PubRank

J Heitman

Author PubWeight™ 174.35‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Nuclear protein localization. Biochim Biophys Acta 1991 6.43
2 The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev 1999 5.80
3 Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev 2000 5.49
4 A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature 2001 4.33
5 Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes Dev 1997 4.28
6 Gene disruption with PCR products in Saccharomyces cerevisiae. Gene 1995 4.06
7 Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J 1997 3.67
8 Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. EMBO J 1997 3.41
9 Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Mol Cell Biol 1999 3.22
10 Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. Mol Cell Biol 2001 3.11
11 The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. EMBO J 1998 3.09
12 Site-specific methylases induce the SOS DNA repair response in Escherichia coli. J Bacteriol 1987 2.94
13 Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway. Mol Cell Biol 1998 2.91
14 The TOR kinases link nutrient sensing to cell growth. J Biol Chem 2001 2.67
15 Serotype AD strains of Cryptococcus neoformans are diploid or aneuploid and are heterozygous at the mating-type locus. Infect Immun 2001 2.39
16 TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. J Biol Chem 1995 2.39
17 The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics 2000 2.35
18 RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans. Mol Microbiol 2000 2.30
19 Characterization of alcohol-induced filamentous growth in Saccharomyces cerevisiae. Mol Biol Cell 2000 2.27
20 Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains. Genetics 1998 2.21
21 All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 1997 2.14
22 Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans. Fungal Genet Biol 2000 2.06
23 Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. EMBO J 1994 2.06
24 Conserved cAMP signaling cascades regulate fungal development and virulence. FEMS Microbiol Rev 2001 2.04
25 The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans. Mol Cell Biol 2000 2.03
26 Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct. Proc Natl Acad Sci U S A 2000 1.96
27 FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. EMBO J 1995 1.94
28 The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. EMBO J 2000 1.88
29 Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. Mol Microbiol 2001 1.87
30 Calcineurin. Structure, function, and inhibition. Cell Biochem Biophys 1999 1.82
31 Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. EMBO J 2000 1.76
32 TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals. Mol Cell Endocrinol 1999 1.76
33 Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. MBio 2011 1.76
34 The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. Genetics 1999 1.75
35 Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. Proc Natl Acad Sci U S A 1994 1.72
36 Diploid strains of the pathogenic basidiomycete Cryptococcus neoformans are thermally dimorphic. Fungal Genet Biol 2000 1.69
37 Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Antimicrob Agents Chemother 2000 1.66
38 Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol Cell Biol 1999 1.64
39 Protection from nitrosative stress by yeast flavohemoglobin. Proc Natl Acad Sci U S A 2000 1.60
40 Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. Curr Opin Microbiol 2000 1.60
41 Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. Mol Cell Biol 2000 1.57
42 Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. EMBO J 2000 1.54
43 The TOR signal transduction cascade controls cellular differentiation in response to nutrients. Mol Biol Cell 2001 1.53
44 Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. Mol Biol Cell 1999 1.53
45 Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. EMBO J 1995 1.47
46 Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. Infect Immun 2000 1.46
47 Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. EMBO Rep 2001 1.46
48 Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. EMBO J 2001 1.45
49 Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin. Antimicrob Agents Chemother 2000 1.42
50 Cryptococcus neoformans shows a remarkable genotypic diversity in Brazil. J Clin Microbiol 2004 1.41
51 Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans. Fungal Genet Biol 1998 1.41
52 Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR. Antimicrob Agents Chemother 2001 1.37
53 Morphogenesis of Cryptococcus neoformans. Contrib Microbiol 2000 1.34
54 CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90. Mol Cell Biol 1998 1.30
55 Signal transduction cascades regulating mating, filamentation, and virulence in Cryptococcus neoformans. Curr Opin Microbiol 1999 1.27
56 Characterization of the MFalpha pheromone of the human fungal pathogen cryptococcus neoformans. Mol Microbiol 2000 1.27
