00
77 Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. J Exp Med 1998 1.99
78 VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments. EMBO J 1986 1.99
79 Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro. J Biol Chem 2000 1.98
80 Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement. Immunity 1996 1.96
81 CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc Natl Acad Sci U S A 1994 1.96
82 Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts. J Biol Chem 1979 1.92
83 Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc Natl Acad Sci U S A 2001 1.91
84 Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. J Exp Med 1990 1.91
85 Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc Natl Acad Sci U S A 2000 1.90
86 CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression. Int Immunol 1994 1.89
87 Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev 2000 1.87
88 Expression of J chain RNA in cell lines representing different stages of B lymphocyte differentiation. Cell 1981 1.86
89 Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells. J Exp Med 1988 1.86
90 Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. EMBO J 1989 1.86
91 Developmentally regulated and strain-specific expression of murine VH gene families. J Exp Med 1988 1.85
92 S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J 1994 1.84
93 Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc Natl Acad Sci U S A 2000 1.83
94 A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon. EMBO J 1993 1.82
95 B cell development in mice that lack one or both immunoglobulin kappa light chain genes. EMBO J 1993 1.82
96 Mechanism and developmental program of immunoglobulin gene rearrangement in mammals. Annu Rev Genet 1989 1.81
97 Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harb Symp Quant Biol 1978 1.81
98 DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene 2001 1.81
99 TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. Immunity 2001 1.80
100 Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J 1993 1.80
101 Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA. J Biol Chem 1976 1.79
102 Structure and expression of germ line immunoglobulin gamma 2b transcripts. Mol Cell Biol 1988 1.79
103 Structure and expression of the human and mouse T4 genes. Proc Natl Acad Sci U S A 1987 1.77
104 The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 1994 1.75
105 The human myc gene family. Cold Spring Harb Symp Quant Biol 1986 1.74
106 Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol Cell 2001 1.68
107 Enhanced expression of the N-myc gene in Wilms' tumors. Cancer Res 1986 1.67
108 RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity 1999 1.66
109 Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion. Immunity 1999 1.66
110 Structure and expression of the murine L-myc gene. EMBO J 1987 1.64
111 SIRT6 in DNA repair, metabolism and ageing. J Intern Med 2008 1.61
112 Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers. J Exp Med 1998 1.58
113 Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. Genes Dev 1994 1.58
114 Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature 2000 1.57
115 The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev 1998 1.55
116 Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol 2000 1.55
117 A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol Cell Biol 1993 1.54
118 A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation. J Biol Chem 1994 1.53
119 Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc Natl Acad Sci U S A 1996 1.51
120 Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon. Mol Cell Biol 1990 1.50
121 N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization. J Cell Biol 1988 1.47
122 Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity 2000 1.44
123 Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development. Proc Natl Acad Sci U S A 1981 1.44
124 Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions. Proc Natl Acad Sci U S A 1999 1.44
125 T cell responses in calcineurin A alpha-deficient mice. J Exp Med 1996 1.44
126 High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination. Mol Cell Biol 1990 1.43
127 IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression. EMBO J 1989 1.42
128 Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line. Cell 1984 1.42
129 Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas. Oncogene 2007 1.40
130 Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching. Proc Natl Acad Sci U S A 1993 1.39
131 Structure and expression of germline immunoglobulin gamma 3 heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching. Int Immunol 1990 1.39
132 Activated Ras signals differentiation and expansion of CD4+8+ thymocytes. Proc Natl Acad Sci U S A 1996 1.38
133 Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes. J Exp Med 1999 1.38
134 Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science 1998 1.37
135 Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs. Mol Cell 2001 1.37
136 Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. Proc Natl Acad Sci U S A 1999 1.36
137 LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc Natl Acad Sci U S A 1993 1.36
138 Developmental regulation of V(D)J recombination and lymphocyte differentiation. Curr Opin Genet Dev 1996 1.32
139 Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor. J Immunol 1997 1.32
140 Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching. Int Immunol 1994 1.31
141 Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene. J Exp Med 1989 1.30
