Published in Nat Med on November 01, 1995
Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev (2000) 4.57
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci U S A (1997) 3.81
Molecular mechanisms of cancer development in obesity. Nat Rev Cancer (2011) 3.65
Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest (1997) 3.56
Identification of targets of leptin action in rat hypothalamus. J Clin Invest (1996) 3.49
Leptin mediates the increase in blood pressure associated with obesity. Cell (2014) 3.09
Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A (1996) 2.77
Intermittent hypoxia increases insulin resistance in genetically obese mice. J Physiol (2003) 2.71
Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest (1996) 2.68
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci U S A (1996) 2.68
Adiponectin and leptin levels in migraineurs in the Atherosclerosis Risk in Communities Study. Neurology (2014) 2.66
Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest (1999) 2.48
Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J Neurosci (2010) 2.42
Leptin at 14 y of age: an ongoing story. Am J Clin Nutr (2009) 2.33
Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci U S A (1999) 2.33
Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J Clin Invest (1998) 2.23
Sixteen years and counting: an update on leptin in energy balance. J Clin Invest (2011) 2.21
The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies. CMAJ (2006) 2.20
Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Hum Mol Genet (2009) 2.16
Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med (2012) 2.13
Body size and risk of MS in two cohorts of US women. Neurology (2009) 1.89
Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest (1997) 1.89
Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice. J Clin Invest (2011) 1.81
Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology (2010) 1.80
Leptin accelerates the onset of puberty in normal female mice. J Clin Invest (1997) 1.80
Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet (1998) 1.78
Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol (2004) 1.74
Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. Mol Endocrinol (2009) 1.72
Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. Circulation (2009) 1.70
Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest (2000) 1.68
Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res (2000) 1.65
Leptin regulation of neuronal excitability and cognitive function. Curr Opin Pharmacol (2007) 1.64
Leptin revisited: its mechanism of action and potential for treating diabetes. Nat Rev Drug Discov (2012) 1.63
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci U S A (1997) 1.59
Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses. Nat Commun (2015) 1.57
Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model. J Clin Invest (1998) 1.56
Hyperleptinemia is required for the development of leptin resistance. PLoS One (2010) 1.55
Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis. Neurology (2014) 1.54
Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. Proc Natl Acad Sci U S A (1998) 1.53
Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. J Clin Invest (1996) 1.53
Biology's response to dieting: the impetus for weight regain. Am J Physiol Regul Integr Comp Physiol (2011) 1.53
Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (1996) 1.52
Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins. Am J Physiol Endocrinol Metab (2009) 1.51
Genetic approaches to understanding human obesity. J Clin Invest (2011) 1.50
Adult type 3 adenylyl cyclase-deficient mice are obese. PLoS One (2009) 1.50
Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest (2010) 1.49
Hormone and glucose signalling in POMC and AgRP neurons. J Physiol (2009) 1.48
Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab (2012) 1.47
Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47
Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation. Obesity (Silver Spring) (2010) 1.47
Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds. Diabetes (2015) 1.45
Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol (2015) 1.44
Leptin and its role in hippocampal synaptic plasticity. Prog Lipid Res (2006) 1.43
Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest (2001) 1.41
Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak-/- Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure. PLoS One (2015) 1.40
Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ. Am J Respir Crit Care Med (2011) 1.34
Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. J Clin Invest (1997) 1.33
Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis. EMBO Rep (2012) 1.32
Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure. Endocr Rev (2010) 1.32
Leptin: a diverse regulator of neuronal function. J Neurochem (2006) 1.32
Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism. Proc Natl Acad Sci U S A (2011) 1.31
Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels. J Clin Invest (2010) 1.30
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor. Proc Natl Acad Sci U S A (1998) 1.30
Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology (2008) 1.29
Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Nat Rev Drug Discov (2012) 1.29
Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. J Clin Invest (1996) 1.28
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell Mol Life Sci (2010) 1.27
