Published in J Biol Chem on October 01, 1999
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. J Mol Biol (2008) 2.88
Adaptive value of high mutation rates of RNA viruses: separating causes from consequences. J Virol (2005) 1.46
The cost of replication fidelity in an RNA virus. Proc Natl Acad Sci U S A (2005) 1.28
Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase. Viruses (2010) 1.24
Mutation rates and intrinsic fidelity of retroviral reverse transcriptases. Viruses (2009) 1.19
The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine. J Biol Chem (2010) 1.11
Influence of reverse transcriptase variants, drugs, and Vpr on human immunodeficiency virus type 1 mutant frequencies. J Virol (2003) 1.09
Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise. J Biol Chem (2012) 1.03
A mutation in the primer grip region of HIV-1 reverse transcriptase that confers reduced fidelity of DNA synthesis. Nucleic Acids Res (2001) 1.02
The cost of replication fidelity in human immunodeficiency virus type 1. Proc Biol Sci (2007) 0.96
Mutations proximal to the minor groove-binding track of human immunodeficiency virus type 1 reverse transcriptase differentially affect utilization of RNA versus DNA as template. J Virol (2003) 0.92
The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity. Antimicrob Agents Chemother (2010) 0.90
Increased G-->A transition frequencies displayed by primer grip mutants of human immunodeficiency virus type 1 reverse transcriptase. J Virol (2004) 0.87
Structure-based evaluation of C5 derivatives in the catechol diether series targeting HIV-1 reverse transcriptase. Chem Biol Drug Des (2014) 0.86
Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern. AIDS Res Hum Retroviruses (2016) 0.77
Computational Analysis of Molecular Interaction Networks Underlying Change of HIV-1 Resistance to Selected Reverse Transcriptase Inhibitors. Bioinform Biol Insights (2010) 0.75
The effects of frequent nocturnal home hemodialysis: the Frequent Hemodialysis Network Nocturnal Trial. Kidney Int (2011) 4.27
Calf 5' to 3' exo/endonuclease must slide from a 5' end of the substrate to perform structure-specific cleavage. J Biol Chem (1995) 2.62
HIV-1 RT-associated ribonuclease H displays both endonuclease and 3'----5' exonuclease activity. EMBO J (1990) 2.54
Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone. J Clin Invest (2001) 2.49
Is the heterocyst the site of nitrogen fixation in blue-green algae? Nature (1968) 2.35
Processing protease and reverse transcriptase from human immunodeficiency virus type I polyprotein in Escherichia coli. J Virol (1988) 2.28
Point mutations in conserved amino acid residues within the C-terminal domain of HIV-1 reverse transcriptase specifically repress RNase H function. FEBS Lett (1989) 2.20
Enzymatic completion of mammalian lagging-strand DNA replication. Proc Natl Acad Sci U S A (1994) 2.11
Effects of long-term treatment with acetylene on nitrogen-fixing microorganisms. Appl Environ Microbiol (1977) 2.08
Metabolic activities of isolated heterocysts of the blue-green alga Anabaena cylindrica. Nature (1966) 2.01
TempliPhi, phi29 DNA polymerase based rolling circle amplification of templates for DNA sequencing. Biotechniques (2002) 2.00
Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1. J Biol Chem (2000) 1.97
Interaction of HIV-1 reverse transcriptase with a synthetic form of its replication primer, tRNA(Lys,3). Nucleic Acids Res (1991) 1.91
The catabolite-sensitive promoter for the chloramphenicol acetyl transferase gene is preceded by two binding sites for the catabolite gene activator protein. J Bacteriol (1982) 1.87
Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase. J Virol (1992) 1.80
Influence of human immunodeficiency virus nucleocapsid protein on synthesis and strand transfer by the reverse transcriptase in vitro. J Biol Chem (1995) 1.79
The heterocysts of blue-green algae. 3. Differentiation and nitrogenase activity. Proc R Soc Lond B Biol Sci (1972) 1.77
Purification and characterization of two new high molecular weight forms of DNA polymerase delta. Biochemistry (1986) 1.75
Polymerization and RNase H activities of the reverse transcriptases from avian myeloblastosis, human immunodeficiency, and Moloney murine leukemia viruses are functionally uncoupled. J Biol Chem (1991) 1.74
