Published in Structure on September 15, 1999
Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev (2008) 17.77
Update of the standard numbering scheme for class B beta-lactamases. Antimicrob Agents Chemother (2004) 2.83
Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family. Nucleic Acids Res (2002) 2.76
Quorum-quenching microbial infections: mechanisms and implications. Philos Trans R Soc Lond B Biol Sci (2007) 1.85
The crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa, defines a third class of sulfatases. Proc Natl Acad Sci U S A (2006) 1.39
Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis. Proc Natl Acad Sci U S A (2005) 1.34
The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase. Proc Natl Acad Sci U S A (2005) 1.33
Characterization of patient mutations in human persulfide dioxygenase (ETHE1) involved in H2S catabolism. J Biol Chem (2012) 1.26
Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures. Biochemistry (2008) 1.22
Thioesterases: a new perspective based on their primary and tertiary structures. Protein Sci (2010) 1.22
Structural studies on a mitochondrial glyoxalase II. J Biol Chem (2005) 1.12
ETHE1 mutations are specific to ethylmalonic encephalopathy. J Med Genet (2005) 1.04
The binding of iron and zinc to glyoxalase II occurs exclusively as di-metal centers and is unique within the metallo-beta-lactamase family. J Biol Inorg Chem (2004) 1.02
Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 2. Substrate modeling and active site mutations. Biochemistry (2008) 1.01
Structure-based phylogeny of the metallo-beta-lactamases. Antimicrob Agents Chemother (2005) 1.00
Identification of a novel type of cGMP phosphodiesterase that is defective in the chemotactic stmF mutants. Mol Biol Cell (2002) 0.99
Functional control of the binuclear metal site in the metallo-beta-lactamase-like fold by subtle amino acid replacements. Protein Sci (2002) 0.93
Designing hydrolytic zinc metalloenzymes. Biochemistry (2014) 0.91
Role of zinc content on the catalytic efficiency of B1 metallo beta-lactamases. J Am Chem Soc (2007) 0.91
Spectroscopic studies on Arabidopsis ETHE1, a glyoxalase II-like protein. J Inorg Biochem (2008) 0.91
Zinc- and iron-dependent cytosolic metallo-beta-lactamase domain proteins exhibit similar zinc-binding affinities, independent of an atypical glutamate at the metal-binding site. Biochem J (2005) 0.91
Mechanism for the hydrolysis of a sulfur-sulfur bond based on the crystal structure of the thiosulfohydrolase SoxB. J Biol Chem (2009) 0.90
Characterization of the gene encoding glyoxalase II from Leishmania donovani: a potential target for anti-parasite drugs. Biochem J (2006) 0.90
Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: an unusual Type II glyoxalase. Protein Sci (2010) 0.87
Human glyoxalase II contains an Fe(II)Zn(II) center but is active as a mononuclear Zn(II) enzyme. Biochemistry (2009) 0.85
Mutations in PNKD causing paroxysmal dyskinesia alters protein cleavage and stability. Hum Mol Genet (2011) 0.85
Conformational changes in the metallo-beta-lactamase ImiS during the catalytic reaction: an EPR spectrokinetic study of Co(II)-spin label interactions. J Am Chem Soc (2008) 0.84
Arabidopsis thaliana mitochondrial glyoxalase 2-1 exhibits beta-lactamase activity. Biochemistry (2009) 0.84
Structure and activity of a novel archaeal β-CASP protein with N-terminal KH domains. Structure (2011) 0.83
The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins. Trends Biochem Sci (2016) 0.81
Arabidopsis thaliana GLX2-1 contains a dinuclear metal binding site, but is not a glyoxalase 2. Biochem J (2009) 0.81
Structure of TTHA1623, a novel metallo-beta-lactamase superfamily protein from Thermus thermophilus HB8. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.80
Structural effects of the active site mutation cysteine to serine in Bacillus cereus zinc-beta-lactamase. Protein Sci (2000) 0.80
Pneumococcal phosphorylcholine esterase, Pce, contains a metal binuclear center that is essential for substrate binding and catalysis. Protein Sci (2005) 0.80
The metal ion requirements of Arabidopsis thaliana Glx2-2 for catalytic activity. J Biol Inorg Chem (2009) 0.80
Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-β-lactamase Superfamily. J Biol Chem (2015) 0.79
Grafting a new metal ligand in the cocatalytic site of B. cereus metallo-beta-lactamase: structural flexibility without loss of activity. Protein Sci (2003) 0.79
Conformational dynamics of metallo-β-lactamase CcrA during catalysis investigated by using DEER spectroscopy. J Biol Inorg Chem (2015) 0.79
Characteristics and function of sulfur dioxygenase in Echiuran worm Urechis unicinctus. PLoS One (2013) 0.79
Evolution of broad spectrum β-lactam resistance in an engineered metallo-β-lactamase. J Biol Chem (2012) 0.79
Structural and functional analysis show that the Escherichia coli uncharacterized protein YjcS is likely an alkylsulfatase. Protein Sci (2014) 0.78
Methylglyoxal metabolism in trypanosomes and leishmania. Semin Cell Dev Biol (2011) 0.78
Metal-dependent inhibition of glyoxalase II: a possible mechanism to regulate the enzyme activity. J Inorg Biochem (2010) 0.78
Estimates of statistical significance for comparison of individual positions in multiple sequence alignments. BMC Bioinformatics (2004) 0.78
Converting GLX2-1 into an active glyoxalase II. Biochemistry (2010) 0.77
Spectroscopic signature of a ubiquitous metal binding site in the metallo-β-lactamase superfamily. J Biol Inorg Chem (2010) 0.77
Linkage of catalysis and 5' end recognition in ribonuclease RNase J. Nucleic Acids Res (2015) 0.75
The dual function of flavodiiron proteins: oxygen and/or nitric oxide reductases. J Biol Inorg Chem (2016) 0.75
Characteristic Variations and Similarities in Biochemical, Molecular, and Functional Properties of Glyoxalases across Prokaryotes and Eukaryotes. Int J Mol Sci (2017) 0.75
Purification, crystallization and preliminary X-ray diffraction analysis of the glyoxalase II from Leishmania infantum. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.75
Use of ferrous iron by metallo-β-lactamases. J Inorg Biochem (2016) 0.75
The CphAII protein from Aquifex aeolicus exhibits a metal-dependent phosphodiesterase activity. Extremophiles (2011) 0.75
Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta (1979) 7.12
Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. Proc Natl Acad Sci U S A (1985) 6.20
The isoenzymes of glutathione transferase. Adv Enzymol Relat Areas Mol Biol (1985) 5.91
Glutathione reductase. Methods Enzymol (1985) 4.80
Glutathione transferase (human placenta). Methods Enzymol (1981) 3.59
Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J Biol Chem (1975) 2.96
Nomenclature for human glutathione transferases. Biochem J (1992) 2.71
Binary combinations of four protein subunits with different catalytic specificities explain the relationship between six basic glutathione S-transferases in rat liver cytosol. J Biol Chem (1982) 2.53
4-Hydroxyalk-2-enals are substrates for glutathione transferase. FEBS Lett (1985) 2.21
Molecular and catalytic properties of glutathione transferase mu from human liver: an enzyme efficiently conjugating epoxides. Biochemistry (1983) 2.08
Glutathione transferases: nomenclature. Biochem Pharmacol (1984) 2.06
Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases. Proc Natl Acad Sci U S A (1994) 2.02
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons. Carcinogenesis (1998) 1.88
Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products. J Mol Biol (1999) 1.83
Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation. Biochem J (1998) 1.76
Regression analysis, experimental error, and statistical criteria in the design and analysis of experiments for discrimination between rival kinetic models. Methods Enzymol (1982) 1.68
Isothiocyanates as substrates for human glutathione transferases: structure-activity studies. Biochem J (1995) 1.67
Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes. Biochem J (1997) 1.61
Rat glutathione transferase 8-8, an enzyme efficiently detoxifying 4-hydroxyalk-2-enals. FEBS Lett (1986) 1.57
Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping. EMBO J (1997) 1.54
Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing. Anal Biochem (1985) 1.49
Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases. Biochem J (1987) 1.44
Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases. Biochem Biophys Res Commun (1995) 1.44
Glutathione peroxidase. Methods Enzymol (1985) 1.44
Mutation of an evolutionarily conserved tyrosine residue in the active site of a human class Alpha glutathione transferase. FEBS Lett (1991) 1.43
Purification and characterization of two glutathione S-aryltransferase activities from rat liver. Biochem J (1975) 1.43
Single-step purification and h.p.l.c. analysis of glutathione transferase 8-8 in rat tissues. Biochem J (1989) 1.39
Immobilized metal ion affinity adsorption and immobilized metal ion affinity chromatography of biomaterials. Serum protein affinities for gel-immobilized iron and nickel ions. Biochemistry (1983) 1.36
Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105. J Mol Biol (1998) 1.36
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. Hum Mol Genet (1997) 1.36
Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate. Structure (1995) 1.35
Error structure of enzyme kinetic experiments. Implications for weighting in regression analysis of experimental data. Eur J Biochem (1976) 1.34
Purification and characterization of three distinct glutathione transferases from mouse liver. Biochemistry (1986) 1.32
Kinetic independence of the subunits of cytosolic glutathione transferase from the rat. Biochem J (1985) 1.32
Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1. J Mol Biol (1995) 1.30
Purification of a new glutathione S-transferase (transferase mu) from human liver having high activity with benzo(alpha)pyrene-4,5-oxide. Biochem Biophys Res Commun (1981) 1.28
Inhibitors for distinction of three types of human glutathione transferase. FEBS Lett (1985) 1.26
Purification of glutathione-S-transferase from human placenta. Acta Chem Scand B (1979) 1.25
Structural evidence for three different types of glutathione transferase in human tissues. FEBS Lett (1985) 1.25
Purification of glutathione S-transferases from rat lung by affinity chromatography. Evidence for an enzyme form absent in rat liver. Biochem Biophys Res Commun (1979) 1.23
Participation of the phenolic hydroxyl group of Tyr-8 in the catalytic mechanism of human glutathione transferase P1-1. Biochem J (1992) 1.23
Glutathione transferases from human liver. Methods Enzymol (1985) 1.23
Cytosolic rat liver glutathione transferase 4-4. Primary structure of the protein reveals extensive differences between homologous glutathione transferases of classes alpha and mu. Eur J Biochem (1986) 1.22
Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases. Biochem J (1998) 1.22
Glutathione transferase from rat testis. Methods Enzymol (1985) 1.19
Cytosolic glutathione transferases from rat liver. Primary structure of class alpha glutathione transferase 8-8 and characterization of low-abundance class Mu glutathione transferases. Biochem J (1989) 1.19
Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue. Biochemistry (1999) 1.18
Glutathione transferases in rat testis. Acta Chem Scand B (1983) 1.18
Heterologous expression of the allelic variant mu-class glutathione transferases mu and psi. Biochem J (1991) 1.18
Purification and characterization of cytoplasmic thioltransferase (glutathione:disulfide oxidoreductase) from rat liver. Biochemistry (1978) 1.18
A steady-state-kinetic random mechanism for glutathione S-transferase A from rat liver. A model involving kinetically significant enzyme-product complexes in the forward reaction. Eur J Biochem (1977) 1.17
The trans-stilbene oxide-active glutathione transferase in human mononuclear leucocytes is identical with the hepatic glutathione transferase mu. Biochem J (1987) 1.14
Glutathione S-transferase (transferase pi) from human placenta is identical or closely related to glutathione S-transferase (transferase rho) from erythrocytes. Biochim Biophys Acta (1981) 1.14
Isoenzymes of glutathione transferase in rat kidney cytosol. Biochem J (1985) 1.13
A procedure based on statistical criteria for discrimination between steady state kinetic models. FEBS Lett (1972) 1.13
Glutathione transferase activity and isoenzyme composition in primary human breast cancers. Cancer Res (1990) 1.12
Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells. Cancer Res (1989) 1.12
Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem (2001) 1.11
Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation. Proc Natl Acad Sci U S A (2000) 1.10
Optimized heterologous expression of the human zinc enzyme glyoxalase I. Biochem J (1996) 1.10
Heterologous expression of recombinant human glutathione transferase A1-1 from a hepatoma cell line. Protein Expr Purif (1992) 1.10
Glutathione S-transferases in earthworms (Lumbricidae). Biochem J (1979) 1.09
Simple inhibition studies for distinction between homodimeric and heterodimeric isoenzymes of glutathione transferase. J Biol Chem (1986) 1.09
Cloning and heterologous expression of cDNA encoding class alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic alpha,beta-unsaturated carbonyl compounds. Biochem J (1992) 1.08
Discrimination between mathematical models of biological systems exemplified by enzyme steady state kinetics. Acta Biol Med Ger (1973) 1.08
Design of two chimaeric human-rat class alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties. Biochem J (1992) 1.08
Human class Mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome. J Biol Chem (1997) 1.06
Relative contributions of thioltransferase-and thioredoxin-dependent systems in reduction of low-molecular-mass and protein disulphides. Biochem J (1983) 1.06
Identification of a new glutathione S-transferase in human liver. Acta Chem Scand B (1980) 1.05
Identification of a novel glutathione transferase in human skin homologous with class alpha glutathione transferase 2-2 in the rat. Biochem J (1987) 1.05
Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1. Chem Res Toxicol (1997) 1.05
Examination of the transcription factor NtcA-binding motif by in vitro selection of DNA sequences from a random library. J Mol Biol (2000) 1.05
Induction of glutathione S-transferases A, B and C in rat liver cytosol by trans-stilbene oxide. Biochim Biophys Acta (1980) 1.05
Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones. Biochem Biophys Res Commun (2000) 1.05
Glyoxalase I, a zinc metalloenzyme of mammals and yeast. Biochem Biophys Res Commun (1978) 1.04
Effects of directed mutagenesis on conserved arginine residues in a human Class Alpha glutathione transferase. Biochem J (1991) 1.04
Thioltransferase. Methods Enzymol (1981) 1.03
Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione. Biochim Biophys Acta (1977) 1.03
A set of inhibitors for discrimination between the basic isozymes of glutathione transferase in rat liver. Biochem Biophys Res Commun (1983) 1.03
Benzo(alpha)pyrene quinones can be generated by lipid peroxidation and are conjugated with glutathione by glutathione S-transferase b from rat liver. Biochem Biophys Res Commun (1981) 1.02
Selective expression of glutathione transferase isoenzymes in chemically induced preneoplastic rat hepatocyte nodules. FEBS Lett (1985) 1.01
Mechanism of action of enzymes catalyzing thiol-disulfide interchange. Thioltransferases rather than transhydrogenases. FEBS Lett (1974) 1.00
A conserved "hydrophobic staple motif" plays a crucial role in the refolding of human glutathione transferase P1-1. J Biol Chem (2000) 1.00
Differences among human tumor cell lines in the expression of glutathione transferases and other glutathione-linked enzymes. Carcinogenesis (1990) 0.99
Comparison of glyoxalase I purified from yeast (Saccharomyces cerevisiae) with the enzyme from mammalian sources. Biochem J (1979) 0.99
A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes. Arch Biochem Biophys (1994) 0.98
Leukotriene C4 formation catalyzed by three distinct forms of human cytosolic glutathione transferase. Biochem Biophys Res Commun (1985) 0.98
Characterization of glyoxalase I purified from pig erythrocytes by affinity chromatography. Biochem J (1977) 0.98
Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling. J Mol Biol (1999) 0.98
Tyrosine 50 at the subunit interface of dimeric human glutathione transferase P1-1 is a structural key residue for modulating protein stability and catalytic function. Biochem Biophys Res Commun (2000) 0.98
Transformation of leukotriene A4 methyl ester to leukotriene C4 monomethyl ester by cytosolic rat glutathione transferases. FEBS Lett (1984) 0.98