Published in J Exp Med on December 06, 1999
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc Natl Acad Sci U S A (2000) 7.39
Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes. Arthritis Rheum (2013) 1.70
Epigenetic alterations in human prostate cancers. Endocrinology (2009) 1.55
Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin. Proc Natl Acad Sci U S A (2013) 1.43
Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation. PLoS One (2013) 1.41
Epigenetic control in rheumatoid arthritis synovial fibroblasts. Nat Rev Rheumatol (2009) 1.32
Epigenetic reprogramming of host genes in viral and microbial pathogenesis. Trends Microbiol (2010) 1.32
Eradication of Helicobacter pylori infection reverses E-cadherin promoter hypermethylation. Gut (2006) 1.26
Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? Proteomics (2007) 1.21
Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int J Cancer (2010) 1.18
Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation. Neoplasia (2007) 1.15
Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans. Gastroenterology (2010) 1.13
E-cadherin in gastric cancer. World J Gastroenterol (2006) 1.11
Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype. Lab Invest (2009) 1.10
SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients. Lab Invest (2008) 1.05
How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology. Soc Sci Med (2011) 1.05
Interplay between DNA repair and inflammation, and the link to cancer. Crit Rev Biochem Mol Biol (2014) 0.96
Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action. Steroids (2010) 0.92
Modulation of learning and memory by cytokines: signaling mechanisms and long term consequences. Neurobiol Learn Mem (2014) 0.91
Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil. World J Gastroenterol (2007) 0.90
Gene methylation in non-neoplastic mucosa of gastric cancer: age or Helicobacter pylori related? Am J Pathol (2003) 0.89
Epigenetics and periodontal disease: future perspectives. Inflamm Res (2009) 0.89
Pathways to acute humoral rejection. Am J Pathol (2004) 0.87
Chronic inflammation and the development of malignancy in the GI tract. Trends Immunol (2015) 0.87
CpG island hypermethylation in gastric carcinoma and its premalignant lesions. Korean J Pathol (2012) 0.87
Association between Helicobacter pylori infection and interleukin 1beta polymorphism predispose to CpG island methylation in gastric cancer. Gut (2007) 0.87
The diet as a cause of human prostate cancer. Cancer Treat Res (2014) 0.86
Epigenetic regulation of beta2-adrenergic receptor expression in T(H)1 and T(H)2 cells. Brain Behav Immun (2010) 0.84
Helicobacter pylori infection in relation to E-cadherin gene promoter polymorphism and hypermethylation in sporadic gastric carcinomas. World J Gastroenterol (2005) 0.83
Epigenetic biomarkers: a step forward for understanding periodontitis. J Periodontal Implant Sci (2013) 0.82
Genome-wide DNA methylation profiles altered by Helicobacter pylori in gastric mucosa and blood leukocyte DNA. Oncotarget (2016) 0.81
Influence of IL1B polymorphism on CpG island hypermethylation in Helicobacter pylori-infected gastric cancer. Virchows Arch (2010) 0.79
Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment. Cell Death Dis (2013) 0.78
Epigenetic impact of infection on carcinogenesis: mechanisms and applications. Genome Med (2016) 0.78
Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer. Clin Transl Gastroenterol (2015) 0.77
The implications of hyponitroxia in cancer. Transl Oncol (2014) 0.76
Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes. Clin Exp Metastasis (2000) 0.76
Interleukin-1β increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model. Oncol Lett (2016) 0.75
Transcript Isoform Variation Associated with Cytosine Modification in Human Lymphoblastoid Cell Lines. Genetics (2016) 0.75
Inflammasomes in Inflammation-Induced Cancer. Front Immunol (2017) 0.75
Gastric cancer development after the successful eradication of Helicobacter pylori. World J Gastrointest Oncol (2016) 0.75
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell (1992) 27.80
