Published in Proc Natl Acad Sci U S A on October 12, 1999
Association mapping in structured populations. Am J Hum Genet (2000) 16.79
Prospective study of one million deaths in India: rationale, design, and validation results. PLoS Med (2005) 5.05
Human population genetic structure and inference of group membership. Am J Hum Genet (2003) 4.73
Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility. Cell Host Microbe (2008) 4.55
From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet (2009) 2.98
CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals. Nat Med (2008) 2.94
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A (2008) 2.38
Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: impact on the epidemiology of the HIV-1 pandemic. Proc Natl Acad Sci U S A (2001) 2.35
HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. Proc Natl Acad Sci U S A (2002) 2.31
R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms. Proc Natl Acad Sci U S A (2003) 2.00
A strong signature of balancing selection in the 5' cis-regulatory region of CCR5. Proc Natl Acad Sci U S A (2002) 1.78
HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles. PLoS One (2008) 1.69
CCL3L1 gene-containing segmental duplications and polymorphisms in CCR5 affect risk of systemic lupus erythaematosus. Ann Rheum Dis (2007) 1.62
Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease. J Infect Dis (2005) 1.49
CCR5 promoter polymorphism determines macrophage CCR5 density and magnitude of HIV-1 propagation in vitro. Clin Immunol (2003) 1.48
Negative association between the chemokine receptor CCR5-Delta32 polymorphism and rheumatoid arthritis: a meta-analysis. Genes Immun (2006) 1.46
Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. J Virol (2005) 1.30
CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation. J Immunol (2009) 1.26
Host and viral genetic correlates of clinical definitions of HIV-1 disease progression. PLoS One (2010) 1.23
Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands. Virology (2007) 1.21
Combinatorial content of CCL3L and CCL4L gene copy numbers influence HIV-AIDS susceptibility in Ukrainian children. AIDS (2009) 1.17
Role of CCL3L1-CCR5 genotypes in the epidemic spread of HIV-1 and evaluation of vaccine efficacy. PLoS One (2008) 1.15
Contrasting effects of natural selection on human and chimpanzee CC chemokine receptor 5. Am J Hum Genet (2004) 1.10
CCL3L1-CCR5 genotype improves the assessment of AIDS Risk in HIV-1-infected individuals. PLoS One (2008) 1.02
CCR5 promoter polymorphisms in a Kenyan perinatal human immunodeficiency virus type 1 cohort: association with increased 2-year maternal mortality. J Infect Dis (2001) 1.00
CCR5 haplotypes and mother-to-child HIV transmission in Malawi. PLoS One (2007) 0.99
Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritis. Genes Immun (2006) 0.96
Concordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression rates. J Infect Dis (2011) 0.96
The signature of long-standing balancing selection at the human defensin beta-1 promoter. Genome Biol (2008) 0.95
Human leukocyte antigen variants B*44 and B*57 are consistently favorable during two distinct phases of primary HIV-1 infection in sub-Saharan Africans with several viral subtypes. J Virol (2011) 0.94
Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success. J Infect Dis (2011) 0.93
Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians. Retrovirology (2011) 0.93
Recent human evolution has shaped geographical differences in susceptibility to disease. BMC Genomics (2011) 0.89
Influence of CCR5 and CCR2 genetic variants in the resistance/susceptibility to HIV in serodiscordant couples from Colombia. AIDS Res Hum Retroviruses (2013) 0.88
Independent effects of genetic variations in mannose-binding lectin influence the course of HIV disease: the advantage of heterozygosity for coding mutations. J Infect Dis (2008) 0.88
The HIV-1 pandemic: does the selective sweep in chimpanzees mirror humankind's future? Retrovirology (2013) 0.87
Donor and recipient chemokine receptor CCR5 genotype is associated with survival after bone marrow transplantation. Blood (2010) 0.87
Evidence for selection at HIV host susceptibility genes in a West Central African human population. BMC Evol Biol (2012) 0.87
Haplotype structure and linkage disequilibrium in chemokine and chemokine receptor genes. Hum Genomics (2004) 0.87
Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. Proc Natl Acad Sci U S A (2015) 0.87