Revised nomenclature for eukaryotic DNA polymerases. Eur J Biochem (1990) 1.73
Strand transfer mediated by human immunodeficiency virus reverse transcriptase in vitro is promoted by pausing and results in misincorporation. J Biol Chem (1995) 1.68
Site-specific pausing of deoxyribonucleic acid synthesis catalyzed by four forms of Escherichia coli DNA polymerase III. Biochemistry (1983) 1.63
Evidence for a unique mechanism of strand transfer from the transactivation response region of HIV-1. J Biol Chem (1997) 1.62
Exonucleolytic proofreading by calf thymus DNA polymerase delta. Proc Natl Acad Sci U S A (1987) 1.61
Pathogenesis of high-altitude pulmonary oedema: direct evidence of stress failure of pulmonary capillaries. Eur Respir J (1995) 1.59
Structural basis for the specificity of the initiation of HIV-1 reverse transcription. EMBO J (1999) 1.59
Completion of mammalian lagging strand DNA replication using purified proteins. J Biol Chem (1993) 1.57
Analogs of cyclic AMP that elicit the biochemically defined conformational change in catabolite gene activator protein (CAP) but do not stimulate binding to DNA. J Mol Biol (1985) 1.55
Size classes of products synthesized processively by DNA polymerase III and DNA polymerase III holoenzyme of Escherichia coli. J Biol Chem (1981) 1.52
Nitrogen metabolism and ultrastructure in Anabaena cylindrica. I. The effect of nitrogen starvation. Arch Mikrobiol (1974) 1.51
Cell differentiation and pigment composition in Anabaena cylindrica. Arch Mikrobiol (1969) 1.50
The calf 5'- to 3'-exonuclease is also an endonuclease with both activities dependent on primers annealed upstream of the point of cleavage. J Biol Chem (1994) 1.49
Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase. Nucleic Acids Res (1993) 1.46
Expression of biologically active human T-cell lymphotropic virus type III reverse transcriptase in Bacillus subtilis. Gene (1987) 1.43
Fidelity of mammalian DNA replication and replicative DNA polymerases. Biochemistry (1991) 1.43
Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansion. J Biol Chem (2000) 1.42
Two-dimensional crystallization of histidine-tagged, HIV-1 reverse transcriptase promoted by a novel nickel-chelating lipid. J Struct Biol (1995) 1.41
Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization. Biochemistry (1996) 1.39
Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function. J Biol Chem (1997) 1.38
Binding and kinetic properties of HIV-1 reverse transcriptase markedly differ during initiation and elongation of reverse transcription. EMBO J (1996) 1.36
Alanine-scanning mutations in the "primer grip" of p66 HIV-1 reverse transcriptase result in selective loss of RNA priming activity. J Biol Chem (1997) 1.36
Human immunodeficiency virus reverse transcriptase displays a partially processive 3' to 5' endonuclease activity. J Biol Chem (1991) 1.35
Nuclease footprinting of human immunodeficiency virus reverse transcriptase/tRNA(Lys-3) complexes. J Biol Chem (1993) 1.33
Helix structure and ends of RNA/DNA hybrids direct the cleavage specificity of HIV-1 reverse transcriptase RNase H. J Biol Chem (1996) 1.32
Prognostic value of 18F-FDG PET/CT before and after radiotherapy for locally advanced nasopharyngeal carcinoma. Ann Oncol (2009) 1.32
Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant. J Virol (1993) 1.32
Hydroxyl radical footprint analysis of human immunodeficiency virus reverse transcriptase-template.primer complexes. Proc Natl Acad Sci U S A (1993) 1.32
Binding of RNA polymerase and the catabolite gene activator protein within the cat promoter in Escherichia coli. J Mol Biol (1981) 1.32
Sequence requirements for estrogen receptor binding to estrogen response elements. J Biol Chem (1998) 1.32
A 5' to 3' exonuclease functionally interacts with calf DNA polymerase epsilon. Proc Natl Acad Sci U S A (1992) 1.31
Localisation of the transcription initiation site of the chloramphenicol resistance gene on plasmid pAC184. FEBS Lett (1980) 1.31
Junction ribonuclease: an activity in Okazaki fragment processing. Proc Natl Acad Sci U S A (1998) 1.31
Size classes of products synthesized processively by two subassemblies of Escherichia coli DNA polymerase III holoenzyme. J Biol Chem (1982) 1.30
