Published in Science on December 04, 1987
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol (1991) 8.60
Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet (1993) 6.02
An interspersed repeated sequence specific for human subtelomeric regions. EMBO J (1990) 5.30
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients. Proc Natl Acad Sci U S A (1992) 4.13
Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5. Am J Hum Genet (1988) 3.58
Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein. Mol Cell Biol (1991) 3.45
The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J Cell Biol (1992) 2.76
CpG island clones from a deletion encompassing the gene for adenomatous polyposis coli. Proc Natl Acad Sci U S A (1989) 2.66
Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J Clin Invest (1993) 2.29
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proc Natl Acad Sci U S A (2002) 2.17
Architecture of inherited susceptibility to common cancer. Nat Rev Cancer (2010) 2.14
pp60c-src activation in human colon carcinoma. J Clin Invest (1989) 2.07
Dimer formation by an N-terminal coiled coil in the APC protein. Proc Natl Acad Sci U S A (1993) 2.05
Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 1.90
Identification and regional localization of DNA markers on chromosome 7 for the cloning of the cystic fibrosis gene. Am J Hum Genet (1988) 1.80
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis. Proc Natl Acad Sci U S A (1990) 1.76
Mutational analysis of patients with adenomatous polyposis: identical inactivating mutations in unrelated individuals. Am J Hum Genet (1993) 1.72
Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. Mol Cell Biol (1992) 1.62
An epidemiologic approach to gene-environment interaction. Genet Epidemiol (1990) 1.59
Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. Proc Natl Acad Sci U S A (1992) 1.56
Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene. Am J Hum Genet (1993) 1.53
Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Proc Natl Acad Sci U S A (1991) 1.52
The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO J (1995) 1.48
Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus. Am J Hum Genet (1992) 1.37
The genetics of FAP and FAP-like syndromes. Fam Cancer (2006) 1.34
Phenotypic, cytogenetic, and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis. Am J Hum Genet (1992) 1.32
Molecular biology of colorectal neoplasia. Gut (1993) 1.31
Novel germline APC gene mutation in a large familial adenomatous polyposis kindred displaying variable phenotypes. Gut (1995) 1.30
Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease. Am J Pathol (2000) 1.30
APC and its modifiers in colon cancer. Adv Exp Med Biol (2009) 1.28
Correlation between the development of extracolonic manifestations in FAP patients and mutations beyond codon 1403 in the APC gene. J Med Genet (1996) 1.22
The ninth Gordon Hamilton-Fairley memorial lecture. Hereditary cancers: clues to mechanisms of carcinogenesis. Br J Cancer (1989) 1.22
A CA-repeat polymorphism close to the adenomatous polyposis coli (APC) gene offers improved diagnostic testing for familial APC. Am J Hum Genet (1993) 1.21
Trisomies 8 and 20 characterize a subgroup of benign fibrous lesions arising in both soft tissue and bone. Am J Pathol (1999) 1.21
Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia. Med Mol Morphol (2007) 1.20
The gene for Treacher Collins syndrome maps to the long arm of chromosome 5. Am J Hum Genet (1991) 1.19
Genetic linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis on chromosome 5. Am J Hum Genet (1990) 1.17
Tourette syndrome in a pedigree with a 7;18 translocation: identification of a YAC spanning the translocation breakpoint at 18q22.3. Am J Hum Genet (1996) 1.16
Predictive diagnosis of familial adenomatous polyposis with linked DNA markers: population based study. BMJ (1992) 1.14
A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36. J Med Genet (1996) 1.13
Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas. J Clin Invest (1991) 1.11
Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia. Genomics (1989) 1.09
Value of combined phenotypic markers in identifying inheritance of familial adenomatous polyposis. Gut (1991) 1.07
Comparative clinicopathological and immunohistochemical study of ras and p53 in flat and polypoid type colorectal tumours. Gut (1994) 1.04
Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations. Mol Cancer (2010) 1.03
Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant. Am J Hum Genet (1990) 1.03
Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families. Mutat Res (2009) 1.00
Familial adenomatous polyposis: a case report and review of the literature. J Natl Med Assoc (2001) 0.99
Mutations of Ki-ras and p53 genes in colorectal cancer and their prognostic significance. Gut (1994) 0.98
Phenotypic differences in familial adenomatous polyposis based on APC gene mutation status. Gut (1998) 0.95
Value of the congenital hypertrophy of the retinal pigment epithelium in the diagnosis of familial adenomatous polyposis. Int Ophthalmol (2004) 0.95
Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11-q13 region: new data and a reanalysis of previous reports. Am J Hum Genet (1990) 0.93
Chromosome 5 allele loss in familial and sporadic colorectal adenomas. Br J Cancer (1989) 0.92
Familial adenomatous polyposis in a 5 year old child: a clinical, pathological, and molecular genetic study. J Med Genet (1996) 0.91
Evidence that the familial adenomatous polyposis gene is involved in a subset of colon cancers with a complementable defect in c-myc regulation. Proc Natl Acad Sci U S A (1989) 0.90
Iron: an emerging factor in colorectal carcinogenesis. World J Gastroenterol (2010) 0.90
A constitutional 5q23 deletion. J Med Genet (1990) 0.88
Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors. Med Mol Morphol (2013) 0.88
Intestinal iron homeostasis and colon tumorigenesis. Nutrients (2013) 0.88
Familial 5q11.2----q13.3 segmental duplication cosegregating with multiple anomalies, including schizophrenia. Am J Med Genet (1990) 0.87
Genetics of colorectal cancer. MedGenMed (2004) 0.87
Mutational spectrum of the APC and MUTYH genes and genotype-phenotype correlations in Brazilian FAP, AFAP, and MAP patients. Orphanet J Rare Dis (2013) 0.87
Familial/bilateral and sporadic testicular germ cell tumors show frequent genetic changes at loci with suggestive linkage evidence. Neoplasia (2001) 0.85
Presymptomatic diagnosis in families with adenomatous polyposis using highly polymorphic dinucleotide CA repeat markers flanking the APC gene. J Med Genet (1994) 0.85
Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines. Int J Exp Pathol (2004) 0.85
Patterns of gene expression that characterize the colonic mucosa in patients at genetic risk for colonic cancer. Proc Natl Acad Sci U S A (1991) 0.85
Colonic aberrant crypts in azoxymethane-treated F344 rats have decreased hexosaminidase activity. Am J Pathol (1990) 0.84
Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion. J Med Genet (1994) 0.83
Hereditary gastrointestinal cancer syndromes. Gastrointest Cancer Res (2011) 0.83
Major signaling pathways in intestinal stem cells. Biochim Biophys Acta (2012) 0.83
Correlation between chromosome 5q deletions and different mechanisms of c-myc overexpression in human colorectal cancer. Br J Cancer (1991) 0.82
Familial colorectal cancer. BMJ (1993) 0.82
Molecular genetics of colorectal carcinoma. BMJ (1989) 0.82
APC gene mutations in Chinese familial adenomatous polyposis patients. World J Gastroenterol (2010) 0.82
Multicolor lineage tracing methods and intestinal tumors. J Gastroenterol (2013) 0.81
Clinical and molecular features of attenuated adenomatous polyposis in northern Italy. Tech Coloproctol (2012) 0.80
The role of congenital hypertrophy of the retinal pigment epithelium in screening for familial adenomatous polyposis. Int J Colorectal Dis (1994) 0.80
Are different events involved in the development of sporadic versus hereditary tumours? The possible importance of the microenvironment in hereditary cancer. Br J Cancer (1990) 0.80
Divergent effects of epidermal growth factor and calcipotriol on human rectal cell proliferation. Gut (1994) 0.80
Risk estimation in familial adenomatous polyposis using DNA probes linked to the familial adenomatous polyposis gene. Gut (1992) 0.80
Two types of putative preneoplastic lesions identified by hexosaminidase activity in whole-mounts of colons from F344 rats treated with carcinogen. Am J Pathol (1993) 0.79
The history of familial adenomatous polyposis. Fam Cancer (2006) 0.79
Microsatellite analysis of the adenomatous polyposis coli (APC) gene and immunoexpression of beta catenin in nephroblastoma: a study including 83 cases treated with preoperative chemotherapy. J Clin Pathol (2005) 0.78
Yeast artificial chromosomes for the molecular analysis of the familial polyposis APC gene region. Proc Natl Acad Sci U S A (1992) 0.78
Architecture of inherited susceptibility to colorectal cancer: a voyage of discovery. Genes (Basel) (2014) 0.77
