Published in Biochem J on July 15, 1992
Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases. Proc Natl Acad Sci U S A (1994) 2.02
Crystal structure of a theta-class glutathione transferase. EMBO J (1995) 1.75
Isothiocyanates as substrates for human glutathione transferases: structure-activity studies. Biochem J (1995) 1.67
MIF protein are theta-class glutathione S-transferase homologs. Protein Sci (1993) 1.23
Mutagenesis of the active site of the human Theta-class glutathione transferase GSTT2-2: catalysis with different substrates involves different residues. Biochem J (1996) 1.06
Plasmodium falciparum glutathione S-transferase--structural and mechanistic studies on ligand binding and enzyme inhibition. Protein Sci (2005) 0.96
Unusual reactivity of Tyr-7 of GSH transferase P1-1. Biochem J (1993) 0.94
The role of tyrosine-9 and the C-terminal helix in the catalytic mechanism of Alpha-class glutathione S-transferases. Biochem J (1999) 0.93
Steady-state kinetics and chemical mechanism of octopus hepatopancreatic glutathione transferase. Biochem J (1995) 0.92
Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases. Biochem J (1999) 0.89
Tyrosine 8 contributes to catalysis but is not required for activity of rat liver glutathione S-transferase, 1-1. Protein Sci (1996) 0.88
Co-variation of glutathione transferase expression and cytostatic drug resistance in HeLa cells: establishment of class Mu glutathione transferase M3-3 as the dominating isoenzyme. Biochem J (1994) 0.88
Pressure-dependent ionization of Tyr 9 in glutathione S-transferase A1-1: contribution of the C-terminal helix to a "soft" active site. Protein Sci (1997) 0.85
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A functionally conserved basic residue in glutathione transferases interacts with the glycine moiety of glutathione and is pivotal for enzyme catalysis. Biochem J (2007) 0.80
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Kinetic independence of the subunits of cytosolic glutathione transferase from the rat. Biochem J (1985) 1.32
Spectroscopic and kinetic evidence for the thiolate anion of glutathione at the active site of glutathione S-transferase. Biochemistry (1989) 1.26
Heterologous expression of the allelic variant mu-class glutathione transferases mu and psi. Biochem J (1991) 1.18
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Design of two chimaeric human-rat class alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties. Biochem J (1992) 1.08
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Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases. Proc Natl Acad Sci U S A (1994) 2.02
Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue. Structure (1999) 1.89
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Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation. Biochem J (1998) 1.76
Regression analysis, experimental error, and statistical criteria in the design and analysis of experiments for discrimination between rival kinetic models. Methods Enzymol (1982) 1.68
Isothiocyanates as substrates for human glutathione transferases: structure-activity studies. Biochem J (1995) 1.67
Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes. Biochem J (1997) 1.61
Rat glutathione transferase 8-8, an enzyme efficiently detoxifying 4-hydroxyalk-2-enals. FEBS Lett (1986) 1.57
Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping. EMBO J (1997) 1.54
Structure of a gene encoding a cytosolic acetyl-CoA carboxylase of hexaploid wheat. Proc Natl Acad Sci U S A (1996) 1.50
Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing. Anal Biochem (1985) 1.49
Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases. Biochem J (1987) 1.44
Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases. Biochem Biophys Res Commun (1995) 1.44
Glutathione peroxidase. Methods Enzymol (1985) 1.44
Mutation of an evolutionarily conserved tyrosine residue in the active site of a human class Alpha glutathione transferase. FEBS Lett (1991) 1.43
Purification and characterization of two glutathione S-aryltransferase activities from rat liver. Biochem J (1975) 1.43
Single-step purification and h.p.l.c. analysis of glutathione transferase 8-8 in rat tissues. Biochem J (1989) 1.39
Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105. J Mol Biol (1998) 1.36
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. Hum Mol Genet (1997) 1.36
Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate. Structure (1995) 1.35
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Purification and characterization of three distinct glutathione transferases from mouse liver. Biochemistry (1986) 1.32
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Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1. J Mol Biol (1995) 1.30
Purification of a new glutathione S-transferase (transferase mu) from human liver having high activity with benzo(alpha)pyrene-4,5-oxide. Biochem Biophys Res Commun (1981) 1.28
Inhibitors for distinction of three types of human glutathione transferase. FEBS Lett (1985) 1.26
Purification of glutathione-S-transferase from human placenta. Acta Chem Scand B (1979) 1.25
Structural evidence for three different types of glutathione transferase in human tissues. FEBS Lett (1985) 1.25
Purification of glutathione S-transferases from rat lung by affinity chromatography. Evidence for an enzyme form absent in rat liver. Biochem Biophys Res Commun (1979) 1.23
Glutathione transferases from human liver. Methods Enzymol (1985) 1.23
Cytosolic rat liver glutathione transferase 4-4. Primary structure of the protein reveals extensive differences between homologous glutathione transferases of classes alpha and mu. Eur J Biochem (1986) 1.22
Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases. Biochem J (1998) 1.22
Glutathione transferase from rat testis. Methods Enzymol (1985) 1.19
Cytosolic glutathione transferases from rat liver. Primary structure of class alpha glutathione transferase 8-8 and characterization of low-abundance class Mu glutathione transferases. Biochem J (1989) 1.19
Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue. Biochemistry (1999) 1.18
Heterologous expression of the allelic variant mu-class glutathione transferases mu and psi. Biochem J (1991) 1.18
Glutathione transferases in rat testis. Acta Chem Scand B (1983) 1.18
Purification and characterization of cytoplasmic thioltransferase (glutathione:disulfide oxidoreductase) from rat liver. Biochemistry (1978) 1.18
A steady-state-kinetic random mechanism for glutathione S-transferase A from rat liver. A model involving kinetically significant enzyme-product complexes in the forward reaction. Eur J Biochem (1977) 1.17
The trans-stilbene oxide-active glutathione transferase in human mononuclear leucocytes is identical with the hepatic glutathione transferase mu. Biochem J (1987) 1.14
Glutathione S-transferase (transferase pi) from human placenta is identical or closely related to glutathione S-transferase (transferase rho) from erythrocytes. Biochim Biophys Acta (1981) 1.14
Isoenzymes of glutathione transferase in rat kidney cytosol. Biochem J (1985) 1.13
A procedure based on statistical criteria for discrimination between steady state kinetic models. FEBS Lett (1972) 1.13
Glutathione transferase activity and isoenzyme composition in primary human breast cancers. Cancer Res (1990) 1.12
Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells. Cancer Res (1989) 1.12
Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem (2001) 1.11
Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation. Proc Natl Acad Sci U S A (2000) 1.10
Optimized heterologous expression of the human zinc enzyme glyoxalase I. Biochem J (1996) 1.10
Heterologous expression of recombinant human glutathione transferase A1-1 from a hepatoma cell line. Protein Expr Purif (1992) 1.10
Glutathione S-transferases in earthworms (Lumbricidae). Biochem J (1979) 1.09
Simple inhibition studies for distinction between homodimeric and heterodimeric isoenzymes of glutathione transferase. J Biol Chem (1986) 1.09
Cloning and heterologous expression of cDNA encoding class alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic alpha,beta-unsaturated carbonyl compounds. Biochem J (1992) 1.08
Discrimination between mathematical models of biological systems exemplified by enzyme steady state kinetics. Acta Biol Med Ger (1973) 1.08
Design of two chimaeric human-rat class alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties. Biochem J (1992) 1.08
