Published in Trends Cell Biol on November 01, 1999
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol (2003) 9.27
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev (2000) 6.43
The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev (2001) 4.82
Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J (2002) 4.54
Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol (2002) 4.50
Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J Cell Biol (2001) 3.86
Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol (2002) 3.69
Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer (2006) 3.34
Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev (2002) 2.51
Cytokinesis in eukaryotes. Microbiol Mol Biol Rev (2002) 2.43
Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. J Biol Chem (2002) 2.40
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol (2000) 2.36
Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol (2001) 2.31
The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis. J Cell Biol (2002) 2.11
Individual retinal progenitor cells display extensive heterogeneity of gene expression. PLoS One (2008) 1.91
Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev (2002) 1.87
Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A. Proc Natl Acad Sci U S A (2002) 1.80
MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy. Mol Cell Biol (2007) 1.79
The NPK1 mitogen-activated protein kinase kinase kinase is a regulator of cell-plate formation in plant cytokinesis. Genes Dev (2001) 1.79
Aurora-A site specificity: a study with synthetic peptide substrates. Biochem J (2005) 1.77
Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. Br J Cancer (2001) 1.77
NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol (2006) 1.69
Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol Cell Biol (2005) 1.54
Transcriptome analysis during cell division in plants. Proc Natl Acad Sci U S A (2002) 1.49
Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association. Mol Cell Biol (2005) 1.41
Spermatogenesis-specific features of the meiotic program in Caenorhabditis elegans. PLoS Genet (2009) 1.35
The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis. Mol Biol Cell (2002) 1.33
The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is required for the localization of a BimC kinesin to meiotic and mitotic spindles. Mol Biol Cell (2004) 1.31
Arabidopsis kinome: after the casting. Funct Integr Genomics (2004) 1.24
Changing roles of aurora-B kinase in two life cycle stages of Trypanosoma brucei. Eukaryot Cell (2006) 1.22
Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma. Am J Pathol (2005) 1.19
Identification and dynamics of two classes of aurora-like kinases in Arabidopsis and other plants. Plant Cell (2005) 1.15
KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1. J Biol Chem (2011) 1.14
Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition. EMBO Mol Med (2010) 1.08
Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis. Mol Cell Biol (2004) 1.07
A small C-terminal sequence of Aurora B is responsible for localization and function. Mol Biol Cell (2004) 1.07
A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc Natl Acad Sci U S A (2009) 1.06
Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells. J Cell Biol (2001) 1.06
Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage. Proc Natl Acad Sci U S A (2005) 1.05
A dominant negative mutant of TLK1 causes chromosome missegregation and aneuploidy in normal breast epithelial cells. BMC Cell Biol (2003) 1.05
Conditional transgenic system for mouse aurora a kinase: degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein. Mol Cell Biol (2005) 1.04
Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes. EMBO J (2003) 1.03
Schizosaccharomyces pombe Bir1p, a nuclear protein that localizes to kinetochores and the spindle midzone, is essential for chromosome condensation and spindle elongation during mitosis. Genetics (2002) 1.03
Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. Protein Sci (2008) 1.02
Biphasic activation of Aurora-A kinase during the meiosis I- meiosis II transition in Xenopus oocytes. Mol Cell Biol (2003) 1.02
Extranodal NK/T-cell lymphoma: toward the identification of clinical molecular targets. J Biomed Biotechnol (2011) 1.02
Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. Mol Biol Cell (2003) 1.01
Functional interaction of Aurora-A and PP2A during mitosis. Mol Biol Cell (2007) 1.01
Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation. J Transl Med (2011) 0.98
Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B. Mol Biol Cell (2009) 0.97
KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis. J Biol Chem (2012) 0.97
Quantitative proteome analysis of pluripotent cells by iTRAQ mass tagging reveals post-transcriptional regulation of proteins required for ES cell self-renewal. Mol Cell Proteomics (2010) 0.96
Regulation of Aurora-A kinase on the mitotic spindle. Chromosoma (2003) 0.96
Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer. Mol Cell Proteomics (2011) 0.95
A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. J Biol Chem (2009) 0.95
Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines. Cancer Res (2009) 0.93
Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors. Cancer Chemother Pharmacol (2010) 0.92
Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues. Endocr Relat Cancer (2007) 0.90
The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers. Mol Cancer (2006) 0.86
Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway. Biochem J (2007) 0.85
Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. J Clin Invest (2009) 0.85
The molecular mechanism studies of chirality effect of PHA-739358 on Aurora kinase A by molecular dynamics simulation and free energy calculations. J Comput Aided Mol Des (2011) 0.85
KIBRA: In the brain and beyond. Cell Signal (2014) 0.85
Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora A. Mol Biol Cell (2008) 0.84
A complex cell division machinery was present in the last common ancestor of eukaryotes. PLoS One (2009) 0.84
Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT. BMC Cancer (2011) 0.83
HURP expression-assisted risk scores identify prognosis distinguishable subgroups in early stage liver cancer. PLoS One (2011) 0.82
Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors. J Carcinog (2010) 0.80
Ashwagandha derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity. PLoS One (2012) 0.79
Structure-based design of Aurora A & B inhibitors. J Comput Aided Mol Des (2008) 0.79
A new aurora in anaplastic thyroid cancer therapy. Int J Endocrinol (2014) 0.79
Expression of mitotic Aurora/Ipl1p-related kinases in renal cell carcinomas: an immunohistochemical study. Urol Res (2003) 0.79
AURKA Phe31Ile polymorphism interacted with use of alcohol, betel quid, and cigarettes at multiplicative risk of oral cancer occurrence. Clin Oral Investig (2015) 0.78
ESCRT function in cytokinesis: location, dynamics and regulation by mitotic kinases. Int J Mol Sci (2014) 0.78
Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway. BMC Cancer (2009) 0.77
The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic. Front Cell Dev Biol (2015) 0.77
Control of plant cytokinesis by an NPK1-mediated mitogen-activated protein kinase cascade. Philos Trans R Soc Lond B Biol Sci (2002) 0.77
Deregulated expression of Aurora kinases is not a prognostic biomarker in papillary thyroid cancer patients. PLoS One (2015) 0.76
Aurora-A interacts with AP-2α and down regulates its transcription activity. PLoS One (2011) 0.76
Chromosomal Instability in Gastric Cancer Biology. Neoplasia (2017) 0.75
HPV16 E6 upregulates Aurora A expression. Oncol Lett (2016) 0.75
KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity. J Biomed Sci (2015) 0.75
Quercetin suppresses lung cancer growth by targeting Aurora B kinase. Cancer Med (2016) 0.75
ARD1-mediated aurora kinase A acetylation promotes cell proliferation and migration. Oncotarget (2017) 0.75
Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers. Oncotarget (2017) 0.75
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J (1998) 7.39
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature (1995) 6.14
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