Screening for APC mutations based on detection of truncated APC proteins. Dig Dis Sci (1998) 0.77
Familial adenomatous polyposis and extracolonic cancer. Dig Dis Sci (2001) 0.77
Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers. Virchows Arch (2003) 0.76
Clinical Characteristics of Multiple Colorectal Adenoma Patients Without Germline APC or MYH Mutations. J Clin Gastroenterol (2016) 0.76
Inherited colorectal cancer syndromes. Clin Colon Rectal Surg (2005) 0.75
The genetics of inherited colon cancer. Clin Mol Pathol (1996) 0.75
Genetics of colon cancer. West J Med (1991) 0.75
The use of DNA from paraffin wax preserved tissue for predictive diagnosis in familial adenomatous polyposis. J Med Genet (1992) 0.75
A clinically homogeneous group of families with facioscapulohumeral (Landouzy-Déjérine) muscular dystrophy: linkage analysis of six autosomes. Am J Hum Genet (1990) 0.75
Oncology. Postgrad Med J (1990) 0.75
Exclusion of the retinoblastoma gene and chromosome 13q as the site of a primary lesion for human breast cancer. Am J Hum Genet (1990) 0.75
Tumor-suppressor genes: cardinal factors in inherited predisposition to human cancers. Environ Health Perspect (1992) 0.75
DNA markers and biological vulnerability markers in families multiply affected with schizophrenia. Eur Arch Psychiatry Clin Neurosci (1991) 0.75
Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82
Variable number of tandem repeat (VNTR) markers for human gene mapping. Science (1987) 25.71
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet (1997) 10.93
Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial. JAMA (2000) 10.40
Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature (1975) 10.33
Comparative genomics of the lactic acid bacteria. Proc Natl Acad Sci U S A (2006) 10.24
Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature (1987) 10.21
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (1991) 9.89
Passive smoking and the risk of coronary heart disease--a meta-analysis of epidemiologic studies. N Engl J Med (1999) 9.26
Endogenous opioid peptides: multiple agonists and receptors. Nature (1977) 8.21
A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations. Cell (1990) 8.10
A closely linked genetic marker for cystic fibrosis. Nature (1985) 7.85
Quantum computers. Nature (2010) 6.79
Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. N Engl J Med (2000) 6.53
Clinical and epidemiologic features of primary HIV infection. Ann Intern Med (1996) 6.04
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature (2000) 6.01
When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function. Pain (1995) 5.97
Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature (1993) 5.81
Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. N Engl J Med (1997) 5.72
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
Allelotype of colorectal carcinomas. Science (1989) 5.54
The action of tetrodotoxin on electrogenic components of squid giant axons. J Gen Physiol (1965) 5.42
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26
The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell (1990) 5.24
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (1993) 5.22
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet (1992) 5.14
Comorbidities, complications, and coding bias. Does the number of diagnosis codes matter in predicting in-hospital mortality? JAMA (1992) 5.07
Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res (2000) 4.94
A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet (1998) 4.89
Harnessing peer networks as an instrument for AIDS prevention: results from a peer-driven intervention. Public Health Rep (1998) 4.85
The impact of smoke-free workplaces on declining cigarette consumption in Australia and the United States. Am J Public Health (1999) 4.84
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell (1990) 4.84
Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (1993) 4.63
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell (2001) 4.60
Evaluation of mechanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens. Br J Pharmacol (1972) 4.45
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension (2001) 4.41
Transient regulation of protein synthesis in Escherichia coli upon shift-up of growth temperature. J Bacteriol (1978) 4.38
DiGeorge syndrome: part of CATCH 22. J Med Genet (1993) 4.30
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120. DNA Res (2001) 4.27
A primary genetic map of markers of human chromosome 10. Genomics (1988) 4.23
