Published in Diabetes on November 01, 1999
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes (2009) 2.51
In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes? Diabetes Care (2008) 1.52
Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: the Inter99 study. Diabetes Care (2008) 1.50
The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance. Am J Physiol Endocrinol Metab (2008) 1.37
The prediabetic period: review of clinical aspects. Diabetes Metab J (2011) 1.34
Cardiovascular disease in type 2 diabetes from population to man to mechanisms: the Kelly West Award Lecture 2008. Diabetes Care (2010) 1.33
Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes (2012) 1.32
The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose. Clin Endocrinol (Oxf) (2009) 1.27
Plasma glucose concentration and prediction of future risk of type 2 diabetes. Diabetes Care (2009) 1.25
From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation. Diabetes Care (2010) 1.21
Minimal contribution of fasting hyperglycemia to the incidence of type 2 diabetes in subjects with normal 2-h plasma glucose. Diabetes Care (2009) 1.11
Diabetes and pre-diabetes are associated with cardiovascular risk factors and carotid/femoral intima-media thickness independently of markers of insulin resistance and adiposity. Cardiovasc Diabetol (2007) 1.11
Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations. Diabetes Metab Res Rev (2007) 1.11
Distinct β-cell defects in impaired fasting glucose and impaired glucose tolerance. Diabetes (2012) 1.10
Pathogenesis of prediabetes: role of the liver in isolated fasting hyperglycemia and combined fasting and postprandial hyperglycemia. J Clin Endocrinol Metab (2013) 1.04
Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of prediabetes? Am J Physiol Endocrinol Metab (2008) 0.98
Prevention of diabetes with pioglitazone in ACT NOW: physiologic correlates. Diabetes (2013) 0.97
Evidence of reduced β-cell function in Asian Indians with mild dysglycemia. Diabetes Care (2013) 0.96
Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats. Am J Physiol Endocrinol Metab (2011) 0.93
Modeling hepatic insulin sensitivity during a meal: validation against the euglycemic hyperinsulinemic clamp. Am J Physiol Endocrinol Metab (2013) 0.90
Association of obstructive sleep apnea and glucose metabolism in subjects with or without obesity. Diabetes Care (2013) 0.89
Cardiovascular characteristics in subjects with increasing levels of abnormal glucose regulation: the Strong Heart Study. Diabetes Care (2012) 0.88
Levels of free fatty acids (FFA) are associated with insulin resistance but do not explain the relationship between adiposity and insulin resistance in Hispanic Americans: the IRAS Family Study. J Clin Endocrinol Metab (2012) 0.87
Determinants of impaired fasting glucose versus glucose intolerance in polycystic ovary syndrome. Diabetes Care (2010) 0.87
Variant in the 3' region of the IkappaBalpha gene associated with insulin resistance in Hispanic Americans: The IRAS Family Study. Obesity (Silver Spring) (2009) 0.86
The impact of obesity, sex, and diet on hepatic glucose production in cats. Am J Physiol Regul Integr Comp Physiol (2009) 0.84
Association between family history risk categories and prevalence of diabetes in Chinese population. PLoS One (2015) 0.84
Quantifying the improvement of surrogate indices of hepatic insulin resistance using complex measurement techniques. PLoS One (2012) 0.83
Differential relationship between physical activity and progression to diabetes by glucose tolerance status: the Inter99 Study. Diabetologia (2009) 0.83
Modifiable risk factors associated with prediabetes in men and women: a cross-sectional analysis of the cohort study in primary health care on the evolution of patients with prediabetes (PREDAPS-Study). BMC Fam Pract (2015) 0.82
Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents. Acta Diabetol (2014) 0.81
Prevalence of Diabetes Mellitus and Prediabetes in Dalseong-gun, Daegu City, Korea. Diabetes Metab J (2011) 0.79
Hemoglobin A1c and postpartum abnormal glucose tolerance among women with gestational diabetes mellitus. Obstet Gynecol (2012) 0.79
Linking pre-diabetes with benign prostate hyperplasia. IGFBP-3: a conductor of benign prostate hyperplasia development orchestra? PLoS One (2013) 0.79
Relationship and factors responsible for regulating fasting and post-challenge plasma glucose levels in the early stage development of type 2 diabetes mellitus. J Diabetes Investig (2014) 0.78
Impact of glucose tolerance status, sex, and body size on glucose absorption patterns during OGTTs. Diabetes Care (2013) 0.78
Early insulin secretory dysfunction in korean prediabetic subjects: should we change the criteria for "prediabetes?". Korean Diabetes J (2010) 0.78
