Published in Proc Natl Acad Sci U S A on April 08, 2009
Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer (2010) 3.74
Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol (2009) 2.61
Cell division: control of the chromosomal passenger complex in time and space. Chromosoma (2013) 1.34
Aurora kinase inhibitors as anticancer molecules. Biochim Biophys Acta (2010) 1.33
Spatial Regulation of Kinetochore Microtubule Attachments by Destabilization at Spindle Poles in Meiosis I. Curr Biol (2015) 1.30
The aurora kinases in cell cycle and leukemia. Oncogene (2014) 1.20
Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle. Open Biol (2013) 1.09
On the molecular mechanisms of mitotic kinase activation. Open Biol (2012) 1.08
The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes. J Cell Sci (2010) 1.04
Uncovering new substrates for Aurora A kinase. EMBO Rep (2010) 1.00
Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation. Sci Rep (2015) 0.92
Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? Open Biol (2013) 0.87
Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly. Proc Natl Acad Sci U S A (2013) 0.84
Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B. J Biol Chem (2015) 0.81
TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux. J Cell Biol (2015) 0.81
Two Cdc2 Kinase Genes with Distinct Functions in Vegetative and Infectious Hyphae in Fusarium graminearum. PLoS Pathog (2015) 0.79
Late mitotic functions of Aurora kinases. Chromosoma (2016) 0.78
The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic. Front Cell Dev Biol (2015) 0.77
Urochordate ascidians possess a single isoform of Aurora kinase that localizes to the midbody via TPX2 in eggs and cleavage stage embryos. PLoS One (2012) 0.77
Ubiquitin-Mediated Degradation of Aurora Kinases. Front Oncol (2016) 0.76
Haspin kinase regulates microtubule-organizing center clustering and stability through Aurora kinase C in mouse oocytes. J Cell Sci (2016) 0.76
Phosphorylation of MAP65-1 by Arabidopsis Aurora kinases is required for efficient cell cycle progression. Plant Physiol (2016) 0.75
Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation. Trends Genet (2017) 0.75
Mitotic phosphorylation of SOX2 mediated by Aurora kinase A is critical for the stem-cell like cell maintenance in PA-1 cells. Cell Cycle (2016) 0.75
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep (2016) 0.75
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol (2003) 9.27
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol (2003) 8.32
Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol (2007) 6.83
The cellular geography of aurora kinases. Nat Rev Mol Cell Biol (2003) 6.40
Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol Cell (2003) 4.51
Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J Cell Biol (2001) 4.38
Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell (2003) 4.28
Aurora-A - a guardian of poles. Nat Rev Cancer (2005) 4.11
Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell (2007) 3.98
Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol (2002) 3.69
The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell (2004) 3.68
INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow. Curr Biol (2000) 3.55
Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Curr Biol (2000) 3.50
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol (2004) 3.49
Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res (2007) 3.20
Aurora-A: the maker and breaker of spindle poles. J Cell Sci (2007) 3.20
Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer (2004) 3.19
Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis. Curr Biol (2002) 3.17
The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell Biol (1999) 3.15
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol Cell (2005) 3.14
Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev (2004) 2.96
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol (2003) 2.86
Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Genetics (1993) 2.82
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J (2003) 2.70
A novel mechanism for activation of the protein kinase Aurora A. Curr Biol (2003) 2.68
INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol (2001) 2.62
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56
Aurora kinases, aneuploidy and cancer, a coincidence or a real link? Trends Cell Biol (2005) 2.41
Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. J Biol Chem (2002) 2.40
Mitotic mechanics: the auroras come into view. Curr Opin Cell Biol (2003) 2.31
The chromosomal passenger complex: guiding Aurora-B through mitosis. J Cell Biol (2006) 2.07
Polo and Aurora kinases: lessons derived from chemical biology. Curr Opin Cell Biol (2008) 1.92
The S. pombe aurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for chromosome segregation. J Cell Sci (2001) 1.71
