IRAK: a kinase associated with the interleukin-1 receptor.

A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci U S A (1998) 8.40

Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases. Proc Natl Acad Sci U S A (2001) 7.01

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med (2003) 5.97

Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene (2008) 4.21

Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med (1998) 4.17

Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology (2004) 4.09

The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J (2000) 3.83

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med (1998) 3.70

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc Natl Acad Sci U S A (2000) 3.69

Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci U S A (1997) 3.68

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A (2002) 3.60

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev (1999) 3.41

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med (2003) 3.24

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol (2010) 3.15

Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. J Exp Med (2000) 3.14

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc Natl Acad Sci U S A (1998) 3.04

Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells. J Immunol (2008) 2.95

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81

Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase. Mol Cell Biol (1999) 2.77

Cytokines in asthma. Thorax (1999) 2.64

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J (2000) 2.48

Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol (2002) 2.47

Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol Cell Biol (2001) 2.36

Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. Mol Cell Biol (2008) 2.32

IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. Proc Natl Acad Sci U S A (2007) 2.27

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev (1999) 2.17

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A (2006) 2.13

Molecular basis of NF-κB signaling. Annu Rev Biophys (2013) 2.03

A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J Exp Med (2007) 2.03

Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. Am J Physiol Heart Circ Physiol (2008) 1.95

Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol Cell Biol (2001) 1.93

Plant and animal pathogen recognition receptors signal through non-RD kinases. PLoS Pathog (2006) 1.87

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J (2008) 1.87

Toll-like receptor signaling in cell proliferation and survival. Cytokine (2009) 1.79

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production. J Exp Med (1998) 1.75

Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc Natl Acad Sci U S A (1997) 1.67

Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry (2009) 1.64

TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling. Mol Cell Biol (2003) 1.61

Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity. Mol Cell Biol (1999) 1.57

Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer. Neoplasia (2011) 1.56

Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol (2002) 1.53

Toll receptors: a central element in innate immune responses. Infect Immun (2002) 1.53

CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion. J Cell Biol (2006) 1.49

Molecular determinants of NF-kappaB-inducing kinase action. Mol Cell Biol (1998) 1.49

Drosophila MyD88 is an adapter in the Toll signaling pathway. Proc Natl Acad Sci U S A (2001) 1.47

Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production. J Exp Med (1999) 1.45

A heterotrimeric death domain complex in Toll signaling. Proc Natl Acad Sci U S A (2002) 1.35

Interleukin-1 inhibits hepatitis C virus subgenomic RNA replication by activation of extracellular regulated kinase pathway. J Virol (2003) 1.31

The involvement of microRNAs in neurodegenerative diseases. Front Cell Neurosci (2013) 1.30

The IL-1 receptor and Rho directly associate to drive cell activation in inflammation. J Clin Invest (1999) 1.30

Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice. J Exp Med (1999) 1.30

Identifying components of the NF-kappaB pathway in the beneficial Euprymna scolopes-Vibrio fischeri light organ symbiosis. Appl Environ Microbiol (2005) 1.30

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A (2006) 1.25

Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance. J Biol Chem (2007) 1.24

A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets. J Exp Med (1999) 1.22

Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. J Exp Med (2001) 1.21

Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily. Sci Signal (2012) 1.20

Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases. J Biol Chem (2009) 1.17

Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. Mol Cell Biol (2003) 1.17

Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. J Immunol (2009) 1.16

Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB. Biochem J (1999) 1.14

Tube Is an IRAK-4 homolog in a Toll pathway adapted for development and immunity. J Innate Immun (2009) 1.14

Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients. Mol Psychiatry (2009) 1.14

Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity. Nat Immunol (2011) 1.14

IRAK-4 inhibitors for inflammation. Curr Top Med Chem (2009) 1.13

T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A (2000) 1.11

Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. J Biol Chem (2006) 1.11

Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation. J Biol Chem (2008) 1.10

Retracted Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. J Exp Med (2008) 1.09