Association between TLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users. Infect Genet Evol (2013) 0.85
Host genetics influences on HIV type-1 disease. Antivir Ther (2009) 0.85
Influence of variations in CCL3L1 and CCR5 on tuberculosis in a northwestern Colombian population. J Infect Dis (2011) 0.83
Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia. PLoS Genet (2011) 0.82
Genetic variation within the gene encoding the HIV-1 CCR5 coreceptor in two South African populations. Infect Genet Evol (2010) 0.82
Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor. Proc Natl Acad Sci U S A (2015) 0.82
Genetic and Immunological Factors Involved in Natural Resistance to HIV-1 Infection. Open Virol J (2011) 0.81
Genetic correlates influencing immunopathogenesis of HIV infection. Indian J Med Res (2011) 0.80
Genetics of Sub-Saharan African Human Population: Implications for HIV/AIDS, Tuberculosis, and Malaria. Int J Evol Biol (2014) 0.80
Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller. PLoS One (2012) 0.79
African ancestry influences CCR5 -2459G>A genotype-associated virologic success of highly active antiretroviral therapy. J Acquir Immune Defic Syndr (2014) 0.79
Differential use of CCR5 by HIV-1 clinical isolates resistant to small-molecule CCR5 antagonists. Antimicrob Agents Chemother (2012) 0.78
Pharmacogenomic implications of the evolutionary history of infectious diseases in Africa. Pharmacogenomics J (2016) 0.78
CCR5 haplotypes influence HCV serostatus in Caucasian intravenous drug users. PLoS One (2013) 0.77
Genetic diversity and linkage disequilibrium in the chemokine receptor CCR2-CCR5 region among individuals and populations. Cytokine (2013) 0.77
CCR5 promoter haplotypes differentially influence CCR5 expression on natural killer and T cell subsets in ethnically divergent HIV-1 uninfected South African populations. Immunogenetics (2012) 0.77
Risk of all-cause mortality in HIV infected patients is associated with clinical, immunologic predictors and the CCR5 Δ32 deletion. PLoS One (2011) 0.77
Genome-Wide Association Study of Human Immunodeficiency Virus (HIV)-1 Coreceptor Usage in Treatment-Naive Patients from An AIDS Clinical Trials Group Study. Open Forum Infect Dis (2014) 0.76
Genetics and the general physician: insights, applications and future challenges. QJM (2009) 0.76
Association between HIV-1 tropism and CCR5 human haplotype E in a Caucasian population. J Acquir Immune Defic Syndr (2014) 0.76
Mendelian randomization: potential use of genetics to enable causal inferences regarding HIV-associated biomarkers and outcomes. Curr Opin HIV AIDS (2010) 0.76
Analysis of Social and Genetic Factors Influencing Heterosexual Transmission of HIV within Serodiscordant Couples in the Henan Cohort. PLoS One (2015) 0.76
Distribution of CC-chemokine receptor-5-∆32 allele among the tribal and caste population of Vidarbha region of Maharashtra state. Indian J Hum Genet (2013) 0.75
Genetic diversity and prevalence of CCR2-CCR5 gene polymorphisms in the Omani population. Genet Mol Biol (2013) 0.75
CCR2, CCR5, and CXCL12 variation and HIV/AIDS in Papua New Guinea. Infect Genet Evol (2015) 0.75
Host genetic factors associated with symptomatic primary HIV infection and disease progression among Argentinean seroconverters. PLoS One (2014) 0.75
Targeting CCR5 for anti-HIV research. Eur J Clin Microbiol Infect Dis (2014) 0.75
CCR5 expression, haplotype and immune activation in protection from infection in HIV-exposed uninfected individuals in HIV serodiscordant relationships. Immunology (2017) 0.75
Host and Viral Factors in HIV-Mediated Bystander Apoptosis. Viruses (2017) 0.75
Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature (1999) 10.97
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med (1996) 10.62
Co-receptors for HIV-1 entry. Curr Opin Immunol (1997) 4.31
The immunogenetics of human infectious diseases. Annu Rev Immunol (1998) 3.73
Genetic acceleration of AIDS progression by a promoter variant of CCR5. Science (1998) 3.60
The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nat Med (1997) 3.36
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med (1998) 3.15
CCR5 promoter polymorphism and HIV-1 disease progression. Multicenter AIDS Cohort Study (MACS). Lancet (1998) 2.45
Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression. Nat Med (1998) 2.01
Host factors in the pathogenesis of HIV disease. Immunol Rev (1997) 1.64
Phylogenetic associations of human and simian T-cell leukemia/lymphotropic virus type I strains: evidence for interspecies transmission. J Virol (1994) 1.61