CpG-rich islands and the function of DNA methylation. Nature (1986) 24.90
The L-arginine-nitric oxide pathway. N Engl J Med (1993) 14.38
Nitric oxide as a secretory product of mammalian cells. FASEB J (1992) 13.38
Role for DNA methylation in genomic imprinting. Nature (1993) 12.65
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med (1995) 9.10
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet (1998) 7.52
TRAF6 is a signal transducer for interleukin-1. Nature (1996) 7.38
Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome. Science (1991) 7.16
The essentials of DNA methylation. Cell (1992) 6.72
Sp1 elements protect a CpG island from de novo methylation. Nature (1994) 5.60
IRAK: a kinase associated with the interleukin-1 receptor. Science (1996) 5.32
Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem (1994) 5.11
Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science (1993) 4.80
Direct diagnosis by DNA analysis of the fragile X syndrome of mental retardation. N Engl J Med (1991) 4.61
CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J (1998) 4.61
DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science (1991) 4.59
DNA methylation and gene expression. Microbiol Rev (1991) 4.44
Suppression of intestinal neoplasia by DNA hypomethylation. Cell (1995) 4.16
Effects of DNA methylation on DNA-binding proteins and gene expression. Curr Opin Genet Dev (1993) 3.64
DNA hypomethylation leads to elevated mutation rates. Nature (1998) 3.60
Trinucleotide repeat amplification and hypermethylation of a CpG island in FRAXE mental retardation. Cell (1993) 3.28
Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell (1997) 3.17
Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. EMBO J (1992) 3.06
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell (1996) 3.00
Role of DNA methylation in the regulation of transcription. Curr Opin Genet Dev (1994) 2.61
Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells. Nat Genet (1999) 2.59
A role for nuclear NF-kappaB in B-cell-specific demethylation of the Igkappa locus. Nat Genet (1996) 2.16
Studies on the mechanism of the antifungal action of benzoate. Biochem J (1983) 1.97
Regulation by hypoxia of methionine adenosyltransferase activity and gene expression in rat hepatocytes. Gastroenterology (1998) 1.96
Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science (1999) 1.83
An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA. EMBO J (1998) 1.74
Epigenetic variation illustrated by DNA methylation patterns of the fragile-X gene FMR1. Hum Mol Genet (1997) 1.70
DNA methylation is a reversible biological signal. Proc Natl Acad Sci U S A (1999) 1.69
High functioning fragile X males: demonstration of an unmethylated fully expanded FMR-1 mutation associated with protein expression. Am J Med Genet (1994) 1.68
In vitro reactivation of the FMR1 gene involved in fragile X syndrome. Hum Mol Genet (1998) 1.34
Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway. J Biol Chem (1995) 1.21
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide. Proc Natl Acad Sci U S A (1997) 1.19
The mouse DNA methyltransferase 5'-region. A unique housekeeping gene promoter. J Biol Chem (1992) 1.15
Microassay for DNA methyltransferase. J Biochem Biophys Methods (1991) 1.01
Peptide mapping of the murine DNA methyltransferase reveals a major phosphorylation site and the start of translation. J Biol Chem (1997) 1.00
Characterization of FMR1 promoter elements by in vivo-footprinting analysis. Am J Hum Genet (1997) 0.95
Adenosine: a mediator of interleukin-1beta-induced hippocampal synaptic inhibition. J Neurosci (1999) 0.95
Assessment of FMR1 expression by reverse transcriptase-polymerase chain reaction of KH domains. J Lab Clin Med (1998) 0.95
Molecular analysis and test of linkage between the FMR-1 gene and infantile autism in multiplex families. Am J Hum Genet (1994) 0.94
5-Azadeoxycytidine-induced chromatin remodeling of the inactive X-linked HPRT gene promoter occurs prior to transcription factor binding and gene reactivation. J Biol Chem (1997) 0.91
Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase. Endocrinology (1993) 0.86
