Published in Mol Cell Biol on January 01, 2000
Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev (2000) 5.49
Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. Infect Immun (2003) 3.61
Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. Eukaryot Cell (2002) 2.21
Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct. Proc Natl Acad Sci U S A (2000) 1.96
Regulatory circuitry governing fungal development, drug resistance, and disease. Microbiol Mol Biol Rev (2011) 1.90
Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade. Eukaryot Cell (2005) 1.75
Mitogen-activated protein kinase pathways and fungal pathogenesis. Eukaryot Cell (2007) 1.71
A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans. EMBO J (2009) 1.68
A filamentous growth response mediated by the yeast mating pathway. Genetics (2001) 1.60
Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. Eukaryot Cell (2004) 1.59
Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. Eukaryot Cell (2002) 1.55
G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. Mol Biol Cell (2005) 1.50
Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. EMBO Rep (2001) 1.46
Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. EMBO J (2001) 1.45
Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. Eukaryot Cell (2004) 1.42
Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation. PLoS Genet (2006) 1.40
Identification of virulence mutants of the fungal pathogen Cryptococcus neoformans using signature-tagged mutagenesis. Genetics (2001) 1.38
The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans. Genetics (2005) 1.34
A G-protein beta subunit required for sexual and vegetative development and maintenance of normal G alpha protein levels in Neurospora crassa. Eukaryot Cell (2002) 1.34
Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans. Eukaryot Cell (2002) 1.32
A genetic linkage map of Cryptococcus neoformans variety neoformans serotype D (Filobasidiella neoformans). Genetics (2004) 1.32
Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. Eukaryot Cell (2006) 1.32
Mutation of the regulator of G protein signaling Crg1 increases virulence in Cryptococcus neoformans. Eukaryot Cell (2004) 1.30
Signalling pathways in the pathogenesis of Cryptococcus. Cell Microbiol (2008) 1.26
G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans. Mol Biol Cell (2007) 1.24
The heterotrimeric G-protein subunits GNG-1 and GNB-1 form a Gbetagamma dimer required for normal female fertility, asexual development, and galpha protein levels in Neurospora crassa. Eukaryot Cell (2005) 1.19
The second STE12 homologue of Cryptococcus neoformans is MATa-specific and plays an important role in virulence. Proc Natl Acad Sci U S A (2001) 1.19
PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans. Mol Biol Cell (2004) 1.12
ras2 Controls morphogenesis, pheromone response, and pathogenicity in the fungal pathogen Ustilago maydis. Eukaryot Cell (2002) 1.10
Isolation and characterization of the Cryptococcus neoformans MATa pheromone gene. Genetics (2002) 1.09
Canonical heterotrimeric G proteins regulating mating and virulence of Cryptococcus neoformans. Mol Biol Cell (2007) 1.08
The link between morphotype transition and virulence in Cryptococcus neoformans. PLoS Pathog (2012) 1.07
Profiling a killer, the development of Cryptococcus neoformans. FEMS Microbiol Rev (2011) 1.06
Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans. Eukaryot Cell (2006) 1.04
Fungal mating pheromones: choreographing the dating game. Fungal Genet Biol (2011) 1.04
Molecular analysis of CPRalpha, a MATalpha-specific pheromone receptor gene of Cryptococcus neoformans. Eukaryot Cell (2002) 1.04
Clonality despite sex: the evolution of host-associated sexual neighborhoods in the pathogenic fungus Penicillium marneffei. PLoS Pathog (2012) 1.04
The information highways of a biotechnological workhorse--signal transduction in Hypocrea jecorina. BMC Genomics (2008) 1.03
The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. Infect Immun (2008) 1.03
A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans. Curr Genet (2004) 1.00
The phosducin-like protein PhLP1 impacts regulation of glycoside hydrolases and light response in Trichoderma reesei. BMC Genomics (2011) 1.00
Importance of a developmentally regulated pheromone receptor of Cryptococcus neoformans for virulence. Infect Immun (2003) 0.99