Alcohol-induced interactive phosphorylation of Src and toll-like receptor regulates the secretion of inflammatory mediators by human astrocytes. J Neuroimmune Pharmacol (2010) 1.09

NF-κB and cancer: a paradigm of Yin-Yang. Am J Cancer Res (2010) 1.08

Oral inflammatory diseases and systemic inflammation: role of the macrophage. Front Immunol (2012) 1.07

The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation. Cytokine (2008) 1.07

IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production. EMBO J (2013) 1.06

CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells. Mol Cell Biol (2005) 1.06

Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. Genes Dev (1999) 1.05

Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1. Mol Cell Biol (2001) 1.05

MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling. Mol Cell Biol (2001) 1.05

Caveolin-1 deficiency dampens Toll-like receptor 4 signaling through eNOS activation. Am J Pathol (2010) 1.04

A role for CKII phosphorylation of the cactus PEST domain in dorsoventral patterning of the Drosophila embryo. Genes Dev (1997) 1.03

Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin 1. J Exp Med (1996) 1.03

The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation. J Biol Chem (2008) 1.02

Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation. Proc Natl Acad Sci U S A (2001) 1.00

Neuron-specific effects of interleukin-1β are mediated by a novel isoform of the IL-1 receptor accessory protein. J Neurosci (2011) 1.00

Heterotrimeric G protein signaling outside the realm of seven transmembrane domain receptors. Mol Pharmacol (2010) 0.99

Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPase. Mol Cell Biol (2001) 0.99

Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6. Cell Signal (2009) 0.99

Taurodeoxycholate stimulates intestinal cell proliferation and protects against apoptotic cell death through activation of NF-kappaB. Dig Dis Sci (2004) 0.97

Butyrate modulates intestinal epithelial cell-mediated neutrophil migration. Clin Exp Immunol (2003) 0.96

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use. Sci Signal (2016) 0.95

UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination. Cell Res (2013) 0.95

A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice. J Exp Med (2009) 0.93

Use of forward genetics to discover novel regulators of NF-kappaB. Cold Spring Harb Perspect Biol (2009) 0.93

The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT. Mol Immunol (2008) 0.92

Differential IRAK signaling in hematologic malignancies. Exp Hematol (2013) 0.92

Genomics of the NF-κB signaling pathway: hypothesized role in ovarian cancer. Cancer Causes Control (2011) 0.91

Augmentation of therapeutic responses in melanoma by inhibition of IRAK-1,-4. Cancer Res (2012) 0.90

Toll-like receptors in multiple sclerosis. Curr Top Microbiol Immunol (2009) 0.90

Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha. J Biol Chem (2011) 0.90

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell (1997) 12.83

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A (1998) 9.32

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet (2000) 8.58

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell (1992) 8.10

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science (1997) 7.57

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun (1989) 7.39

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell (1995) 7.18

Identification and characterization of an IkappaB kinase. Cell (1997) 6.71

A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast. Nature (1989) 6.48

Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat Biotechnol (2001) 6.30

Human tumor necrosis factor. Production, purification, and characterization. J Biol Chem (1985) 6.28

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell (1994) 5.94

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. Nature (1985) 5.41

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity (1997) 5.23

A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver. Proc Natl Acad Sci U S A (2001) 4.73

An interleukin-4-induced transcription factor: IL-4 Stat. Science (1994) 4.71

Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet (1999) 4.55

Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature (1988) 4.40

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Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nat Med (1995) 3.61

HLA and AIDS: a cautionary tale. Trends Mol Med (2001) 3.51

IKAP is a scaffold protein of the IkappaB kinase complex. Nature (1998) 3.28

An endothelial ligand for L-selectin is a novel mucin-like molecule. Cell (1992) 3.17

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature (1994) 3.13

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Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J (2000) 2.48

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem (1999) 2.43

Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development (2001) 2.37

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Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc Natl Acad Sci U S A (1997) 1.67

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