Nitric oxide as a carcinogen: analysis by yeast functional assay of inactivating p53 mutations induced by nitric oxide. Mutat Res (1997) 0.83
Regulation of fructose 2,6-bisphosphate levels in cold-acclimated brown adipose tissue of rat. FEBS Lett (1988) 0.78
Interleukin 1beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells. Cytokine (1999) 0.77
Instability of the CGG repeat at the FRAXA locus and variable phenotypic expression in a large fragile X pedigree. J Med Genet (1995) 0.77
Nucleotide-selective cleavage of duplex DNA by nitric oxide. Biochem Biophys Res Commun (1995) 0.77
The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance--a review. Gene (1985) 3.42
Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture. Virology (1983) 3.04
Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma. J Virol (1994) 2.41
Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies. J Virol (1991) 1.89
Establishment of cell lines persistently infected with foot-and-mouth disease virus. Virology (1985) 1.84
Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades. J Virol (1992) 1.72
Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus. Proc Natl Acad Sci U S A (1989) 1.71
Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. J Biol Chem (1999) 1.59
A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C. J Gen Virol (1990) 1.57
Fixation of mutations in the viral genome during an outbreak of foot-and-mouth disease: heterogeneity and rate variations. Gene (1986) 1.53
Difference in glucose sensitivity of liver glycolysis and glycogen synthesis. Relationship between lactate production and fructose 2,6-bisphosphate concentration. Biochem J (1984) 1.49
A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants. J Virol (1997) 1.36
A single amino acid substitution in nonstructural protein 3A can mediate adaptation of foot-and-mouth disease virus to the guinea pig. J Virol (2001) 1.29
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat. J Biol Chem (1986) 1.23
Design of primers for PCR amplification of highly variable genomes. Comput Appl Biosci (1993) 1.16
Genetic and immunogenic variations among closely related isolates of foot-and-mouth disease virus. Gene (1988) 1.12
VPg gene amplification correlates with infective particle formation in foot-and-mouth disease virus. J Virol (1992) 1.10
Identification of neutralizing antigenic sites on VP1 and VP2 of type A5 foot-and-mouth disease virus, defined by neutralization-resistant variants. J Virol (1991) 1.07
Gene encoding capsid protein VP1 of foot-and-mouth disease virus: a quasispecies model of molecular evolution. Proc Natl Acad Sci U S A (1988) 1.05
Rapid kinetics of agonist-evoked changes in cytosolic free Ca2+ concentration in fura-2-loaded human neutrophils. Biochem J (1990) 1.02
Recombinant viruses expressing the foot-and-mouth disease virus capsid precursor polypeptide (P1) induce cellular but not humoral antiviral immunity and partial protection in pigs. Virology (1999) 1.02
Deletion or substitution of the aphthovirus 3' NCR abrogates infectivity and virus replication. J Gen Virol (2001) 1.01
Infection with foot-and-mouth disease virus results in a rapid reduction of MHC class I surface expression. J Gen Virol (1998) 1.00
Genetic and phenotypic variability during replication of foot-and-mouth disease virus in swine. Virology (1990) 0.96
In vivo analysis of the stability and fitness of variants recovered from foot-and-mouth disease virus quasispecies. J Gen Virol (1998) 0.96
Immunogenicity of non-structural proteins of foot-and-mouth disease virus: differences between infected and vaccinated swine. Arch Virol (1994) 0.95
Assessment of FMR1 expression by reverse transcriptase-polymerase chain reaction of KH domains. J Lab Clin Med (1998) 0.95
Primer design for specific diagnosis by PCR of highly variable RNA viruses: typing of foot-and-mouth disease virus. Virology (1992) 0.95
Comparison of vaccine strains and the virus causing the 1986 foot-and-mouth disease outbreak in Spain: epizootiological analysis. Virus Res (1990) 0.95
Identification of T-cell epitopes in nonstructural proteins of foot-and-mouth disease virus. J Virol (2001) 0.95