57 Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J Biol Chem 2000 1.26
58 STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae. J Biol Chem 1997 1.26
59 The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob Agents Chemother 1997 1.24
60 vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly. Genetics 1995 1.24
61 A yeast cyclophilin gene essential for lactate metabolism at high temperature. Proc Natl Acad Sci U S A 1992 1.23
62 Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein. Infect Immun 1999 1.22
63 Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action. Clin Microbiol Rev 1999 1.21
64 A STE12 homolog is required for mating but dispensable for filamentation in candida lusitaniae. Genetics 2000 1.19
65 Signal-transduction cascades as targets for therapeutic intervention by natural products. Trends Biotechnol 1998 1.19
66 Molecular analysis of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption. Fungal Genet Biol 1999 1.18
67 Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target. Genetics 1999 1.15
68 Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast. Genes Dev 1996 1.14
69 Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells. Biochem Biophys Res Commun 1997 1.13
70 Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. J Biol Chem 2001 1.12
71 Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. J Biol Chem 1996 1.06
72 Nomenclature relating to restriction of modified DNA in Escherichia coli. J Bacteriol 1991 1.03
73 Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans. Microbiology 1999 0.99
74 A new face of the Rhesus antigen. Nat Genet 2000 0.97
75 FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae. Mol Cell Biol 1997 0.96
76 Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae. J Biol Chem 1995 0.96
77 Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. J Biol Chem 1995 0.95
78 Isolation of Cryptococcus gattii and Cryptococcus neoformans var. grubii from the flowers and bark of Eucalyptus trees in India. Med Mycol 2005 0.94
79 Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase. Redox Rep 2001 0.93
80 Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae. Mol Biol Cell 1997 0.92
81 Calcineurin mutants render T lymphocytes resistant to cyclosporin A. Mol Pharmacol 1996 0.92
82 Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. Curr Opin Nephrol Hypertens 1995 0.91
83 Regional bivalent-univalent pairing versus trivalent pairing of a trisomic chromosome in Saccharomyces cerevisiae. Genetics 1996 0.90
84 Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother 1999 0.90
85 Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. Genetics 1999 0.90
86 Tn5-mediated bleomycin resistance in Escherichia coli requires the expression of host genes. Mol Microbiol 1993 0.88
87 Quantitation of residual white cells in filtered blood components by polymerase chain reaction amplification of HLA DQ-A DNA. Transfusion 1994 0.87
88 Allogeneic leukocytes but not therapeutic blood elements induce reactivation and dissemination of latent human immunodeficiency virus type 1 infection: implications for transfusion support of infected patients. Blood 1992 0.87
89 FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. Cell Growth Differ 1998 0.84
90 Proline isomerases in microorganisms and small eukaryotes. Ann N Y Acad Sci 1993 0.83
91 Role of calcium in T-lymphocyte activation. Adv Second Messenger Phosphoprotein Res 1995 0.83
92 Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants. Gene 1995 0.82
93 Mutational analysis of the function of Met137 and Ile197, two amino acids implicated in sequence-specific DNA recognition by the EcoRI endonuclease. Biol Chem 1998 0.82
94 Cyclophilin active site mutants have native prolyl isomerase activity with a protein substrate. FEBS Lett 1997 0.82
95 Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae. Mol Gen Genet 1999 0.80
96 R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays. FEBS Lett 1999 0.79
97 Molecular cloning and characterization of Aspergillus nidulans cyclophilin B. Fungal Genet Biol 1999 0.79
98 Temperature-sensitive mutants of the EcoRI endonuclease. J Mol Biol 1997 0.79
99 It infects me, it infects me not: phenotypic switching in the fungal pathogen Cryptococcus neoformans. J Clin Invest 2001 0.79
100 Human immunodeficiency virus. Chaperoning a pathogen. Nature 1994 0.78
101 Retracted Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae. J Biol Chem 1996 0.77
102 Rapid freezing of whole blood or buffy coat samples for polymerase chain reaction and cell culture analysis: application to detection of human immunodeficiency virus in blood donor and recipient repositories. The Transfusion Safety Study Group. Transfusion 1993 0.77
103 Cyclosporin and asthma. Lancet 1992 0.75
104 Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae. J Biol Chem 1999 0.75
105 Dismantling the Cryptococcus coat. Trends Microbiol 2001 0.75
106 Disheartening losses in U.S. steel industry. Occup Health Saf 2001 0.75