142 Molecular characterization of the lymphoid V(D)J recombination activity. J Biol Chem 1989 1.28
143 Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line. Mol Cell Biol 1984 1.27
144 Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most JH-proximal D segment (DQ52) and two unusual VH-related rearrangements. J Exp Med 1989 1.27
145 Immunoglobulin heavy chain gene rearrangements in X-linked agammaglobulinemia. Eur J Immunol 1986 1.23
146 SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity 1998 1.22
147 Are myc proteins transcription factors? Cancer Cells 1990 1.21
148 Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines. EMBO J 1992 1.21
149 Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity. Proc Natl Acad Sci U S A 1997 1.20
150 Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion. J Exp Med 1998 1.19
151 Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells. EMBO J 1987 1.19
152 CD3 epsilon and CD3 zeta cytoplasmic domains can independently generate signals for T cell development and function. Immunity 1995 1.19
153 Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice. J Exp Med 1990 1.17
154 Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status. J Exp Med 1993 1.16
155 Accessibility control of variable region gene assembly during T-cell development. Immunol Rev 1998 1.14
156 Gene rearrangement and B-cell development. Curr Opin Immunol 1993 1.14
157 Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia. Int Immunol 1989 1.14
158 Sequence and organization of the human T cell delta chain gene. Eur J Immunol 1988 1.13
159 Developmental regulation of TCR delta locus accessibility and expression by the TCR delta enhancer. Immunity 1999 1.13
160 T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line. Int Immunol 1989 1.13
161 Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice. J Exp Med 2000 1.12
162 Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes. Genes Dev 1992 1.12
163 Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus. Int Immunol 1998 1.12
164 DNA binding by N- and L-Myc proteins. Oncogene 1993 1.11
165 Activities involved in V(D)J recombination. Curr Top Microbiol Immunol 1992 1.11
166 Fine specificity, idiotypy, and nature of cloned heavy-chain variable region genes of murine monoclonal rheumatoid factor antibodies. Proc Natl Acad Sci U S A 1986 1.10
167 Expression and function of myc family genes. Crit Rev Oncog 1990 1.10
168 Molecular genetic characterization of XRCC4 function. Int Immunol 1997 1.08
169 Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras. Proc Natl Acad Sci U S A 1999 1.06
170 Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments. Proc Natl Acad Sci U S A 2000 1.04
171 Regulation of immunoglobulin light chain isotype expression. Adv Immunol 1998 1.04
172 Probing immune functions in RAG-deficient mice. Curr Opin Immunol 1994 1.03
173 A novel fluorescence-based system for assaying and separating live cells according to VDJ recombinase activity. Mol Cell Biol 1990 1.03
174 IL-2 receptor alpha chain expression during early B lymphocyte differentiation. Int Immunol 1994 1.02
175 Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. J Exp Med 1998 1.02
176 Differential regulation of the N-myc gene in transfected cells and transgenic mice. Mol Cell Biol 1990 1.02
177 A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. EMBO J 1992 1.00
178 Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus. Proc Natl Acad Sci U S A 1996 1.00
179 The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination. Int Immunol 1999 1.00
180 Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors. Mol Med 1997 1.00
181 Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis. Cold Spring Harb Symp Quant Biol 1999 1.00
182 IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis. EMBO J 1990 1.00
183 Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation. Immunity 1998 0.99
184 Promotion of V(D)J recombinational accessibility by the intronic E kappa element: role of the kappa B motif. Int Immunol 1995 0.99
185 Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells. Immunity 1997 0.99
186 Transcriptional down-regulation of N-myc expression during B-cell development. Mol Cell Biol 1992 0.98
187 VH gene usage in humans: biased usage of the VH6 gene in immature B lymphoid cells. Eur J Immunol 1991 0.98
188 Mechanisms that control antigen receptor variable region gene assembly. Semin Immunol 1994 0.97
189 Ig heavy chain class switching in Rag-deficient mice. Int Immunol 1998 0.97
190 RAG2 is regulated differentially in B and T cells by elements 5' of the promoter. Proc Natl Acad Sci U S A 1999 0.97
191 VH to VHDJH rearrangement is mediated by the internal VH heptamer. Int Immunol 1990 0.97
192 Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells. Immunity 1994 0.96
193 The role of short homology repeats and TdT in generation of the invariant gamma delta antigen receptor repertoire in the fetal thymus. Immunity 1995 0.96
194 Expression and induction of nuclear factor-kappa B-related proteins in thymocytes. J Immunol 1995 0.96
195 The molecular events in heavy chain class-switching. Semin Immunol 1989 0.95
196 Mechanism of endogenous myc gene down-regulation in E mu-N-myc tumors. Mol Cell Biol 1991 0.95
197 Potential targets for autosomal SCID mutations. Curr Opin Immunol 1995 0.95
198 Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein. J Exp Med 1999 0.94
199 CD40 expression and function in murine B cell ontogeny. Int Immunol 1996 0.94
