Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype.

PubWeight™: 1.28‹?› | Rank: Top 10%

🔗 View Article (PMC 508424)

Published in J Clin Invest on November 01, 1997

Authors

P W Cook1, M Piepkorn, C H Clegg, G D Plowman, J M DeMay, J R Brown, M R Pittelkow

Author Affiliations

1: Department of Dermatology, The Oregon Health Sciences University, Portland 97201, USA. cookp@ohsu.edu

Articles citing this

Immunology of psoriasis. Annu Rev Immunol (2014) 2.06

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. J Clin Invest (2006) 1.65

Amphiregulin carboxy-terminal domain is required for autocrine keratinocyte growth. J Invest Dermatol (2010) 1.62

Psoriasis: what we have learned from mouse models. Nat Rev Rheumatol (2010) 1.61

Functional selectivity of EGF family peptide growth factors: implications for cancer. Pharmacol Ther (2008) 1.52

Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol (2008) 1.47

Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis. PLoS One (2011) 1.41

Involvement of TNF-α converting enzyme in the development of psoriasis-like lesions in a mouse model. PLoS One (2014) 1.41

Transgenic expression of human amphiregulin in mouse skin: inflammatory epidermal hyperplasia and enlarged sebaceous glands. Exp Dermatol (2016) 1.40

Psoriasis genetics: breaking the barrier. Trends Genet (2010) 1.38

Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation. Mol Cell Biol (2002) 1.25

Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J Clin Invest (2006) 1.22

Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. Neoplasia (2001) 1.14

Role of LIM kinases in normal and psoriatic human epidermis. Mol Biol Cell (2006) 1.14

Metalloproteinase-mediated, context-dependent function of amphiregulin and HB-EGF in human keratinocytes and skin. J Invest Dermatol (2010) 1.11

Putting together the psoriasis puzzle: an update on developing targeted therapies. Dis Model Mech (2012) 1.09

Suppression of molecular inflammatory pathways by Toll-like receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation. PLoS One (2013) 1.07

LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII. Oncogene (2008) 1.04

KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development (2009) 1.03

Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK. Mol Biol Cell (2004) 1.01

Mechanisms of ErbB receptor negative regulation and relevance in cancer. Exp Cell Res (2008) 0.99

Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesis. Cancer Res (2007) 0.98

Amphiregulin and epidermal hyperplasia: amphiregulin is required to maintain the psoriatic phenotype of human skin grafts on severe combined immunodeficient mice. Am J Pathol (2005) 0.94

EGFR Signaling in Liver Diseases. Int J Mol Sci (2015) 0.90

Activation of the epidermal growth factor receptor promotes lymphangiogenesis in the skin. J Dermatol Sci (2013) 0.84

Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A (2014) 0.84

Amphiregulin overexpression results in rapidly growing keratinocytic tumors: an in vivo xenograft model of keratoacanthoma. Am J Pathol (2003) 0.84

EGFR signaling blunts allergen-induced IL-6 production and Th17 responses in the skin and attenuates development and relapse of atopic dermatitis. J Immunol (2013) 0.83

A medical conundrum: onset of psoriasis in patients receiving anti-tumour necrosis factor agents. Ann Rheum Dis (2006) 0.79

Human antigen R-mediated mRNA stabilization is required for ultraviolet B-induced autoinduction of amphiregulin in keratinocytes. J Biol Chem (2013) 0.78

Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis. Mediators Inflamm (2015) 0.78

Membrane-Tethered Intracellular Domain of Amphiregulin Promotes Keratinocyte Proliferation. J Invest Dermatol (2016) 0.77

Tyrosine kinases in inflammatory dermatologic disease. J Am Acad Dermatol (2010) 0.76

Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model. Front Pharmacol (2016) 0.75

Articles cited by this

Programming gene expression in developing epidermis. Development (1994) 3.60

Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc Natl Acad Sci U S A (1989) 3.55

Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science (1989) 3.13

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev (1991) 2.78

Dermal injection of immunocytes induces psoriasis. J Clin Invest (1996) 2.64

Overexpression of transforming growth factor alpha in psoriatic epidermis. Science (1989) 2.63

Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury. Proc Natl Acad Sci U S A (1993) 2.51

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein. J Biol Chem (1992) 2.37

Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell (1995) 2.24

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Mol Cell Biol (1990) 2.21

Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Nat Med (1995) 2.09

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. Mol Cell Biol (1991) 1.93

Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. Proc Natl Acad Sci U S A (1988) 1.91

Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes. J Biol Chem (1994) 1.76

Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J (1993) 1.70

Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes Dev (1992) 1.68

Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. J Cell Biol (1989) 1.64

A morphometric and histologic study of the scalp in psoriasis. Paradoxical sebaceous gland atrophy and decreased hair shaft diameters without alopecia. Arch Dermatol (1989) 1.51

Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis. Proc Natl Acad Sci U S A (1995) 1.46

Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proc Natl Acad Sci U S A (1992) 1.37

Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas. Cell Growth Differ (1993) 1.33

Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. Cancer Res (1992) 1.32

Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis. Arch Dermatol (1992) 1.32

Murine psoriasis-like disorder induced by naive CD4+ T cells. Nat Med (1997) 1.29

Transgenic mice expressing IFN-gamma in the epidermis have eczema, hair hypopigmentation, and hair loss. J Invest Dermatol (1997) 1.24

Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture. J Clin Invest (1997) 1.23

Growth of normal human keratinocytes and fibroblasts in serum-free medium is stimulated by acidic and basic fibroblast growth factor. J Cell Physiol (1989) 1.20

Kinetics and regulation of human keratinocyte stem cell growth in short-term primary ex vivo culture. Cooperative growth factors from psoriatic lesional T lymphocytes stimulate proliferation among psoriatic uninvolved, but not normal, stem keratinocytes. J Clin Invest (1995) 1.19

Human hair growth in vitro: a model for the study of hair follicle biology. J Dermatol Sci (1994) 1.18

Resolution of immune-mediated diseases following allogeneic bone marrow transplantation for leukaemia. Bone Marrow Transplant (1992) 1.17

Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions. J Cell Biol (1996) 1.13

Schwannoma-derived growth factor must be transported into the nucleus to exert its mitogenic activity. Proc Natl Acad Sci U S A (1993) 1.10

Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes. Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease. J Clin Invest (1996) 1.06

Psoriasis after allogeneic bone marrow transplantation. Arch Dermatol (1990) 1.02

Amphiregulin-dependent proliferation of cultured human keratinocytes: autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans. J Cell Physiol (1994) 1.01

Epidermal expression of intercellular adhesion molecule 1 is not a primary inducer of cutaneous inflammation in transgenic mice. Proc Natl Acad Sci U S A (1994) 0.96

Modulation of epidermal growth factor receptors in psoriatic lesions during treatment with topical EGF. J Invest Dermatol (1992) 0.95

Expression of amphiregulin is regulated in cultured human keratinocytes and in developing fetal skin. J Invest Dermatol (1995) 0.95

Growth factor-independent proliferation of normal human neonatal keratinocytes: production of autocrine- and paracrine-acting mitogenic factors. J Cell Physiol (1991) 0.94

Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases. Am J Dermatopathol (1996) 0.90

Psoriatic alopecia. Br J Dermatol (1972) 0.89

Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens. Proc Natl Acad Sci U S A (1994) 0.89

Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy. Cell Growth Differ (1993) 0.88

Response to and expression of amphiregulin by ovarian carcinoma and normal ovarian surface epithelial cells: nuclear localization of endogenous amphiregulin. Biochem Biophys Res Commun (1991) 0.88

Psoriatic alopecia: acute and chronic hair loss in 47 patients with scalp psoriasis. Dermatology (1992) 0.86

Scarring alopecia in psoriasis. Acta Derm Venereol (1990) 0.86

[Resolution of psoriasis vulgaris following allogeneic bone marrow transplantation for aplastic anemia]. Rinsho Ketsueki (1996) 0.83

Differential effects of a heparin antagonist (hexadimethrine) or chlorate on amphiregulin, basic fibroblast growth factor, and heparin-binding EGF-like growth factor activity. J Cell Physiol (1995) 0.82

Amphiregulin and nerve growth factor expression are regulated by barrier status in murine epidermis. J Invest Dermatol (1997) 0.82

Topical therapy for psoriasis. Int J Dermatol (1995) 0.81

Carboxyl-terminal truncation of leucine76 converts heparin-binding EGF-like growth factor from a heparin-enhancible to a heparin-suppressible growth factor. J Cell Physiol (1995) 0.79

Methotrexate therapy of psoriasis: differential sensitivity of proliferating lymphoid and epithelial cells to the cytotoxic and growth-inhibitory effects of methotrexate. J Invest Dermatol (1995) 0.78

[Psoriatic alopecia manifestation, course and therapy in 34 patients]. Z Hautkr (1989) 0.77

Inhibition of autonomous human keratinocyte proliferation and amphiregulin mitogenic activity by sulfated polysaccharides. In Vitro Cell Dev Biol (1992) 0.77

The hair root pattern in psoriasis of the scalp. Acta Derm Venereol (1992) 0.77

Cyclosporine in the treatment of dermatologic disease: an update. Mayo Clin Proc (1996) 0.77