Heterotypic lymphoproliferative response in pigs vaccinated with foot-and-mouth disease virus. Involvement of isolated capsid proteins. J Gen Virol (1992) 0.94
Molecular analysis and test of linkage between the FMR-1 gene and infantile autism in multiplex families. Am J Hum Genet (1994) 0.94
The glucokinase glucose sensor in human pancreatic islet tissue. Diabetes (1986) 0.93
Association of bovine DRB3 alleles with immune response to FMDV peptides and protection against viral challenge. Vaccine (2000) 0.91
Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic beta-cells: induction of argininosuccinate synthetase by cytokines. Endocrinology (1995) 0.90
Radiometric oil well assay for glucokinase in microscopic structures. Anal Biochem (1985) 0.90
Cyclosporin A inhibits phorbol ester-induced activation of superoxide production in resident mouse peritoneal macrophages. Biochem J (1989) 0.90
Antigenic comparison of different foot-and-mouth disease virus types using monoclonal antibodies defining multiple neutralizing epitopes on FMDV A5 subtypes. Virus Res (1989) 0.90
A method for determining the position and size of optimal sequence regions for phylogenetic analysis. J Mol Evol (1995) 0.89
p53 transactivation of the HIV-1 long terminal repeat is blocked by PD 144795, a calcineurin-inhibitor with anti-HIV properties. J Biol Chem (1998) 0.89
A RT-PCR assay for the differential diagnosis of vesicular viral diseases of swine. J Virol Methods (1998) 0.89
Interspecies major histocompatibility complex-restricted Th cell epitope on foot-and-mouth disease virus capsid protein VP4. J Virol (2000) 0.88
NO induces a cGMP-independent release of cytochrome c from mitochondria which precedes caspase 3 activation in insulin producing RINm5F cells. FEBS Lett (1999) 0.88
Nitric oxide repression of Nanog promotes mouse embryonic stem cell differentiation. Cell Death Differ (2010) 0.88
Hormonal regulation of fructose 2,6-bisphosphate levels in epididymal adipose tissue of rat. FEBS Lett (1985) 0.87
Calcium release induced by inositol 1,4,5-trisphosphate in thymocyte microsomes. Inhibition by barium and strontium. Cell Calcium (1989) 0.87
Glucokinase in B-cell-depleted islets of Langerhans. J Histochem Cytochem (1987) 0.87
Evidence of partial protection against foot-and-mouth disease in cattle immunized with a recombinant adenovirus vector expressing the precursor polypeptide (P1) of foot-and-mouth disease virus capsid proteins. J Gen Virol (1999) 0.87
Low concentrations of nitric oxide delay the differentiation of embryonic stem cells and promote their survival. Cell Death Dis (2010) 0.87
A porcine CD8+ T cell clone with heterotypic specificity for foot-and-mouth disease virus. J Gen Virol (1996) 0.86
Fixation of mutations at the VP1 gene of foot-and-mouth disease virus. Can quasispecies define a transient molecular clock? Gene (1991) 0.86
Antigenic specificity of porcine T cell response against foot-and-mouth disease virus structural proteins: identification of T helper epitopes in VP1. Virology (1994) 0.86
Elevated secretion of myeloperoxidase by neutrophils from asthmatic patients: the effect of immunotherapy. J Allergy Clin Immunol (2001) 0.85
Specific inhibition of aphthovirus infection by RNAs transcribed from both the 5' and the 3' noncoding regions. J Virol (1994) 0.85
Transient inhibition of foot-and-mouth disease virus infection of BHK-21 cells by antisense oligonucleotides directed against the second functional initiator AUG. Antiviral Res (1993) 0.85
A computer program for the design of PCR primers for diagnosis of highly variable genomes. J Virol Methods (1993) 0.84
Evidence for involvement of c-Src in the anti-apoptotic action of nitric oxide in serum-deprived RINm5F cells. Cell Signal (2001) 0.83
Molecular epidemiology of foot-and-mouth disease virus type O. J Gen Virol (1993) 0.83
Estimates by computer simulation of genetic distances from comparisons of RNAse A mismatch cleavage patterns. J Virol Methods (1993) 0.83
Modulation of the inhibition of respiratory burst in mouse macrophages by cyclosporin A: effect of in vivo treatment, glucocorticoids and the state of activation of cells. Immunology (1991) 0.83