Seroepidemiologic, molecular, and phylogenetic analyses of simian T-cell leukemia viruses (STLV-I) from various naturally infected monkey species from central and western Africa. Virology (1994) 1.28
The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5'-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons. J Biol Chem (1997) 1.23
CCR2 polymorphism and HIV disease. Swiss HIV Cohort. Nat Med (1998) 1.07
Role of CCR2 genotype in the clinical course of syncytium-inducing (SI) or non-SI human immunodeficiency virus type 1 infection and in the time to conversion to SI virus variants. J Infect Dis (1998) 1.07
Prevalence of hepatitis C virus and other blood-borne viruses in Pygmies and neighbouring Bantus in southern Cameroon. Trans R Soc Trop Med Hyg (1996) 1.05
Infections among pygmies in the Eastern Province of Cameroon. Med Microbiol Immunol (1993) 0.97
Chemokine-receptor polymorphisms: clarity or confusion for HIV-1 prognosis? Lancet (1998) 0.96
True HIV-1 infection in a pygmy. Lancet (1987) 0.88
Lack of evidence for human or simian T-lymphotropic viruses type III infection in pygmies. Lancet (1986) 0.85
Variable number of tandem repeat (VNTR) markers for human gene mapping. Science (1987) 25.71
Cutaneous wound healing. N Engl J Med (1999) 19.12
Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am J Respir Crit Care Med (1995) 15.80
A genetic linkage map of the human genome. Cell (1987) 13.37
Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science (1994) 12.83
Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS (2001) 8.89
A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations. Cell (1990) 8.10
A closely linked genetic marker for cystic fibrosis. Nature (1985) 7.85
Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients. Circulation (1996) 7.29
Molecular beacon sequence analysis for detecting drug resistance in Mycobacterium tuberculosis. Nat Biotechnol (1998) 6.59
Signatures of population expansion in microsatellite repeat data. Genetics (1998) 5.76
Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation. J Cell Biol (1983) 5.73
The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell (1990) 5.24
An audit of the 'two-glass' test for urethritis. Int J STD AIDS (2000) 5.18
Microsatellite diversity and the demographic history of modern humans. Proc Natl Acad Sci U S A (1997) 4.96
Detection of rifampin resistance in Mycobacterium tuberculosis in a single tube with molecular beacons. J Clin Microbiol (2001) 4.89
Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Cell (1999) 4.87
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell (1990) 4.84
Granulocyte chemotaxis: an improved in vitro assay employing 51 Cr-labeled granulocytes. J Immunol (1973) 4.61
The gene for familial polyposis coli maps to the long arm of chromosome 5. Science (1987) 4.48
Thermodynamic basis of the enhanced specificity of structured DNA probes. Proc Natl Acad Sci U S A (1999) 4.46
Case-finding for depression in primary care: a randomized trial. Am J Med (1999) 4.46
Biological and chemical detection of trichothecene mycotoxins of Fusarium species. Appl Microbiol (1973) 4.37
Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis. Mol Microbiol (1999) 4.27
A primary genetic map of markers of human chromosome 10. Genomics (1988) 4.23
ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J Cell Biol (1994) 4.09
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol (1996) 4.06
A primary genetic map of chromosome 13q. Am J Hum Genet (1986) 4.01
Childhood antecedents of adult obesity. Do chubby infants become obese adults? N Engl J Med (1976) 3.72
The APOL1 gene and allograft survival after kidney transplantation. Am J Transplant (2011) 3.69
Relapsing illness due to Rochalimaea henselae in immunocompetent hosts: implication for therapy and new epidemiological associations. Clin Infect Dis (1992) 3.61
Defective granulocyte chemotaxis in the Chediak-Higashi syndrome. J Clin Invest (1971) 3.58
Modeling for health care and other policy decisions: uses, roles, and validity. Value Health (2001) 3.56
A mapped set of DNA markers for human chromosome 17. Genomics (1988) 3.55
A pooled analysis of magnetic fields and childhood leukaemia. Br J Cancer (2000) 3.49
Precise localization of NF1 to 17q11.2 by balanced translocation. Am J Hum Genet (1989) 3.27
Origin and molecular specification of striatal interneurons. J Neurosci (2000) 3.24
Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src. Science (1990) 3.15
