An oligomeric form of E. coli UvrD is required for optimal helicase activity.

Helicase-dependent isothermal DNA amplification. EMBO Rep (2004) 2.51

Single-molecule assay reveals strand switching and enhanced processivity of UvrD. Proc Natl Acad Sci U S A (2004) 2.24

PcrA helicase dismantles RecA filaments by reeling in DNA in uniform steps. Cell (2010) 2.10

A nonuniform stepping mechanism for E. coli UvrD monomer translocation along single-stranded DNA. Mol Cell (2007) 2.00

General methods for analysis of sequential "n-step" kinetic mechanisms: application to single turnover kinetics of helicase-catalyzed DNA unwinding. Biophys J (2003) 1.70

Escherichia coli DbpA is an RNA helicase that requires hairpin 92 of 23S rRNA. EMBO J (2001) 1.58

Characterization of a thermostable UvrD helicase and its participation in helicase-dependent amplification. J Biol Chem (2005) 1.53

The 2B domain of the Escherichia coli Rep protein is not required for DNA helicase activity. Proc Natl Acad Sci U S A (2002) 1.37

Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res (2000) 1.34

Pre-steady-state DNA unwinding by bacteriophage T4 Dda helicase reveals a monomeric molecular motor. Proc Natl Acad Sci U S A (2002) 1.26

Protein structure. Direct observation of structure-function relationship in a nucleic acid-processing enzyme. Science (2015) 1.21

Evidence for a functional dimeric form of the PcrA helicase in DNA unwinding. Nucleic Acids Res (2008) 1.10

Direct imaging of single UvrD helicase dynamics on long single-stranded DNA. Nat Commun (2013) 1.08

The protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase. J Biol Chem (2010) 1.06

Insight into helicase mechanism and function revealed through single-molecule approaches. Q Rev Biophys (2010) 1.03

Sequence-dependent base pair stepping dynamics in XPD helicase unwinding. Elife (2013) 1.02

Mutations that affect dimer formation and helicase activity of the hepatitis C virus helicase. J Virol (2001) 1.00

The unstructured C-terminal extension of UvrD interacts with UvrB, but is dispensable for nucleotide excision repair. DNA Repair (Amst) (2009) 1.00

Translocation of Saccharomyces cerevisiae Pif1 helicase monomers on single-stranded DNA. Nucleic Acids Res (2013) 0.89

Single-molecule imaging of the oligomer formation of the nonhexameric Escherichia coli UvrD helicase. Biophys J (2013) 0.89

Modulation of UvrD helicase activity by covalent DNA-protein cross-links. J Biol Chem (2010) 0.86

Structure and Mechanisms of SF1 DNA Helicases. Adv Exp Med Biol (2013) 0.86

Grip it and rip it: structural mechanisms of DNA helicase substrate binding and unwinding. Protein Sci (2014) 0.86

RecQ helicase translocates along single-stranded DNA with a moderate processivity and tight mechanochemical coupling. Proc Natl Acad Sci U S A (2012) 0.86

A parallel quadruplex DNA is bound tightly but unfolded slowly by pif1 helicase. J Biol Chem (2015) 0.85

Mutual inhibition of RecQ molecules in DNA unwinding. J Biol Chem (2010) 0.83

Ensemble and single-molecule fluorescence-based assays to monitor DNA binding, translocation, and unwinding by iron-sulfur cluster containing helicases. Methods (2010) 0.81

The UvrD303 hyper-helicase exhibits increased processivity. J Biol Chem (2014) 0.78

RNA Remodeling Activity of DEAD Box Proteins Tuned by Protein Concentration, RNA Length, and ATP. Mol Cell (2016) 0.75

Self-assembly of Escherichia coli MutL and its complexes with DNA. Biochemistry (2011) 0.75

Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity. Q Rev Biophys (1978) 9.44

Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP. Cell (1997) 4.71

A double-filter method for nitrocellulose-filter binding: application to protein-nucleic acid interactions. Proc Natl Acad Sci U S A (1993) 4.00

Structure of the DNA binding domain of E. coli SSB bound to ssDNA. Nat Struct Biol (2000) 3.34

Kinetic measurement of the step size of DNA unwinding by Escherichia coli UvrD helicase. Science (1997) 3.21

Two binding modes in Escherichia coli single strand binding protein-single stranded DNA complexes. Modulation by NaCl concentration. J Biol Chem (1985) 3.06

Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution. Proc Natl Acad Sci U S A (1997) 2.23

Interpretation of monovalent and divalent cation effects on the lac repressor-operator interaction. Biochemistry (1977) 2.23

Large-scale overproduction and rapid purification of the Escherichia coli ssb gene product. Expression of the ssb gene under lambda PL control. Biochemistry (1986) 2.20

Escherichia coli rep helicase unwinds DNA by an active mechanism. Biochemistry (1993) 2.14

Allosteric effects of nucleotide cofactors on Escherichia coli Rep helicase-DNA binding. Science (1992) 2.04