Reduced leptin levels in starvation increase susceptibility to endotoxic shock. Am J Pathol (2000) 1.25
Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity. Cell Adh Migr (2008) 1.24
Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study. BMJ (1996) 1.24
Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7. Am J Hum Genet (1996) 1.22
Pediatric obesity: etiology and treatment. Endocrinol Metab Clin North Am (2009) 1.22
Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Proc Natl Acad Sci U S A (1996) 1.19
Leptin and Inflammation. Curr Immunol Rev (2008) 1.19
The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion. J Neurosci (2009) 1.18
Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion. Am J Physiol Endocrinol Metab (2009) 1.17
Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal. Proc Natl Acad Sci U S A (2005) 1.17
Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J Clin Invest (1997) 1.17
Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression. J Clin Invest (1997) 1.16
HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. Am J Physiol Endocrinol Metab (2008) 1.16
Obesity-related metabolic syndrome: mechanisms of sympathetic overactivity. Int J Endocrinol (2013) 1.16
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci U S A (1997) 1.15
Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. Hypertension (2009) 1.14
Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin. Proc Natl Acad Sci U S A (1997) 1.13
Mechanisms linking obesity and cancer. Biochim Biophys Acta (2013) 1.12
Relationships between plasma leptin concentrations and human brain structure: a voxel-based morphometric study. Neurosci Lett (2006) 1.12
Hippocampal leptin signaling reduces food intake and modulates food-related memory processing. Neuropsychopharmacology (2011) 1.11
The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders. Hum Genet (2010) 1.11
Race-ethnic differences in adipokine levels: the Study of Women's Health Across the Nation (SWAN). Metabolism (2012) 1.11
A paleolithic diet is more satiating per calorie than a mediterranean-like diet in individuals with ischemic heart disease. Nutr Metab (Lond) (2010) 1.10
From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy. J Physiol (2007) 1.09
Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1. Mol Cell Biol (2012) 1.09
Sustained weight loss after Roux-en-Y gastric bypass is characterized by down regulation of endocannabinoids and mitochondrial function. Ann Surg (2008) 1.09
Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. PLoS One (2011) 1.08
Altered hypothalamic function in diet-induced obesity. Int J Obes (Lond) (2011) 1.08
Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest (1997) 1.08
Leptin and ghrelin levels in patients with schizophrenia during different antipsychotics treatment: a review. Schizophr Bull (2007) 1.08
Leptin signaling and leptin resistance. Front Med (2013) 1.08
Leptin expression and action: new experimental paradigms. Proc Natl Acad Sci U S A (1997) 1.07
Electric field effect in atomically thin carbon films. Science (2004) 45.10
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature (1999) 16.97
IntAct--open source resource for molecular interaction data. Nucleic Acids Res (2006) 13.82
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (2000) 13.62
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol (2000) 11.62
Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med (2000) 11.12
Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell (2000) 11.09
Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol (2001) 10.20
Genome cross-referencing and XREFdb: implications for the identification and analysis of genes mutated in human disease. Nat Genet (1997) 10.14
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab (2001) 9.53
Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat Med (1996) 8.94
Smoking in China: findings of the 1996 National Prevalence Survey. JAMA (1999) 8.67
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell (2001) 8.60
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 8.38
Mammalian sweet taste receptors. Cell (2001) 8.04
Disruption of IRS-2 causes type 2 diabetes in mice. Nature (1998) 7.94
The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health (1994) 7.38
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest (1999) 7.35
The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med (1993) 6.89
Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res (1999) 6.85
Significant acidification in major Chinese croplands. Science (2010) 6.68
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell (1995) 6.43
TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33
Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet (2001) 6.23
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13
Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J (1998) 5.96
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab (2001) 5.76
An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum (1998) 5.72
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet (1999) 5.61
Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes. Science (1990) 5.35
Smads: transcriptional activators of TGF-beta responses. Cell (1998) 5.33
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science (2001) 5.25
Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J Clin Invest (1986) 5.18
Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med (1992) 5.05
Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell (2001) 5.04
Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Mol Cell Biol (1998) 5.01
Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology. Proc Natl Acad Sci U S A (2000) 4.79
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science (1996) 4.59
Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J Am Chem Soc (2001) 4.46
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene (2012) 4.30
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A (1997) 4.29
Circulating ghrelin levels are decreased in human obesity. Diabetes (2001) 4.28
PCR amplification and restriction endonuclease analysis of a 65-kilodalton heat shock protein gene sequence for taxonomic separation of rapidly growing mycobacteria. J Clin Microbiol (1995) 4.27
Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex. J Neurosci (1997) 4.26
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem (2001) 4.23
Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3. EMBO J (2001) 4.23
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res (2001) 4.22
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med (2001) 4.22
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci U S A (1994) 4.21
Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue. J Virol (1998) 4.17
Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs. Science (2013) 4.17
A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) Investigators. N Engl J Med (2000) 4.14
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med (1997) 4.10
Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (2000) 4.08
Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum (1997) 4.08
The effect of postmenopausal estrogen therapy on bone density in elderly women. N Engl J Med (1993) 4.04
Specific and nonspecific NK cell activation during virus infection. Nat Immunol (2001) 4.02
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. Proc Natl Acad Sci U S A (1998) 3.99
Multiattribute utility function for a comprehensive health status classification system. Health Utilities Index Mark 2. Med Care (1996) 3.96
The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum (1995) 3.93
Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am J Epidemiol (2000) 3.87
Molecular dynamics simulations of a lipid bilayer and of hexadecane: an investigation of membrane fluidity. Science (1993) 3.81
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Imaging membrane protein helical wheels. J Magn Reson (2000) 3.80
High-level semi-synthetic production of the potent antimalarial artemisinin. Nature (2013) 3.80
Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis. Antimicrob Agents Chemother (1997) 3.75
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem (2000) 3.74
Characterization of a virtually full-length human immunodeficiency virus type 1 genome of a prevalent intersubtype (C/B') recombinant strain in China. J Virol (2000) 3.70
Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet (2000) 3.68
DNA large restriction fragment patterns of sporadic and epidemic nosocomial strains of Mycobacterium chelonae and Mycobacterium abscessus. J Clin Microbiol (1993) 3.65
Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64
Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia (2000) 3.63
Discovery of a three-dimensional topological Dirac semimetal, Na3Bi. Science (2014) 3.54
A cytoplasmic chaperonin that catalyzes beta-actin folding. Cell (1992) 3.50
Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms. Antimicrob Agents Chemother (1997) 3.46
"Fluorescent timer": protein that changes color with time. Science (2000) 3.42
Energy expenditure by doubly labeled water: validation in humans and proposed calculation. Am J Physiol (1986) 3.35
Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci U S A (1995) 3.33
Structural basis of the redox switch in the OxyR transcription factor. Cell (2001) 3.32
Inhibition of human immunodeficiency virus gene amplification by heparin. J Clin Microbiol (1991) 3.32
Structure of the transmembrane region of the M2 protein H(+) channel. Protein Sci (2001) 3.31
Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. J Bone Miner Res (1993) 3.31
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem (2001) 3.27
Chemical and molecular regulation of enzymes that detoxify carcinogens. Proc Natl Acad Sci U S A (1993) 3.24
Role of IRS-2 in insulin and cytokine signalling. Nature (1995) 3.23
Identification of sequences in a yeast histone promoter involved in periodic transcription. Cell (1986) 3.22
Cell-cycle arrest versus cell death in cancer therapy. Nat Med (1997) 3.18
The fragile X mental retardation protein inhibits translation via interacting with mRNA. Nucleic Acids Res (2001) 3.18
Cloning and expression of a rat brain L-glutamate transporter. Nature (1992) 3.14
Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling. Nat Cell Biol (2001) 3.10
Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes Dev (1999) 3.08
A mutation in Rab27a causes the vesicle transport defects observed in ashen mice. Proc Natl Acad Sci U S A (2000) 3.07
The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res (1995) 3.04
The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008. Parasitology (2009) 3.03
Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family. Infect Immun (1998) 3.02