Comparative transcriptome analysis of the CO2 sensing pathway via differential expression of carbonic anhydrase in Cryptococcus neoformans. Genetics (2010) 0.99
Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication. Curr Biol (2016) 0.92
The RGS protein Crg2 regulates pheromone and cyclic AMP signaling in Cryptococcus neoformans. Eukaryot Cell (2008) 0.92
Heterotrimeric G-protein subunit function in Candida albicans: both the alpha and beta subunits of the pheromone response G protein are required for mating. Eukaryot Cell (2008) 0.91
Pleiotropic function of intersectin homologue Cin1 in Cryptococcus neoformans. Mol Microbiol (2010) 0.91
Allelic exchange of pheromones and their receptors reprograms sexual identity in Cryptococcus neoformans. PLoS Genet (2010) 0.90
The Gbeta-subunit-encoding gene bpp1 controls cyclic-AMP signaling in Ustilago maydis. Eukaryot Cell (2004) 0.89
A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans. Eukaryot Cell (2005) 0.86
Differential gene expression in auristatin PHE-treated Cryptococcus neoformans. Antimicrob Agents Chemother (2004) 0.85
The iron-responsive, GATA-type transcription factor Cir1 influences mating in Cryptococcus neoformans. Mol Cells (2010) 0.85
The production of monokaryotic hyphae by Cryptococcus neoformans can be induced by high temperature arrest of the cell cycle and is independent of same-sex mating. PLoS Pathog (2013) 0.85
Noncanonical Gβ Gib2 is a scaffolding protein promoting cAMP signaling through functions of Ras1 and Cac1 proteins in Cryptococcus neoformans. J Biol Chem (2014) 0.84
Biochemical systems analysis of signaling pathways to understand fungal pathogenicity. Methods Mol Biol (2011) 0.82
Sexual reproduction of human fungal pathogens. Cold Spring Harb Perspect Med (2014) 0.82
The beta subunit of the heterotrimeric G protein triggers the Kluyveromyces lactis pheromone response pathway in the absence of the gamma subunit. Mol Biol Cell (2009) 0.81
Ras-Mediated Signal Transduction and Virulence in Human Pathogenic Fungi. Fungal Genom Biol (2012) 0.80
G(alpha) and Gbeta proteins regulate the cyclic AMP pathway that is required for development and pathogenicity of the phytopathogen Mycosphaerella graminicola. Eukaryot Cell (2009) 0.80
G-protein beta subunit of Cochliobolus heterostrophus involved in virulence, asexual and sexual reproductive ability, and morphogenesis. Eukaryot Cell (2004) 0.80
Wsp1, a GBD/CRIB domain-containing WASP homolog, is required for growth, morphogenesis, and virulence of Cryptococcus neoformans. Eukaryot Cell (2011) 0.79
The late endosomal HOPS complex anchors active G-protein signaling essential for pathogenesis in magnaporthe oryzae. PLoS Pathog (2013) 0.79
Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in Cryptococcus neoformans. Sci Rep (2015) 0.79
The cAMP pathway is important for controlling the morphological switch to the pathogenic yeast form of Paracoccidioides brasiliensis. Mol Microbiol (2007) 0.79
A Ric8/synembryn homolog promotes Gpa1 and Gpa2 activation to respectively regulate cyclic AMP and pheromone signaling in Cryptococcus neoformans. Eukaryot Cell (2014) 0.79
The cAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis. J Microbiol (2015) 0.78
'Popping the clutch': novel mechanisms regulating sexual development in Cryptococcus neoformans. Mycopathologia (2011) 0.76
The RGS protein Crg2 is required for establishment and progression of murine pulmonary cryptococcosis. Med Mycol (2010) 0.76
RNA biology and the adaptation of Cryptococcus neoformans to host temperature and stress. Wiley Interdiscip Rev RNA (2014) 0.76
Regulatory roles of phosphorylation in model and pathogenic fungi. Med Mycol (2015) 0.75
The Gα subunit signals through the Ste50 protein during the mating pheromone response in the yeast Kluyveromyces lactis. Eukaryot Cell (2011) 0.75
Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation. PLoS Genet (2017) 0.75
G proteins: transducers of receptor-generated signals. Annu Rev Biochem (1987) 27.41
A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene (1987) 25.43
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics (1996) 24.62
Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell (1992) 10.94
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans. Clin Microbiol Rev (1995) 8.81
The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature (1987) 6.05
Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science (1993) 5.86
Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice. J Bacteriol (1982) 5.40