Nonspecific interaction of lac repressor with DNA: an association reaction driven by counterion release. Biochemistry (1977) 1.95

Salt-dependent changes in the DNA binding co-operativity of Escherichia coli single strand binding protein. J Mol Biol (1986) 1.94

Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super-families of helicases. Protein Sci (1998) 1.93

Escherichia coli helicase II (uvrD) protein can completely unwind fully duplex linear and nicked circular DNA. J Biol Chem (1989) 1.88

Escherichia coli single-strand binding protein forms multiple, distinct complexes with single-stranded DNA. Biochemistry (1986) 1.86

Pentalysine-deoxyribonucleic acid interactions: a model for the general effects of ion concentrations on the interactions of proteins with nucleic acids. Biochemistry (1980) 1.78

E. coli Rep oligomers are required to initiate DNA unwinding in vitro. J Mol Biol (2001) 1.69

Nonspecific interactions of Escherichia coli RNA polymerase with native and denatured DNA: differences in the binding behavior of core and holoenzyme. Biochemistry (1978) 1.67

Overexpression, purification, DNA binding, and dimerization of the Escherichia coli uvrD gene product (helicase II). Biochemistry (1993) 1.60

DNA-induced dimerization of the Escherichia coli rep helicase. Allosteric effects of single-stranded and duplex DNA. J Biol Chem (1992) 1.52

DNA-induced dimerization of the Escherichia coli Rep helicase. J Mol Biol (1991) 1.49

Equilibrium binding of Escherichia coli single-strand binding protein to single-stranded nucleic acids in the (SSB)65 binding mode. Cation and anion effects and polynucleotide specificity. Biochemistry (1988) 1.46

Thermodynamic extent of counterion release upon binding oligolysines to single-stranded nucleic acids. Proc Natl Acad Sci U S A (1990) 1.45

Thermodynamic methods for model-independent determination of equilibrium binding isotherms for protein-DNA interactions: spectroscopic approaches to monitor binding. Methods Enzymol (1991) 1.42

Kinetics of protein-nucleic acid interactions: use of salt effects to probe mechanisms of interaction. CRC Crit Rev Biochem (1986) 1.41

Binding mode transitions of Escherichia coli single strand binding protein-single-stranded DNA complexes. Cation, anion, pH, and binding density effects. J Biol Chem (1988) 1.38

Co-operative binding of Escherichia coli SSB tetramers to single-stranded DNA in the (SSB)35 binding mode. J Mol Biol (1994) 1.37

Na+ effects on transition of DNA and polynucleotides of variable linear charge density. Biopolymers (1976) 1.36

Escherichia coli helicase II (UvrD) protein initiates DNA unwinding at nicks and blunt ends. Proc Natl Acad Sci U S A (1990) 1.33

Single-turnover kinetics of helicase-catalyzed DNA unwinding monitored continuously by fluorescence energy transfer. Biochemistry (1994) 1.28

Negative co-operativity in Escherichia coli single strand binding protein-oligonucleotide interactions. II. Salt, temperature and oligonucleotide length effects. J Mol Biol (1989) 1.26

The importance of coulombic end effects: experimental characterization of the effects of oligonucleotide flanking charges on the strength and salt dependence of oligocation (L8+) binding to single-stranded DNA oligomers. Biophys J (1999) 1.25

Apparent heat capacity change accompanying a nonspecific protein-DNA interaction. Escherichia coli SSB tetramer binding to oligodeoxyadenylates. Biochemistry (1994) 1.24

Kinetics and mechanism of dissociation of cooperatively bound T4 gene 32 protein-single-stranded nucleic acid complexes. 1. Irreversible dissociation induced by sodium chloride concentration jumps. Biochemistry (1984) 1.24

Kinetics and mechanism of the association of the bacteriophage T4 gene 32 (helix destabilizing) protein with single-stranded nucleic acids. Evidence for protein translocation. J Mol Biol (1981) 1.22

Calorimetric studies of E. coli SSB protein-single-stranded DNA interactions. Effects of monovalent salts on binding enthalpy. J Mol Biol (1998) 1.21

A general method of analysis of ligand-macromolecule equilibria using a spectroscopic signal from the ligand to monitor binding. Application to Escherichia coli single-strand binding protein-nucleic acid interactions. Biochemistry (1987) 1.17

Limited co-operativity in protein-nucleic acid interactions. A thermodynamic model for the interactions of Escherichia coli single strand binding protein with single-stranded nucleic acids in the "beaded", (SSB)65 mode. J Mol Biol (1987) 1.16

Negative co-operativity in Escherichia coli single strand binding protein-oligonucleotide interactions. I. Evidence and a quantitative model. J Mol Biol (1989) 1.16

Adenine base unstacking dominates the observed enthalpy and heat capacity changes for the Escherichia coli SSB tetramer binding to single-stranded oligoadenylates. Biochemistry (1999) 1.15