On the role of aurora-A in centrosome function. Oncogene (2002) 1.68
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Mol Biol Cell (2006) 1.68
Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation. J Cell Sci (2003) 1.62
Regulation of Xenopus Aurora A activation by TPX2. J Biol Chem (2003) 1.58
Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. J Biol Chem (2003) 1.50
An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles. Dev Cell (2005) 1.27
Determinants for Aurora-A activation and Aurora-B discrimination by TPX2. Cell Cycle (2004) 1.09
A small C-terminal sequence of Aurora B is responsible for localization and function. Mol Biol Cell (2004) 1.07
Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells. Cell Cycle (2008) 0.99
The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2. Cell Cycle (2005) 0.91
Dictyostelium Aurora kinase has properties of both Aurora A and Aurora B kinases. Eukaryot Cell (2008) 0.91
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet (2007) 4.31
Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res (2007) 3.20
Spatial and temporal coordination of mitosis by Ran GTPase. Nat Rev Mol Cell Biol (2008) 2.84
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47
Most efficient cocaine hydrolase designed by virtual screening of transition states. J Am Chem Soc (2008) 2.33
Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease. Br J Haematol (2006) 1.99
Pathologic changes of Achilles tendon in leptin-deficient mice. Rheumatol Int (2009) 1.98
A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet (2008) 1.91
Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis. Nat Genet (2013) 1.90
The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol (2007) 1.84
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis (2010) 1.75
Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Res (2008) 1.73
Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nat Cell Biol (2012) 1.60
Hydrogen-bond memory and water-skin supersolidity resolving the Mpemba paradox. Phys Chem Chem Phys (2014) 1.54
Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. Mol Pharmacol (2010) 1.48
PotD protein stimulates biofilm formation by Escherichia coli. Biotechnol Lett (2013) 1.44
Localized lower extremity ischemic preconditioning prevents against local thrombus formation. Vasa (2015) 1.41
Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells. Curr Biol (2002) 1.40
Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis. Nat Genet (2008) 1.37
Anti-inflammatory properties of alpha- and gamma-tocopherol. Mol Aspects Med (2007) 1.31
A plant DNA ligase is an important determinant of seed longevity. Plant J (2010) 1.29
Meta-analysis of association between the ASPN D-repeat and osteoarthritis. Hum Mol Genet (2007) 1.28
Vitamin E, γ-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers. Free Radic Biol Med (2013) 1.26
Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin beta. J Cell Sci (2007) 1.26
The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus. Proc Natl Acad Sci U S A (2005) 1.23
Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment. J Cell Sci (2010) 1.22
Notch2 activation in the embryonic kidney depletes nephron progenitors. J Am Soc Nephrol (2010) 1.18
Multiwalled carbon nanotubes as gigahertz oscillators. Phys Rev Lett (2002) 1.18
Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. J Cell Sci (2009) 1.17
PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry. J Cell Sci (2013) 1.15
Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations. Hum Mol Genet (2009) 1.15
Nanoporous gold supported cobalt oxide microelectrodes as high-performance electrochemical biosensors. Nat Commun (2013) 1.14
Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study. Arthritis Res Ther (2008) 1.13
In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects. Free Radic Biol Med (2008) 1.12
Comparison between the NERS (New Risk Stratification) score and the SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) score in outcome prediction for unprotected left main stenting. JACC Cardiovasc Interv (2010) 1.11
Disruption of the Arabidopsis AtKu80 gene demonstrates an essential role for AtKu80 protein in efficient repair of DNA double-strand breaks in vivo. Plant J (2002) 1.11
Density functional theory calculations for two-dimensional silicene with halogen functionalization. Phys Chem Chem Phys (2011) 1.10
Design of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency. Biochemistry (2010) 1.09
Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. Proc Natl Acad Sci U S A (2007) 1.08
Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population. BMC Med Genet (2008) 1.07
Characterization of Arabidopsis photolyase enzymes and analysis of their role in protection from ultraviolet-B radiation. J Exp Bot (2002) 1.06