Genetic association of mating types and virulence in Cryptococcus neoformans. Infect Immun (1992) 5.27
Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. J Bacteriol (1993) 5.14
The STE4 and STE18 genes of yeast encode potential beta and gamma subunits of the mating factor receptor-coupled G protein. Cell (1989) 5.07
Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans. Infect Immun (1986) 4.91
The yeast SCG1 gene: a G alpha-like protein implicated in the a- and alpha-factor response pathway. Cell (1987) 4.85
Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia (1977) 4.83
MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell (1997) 4.69
GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Cell (1987) 4.50
Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes Dev (1997) 4.28
Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence. Mol Cell Biol (1994) 4.22
Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. Nature (1994) 4.05
Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. J Clin Invest (1985) 3.98
The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components. EMBO J (1992) 3.91
Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans. J Exp Med (1996) 3.76
Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J (1997) 3.67
Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase. J Bacteriol (1994) 3.59
Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs. Proc Natl Acad Sci U S A (1986) 3.59
Distribution of alpha and alpha mating types of Cryptococcus neoformans among natural and clinical isolates. Am J Epidemiol (1978) 3.55
Cryptococcus neoformans melanin and virulence: mechanism of action. Infect Immun (1995) 3.43
Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. EMBO J (1997) 3.41
Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type. Proc Natl Acad Sci U S A (1996) 3.35
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science (1991) 3.00
Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway. Nature (1997) 2.85
The alpha-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene. Mol Cell Biol (1993) 2.81
The second capsule gene of cryptococcus neoformans, CAP64, is essential for virulence. Infect Immun (1996) 2.67
New roles for G-protein beta gamma-dimers in transmembrane signalling. Nature (1993) 2.66
Gpa2p, a G-protein alpha-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism. J Biol Chem (1997) 2.63
Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway. Genes Dev (1998) 2.55
byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype. Mol Cell Biol (1991) 2.48
Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C. Nature (1992) 2.47
Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants. Infect Immun (1994) 2.41
The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium. J Cell Biol (1995) 2.40
Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition. Genes Dev (1992) 2.36
Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Mol Biol Cell (1993) 2.09
Regulation of cryptococcal capsular polysaccharide by iron. J Infect Dis (1993) 2.03
Isolation and characterization of a gene encoding a G-protein alpha subunit from Schizosaccharomyces pombe: involvement in mating and sporulation pathways. Proc Natl Acad Sci U S A (1991) 1.98
Isolation of telomerelike sequences from Cryptococcus neoformans and their use in high-efficiency transformation. Mol Cell Biol (1992) 1.97
Pheromone response elements are necessary and sufficient for basal and pheromone-induced transcription of the FUS1 gene of Saccharomyces cerevisiae. Mol Cell Biol (1991) 1.96
The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. Infect Immun (1993) 1.96
Distinct roles for two G protein alpha subunits in fungal virulence, morphology, and reproduction revealed by targeted gene disruption. Proc Natl Acad Sci U S A (1996) 1.84
The Cryptococcus neoformans STE12alpha gene: a putative Saccharomyces cerevisiae STE12 homologue that is mating type specific. Mol Microbiol (1997) 1.79
Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases. Nature (1998) 1.77
The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. Genetics (1999) 1.75
Yeast STE7, STE11, and STE12 genes are required for expression of cell-type-specific genes. Mol Cell Biol (1988) 1.73
Selection of ura5 and ura3 mutants from the two varieties of Cryptococcus neoformans on 5-fluoroorotic acid medium. J Med Vet Mycol (1992) 1.71
