The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription.

PubWeight™: 1.71‹?› | Rank: Top 3%

🔗 View Article (PMID 10559189)

Published in J Biol Chem on November 19, 1999

Authors

C Y Choi1, Y H Kim, H J Kwon, Y Kim

Author Affiliations

1: Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA.

Articles citing this

All Tcf HMG box transcription factors interact with Groucho-related co-repressors. Nucleic Acids Res (2001) 2.98

Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res (2007) 2.51

Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins. EMBO Rep (2002) 2.21

Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev (2004) 1.87

Identification and characterization of three new components of the mSin3A corepressor complex. Mol Cell Biol (2003) 1.86

Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family. EMBO J (2000) 1.79

Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery. PLoS Pathog (2009) 1.78

Integrating differentiation and cancer: the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis. Differentiation (2008) 1.55

Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split. Mol Cell Biol (2002) 1.52

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol (2004) 1.46

Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. Mol Cell Biol (2003) 1.38

Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex. Mol Cell Biol (2001) 1.37

Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J (2006) 1.37

Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol (2006) 1.36

Groucho oligomerization is required for repression in vivo. Mol Cell Biol (2004) 1.36

Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. Proc Natl Acad Sci U S A (2005) 1.35

The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. Mol Cell Biol (2001) 1.32

Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. Dev Cell (2010) 1.29

Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol (2003) 1.25

Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression. Mol Cell Biol (2002) 1.24

Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation. Blood (2010) 1.12

DNA-binding sequence of the human prostate-specific homeodomain protein NKX3.1. Nucleic Acids Res (2000) 1.11

An eh1-like motif in odd-skipped mediates recruitment of Groucho and repression in vivo. Mol Cell Biol (2005) 1.10

Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis. Mol Cell Biol (2006) 1.09

Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho. Genes Dev (2007) 1.09

Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha. PLoS One (2009) 1.08

Groucho augments the repression of multiple Even skipped target genes in establishing parasegment boundaries. Development (2001) 1.08

A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. PLoS One (2010) 1.04

Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density. PLoS One (2010) 0.99

A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes. Immunology (2002) 0.97

Mutations that affect the ability of the vnd/NK-2 homeoprotein to regulate gene expression: transgenic alterations and tertiary structure. Proc Natl Acad Sci U S A (2003) 0.96

Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells. Biochem J (2006) 0.95

The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1. Mol Cell Biol (2001) 0.94

Characterization of two functional NKX3.1 binding sites upstream of the PCAN1 gene that are involved in the positive regulation of PCAN1 gene transcription. BMC Mol Biol (2008) 0.94

The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors. Biochem J (2009) 0.92

Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors. Mol Cell Biol (2006) 0.91

The homeodomain protein Cux1 interacts with Grg4 to repress p27 kip1 expression during kidney development. Gene (2009) 0.91

AES/GRG5: more than just a dominant-negative TLE/GRG family member. Dev Dyn (2010) 0.90

Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. PLoS One (2009) 0.85

Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility. J Biol Chem (2011) 0.81

A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression. J Proteome Res (2013) 0.81

Homeodomain-interacting protein kinase 2-dependent repression of myogenic differentiation is relieved by its caspase-mediated cleavage. Nucleic Acids Res (2013) 0.81

Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation. F1000Res (2014) 0.79

US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest. J Virol (2004) 0.79

The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor. J Biol Chem (2015) 0.77

The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub. J Biol Chem (2015) 0.77

PARP1 regulates the protein stability and proapoptotic function of HIPK2. Cell Death Dis (2016) 0.76

HIPK2 modification code for cell death and survival. Mol Cell Oncol (2014) 0.76

Mechanisms of Groucho-mediated repression revealed by genome-wide analysis of Groucho binding and activity. BMC Genomics (2017) 0.75

Articles by these authors

(truncated to the top 100)

Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol (2000) 9.76

Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 Non-Small Cell Lung Cancer Study Group. J Clin Oncol (2000) 6.88

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron (2001) 4.42

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res (1999) 4.23

Similarities and differences among 105 members of the Int family of site-specific recombinases. Nucleic Acids Res (1998) 3.71

A methodology for evaluation of boundary detection algorithms on medical images. IEEE Trans Med Imaging (1997) 3.47

Influence of encapsulation on staphylococcal opsonization and phagocytosis by human polymorphonuclear leukocytes. Infect Immun (1978) 3.23

Preventing ventricular fibrillation by flattening cardiac restitution. Proc Natl Acad Sci U S A (2000) 3.15

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat Med (2001) 3.07

Transcription activation at class II CAP-dependent promoters: two interactions between CAP and RNA polymerase. Cell (1996) 2.88

The key role of peptidoglycan in the opsonization of Staphylococcus aureus. J Clin Invest (1978) 2.83

Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. Oncogene (2008) 2.83

Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy. Nat Struct Biol (1999) 2.75