Advances in psoriasis therapy. Adv Dermatol (1997) 0.77

Epidermal growth factor/transforming growth factor alpha receptors and psoriasis. J Invest Dermatol (1990) 0.76

Articles by these authors

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J (1998) 7.39

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature (2000) 6.54

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature (1995) 6.14

Location of disulphide bridges by diagonal paper electrophoresis. The disulphide bridges of bovine chymotrypsinogen A. Biochem J (1966) 5.98

Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature (1987) 4.19

The protein kinases of budding yeast: six score and more. Trends Biochem Sci (1997) 3.88

Human actinomycosis. A study of 181 subjects. Hum Pathol (1973) 3.63

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell (1990) 3.55

A genomic analysis of two-component signal transduction in Streptococcus pneumoniae. Mol Microbiol (2000) 3.50

TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity (2001) 3.43

Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cell-mediated vitiligo. J Exp Med (2000) 3.32

Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor. J Cell Biol (1987) 3.28

Evolutionary similarities between pancreatic proteolytic enzymes. Nature (1965) 3.18

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell Biol (1999) 3.15

Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science (1989) 3.13

Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. EMBO J (1997) 3.11

The cellular response to neuregulins is governed by complex interactions of the erbB receptor family. Mol Cell Biol (1995) 3.09

Hydroxyurea-induced leg ulceration in 14 patients. Ann Intern Med (1998) 3.03

cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. DNA Cell Biol (1992) 2.91

Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium. Cancer Res (1986) 2.83

Genomic sequence of hyperthermophile, Pyrococcus furiosus: implications for physiology and enzymology. Methods Enzymol (2001) 2.67

Overexpression of transforming growth factor alpha in psoriatic epidermis. Science (1989) 2.63

Systematic identification of selective essential genes in Helicobacter pylori by genome prioritization and allelic replacement mutagenesis. J Bacteriol (2001) 2.63

Evolution of two-component signal transduction. Mol Biol Evol (2000) 2.55

Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum Pathol (1999) 2.50

Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci. J Bacteriol (2000) 2.50

Structural origins of mammalian albumin. Fed Proc (1976) 2.49

Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes. Proc Natl Acad Sci U S A (1993) 2.46

ESSAYS ON SCIENCE AND SOCIETY: Privatizing the University--the New Tragedy of the Commons. Science (2000) 2.44

Differential diagnostic patterns of dysarthria. J Speech Hear Res (1969) 2.34

Regulation of transcription by cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A (1989) 2.33

Myogenic differentiation in permanent clonal mouse myoblast cell lines: regulation by macromolecular growth factors in the culture medium. Dev Biol (1981) 2.20

Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart. Biochemistry (1978) 2.10

Clusters of deviant speech dimensions in the dysarthrias. J Speech Hear Res (1969) 2.00

A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem (1997) 1.99

FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Proc Natl Acad Sci U S A (1997) 1.98

Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family. Mol Cell Biol (1985) 1.97

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. Mol Cell Biol (1991) 1.93

The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. Cell (1995) 1.91

Psychosexual trauma of an abnormal cervical smear. Br J Obstet Gynaecol (1988) 1.90

Control of mouse myoblast commitment to terminal differentiation by mitogens. J Supramol Struct (1980) 1.89

Phylogenetic analyses do not support horizontal gene transfers from bacteria to vertebrates. Nature (2001) 1.85

Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and immunologic correlates. J Infect Dis (1997) 1.84

Integrated control of growth and differentiation of normal human prokeratinocytes cultured in serum-free medium: clonal analyses, growth kinetics, and cell cycle studies. J Cell Physiol (1984) 1.81

Characterization of reproductive hormonal dynamics in the perimenopause. J Clin Endocrinol Metab (1996) 1.80

Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome: a reappraisal of paraneoplastic pemphigus. Arch Dermatol (2001) 1.79

Immunohistochemical characterization of dermatofibrosarcoma protuberans with practical applications for diagnosis and treatment. J Am Acad Dermatol (1997) 1.79

Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta. Oncogene (1996) 1.78

Possible role of transforming growth factor alpha in the pathogenesis of Ménétrier's disease: supportive evidence form humans and transgenic mice. Gastroenterology (1992) 1.77

Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. Oncogene (1995) 1.75

Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants. Proc Natl Acad Sci U S A (1995) 1.74

Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice. Proc Natl Acad Sci U S A (1996) 1.74

Hydroxyurea dermopathy: a unique lichenoid eruption complicating long-term therapy with hydroxyurea. J Am Acad Dermatol (1997) 1.68

Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion. Mol Cell Biol (1998) 1.67

Length heteroplasmy of sturgeon mitochondrial DNA: an illegitimate elongation model. Genetics (1990) 1.65

