TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

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Published in J Biol Chem on November 17, 1995

Authors

M C Lorenz1, J Heitman

Author Affiliations

1: Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA.

Associated clinical trials:

Phase I Study of DOXIL and Temsirolimus in Resistant Solid Malignancies | NCT00703170

Erlotinib and Temsirolimus for Solid Tumors | NCT00770263

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