Pheromone-induced phosphorylation of a G protein beta subunit in S. cerevisiae is associated with an adaptive response to mating pheromone. Cell (1991) 1.63
Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8). Genetics (1994) 1.50
Dominant-negative mutants of a yeast G-protein beta subunit identify two functional regions involved in pheromone signalling. EMBO J (1992) 1.45
The Cryptococcus neoformans GAL7 gene and its use as an inducible promoter. Mol Microbiol (1995) 1.44
Cloning of a Cryptococcus neoformans gene, GPA1, encoding a G-protein alpha-subunit homolog. Infect Immun (1994) 1.39
Targeted disruption of a fungal G-protein beta subunit gene results in increased vegetative growth but reduced virulence. Mol Plant Microbe Interact (1997) 1.38
Molecular analysis of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption. Fungal Genet Biol (1999) 1.18
Cloning of a Drosophila melanogaster guanine nucleotide regulatory protein beta-subunit gene and characterization of its expression during development. Proc Natl Acad Sci U S A (1988) 1.03
The G protein beta subunit Gpb1 of Schizosaccharomyces pombe is a negative regulator of sexual development. Mol Gen Genet (1996) 1.00
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans. Clin Microbiol Rev (1995) 8.81
Nuclear protein localization. Biochim Biophys Acta (1991) 6.43
The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev (1999) 5.80
Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America. Clin Infect Dis (2000) 5.53
Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev (2000) 5.49
Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. J Bacteriol (1993) 5.14
A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature (2001) 4.33
Chronic cryptococcal meningitis: a new experimental model in rabbits. Am J Pathol (1980) 4.28
Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes Dev (1997) 4.28
Gene disruption with PCR products in Saccharomyces cerevisiae. Gene (1995) 4.06
Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy. Clin Infect Dis (2001) 4.01
Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. J Clin Invest (1985) 3.98
Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1. Antimicrob Agents Chemother (1993) 3.79
Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans. J Exp Med (1996) 3.76
Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages. J Clin Invest (1988) 3.69
Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J (1997) 3.67
Urease as a virulence factor in experimental cryptococcosis. Infect Immun (2000) 3.53
Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. EMBO J (1997) 3.41
Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits. Antimicrob Agents Chemother (1986) 3.38
Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Mol Cell Biol (1999) 3.22
Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. Mol Cell Biol (2001) 3.11
The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. EMBO J (1998) 3.09
Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases. Clin Infect Dis (1998) 3.09
Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans. Mol Microbiol (2001) 3.02
Site-specific methylases induce the SOS DNA repair response in Escherichia coli. J Bacteriol (1987) 2.94
Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. J Clin Invest (1990) 2.91
Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway. Mol Cell Biol (1998) 2.91
Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review. Rev Infect Dis (1989) 2.89
In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds. Antimicrob Agents Chemother (1997) 2.76
The TOR kinases link nutrient sensing to cell growth. J Biol Chem (2001) 2.67
Serotype AD strains of Cryptococcus neoformans are diploid or aneuploid and are heterozygous at the mating-type locus. Infect Immun (2001) 2.39
TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. J Biol Chem (1995) 2.39
The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics (2000) 2.35
Morphologic criteria for the preliminary identification of Fusarium, Paecilomyces, and Acremonium species by histopathology. Am J Clin Pathol (1998) 2.30
RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans. Mol Microbiol (2000) 2.30
Characterization of alcohol-induced filamentous growth in Saccharomyces cerevisiae. Mol Biol Cell (2000) 2.27
Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains. Genetics (1998) 2.21
Zygomycosis: the re-emerging fungal infection. Eur J Clin Microbiol Infect Dis (2006) 2.17
