Published in N Engl J Med on May 03, 2001
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 101.79
Prevention of type 2 diabetes. BMJ (2001) 1.11
Lifestyle interventions for type 2 diabetes. Relevance for clinical practice. Can Fam Physician (2003) 1.03
Retinal upregulation of inflammatory and proangiogenic markers in a model of neonatal diabetic rats fed on a high-fat-diet. BMC Ophthalmol (2013) 0.85
Diabetes in a high secure hospital. Postgrad Med J (2004) 0.75
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab (2001) 9.53
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet (2000) 8.33
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest (1999) 7.35
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med (1993) 6.89
Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J Clin Invest (1986) 5.18
Circulating ghrelin levels are decreased in human obesity. Diabetes (2001) 4.28
Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes (1997) 4.17
Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am J Epidemiol (2000) 3.87
Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia (2000) 3.63
Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians. N Engl J Med (1988) 3.41
Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med (1988) 3.19
Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol (1990) 3.01
Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. J Clin Invest (1987) 2.96
Obesity and insulin resistance: lessons learned from the Pima Indians. Diabetes Metab Rev (1988) 2.64
Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Clin Invest (1990) 2.63
Correlation between muscle glycogen synthase activity and in vivo insulin action in man. J Clin Invest (1984) 2.62
Body mass index as a measure of adiposity in children and adolescents: relationship to adiposity by dual energy x-ray absorptiometry and to cardiovascular risk factors. J Clin Endocrinol Metab (2001) 2.52
Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care (2001) 2.33
Effect of satiation on brain activity in obese and lean women. Obes Res (2001) 2.25
An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J Clin Invest (1998) 2.18
Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians. Diabetologia (2002) 2.08
Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes. Diabetologia (2005) 2.03
Energy metabolism in African Americans: potential risk factors for obesity. Am J Clin Nutr (1999) 2.03
Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. J Clin Invest (1984) 2.03
Insulin resistance associated with lower rates of weight gain in Pima Indians. J Clin Invest (1991) 2.02
Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med (1995) 1.99
Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance. Diabetes (1999) 1.98
Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization. Am J Clin Nutr (1989) 1.96
Familial dependence of the resting metabolic rate. N Engl J Med (1986) 1.94
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res (2001) 1.89
Relationship between degree of obesity and in vivo insulin action in man. Am J Physiol (1985) 1.89
Successful dieters have increased neural activity in cortical areas involved in the control of behavior. Int J Obes (Lond) (2006) 1.85
A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. J Clin Invest (2000) 1.85
Differential brain responses to satiation in obese and lean men. Diabetes (2000) 1.81
Body weight gain in free-living Pima Indians: effect of energy intake vs expenditure. Int J Obes Relat Metab Disord (2003) 1.79
Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet (1998) 1.78
Obesity in the Pima Indians: its magnitude and relationship with diabetes. Am J Clin Nutr (1991) 1.77
A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia. Diabetes (2000) 1.73
A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia (1995) 1.70
In vivo insulin action is familial characteristic in nondiabetic Pima Indians. Diabetes (1987) 1.70
Persistence of abnormal neural responses to a meal in postobese individuals. Int J Obes Relat Metab Disord (2004) 1.69
Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. N Engl J Med (1990) 1.54
An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest (1995) 1.51
Determinants of energy expenditure and fuel utilization in man: effects of body composition, age, sex, ethnicity and glucose tolerance in 916 subjects. Int J Obes Relat Metab Disord (1999) 1.51
Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment. Am J Clin Nutr (2000) 1.50
Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change. J Clin Endocrinol Metab (2000) 1.49
Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians. Mol Genet Metab (2002) 1.48
Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians. Diabetologia (2005) 1.47
Relationship between insulin-mediated glucose disposal and lipid metabolism in man. J Clin Invest (1985) 1.44
Skeletal muscle membrane lipid composition is related to adiposity and insulin action. J Clin Invest (1995) 1.41
Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human. J Biol Chem (1996) 1.41
Dicarboxylic acids and glucose utilization in humans: effect of sebacate. JPEN J Parenter Enteral Nutr (1994) 1.40
Effect of muscle glycogen depletion on in vivo insulin action in man. J Clin Invest (1983) 1.35
Glucose storage is a major determinant of in vivo "insulin resistance" in subjects with normal glucose tolerance. J Clin Endocrinol Metab (1986) 1.32
Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima Indians. Mol Genet Metab (2001) 1.32
Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians. J Clin Invest (1984) 1.32
Exaggerated early insulin release and insulin resistance in a diabetes-prone population: a metabolic comparison of Pima Indians and Caucasians. J Clin Endocrinol Metab (1991) 1.30
Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. Mol Genet Metab (1998) 1.27
Abnormal regulation of protein tyrosine phosphatase activities in skeletal muscle of insulin-resistant humans. Diabetes (1991) 1.27
Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans. Diabetes (1998) 1.26
Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men. J Clin Invest (1994) 1.26
Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle. J Clin Invest (1987) 1.25
Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians. Am J Hum Genet (1997) 1.25
Lower daily energy expenditure as measured by a respiratory chamber in subjects with spinal cord injury compared with control subjects. Am J Clin Nutr (1998) 1.25
Increased rate of Cori cycle in obese subjects with NIDDM and effect of weight reduction. Diabetes (1988) 1.23
Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes. Diabetes (2001) 1.23
Short-term energy balance: relationship with protein, carbohydrate, and fat balances. Am J Physiol (1988) 1.23
Reduced insulin secretion: an independent predictor of body weight gain. J Clin Endocrinol Metab (1995) 1.21
Spontaneous physical activity and obesity: cross-sectional and longitudinal studies in Pima Indians. Am J Physiol (1992) 1.19
Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11q21-q22. Pima Diabetes Gene Group. Am J Hum Genet (1997) 1.17
Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med (1997) 1.16
Thermic effect of infused glucose and insulin in man. Decreased response with increased insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Invest (1983) 1.15
Long-term changes in insulin action and insulin secretion associated with gain, loss, regain and maintenance of body weight. Diabetologia (2000) 1.14
Energy expenditure by doubly labeled water: validation in lean and obese subjects. Am J Physiol (1991) 1.14
Lower sedentary metabolic rate in women compared with men. J Clin Invest (1992) 1.14
Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians. J Clin Invest (1995) 1.13
Metabolic factors contributing to increased resting metabolic rate and decreased insulin-induced thermogenesis during the development of type 2 diabetes. Diabetes (1999) 1.13
Impaired insulin-stimulated muscle glycogen synthase activation in vivo in man is related to low fasting glycogen synthase phosphatase activity. J Clin Invest (1988) 1.11
Concomitant interindividual variation in body temperature and metabolic rate. Am J Physiol (1992) 1.11
Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle. J Clin Invest (1990) 1.09
Insulin response of components of whole-body and muscle carbohydrate metabolism in humans. Am J Physiol (1988) 1.08
Racial difference in body core temperature between Pima Indian and Caucasian men. Int J Obes Relat Metab Disord (1995) 1.08
Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes (1984) 1.07
Linkage between stature and a region on chromosome 20 and analysis of a candidate gene, bone morphogenetic protein 2. Am J Med Genet (1995) 1.07
Muscle glycogen synthesis and disposition of infused glucose in humans with reduced rates of insulin-mediated carbohydrate storage. Diabetes (1988) 1.07
No accumulation of glucose in human skeletal muscle during euglycemic hyperinsulinemia. Am J Physiol (1988) 1.06
Multiple disturbances of free fatty acid metabolism in noninsulin-dependent diabetes. Effect of oral hypoglycemic therapy. J Clin Invest (1985) 1.05
A brief overview of human energy metabolism and its relationship to essential obesity. Am J Clin Nutr (1992) 1.05
Energy balance and weight regulation: genetics versus environment. Br J Nutr (2000) 1.05