E. coli single strand binding protein: a new look at helix-destabilizing proteins. Trends Biochem Sci (1988) 1.15

Linkage of pH, anion and cation effects in protein-nucleic acid equilibria. Escherichia coli SSB protein-single stranded nucleic acid interactions. J Mol Biol (1994) 1.14

Large contributions of coupled protonation equilibria to the observed enthalpy and heat capacity changes for ssDNA binding to Escherichia coli SSB protein. Proteins (2000) 1.11

Monomer-tetramer equilibrium of the Escherichia coli ssb-1 mutant single strand binding protein. J Biol Chem (1991) 1.10

Thermodynamics of single-stranded RNA binding to oligolysines containing tryptophan. Biochemistry (1992) 1.09

Thermodynamics of single-stranded RNA and DNA interactions with oligolysines containing tryptophan. Effects of base composition. Biochemistry (1993) 1.05

Thermodynamics of oligoarginines binding to RNA and DNA. Biochemistry (1997) 1.04

On the cooperative binding of large ligands to a one-dimensional homogeneous lattice: the generalized three-state lattice model. Biopolymers (1989) 1.04

Large electrostatic differences in the binding thermodynamics of a cationic peptide to oligomeric and polymeric DNA. Proc Natl Acad Sci U S A (1996) 1.02

DNA and nucleotide-induced conformational changes in the Escherichia coli Rep and helicase II (UvrD) proteins. J Biol Chem (1990) 1.01

Analysis of ion concentration effects of the kinetics of protein-nucleic acid interactions. Application to lac repressor-operator interactions. Biophys Chem (1978) 0.99

A two-site kinetic mechanism for ATP binding and hydrolysis by E. coli Rep helicase dimer bound to a single-stranded oligodeoxynucleotide. J Mol Biol (1999) 0.98

Kinetic mechanism of DNA binding and DNA-induced dimerization of the Escherichia coli Rep helicase. Biochemistry (1996) 0.97

Kinetic mechanism of adenine nucleotide binding to and hydrolysis by the Escherichia coli Rep monomer. 1. Use of fluorescent nucleotide analogues. Biochemistry (1994) 0.97

Linkage of protein assembly to protein-DNA binding. Methods Enzymol (1995) 0.97

Monomers of the Escherichia coli SSB-1 mutant protein bind single-stranded DNA. J Mol Biol (1991) 0.94

Thermodynamics of charged oligopeptide-heparin interactions. Biochemistry (1995) 0.93

Cooperative binding of polyamines induces the Escherichia coli single-strand binding protein-DNA binding mode transitions. Biochemistry (1992) 0.93

ATP hydrolysis stimulates binding and release of single stranded DNA from alternating subunits of the dimeric E. coli Rep helicase: implications for ATP-driven helicase translocation. J Mol Biol (1996) 0.92

ATPase activity of Escherichia coli Rep helicase is dramatically dependent on DNA ligation and protein oligomeric states. Biochemistry (1996) 0.91

Kinetic mechanism of adenine nucleotide binding to and hydrolysis by the Escherichia coli Rep monomer. 2. Application of a kinetic competition approach. Biochemistry (1994) 0.89

Kinetics of Escherichia coli helicase II-catalyzed unwinding of fully duplex and nicked circular DNA. Biochemistry (1993) 0.89

Heterodimer formation between Escherichia coli Rep and UvrD proteins. J Biol Chem (1993) 0.88

A two-site mechanism for ATP hydrolysis by the asymmetric Rep dimer P2S as revealed by site-specific inhibition with ADP-A1F4. Biochemistry (1997) 0.87

Model for the irreversible dissociation kinetics of cooperatively bound protein-nucleic acid complexes. Biopolymers (1983) 0.87

Helicase-catalyzed DNA unwinding: energy coupling by DNA motor proteins. Biophys J (1995) 0.85

Use of difference boundary sedimentation velocity to investigate nonspecific protein-nucleic acid interactions. Biochemistry (1980) 0.85

A mutation in E. coli SSB protein (W54S) alters intra-tetramer negative cooperativity and inter-tetramer positive cooperativity for single-stranded DNA binding. Biophys Chem (1997) 0.83

Kinetics and mechanism of dissociation of cooperatively bound T4 gene 32 protein-single-stranded nucleic acid complexes. 2. Changes in mechanism as a function of sodium chloride concentration and other solution variables. Biochemistry (1984) 0.82

Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of DNA is highly specific for duplex DNA. Biochemistry (1989) 0.81

Kinetics of the t4 gene 32 protein-single-stranded nucleic Acid interaction. Biophys J (1980) 0.79

Kinetic mechanism for the sequential binding of two single-stranded oligodeoxynucleotides to the Escherichia coli Rep helicase dimer. Biochemistry (1998) 0.78

ATPase activity of Escherichia coli Rep helicase crosslinked to single-stranded DNA: implications for ATP driven helicase translocation. Proc Natl Acad Sci U S A (1996) 0.77