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res (1992) 4.21
A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens. Br J Pharmacol (1972) 4.11
Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis. Nucleic Acids Res (2000) 4.11
Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03
A primary genetic map of chromosome 13q. Am J Hum Genet (1986) 4.01
Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature (1988) 3.96
An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature (1998) 3.86
Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antogonist potencies of narcotic analgesics. Br J Pharmacol (1975) 3.76
The use of an optical brightener in the study of plant structure. Stain Technol (1975) 3.70
Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5. Am J Hum Genet (1988) 3.58
A mapped set of DNA markers for human chromosome 17. Genomics (1988) 3.55
Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep (2001) 3.47
Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature (1988) 3.44
Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology (2000) 3.42
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci (2002) 3.28
Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism. J Virol (2000) 3.27
Precise localization of NF1 to 17q11.2 by balanced translocation. Am J Hum Genet (1989) 3.27
Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Res (1975) 3.26
Head and neck schwannomas--a 10 year review. J Laryngol Otol (2000) 3.25
Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes. Proc Natl Acad Sci U S A (1999) 3.21
Rapid confirmation of single copy lambda prophage integration by PCR. Nucleic Acids Res (1994) 3.19
Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res (2001) 3.18
A high-throughput SNP typing system for genome-wide association studies. J Hum Genet (2001) 3.18
Isolation and mapping of a polymorphic DNA sequence (pTHH22) on chromosome 9 [D9S12]. Nucleic Acids Res (1988) 3.17
IL-6 is produced by osteoblasts and induces bone resorption. J Immunol (1990) 3.14
Gene organization deduced from the complete sequence of liverwort Marchantia polymorpha mitochondrial DNA. A primitive form of plant mitochondrial genome. J Mol Biol (1992) 3.11
Chronic conditions and risk of in-hospital death. Health Serv Res (1994) 3.00
Molecular detection of microscopic and submicroscopic deletions associated with Miller-Dieker syndrome. Am J Hum Genet (1988) 2.97
Mapping of mutation causing Friedreich's ataxia to human chromosome 9. Nature (1988) 2.96
A tripeptide 'anticodon' deciphers stop codons in messenger RNA. Nature (2000) 2.90
Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures. Arch Neurol (1991) 2.89
Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet (1993) 2.88
Using conjoint analysis to assess women's preferences for miscarriage management. Health Econ (1997) 2.87
Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients. Am J Hum Genet (1997) 2.85
The positions of three restriction fragment length polymorphisms on chromosome 4 relative to known genetic markers. Hum Genet (1984) 2.84
Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. N Engl J Med (1994) 2.81
Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell (1995) 2.81
A mapped set of genetic markers for human chromosome 9. Genomics (1988) 2.80
Genetic mapping of autosomal dominant Charcot-Marie-Tooth disease in a large French-Acadian kindred: identification of new linked markers on chromosome 17. Am J Hum Genet (1990) 2.77
Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet (1998) 2.77
Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75
Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients. Cancer Res (1992) 2.72
A primary genetic linkage map for human chromosome 12. Genomics (1987) 2.72
Requirement of CD9 on the egg plasma membrane for fertilization. Science (2000) 2.65
Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res (1987) 2.65
Complete structure of the chloroplast genome of Arabidopsis thaliana. DNA Res (1999) 2.63
Mutations of the APC (adenomatous polyposis coli) gene. Hum Mutat (1993) 2.63
A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol (1994) 2.62
Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron (1996) 2.62
Why the tobacco industry fears the passive smoking issue. Int J Health Serv (1990) 2.59
The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. Br J Pharmacol (1977) 2.59
Statistical analysis of array expression data as applied to the problem of tamoxifen resistance. J Natl Cancer Inst (1999) 2.58