Human class Mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome. J Biol Chem (1997) 1.06
Relative contributions of thioltransferase-and thioredoxin-dependent systems in reduction of low-molecular-mass and protein disulphides. Biochem J (1983) 1.06
Identification of a new glutathione S-transferase in human liver. Acta Chem Scand B (1980) 1.05
Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1. Chem Res Toxicol (1997) 1.05
Induction of glutathione S-transferases A, B and C in rat liver cytosol by trans-stilbene oxide. Biochim Biophys Acta (1980) 1.05
Examination of the transcription factor NtcA-binding motif by in vitro selection of DNA sequences from a random library. J Mol Biol (2000) 1.05
Identification of a novel glutathione transferase in human skin homologous with class alpha glutathione transferase 2-2 in the rat. Biochem J (1987) 1.05
Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones. Biochem Biophys Res Commun (2000) 1.05
Glyoxalase I, a zinc metalloenzyme of mammals and yeast. Biochem Biophys Res Commun (1978) 1.04
Effects of directed mutagenesis on conserved arginine residues in a human Class Alpha glutathione transferase. Biochem J (1991) 1.04
Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione. Biochim Biophys Acta (1977) 1.03
Thioltransferase. Methods Enzymol (1981) 1.03
A set of inhibitors for discrimination between the basic isozymes of glutathione transferase in rat liver. Biochem Biophys Res Commun (1983) 1.03
Benzo(alpha)pyrene quinones can be generated by lipid peroxidation and are conjugated with glutathione by glutathione S-transferase b from rat liver. Biochem Biophys Res Commun (1981) 1.02
Selective expression of glutathione transferase isoenzymes in chemically induced preneoplastic rat hepatocyte nodules. FEBS Lett (1985) 1.01
Mechanism of action of enzymes catalyzing thiol-disulfide interchange. Thioltransferases rather than transhydrogenases. FEBS Lett (1974) 1.00
A conserved "hydrophobic staple motif" plays a crucial role in the refolding of human glutathione transferase P1-1. J Biol Chem (2000) 1.00
Comparison of glyoxalase I purified from yeast (Saccharomyces cerevisiae) with the enzyme from mammalian sources. Biochem J (1979) 0.99
Differences among human tumor cell lines in the expression of glutathione transferases and other glutathione-linked enzymes. Carcinogenesis (1990) 0.99
Characterization of glyoxalase I purified from pig erythrocytes by affinity chromatography. Biochem J (1977) 0.98
A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes. Arch Biochem Biophys (1994) 0.98
Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling. J Mol Biol (1999) 0.98
Leukotriene C4 formation catalyzed by three distinct forms of human cytosolic glutathione transferase. Biochem Biophys Res Commun (1985) 0.98
Tyrosine 50 at the subunit interface of dimeric human glutathione transferase P1-1 is a structural key residue for modulating protein stability and catalytic function. Biochem Biophys Res Commun (2000) 0.98
Transformation of leukotriene A4 methyl ester to leukotriene C4 monomethyl ester by cytosolic rat glutathione transferases. FEBS Lett (1984) 0.98
Yeast glyoxalase I is a monomeric enzyme with two active sites. J Biol Chem (2000) 0.98
Oxidation and reduction of 4-hydroxyalkenals catalyzed by isozymes of human alcohol dehydrogenase. Biochemistry (1991) 0.97
Resolution of glutathione-linked enzymes in rat liver and evaluation of their contribution to disulfide reduction via thiol--disulfide interchange. Acta Chem Scand B (1974) 0.97
Glutathione S-transferase A1-1-catalysed conjugation of bay and fjord region diol epoxides or polycyclic aromatic hydrocarbons with glutathione. Carcinogenesis (1996) 0.97
The contribution of the C-terminal sequence to the catalytic activity of GST2, a human alpha-class glutathione transferase. Biochem J (1991) 0.96
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Relaxed thiol substrate specificity of glutathione transferase effected by a non-substrate glutathione derivative. FEBS Lett (1988) 0.96
The binding of substrates and a product of the enzymatic reaction to glutathione S-transferase A. J Biol Chem (1979) 0.95