Human DNA ligase I efficiently seals nicks in nucleosomes. EMBO J (2000) 1.30
Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H. Proc Natl Acad Sci U S A (2000) 1.30
Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16. J Mol Endocrinol (2003) 1.30
Separation and analysis of the RNA polymerase binding sites of a complex Bacillus subtilis promoter. Mol Gen Genet (1986) 1.27
Restoration of tRNA3Lys-primed(-)-strand DNA synthesis to an HIV-1 reverse transcriptase mutant with extended tRNAs. Implications for retroviral replication. J Biol Chem (1996) 1.26
Involvement of HIV-I nucleocapsid protein in the recruitment of reverse transcriptase into nucleoprotein complexes formed in vitro. J Biol Chem (1998) 1.26
Interaction of Bacillus subtilis RNA polymerase with a chromosomal promoter. J Mol Biol (1982) 1.25
Elongation of RNA-primed DNA templates by DNA polymerase alpha from Drosophila melanogaster embryos. J Biol Chem (1981) 1.24
Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures. Biochemistry (1993) 1.24
The kissing hairpin sequence promotes recombination within the HIV-I 5' leader region. J Biol Chem (2001) 1.24
Tetrazolium reduction and nitrogenase activity in heterocystous blue-green algae. Arch Mikrobiol (1972) 1.24
Modulation of HIV-1 reverse transcriptase function in "selectively deleted" p66/p51 heterodimers. J Biol Chem (1994) 1.23
Interaction of retroviral reverse transcriptase with template-primer duplexes during replication. Prog Nucleic Acid Res Mol Biol (1998) 1.23
Factors influencing dark nitrogen fixation in a blue-green alga. Appl Environ Microbiol (1976) 1.22
Mutating the "primer grip" of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization. J Biol Chem (1994) 1.22
DNA ligase I and proliferating cell nuclear antigen form a functional complex. J Biol Chem (2001) 1.22
Calf RTH-1 nuclease can remove the initiator RNAs of Okazaki fragments by endonuclease activity. J Biol Chem (1996) 1.22
Special aspects of nitrogen fixation by blue-green algae. Proc R Soc Lond B Biol Sci (1969) 1.21
Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates. Biochim Biophys Acta (1992) 1.20
Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein. Proc Natl Acad Sci U S A (1997) 1.19
Effect of flap modifications on human FEN1 cleavage. Biochemistry (1999) 1.19
Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage. Mol Cell Biol (2001) 1.19
Truncating alpha-helix E' of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer. J Biol Chem (1995) 1.17
Photostimulation of nitrogen fixation in Anabaena cylindrica. Biochim Biophys Acta (1970) 1.17
Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptase. J Biol Chem (1995) 1.17
Properties of two forms of DNA polymerase delta from calf thymus. Biochemistry (1986) 1.16
Creation and removal of embedded ribonucleotides in chromosomal DNA during mammalian Okazaki fragment processing. J Biol Chem (1997) 1.15
Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice. J Clin Invest (2000) 1.15
Biosynthesis and analysis of a genetically engineered HIV-1 reverse transcriptase/endonuclease polyprotein in Escherichia coli. Gene (1988) 1.15
Calf thymus DNA polymerases alpha and delta are capable of highly processive DNA synthesis. Biochemistry (1988) 1.14
Role of post-transcriptional modifications of primer tRNALys,3 in the fidelity and efficacy of plus strand DNA transfer during HIV-1 reverse transcription. J Biol Chem (1999) 1.14
Purification of a calf thymus DNA-dependent adenosinetriphosphatase that prefers a primer-template junction effector. Biochemistry (1986) 1.13
Footprint analysis of replicating murine leukemia virus reverse transcriptase. Science (1995) 1.13
Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half-sites, and inhibits estrogen-induced gene expression. J Biol Chem (1997) 1.12
Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase. J Biol Chem (1995) 1.12
The mechanism of human immunodeficiency virus reverse transcriptase-catalyzed strand transfer from internal regions of heteropolymeric RNA templates. J Biol Chem (1994) 1.12
Nitrogen metabolism and ultrastructure in Anabaena cylindrica. II. The effect of molybdenum and vanadium. Arch Microbiol (1974) 1.12