Cardiometabolic Risk Profiles in Patients With Impaired Fasting Glucose and/or Hemoglobin A1c 5.7% to 6.4%: Evidence for a Gradient According to Diagnostic Criteria: The PREDAPS Study. Medicine (Baltimore) (2015) 0.78
Diabetes prevention: can insulin secretagogues do the job? Prim Care Diabetes (2010) 0.77
Assessment of factors associated with pre-diabetes in HCV infection including direct and dynamic measurements of insulin action. J Viral Hepat (2011) 0.77
Mild fasting hyperglycemia shifts fuel reliance toward fat during exercise in adults with impaired glucose tolerance. J Appl Physiol (1985) (2013) 0.77
Prediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Training. PLoS One (2016) 0.77
Effect of paternal diabetes on pre-diabetic phenotypes in adult offspring. Diabetes Care (2010) 0.77
Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance. J Diabetes Res (2015) 0.76
Circulating white blood cell count and measures of adipose tissue inflammation predict higher 24-h energy expenditure. Eur J Endocrinol (2009) 0.76
Hepatic glucose sensing is impaired, but can be normalized, in people with impaired fasting glucose. J Clin Endocrinol Metab (2014) 0.76
Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range. J Clin Endocrinol Metab (2014) 0.75
Impact of acute psychological stress on cardiovascular risk factors in face of insulin resistance. Stress (2016) 0.75
Impact of Major Depressive Disorder on Prediabetes by Impairing Insulin Sensitivity. J Diabetes Metab (2016) 0.75
A Unifying Organ Model of Pancreatic Insulin Secretion. PLoS One (2015) 0.75
Associations of lipid profiles with insulin resistance and β cell function in adults with normal glucose tolerance and different categories of impaired glucose regulation. PLoS One (2017) 0.75
Childhood Maltreatment Is an Independent Risk Factor for Prediabetic Disturbances in Glucose Regulation. Front Endocrinol (Lausanne) (2017) 0.75
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab (2001) 9.53
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med (1995) 8.51
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet (2000) 8.33
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest (1999) 7.35
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med (1993) 6.89
Changing habits to delay diabetes. N Engl J Med (2001) 5.30
Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J Clin Invest (1986) 5.18
Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes (1997) 4.17
Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am J Epidemiol (2000) 3.87
Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia (2000) 3.63
Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians. N Engl J Med (1988) 3.41
Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med (1988) 3.19
Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol (1990) 3.01
Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. J Clin Invest (1987) 2.96
Obesity and insulin resistance: lessons learned from the Pima Indians. Diabetes Metab Rev (1988) 2.64
Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Clin Invest (1990) 2.63
Correlation between muscle glycogen synthase activity and in vivo insulin action in man. J Clin Invest (1984) 2.62
Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. Proc Natl Acad Sci U S A (1999) 2.55
Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care (2001) 2.33
Effect of satiation on brain activity in obese and lean women. Obes Res (2001) 2.25
An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J Clin Invest (1998) 2.18
Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians. Diabetologia (2002) 2.08
Energy metabolism in African Americans: potential risk factors for obesity. Am J Clin Nutr (1999) 2.03
Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes. Diabetologia (2005) 2.03
Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. J Clin Invest (1984) 2.03
Insulin resistance associated with lower rates of weight gain in Pima Indians. J Clin Invest (1991) 2.02
Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med (1995) 1.99
Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization. Am J Clin Nutr (1989) 1.96
Familial dependence of the resting metabolic rate. N Engl J Med (1986) 1.94
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res (2001) 1.89
Relationship between degree of obesity and in vivo insulin action in man. Am J Physiol (1985) 1.89
A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. J Clin Invest (2000) 1.85
Differential brain responses to satiation in obese and lean men. Diabetes (2000) 1.81
Body weight gain in free-living Pima Indians: effect of energy intake vs expenditure. Int J Obes Relat Metab Disord (2003) 1.79
Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet (1998) 1.78
Obesity in the Pima Indians: its magnitude and relationship with diabetes. Am J Clin Nutr (1991) 1.77
A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia. Diabetes (2000) 1.73