Expression of the c-erbB-3 protein in normal human adult and fetal tissues. Oncogene (1992) 1.62

Relative cost-effectiveness of treatment of feedlot calves with ivermectin versus treatment with a combination of fenbendazole, permethrin, and fenthion. J Am Vet Med Assoc (2000) 1.60

A homozygous nonsense mutation in the beta 3 chain gene of laminin 5 (LAMB3) in Herlitz junctional epidermolysis bullosa. Genomics (1994) 1.59

WHIM syndrome, an autosomal dominant disorder: clinical, hematological, and molecular studies. Am J Med Genet (2000) 1.58

GATA1 and YY1 are developmental repressors of the human epsilon-globin gene. EMBO J (1995) 1.57

Premature translation of protamine 1 mRNA causes precocious nuclear condensation and arrests spermatid differentiation in mice. Proc Natl Acad Sci U S A (1995) 1.55

Cloning and sequence analysis of simian transforming growth factor-beta cDNA. DNA (1987) 1.54

E-box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscles and cardiac muscle of transgenic mice. Mol Cell Biol (1996) 1.54

Tissue plasminogen activator for treatment of livedoid vasculitis. Mayo Clin Proc (1992) 1.53

Ophthalmic abnormalities in patients with cutaneous T-cell lymphoma. Ophthalmology (1999) 1.53

Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Proc Natl Acad Sci U S A (1991) 1.52

Expression of p53 protein in benign and malignant epidermal pathologic conditions. J Am Acad Dermatol (1993) 1.50

Cell density and culture factors regulate keratinocyte commitment to differentiation and expression of suprabasal K1/K10 keratins. J Invest Dermatol (1995) 1.48

Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence. Proc Natl Acad Sci U S A (1986) 1.46

Activating BRAF mutations in eruptive melanocytic naevi. Br J Dermatol (2010) 1.46

New techniques for the in vitro culture of human skin keratinocytes and perspectives on their use for grafting of patients with extensive burns. Mayo Clin Proc (1986) 1.44

Efficacy of vitamin D3 derivatives in the treatment of psoriasis vulgaris: a preliminary report. Mayo Clin Proc (1993) 1.43

A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc Natl Acad Sci U S A (2001) 1.43

Reticular telangiectatic erythema associated with an implantable cardioverter defibrillator. Arch Dermatol (2001) 1.42

Trichothiodystrophy: update on the sulfur-deficient brittle hair syndromes. J Am Acad Dermatol (2001) 1.40

Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family. J Biol Chem (1994) 1.40

Angiogenesis and vascular growth factor receptor expression in malignant melanoma. Plast Reconstr Surg (1999) 1.39

Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation. Genes Dev (1997) 1.39

Tempo, mode, the progenote, and the universal root. Proc Natl Acad Sci U S A (1994) 1.38

Perilesional linear atrophy and hypopigmentation after intralesional corticosteroid therapy. Report of two cases and review of the literature. J Am Acad Dermatol (1988) 1.35

Trichodysplasia spinulosa--a newly described folliculocentric viral infection in an immunocompromised host. J Investig Dermatol Symp Proc (1999) 1.33

Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins. Proc Natl Acad Sci U S A (1990) 1.33

Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. Cancer Res (1992) 1.32

Experimental actinomycosis in mice. Study of pathogenesis. Arch Pathol (1970) 1.31

Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form. J Biol Chem (1998) 1.30

MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin. EMBO J (1999) 1.30

H2O2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes. J Invest Dermatol (1998) 1.29

Substance P selectively activates TNF-alpha gene expression in murine mast cells. J Immunol (1993) 1.29

Trichothiodystrophy: review of sulfur-deficient brittle hair syndromes and association with the ectodermal dysplasias. J Am Acad Dermatol (1990) 1.28

The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness. Biochim Biophys Acta (1999) 1.28

Observations on halogens as bathing water disinfectants. J Appl Bacteriol (1966) 1.28

The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4. J Biol Chem (1996) 1.28

Analysis of muscle creatine kinase gene regulatory elements in skeletal and cardiac muscles of transgenic mice. Mol Cell Biol (1996) 1.27

Presence of C-type natriuretic peptide in cultured human endothelial cells and plasma. Am J Physiol (1992) 1.27

Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2. J Biol Chem (1998) 1.26

A bacterial antibiotic resistance gene with eukaryotic origins. Curr Biol (1998) 1.26

Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures. J Neurosci (1998) 1.24

Sequence of tRNA(Thr) and tRNA(Pro) from white sturgeon (Acipenser transmontanus) mitochondria. Nucleic Acids Res (1988) 1.23

Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. J Clin Invest (2000) 1.21