All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1997) 2.14
Cryptococcemia. Medicine (Baltimore) (1983) 2.10
Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans. Fungal Genet Biol (2000) 2.06
Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. EMBO J (1994) 2.06
Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity. J Immunol (1986) 2.06
Conserved cAMP signaling cascades regulate fungal development and virulence. FEMS Microbiol Rev (2001) 2.04
Penetration of imidazoles and triazoles into cerebrospinal fluid of rabbits. J Antimicrob Chemother (1985) 2.02
Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct. Proc Natl Acad Sci U S A (2000) 1.96
FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. EMBO J (1995) 1.94
The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. EMBO J (2000) 1.88
Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. Mol Microbiol (2001) 1.87
Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. J Infect Dis (1987) 1.85
Calcineurin. Structure, function, and inhibition. Cell Biochem Biophys (1999) 1.82
Comparison of amphotericin B and N-D-ornithyl amphotericin B methyl ester in experimental cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis. Antimicrob Agents Chemother (1985) 1.78
Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. EMBO J (2000) 1.76
TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals. Mol Cell Endocrinol (1999) 1.76
Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. MBio (2011) 1.76
The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. Genetics (1999) 1.75
Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans. Proc Natl Acad Sci U S A (1994) 1.72
Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. Genes Dev (2001) 1.72
Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. Proc Natl Acad Sci U S A (1994) 1.72
Diploid strains of the pathogenic basidiomycete Cryptococcus neoformans are thermally dimorphic. Fungal Genet Biol (2000) 1.69
Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Antimicrob Agents Chemother (2000) 1.66
A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function. J Bacteriol (1999) 1.65
Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol Cell Biol (1999) 1.64
Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches. Drugs (1997) 1.63
Protection from nitrosative stress by yeast flavohemoglobin. Proc Natl Acad Sci U S A (2000) 1.60
Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. Curr Opin Microbiol (2000) 1.60
Treatment of experimental cryptococcal meningitis with amphotericin B, 5-fluorocytosine, and ketoconazole. J Infect Dis (1982) 1.58
Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. Mol Cell Biol (2000) 1.57
Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis. Ann Intern Med (1983) 1.56
Dominant selection system for use in Cryptococcus neoformans. J Med Vet Mycol (1997) 1.54
Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. EMBO J (2000) 1.54
The TOR signal transduction cascade controls cellular differentiation in response to nutrients. Mol Biol Cell (2001) 1.53
Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. Mol Biol Cell (1999) 1.53
Association of plasma levels of human immunodeficiency virus type 1 RNA and oropharyngeal Candida colonization. J Infect Dis (1999) 1.51
Fungal meningitis. Semin Neurol (2000) 1.50
Cryptococcus neoformans gene expression during experimental cryptococcal meningitis. Eukaryot Cell (2003) 1.49
Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. EMBO J (1995) 1.47
Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. Infect Immun (2000) 1.46
Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. EMBO Rep (2001) 1.46
Disseminated zygomycosis: report of four cases and review. Rev Infect Dis (1989) 1.45
Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. EMBO J (2001) 1.45
Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin. Antimicrob Agents Chemother (2000) 1.42
Cryptococcus neoformans shows a remarkable genotypic diversity in Brazil. J Clin Microbiol (2004) 1.41
Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans. Fungal Genet Biol (1998) 1.41
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR. Antimicrob Agents Chemother (2001) 1.37
Morphogenesis of Cryptococcus neoformans. Contrib Microbiol (2000) 1.34
Combined therapy with amphotericin B and 5-fluorocytosine for Candida meningitis. Rev Infect Dis (1985) 1.31
CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90. Mol Cell Biol (1998) 1.30