Stable expression of antisense RNAs targeted to the 5' non-coding region confers heterotypic inhibition to foot-and-mouth disease virus infection. J Gen Virol (2003) 0.82
Heterotypic inhibition of foot-and-mouth disease virus infection by combinations of RNA transcripts corresponding to the 5' and 3' regions. Antiviral Res (1999) 0.82
Characterization of calcineurin in human neutrophils. Inhibitory effect of hydrogen peroxide on its enzyme activity and on NF-kappaB DNA binding. J Biol Chem (1999) 0.82
Sodium nitroprusside-induced mitochondrial apoptotic events in insulin-secreting RINm5F cells are associated with MAP kinases activation. Exp Cell Res (2001) 0.82
Stimulation of glycolysis as an activation signal in rat peritoneal macrophages. Effect of glucocorticoids on this process. Biochem J (1992) 0.82
Effect of 2-bromostearate on glucose-phosphorylating activities and the dynamics of insulin secretion in islets of Langerhans during fasting. Diabetes (1984) 0.82
Modulation of phorbol ester-induced respiratory burst by vanadate, genistein, and phenylarsine oxide in mouse macrophages. Free Radic Biol Med (1995) 0.82
Glucocorticoids inhibit fructose 2,6-bisphosphate synthesis in rat thymocytes. Opposite effect of cycloheximide. Biochim Biophys Acta (1991) 0.82
IgE-dependent release of myeloperoxidase by neutrophils from allergic patients. Clin Exp Allergy (2001) 0.81
The effect of experimental hypothyroidism on phosphofructokinase activity and fructose 2,6-bisphosphate concentrations in rat heart. Biochem J (1987) 0.81
Age-related changes in membrane lipid composition, fluidity and respiratory burst in rat peritoneal neutrophils. Clin Exp Immunol (2001) 0.81
The inactivation of phosphorylase and activation of glycogen synthase in the adipose tissue. Eur J Biochem (1980) 0.81
An RT-PCR assay for the specific detection of classical swine fever virus in clinical samples. Vet Res (1998) 0.80
Cell therapy for diabetes mellitus: an opportunity for stem cells? Cells Tissues Organs (2008) 0.80
Direct PCR detection of foot-and-mouth disease virus. J Virol Methods (1994) 0.80
Inhibitory effect of cyclosporin A and FK506 on nitric oxide production by cultured macrophages. Evidence of a direct effect on nitric oxide synthase activity. Immunology (1995) 0.80
Control of fructose 2,6-bisphosphate levels in rat macrophages by glucose and phorbol ester. FEBS Lett (1989) 0.80
Effect of prolonged fasting upon insulin and glucagon secretion from isolated rat pancreatic islets. Rev Esp Fisiol (1978) 0.79
Thimerosal induces calcium mobilization, fructose 2,6-bisphosphate synthesis and cytoplasmic alkalinization in rat thymus lymphocytes. Biochim Biophys Acta (1991) 0.79
Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain. Vaccine (1992) 0.79
Decrease in free-radical production with age in rat peritoneal macrophages. Biochem J (1995) 0.79
Short-term effects of cyclosporine on secretagogue-induced insulin release by isolated islets. Transplantation (1990) 0.79
A procedure for detecting selection in highly variable viral genomes: evidence of positive selection in antigenic regions of capsid protein VP1 of foot-and-mouth disease virus. J Virol Methods (1998) 0.79
Nicotinamide inhibits inducible nitric oxide synthase enzyme activity in macrophages by allowing nitric oxide to inhibit its own formation. Life Sci (1997) 0.79
Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment. Cell Death Dis (2013) 0.78
Activation of peritoneal macrophages during the prediabetic phase in low-dose streptozotocin-treated mice. FEBS Lett (1993) 0.78
Myeloperoxidase release after allergen-specific conjunctival challenge. J Asthma (2004) 0.78
Nitric oxide and superoxide anion production decrease with age in resident and activated rat peritoneal macrophages. Cell Immunol (1996) 0.78
Enhancement of Antigen-specific functional responses by neutrophils from allergic patients. J Exp Med (1996) 0.78
Gene expression profiles in the cerebellum of transgenic mice over expressing the human FMR1 gene with CGG repeats in the normal range. Genet Mol Res (2012) 0.78
Histamine release by pharmacological agents in the absence of external free Ca2+. FEBS Lett (1984) 0.78