Opsonic requirements for staphylococcal phagocytosis. Heterogeneity among strains. Immunology (1977) 2.73

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Res (2001) 2.66

Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma. Arch Dermatol (2001) 2.57

Cold shock induces a major ribosomal-associated protein that unwinds double-stranded RNA in Escherichia coli. Proc Natl Acad Sci U S A (1996) 2.55

A large-scale distributed network for covert spatial attention: further anatomical delineation based on stringent behavioural and cognitive controls. Brain (1999) 2.51

Partial volume tissue classification of multichannel magnetic resonance images-a mixel model. IEEE Trans Med Imaging (1991) 2.50

Hunger selectively modulates corticolimbic activation to food stimuli in humans. Behav Neurosci (2001) 2.49

Reduced osmolarity oral rehydration solution for treating dehydration due to diarrhoea in children: systematic review. BMJ (2001) 2.39

Neoantigen of the polymerized ninth component of complement. Characterization of a monoclonal antibody and immunohistochemical localization in renal disease. J Clin Invest (1983) 2.39

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37

Failure to rescue as a source of variation in hospital mortality after hepatic surgery. Br J Surg (2014) 2.34

Evaluation of the medical diagnostic imaging support system based on 2 years of clinical experience. J Digit Imaging (1995) 2.29

Maternal outcomes of a randomized controlled trial of a community-based support program for families of children with chronic illnesses. Arch Pediatr Adolesc Med (2001) 2.28

Restricted deposition of C3 on M+ group A streptococci: correlation with resistance to phagocytosis. J Immunol (1982) 2.27

Structural organization of the RNA polymerase-promoter open complex. Cell (2000) 2.25

Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma. J Clin Oncol (2001) 2.24

Molecular cloning and sequence of cDNA encoding the pyrophosphate-energized vacuolar membrane proton pump of Arabidopsis thaliana. Proc Natl Acad Sci U S A (1992) 2.15

Quality control of cathode-ray tube monitors for medical imaging using a simple photometer. J Digit Imaging (1995) 2.14

Prevalence of diabetes and IGT in Yonchon County, South Korea. Diabetes Care (1995) 2.11

Enzymatic completion of mammalian lagging-strand DNA replication. Proc Natl Acad Sci U S A (1994) 2.11

Barriers to the use of a personal health record by an elderly population. AMIA Annu Symp Proc (2006) 2.10

Increased incidence of herpes zoster in the setting of cytomegalovirus preemptive therapy after kidney transplantation. Transpl Infect Dis (2013) 2.09

Localization of the third component of complement on the cell wall of encapsulated Staphylococcus aureus M: implications for the mechanism of resistance to phagocytosis. Infect Immun (1979) 2.07

The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines. J Virol (1997) 2.06

Activation of complement by cell surface components of Staphylococcus aureus. Infect Immun (1978) 2.03

Opsonization of encapsulated Staphylococcus aureus: the role of specific antibody and complement. J Immunol (1982) 2.02

Impaired intracellular trafficking of adeno-associated virus type 2 vectors limits efficient transduction of murine fibroblasts. J Virol (2000) 2.01

Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1. J Biol Chem (2001) 1.99

Inhibition of alternative complement pathway opsonization by group A streptococcal M protein. J Infect Dis (1979) 1.97

TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family. J Biol Chem (2000) 1.97

Activation of NF-kappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells. Proc Natl Acad Sci U S A (1998) 1.96

Incidence and prevalence of epilepsy among older U.S. Medicare beneficiaries. Neurology (2012) 1.92

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem (1998) 1.90

Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H. Cancer Res (1993) 1.90

Nanoscale mapping of ion diffusion in a lithium-ion battery cathode. Nat Nanotechnol (2010) 1.88

An outbreak of typhoid fever, Xing-An County, People's Republic of China, 1999: estimation of the field effectiveness of Vi polysaccharide typhoid vaccine. J Infect Dis (2001) 1.86

Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. J Biol Chem (2001) 1.86

Autonomic activity during human sleep as a function of time and sleep stage. J Sleep Res (2001) 1.83

Human T-cell lymphotropic virus type III: immunologic characterization and primary structure analysis of the major internal protein, p24. J Virol (1985) 1.82

Potentiation of opsonization and phagocytosis of Streptococcus pyogenes following growth in the presence of clindamycin. J Clin Invest (1981) 1.82

Orientations of amphipathic helical peptides in membrane bilayers determined by solid-state NMR spectroscopy. J Biomol NMR (1991) 1.82

Determinants of Staphylococcus aureus nasal carriage. Clin Diagn Lab Immunol (2001) 1.80

Analysis of errors in medical rapid prototyping models. Int J Oral Maxillofac Surg (2002) 1.76

Concern Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea, May to June 2015. Euro Surveill (2015) 1.75