200 Evolution of immunoglobulin genes: VH families in the amphibian Xenopus. Proc Natl Acad Sci U S A 1989 0.93
201 Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells. Curr Biol 1993 0.93
202 Cloning and sequence analysis of the VH and VL regions of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia. J Immunol 1990 0.93
203 Chromosomal location of N-myc and L-myc genes in the mouse. Oncogene Res 1989 0.93
204 Bone marrow B lymphocyte development in c-abl-deficient mice. Cell Immunol 1995 0.92
205 Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells. Int Immunol 1995 0.92
206 Repertoires of antigen receptors in Tdt congenitally deficient mice. Int Rev Immunol 1996 0.91
207 An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching. Int Immunol 1998 0.90
208 Abnormal peripheral lymphocyte function in c-abl mutant mice. Cell Immunol 1996 0.90
209 The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene. Int Immunol 1996 0.88
210 Complexity of the immunoglobulin light chain V kappa 1 gene family in the New Zealand black mouse. Int Immunol 1991 0.88
211 The role of Bruton's tyrosine kinase in B-cell development and function in mice and man. Ann N Y Acad Sci 1995 0.87
212 Structure and expression of human germline VH transcripts. J Exp Med 1991 0.87
213 Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochem Soc Trans 1999 0.87
214 Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40. Int Immunol 1997 0.86
215 Functional homology between N-myc and c-myc in murine plasmacytomagenesis: plasmacytoma development in N-myc transgenic mice. Oncogene 1992 0.86
216 Discordance between IgA switching at the DNA level and IgA expression at the mRNA level in IgA-deficient patients. Clin Immunol 1999 0.85
217 Expression of the immunoglobulin heavy-chain variable gene repertoire. Curr Top Microbiol Immunol 1987 0.85
218 The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis. Cold Spring Harb Symp Quant Biol 2000 0.85
219 Frequency of VH-gene utilization in human EBV-transformed B-cell lines: the most JH-proximal VH segment encodes autoantibodies. J Autoimmun 1989 0.84
220 A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion. Genomics 1995 0.83
221 V(D)J recombination. From RAGs to stitches. Nature 1997 0.83
222 Comparison of RAG gene expression in normal and transformed precursor lymphocytes. Int Immunol 1993 0.82
223 Genomic organization and chromosomal localization of the mouse Bp3 gene, a member of the CD38/ADP-ribosyl cyclase family. Immunogenetics 1996 0.82
224 Regulation fo immunoglobulin variable region gene assembly: development of the primary antibody repertoire. Bioessays 1986 0.81
225 Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chains. J Exp Med 1997 0.81
226 Exclusive immunoglobulin genes. Nature 1985 0.81
227 High frequency of myelomonocytic tumors in aging E mu L-myc transgenic mice. J Exp Med 1992 0.81
228 X-linked agammaglobulinemia. Clin Immunol Immunopathol 1991 0.81
229 Amplification of IMR-32 clones 8, G21, and N-myc in human neuroblastoma xenografts. Cancer Res 1987 0.80
230 Circular T-cell receptor gene recombination products. Nature 1987 0.80
231 Human heavy chain variable region gene diversity, organization, and expression. Int Rev Immunol 1990 0.80
232 Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice. Curr Top Microbiol Immunol 1988 0.79
233 The cytoskeleton in lymphocyte signaling. Adv Immunol 2000 0.79
234 Diversity of immunoglobulin heavy chain gene segment rearrangement in B lymphoblastoid cell lines from X-linked agammaglobulinemia patients. Eur J Immunol 1991 0.78
235 Structure of the gamma/delta T cell receptor of a human thymocyte clone. J Exp Med 1988 0.78
236 Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene. Mol Cell Biol 2000 0.78
237 Control of immunoglobulin heavy chain constant region gene expression. Adv Exp Med Biol 1991 0.78
238 Nuclear factors that mediate intrathymic signals are developmentally regulated. J Exp Med 1994 0.78
239 Reconstruction of an immune system. Science 1988 0.77
240 N-myc oncogene expression in histopathologically unrelated bilateral pediatric renal tumors. Cancer 1988 0.77
241 Antibody diversity. New mechanism revealed. Nature 1986 0.77
242 Identification of the XRCC4 gene: complementation of the DSBR and V(D)J recombination defects of XR-1 cells. Curr Top Microbiol Immunol 1996 0.76
243 RNA editing meets DNA shuffling. Nature 2000 0.76
244 Regulation of immunoglobulin variable-region gene assembly. Mt Sinai J Med 1986 0.76
245 Gene expression in renal growth and regrowth. J Urol 1988 0.76
246 Structure and expression of canary myc family genes. Mol Cell Biol 1991 0.75
247 Correlation between the occurrence of lupus nephritis, anti-erythrocyte autoantibodies and V kappa haplotype in NZB x 129/J and NZB x SM/J recombinant inbred murine strains. Eur J Immunol 1991 0.75
248 Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. 1978. Biotechnology 1992 0.75
249 Immunology: making antigen-receptor genes. Nature 1990 0.75
250 Differentiation antigens associated with the function of alloreactive T lymphocytes. Transplant Proc 1987 0.75
251 T cell receptor B chain rearrangements in human suppressor T lymphocytes. Transplant Proc 1987 0.75
252 Molecular cloning of a human immunoglobulin heavy chain variable (VH) region with anti-myelin-associated glycoprotein activity. J Neuroimmunol 1990 0.75
253 Molecular cloning of a human immunoglobulin heavy chain variable (vh) region with anti-myelin-associated glycoprotein activity. J Neuroimmunol 1990 0.75