AEG -1 overexpression: a novel indicator for peritoneal dissemination and lymph node metastasis in epithelial ovarian cancers. Int J Gynecol Cancer (2011) 1.00
Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol. Free Radic Biol Med (2007) 1.00
Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant. J Clin Invest (2013) 0.98
Oscillatory interaction between bubbles and confining microvessels and its implications on clinical vascular injuries of shock-wave lithotripsy. IEEE Trans Ultrason Ferroelectr Freq Control (2006) 0.98
Analysis of plasma tocopherols alpha, gamma, and 5-nitro-gamma in rats with inflammation by HPLC coulometric detection. J Lipid Res (2002) 0.98
Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese. Arthritis Res Ther (2011) 0.98
Tumour suppressor CYLD is a negative regulator of the mitotic kinase Aurora-B. J Pathol (2010) 0.98
Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer. J Surg Oncol (2010) 0.98
Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population. J Hum Genet (2007) 0.98
Combined 3D-QSAR modeling and molecular docking study on indolinone derivatives as inhibitors of 3-phosphoinositide-dependent protein kinase-1. J Chem Inf Model (2008) 0.97
Total tubeless versus standard percutaneous nephrolithotomy: a meta-analysis. J Endourol (2013) 0.96
Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovasc Res (2008) 0.96
Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme. J Biol Chem (2009) 0.96
Narrow band imaging diagnosis of bladder cancer: systematic review and meta-analysis. BJU Int (2012) 0.95
Deformation-induced localized solid-state amorphization in nanocrystalline nickel. Sci Rep (2012) 0.94
Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats. Toxicol Pathol (2009) 0.94
Biomarkers of deep venous thrombosis. J Thromb Thrombolysis (2012) 0.94
Regulation of the G(2)/M transition in Xenopus oocytes by the cAMP-dependent protein kinase. J Biol Chem (2005) 0.92
Tubeless vs standard percutaneous nephrolithotomy: a meta-analysis. BJU Int (2011) 0.91
G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion. Nat Commun (2010) 0.91
Aβ43 is the earliest-depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE. Am J Pathol (2013) 0.90
Reaction pathway and free energy profile for butyrylcholinesterase-catalyzed hydrolysis of acetylcholine. J Phys Chem B (2010) 0.90
Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element. Mol Pharmacol (2003) 0.90
Case report: Osteochondral avulsion fracture of the posteromedial bundle of the PCL in knee hyperflexion. Clin Orthop Relat Res (2012) 0.90
Histone deacetylase 4 alters cartilage homeostasis in human osteoarthritis. BMC Musculoskelet Disord (2014) 0.90
Fundamental reaction pathway and free energy profile for hydrolysis of intracellular second messenger adenosine 3',5'-cyclic monophosphate (cAMP) catalyzed by phosphodiesterase-4. J Phys Chem B (2011) 0.89
Reaction pathway and free energy profiles for butyrylcholinesterase-catalyzed hydrolysis of acetylthiocholine. Biochemistry (2012) 0.89
Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells. J Nutr Biochem (2011) 0.89
Versatile roles of V-ATPases accessory subunit Ac45 in osteoclast formation and function. PLoS One (2011) 0.89
Geminin is partially localized to the centrosome and plays a role in proper centrosome duplication. Biol Cell (2009) 0.89
Dual inhibition of PI3K and mTOR mitigates compensatory AKT activation and improves tamoxifen response in breast cancer. Mol Cancer Res (2013) 0.88
Water-soluble Fe3O4 nanoparticles with high solubility for removal of heavy-metal ions from waste water. Dalton Trans (2012) 0.88
Extracorporeal shock wave treatment in nonunions of long bone fractures. Int Orthop (2008) 0.88
Metaphase arrest by cyclin E-Cdk2 requires the spindle-checkpoint kinase Mps1. Curr Biol (2006) 0.88
Identification of a natural human serotype 3 parainfluenza virus. Virol J (2011) 0.88
An efficient CoAuPd/C catalyst for hydrogen generation from formic acid at room temperature. Angew Chem Int Ed Engl (2013) 0.88
Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis. Arthritis Res Ther (2008) 0.88
Pd/C synthesized with citric acid: an efficient catalyst for hydrogen generation from formic acid/sodium formate. Sci Rep (2012) 0.88
Spatial and temporal control of nuclear envelope assembly by Ran GTPase. Symp Soc Exp Biol (2004) 0.87
Requirement for lamin B receptor and its regulation by importin {beta} and phosphorylation in nuclear envelope assembly during mitotic exit. J Biol Chem (2010) 0.87
Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis. J Phys Chem B (2010) 0.87
Formation and stability of G-quadruplexes self-assembled from guanine-rich strands. Chemistry (2007) 0.87
Self-retracting motion of graphite microflakes. Phys Rev Lett (2008) 0.87