Activity of respiratory pump and upper airway muscles during sleep onset. J Appl Physiol (1985) (1998) 1.74

Long-term randomized controlled trial of a novel nanopowder hemostatic agent (TC-325) for control of severe arterial upper gastrointestinal bleeding in a porcine model. Endoscopy (2011) 1.73

Relation between cellular repolarization characteristics and critical mass for human ventricular fibrillation. J Cardiovasc Electrophysiol (1999) 1.69

What is satisfying about satisfying events? Testing 10 candidate psychological needs. J Pers Soc Psychol (2001) 1.68

Site-directed mutagenesis of ricin A-chain and implications for the mechanism of action. Proteins (1991) 1.68

Spatiotemporal heterogeneity in the induction of ventricular fibrillation by rapid pacing: importance of cardiac restitution properties. Circ Res (1999) 1.67

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67

Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature (1997) 1.66

Vacuolar H(+)-translocating pyrophosphatases: a new category of ion translocase. Trends Biochem Sci (1992) 1.65

Expression profile of histone deacetylase 1 in gastric cancer tissues. Jpn J Cancer Res (2001) 1.63

Kinetic mechanism of the histone acetyltransferase GCN5 from yeast. J Biol Chem (2000) 1.62

Strongyloides stercoralis hyperinfection in a patient with the acquired immune deficiency syndrome. Am J Med (1987) 1.61

Life history and cost analysis for continuous rearing of Podisus maculiventris (Say) (Heteroptera: Pentatomidae) on a zoophytophagous artificial diet. J Econ Entomol (2002) 1.61

A prospective longitudinal study evaluating the usefulness of a T-cell-based assay for latent tuberculosis infection in kidney transplant recipients. Am J Transplant (2011) 1.60

fd coat protein structure in membrane environments. J Mol Biol (1993) 1.59

CT differentiation of tuberculous peritonitis and peritoneal carcinomatosis. AJR Am J Roentgenol (1996) 1.59

Distribution and regulation of telencephalic aromatase expression in the zebra finch revealed with a specific antibody. J Comp Neurol (2000) 1.57

Dichotomy between opsonization and serum complement activation by encapsulated staphylococci. Infect Immun (1978) 1.56

Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56

Omental torsion: CT features. Abdom Imaging (2004) 1.55

IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death. J Immunol (2001) 1.55

Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol (1999) 1.55

Trichostatin A attenuates airway inflammation in mouse asthma model. Clin Exp Allergy (2005) 1.53

An adaptive hypothesis for the evolution of the Y chromosome. Genetics (1998) 1.52

Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis. J Biol Chem (2000) 1.52

The influence of egg consumption on the serum cholesterol level in human subjects. Am J Clin Nutr (1977) 1.51

Impregnation of vancomycin, gentamicin, and cefotaxime in a cement spacer for two-stage cementless reconstruction in infected total hip arthroplasty. J Arthroplasty (2001) 1.51

Prevalence of lower urinary tract symptoms in Korean men in a community-based study. Eur Urol (1998) 1.51

Treatment of intertrochanteric fracture with the Gamma AP locking nail or by a compression hip screw--a randomised prospective trial. Int Orthop (1998) 1.50

Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus. Int J Immunopharmacol (1996) 1.50

Differential expression of senescence-associated mRNAs during leaf senescence induced by different senescence-inducing factors in Arabidopsis. Plant Mol Biol (1998) 1.49

Phacoemulsification with a bevel-down phaco tip: phaco-drill. J Cataract Refract Surg (1997) 1.49

Female sexual dysfunction associated with antidepressant administration: a randomized, placebo-controlled study of pharmacologic intervention. Am J Psychiatry (2000) 1.49

Cerebral microbleeds are regionally associated with intracerebral hemorrhage. Neurology (2004) 1.46

Inherited deficiency of the second component of complement (C2) with membranoproliferative glomerulonephritis. Am J Med (1977) 1.46

Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1. Proc Natl Acad Sci U S A (1999) 1.45

Relation between ligament of Marshall and adrenergic atrial tachyarrhythmia. Circulation (1999) 1.45

Structural and functional diversity of lysyl oxidase and the LOX-like proteins. Biochim Biophys Acta (2003) 1.45

Human basophils express CD22 without expression of CD19. Cytometry (1999) 1.44

Opsonization of four Bacteroides species: role of the classical complement pathway and immunoglobulin. Infect Immun (1980) 1.44

Trichloroethylene degradation by two independent aromatic-degrading pathways in Alcaligenes eutrophus JMP134. Appl Environ Microbiol (1990) 1.44

Structure and evolution of four POU domain genes expressed in mouse brain. Proc Natl Acad Sci U S A (1992) 1.43

Identification of deoxynivalenol- and nivalenol-producing chemotypes of Gibberella zeae by using PCR. Appl Environ Microbiol (2001) 1.43