A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia (1995) 1.70
In vivo insulin action is familial characteristic in nondiabetic Pima Indians. Diabetes (1987) 1.70
An epidemiological test of the hyperinsulinemia-hypertension hypothesis. J Clin Endocrinol Metab (1993) 1.56
Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. N Engl J Med (1990) 1.54
An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest (1995) 1.51
Determinants of energy expenditure and fuel utilization in man: effects of body composition, age, sex, ethnicity and glucose tolerance in 916 subjects. Int J Obes Relat Metab Disord (1999) 1.51
Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change. J Clin Endocrinol Metab (2000) 1.49
Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians. Mol Genet Metab (2002) 1.48
Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians. Diabetologia (2005) 1.47
Strength training increases insulin action in healthy 50- to 65-yr-old men. J Appl Physiol (1985) (1994) 1.46
Relationship between insulin-mediated glucose disposal and lipid metabolism in man. J Clin Invest (1985) 1.44
Skeletal muscle membrane lipid composition is related to adiposity and insulin action. J Clin Invest (1995) 1.41
Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human. J Biol Chem (1996) 1.41
Fasting and postprandial plasma concentrations of acylation-stimulation protein (ASP) in lean and obese Pima Indians compared to Caucasians. Obes Res (1999) 1.38
Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men. J Appl Physiol (1985) (1996) 1.37
Effect of muscle glycogen depletion on in vivo insulin action in man. J Clin Invest (1983) 1.35
Glucose storage is a major determinant of in vivo "insulin resistance" in subjects with normal glucose tolerance. J Clin Endocrinol Metab (1986) 1.32
Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima Indians. Mol Genet Metab (2001) 1.32
Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians. J Clin Invest (1984) 1.32
Exaggerated early insulin release and insulin resistance in a diabetes-prone population: a metabolic comparison of Pima Indians and Caucasians. J Clin Endocrinol Metab (1991) 1.30
Abnormal regulation of protein tyrosine phosphatase activities in skeletal muscle of insulin-resistant humans. Diabetes (1991) 1.27
Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. Mol Genet Metab (1998) 1.27
Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men. J Clin Invest (1994) 1.26
Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans. Diabetes (1998) 1.26
Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle. J Clin Invest (1987) 1.25
Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians. Am J Hum Genet (1997) 1.25
Increased rate of Cori cycle in obese subjects with NIDDM and effect of weight reduction. Diabetes (1988) 1.23
Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes. Diabetes (2001) 1.23
Short-term energy balance: relationship with protein, carbohydrate, and fat balances. Am J Physiol (1988) 1.23
Reduced insulin secretion: an independent predictor of body weight gain. J Clin Endocrinol Metab (1995) 1.21
The independent and combined effects of weight loss and aerobic exercise on blood pressure and oral glucose tolerance in older men. Am J Hypertens (1998) 1.20
Strength training accelerates gastrointestinal transit in middle-aged and older men. Med Sci Sports Exerc (1992) 1.20
Spontaneous physical activity and obesity: cross-sectional and longitudinal studies in Pima Indians. Am J Physiol (1992) 1.19
Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11q21-q22. Pima Diabetes Gene Group. Am J Hum Genet (1997) 1.17
Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med (1997) 1.16
Genomic structure and promoter analysis of the human obese gene. J Biol Chem (1996) 1.16
Thermic effect of infused glucose and insulin in man. Decreased response with increased insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Invest (1983) 1.15
Long-term changes in insulin action and insulin secretion associated with gain, loss, regain and maintenance of body weight. Diabetologia (2000) 1.14
Energy expenditure by doubly labeled water: validation in lean and obese subjects. Am J Physiol (1991) 1.14
Lower sedentary metabolic rate in women compared with men. J Clin Invest (1992) 1.14
Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians. J Clin Invest (1995) 1.13
Metabolic factors contributing to increased resting metabolic rate and decreased insulin-induced thermogenesis during the development of type 2 diabetes. Diabetes (1999) 1.13
Impaired insulin-stimulated muscle glycogen synthase activation in vivo in man is related to low fasting glycogen synthase phosphatase activity. J Clin Invest (1988) 1.11
Concomitant interindividual variation in body temperature and metabolic rate. Am J Physiol (1992) 1.11