Angiogenesis in wound healing. J Investig Dermatol Symp Proc (2000) 3.12
Multiplex detection of four pathogenic retroviruses using molecular beacons. Proc Natl Acad Sci U S A (1999) 3.10
Recommendations for treatment of human infections caused by Bartonella species. Antimicrob Agents Chemother (2004) 3.09
Putting the "landscape" in landscape genetics. Heredity (Edinb) (2006) 3.05
Multiplex detection of single-nucleotide variations using molecular beacons. Genet Anal (1999) 2.99
Spectral genotyping of human alleles. Science (1998) 2.95
Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J Cell Biol (1994) 2.93
Multipractice analysis of laparoscopic cholecystectomy in 1,983 patients. Am J Surg (1992) 2.87
Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell (1991) 2.84
Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. N Engl J Med (1994) 2.81
A mapped set of genetic markers for human chromosome 9. Genomics (1988) 2.80
Controlled trial of an audit facilitator in diagnosis and treatment of childhood asthma in general practice. BMJ (1995) 2.77
Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood (1977) 2.76
Comparison of glycated albumin and hemoglobin A(1c) levels in diabetic subjects on hemodialysis. Kidney Int (2008) 2.74
Statistical analysis of array expression data as applied to the problem of tamoxifen resistance. J Natl Cancer Inst (1999) 2.58
Kinetic analysis of chemotactic factor generation in human serum via activation of the classical and alternate complement pathways. Clin Immunol Immunopathol (1975) 2.56
Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system. J Exp Med (1975) 2.56
JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol (1994) 2.55
Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase. Proc Natl Acad Sci U S A (1989) 2.49
Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. J Leukoc Biol (1996) 2.49
FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology (2001) 2.46
Comparative toxicology of trichothec mycotoxins: inhibition of protein synthesis in animal cells. J Biochem (1973) 2.45
The selective eosinophil chemotactic activity of histamine. J Exp Med (1975) 2.45
Iodination by human polymorphonuclear leukocytes: a re-evaluation. J Lab Clin Med (1977) 2.45
Bartonella henselae neuroretinitis in cat scratch disease. Diagnosis, management, and sequelae. Ophthalmology (1998) 2.43
Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet (1999) 2.42
Radixin is a novel member of the band 4.1 family. J Cell Biol (1991) 2.40
Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558. J Clin Invest (1991) 2.38
Toxicological approaches to the metabolites of Fusaria. V. Neosolaniol, T-2 toxin and butenolide, toxic metabolites of Fusarium sporotrichioides NRRL 3510 and Fusarium poae 3287. Jpn J Exp Med (1972) 2.37
Mutations in the alpha 1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia. Nat Genet (1993) 2.35
Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: impact on the epidemiology of the HIV-1 pandemic. Proc Natl Acad Sci U S A (2001) 2.35
Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science (1993) 2.35
Fibronectin fragment(s) are chemotactic for human peripheral blood monocytes. J Immunol (1982) 2.29
Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proc Natl Acad Sci U S A (2000) 2.27
Peroxidase-H2O2-halide system: Cytotoxic effect on mammalian tumor cells. Blood (1975) 2.25
Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome. J Med Genet (1999) 2.25
Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans. Genome Res (1996) 2.24
Two cytosolic neutrophil oxidase components absent in autosomal chronic granulomatous disease. Science (1988) 2.21
What determines levels of passive smoking in children with asthma? Thorax (1997) 2.20
Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. J Cell Sci (1996) 2.20
Novel, ligation-dependent PCR assay for detection of hepatitis C in serum. J Clin Microbiol (1996) 2.19
Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone (2003) 2.17
TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment? Am J Physiol Lung Cell Mol Physiol (2000) 2.17
Wound repair in the context of extracellular matrix. Curr Opin Cell Biol (1994) 2.14
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol (1999) 2.14
Isolation and mapping of a cloned ribosomal protein gene of Drosophila melanogaster. Nature (1980) 2.12
Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction. J Cell Biol (1990) 2.12
A detailed genetic map of the long arm of chromosome 11. Genomics (1990) 2.11