Published in Cell Immunol on November 01, 1999
The functional network of ion channels in T lymphocytes. Immunol Rev (2009) 3.21
K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci (2004) 3.12
The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. J Clin Invest (2003) 3.02
Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A (2001) 2.63
Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol (2005) 2.08
Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol (2001) 1.85
Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon (2011) 1.59
Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers. Cardiovasc Res (2010) 1.57
K+ channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem Rev (2008) 1.52
Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis. J Invest Dermatol (2007) 1.41
Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle. Proc Natl Acad Sci U S A (2002) 1.32
Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases. Inflamm Allergy Drug Targets (2011) 1.15
Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. PLoS One (2008) 1.12
Functional up-regulation of KCNA gene family expression in murine mesenteric resistance artery smooth muscle. J Physiol (2004) 1.11
Probing the cavity of the slow inactivated conformation of shaker potassium channels. J Gen Physiol (2007) 1.05
Expression and function of native potassium channel [K(V)alpha1] subunits in terminal arterioles of rabbit. J Physiol (2001) 1.04
The Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression. Drug Dev Res (2011) 0.98
Monte Carlo-energy minimization of correolide in the Kv1.3 channel: possible role of potassium ion in ligand-receptor interactions. BMC Struct Biol (2007) 0.91
KvAP-based model of the pore region of shaker potassium channel is consistent with cadmium- and ligand-binding experiments. Biophys J (2005) 0.84
Spiro azepane-oxazolidinones as Kv1.3 potassium channel blockers: WO2010066840. Expert Opin Ther Pat (2010) 0.76
The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry (1998) 65.11
The effects of intravascular injections of extracts of animal tissues. J Physiol (1903) 19.71
The physiological effects of extracts of nervous tissues. J Physiol (1900) 12.95
The nature of the principal type 1 interferon-producing cells in human blood. Science (1999) 10.90
Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature (1996) 5.80
Mitochondrial diversity and the origins of African and European cattle. Proc Natl Acad Sci U S A (1996) 5.55
Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs". Genome Res (2001) 5.10
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell (1989) 4.99
Evidence for two independent domestications of cattle. Proc Natl Acad Sci U S A (1994) 4.70
Continuity of care and trust in one's physician: evidence from primary care in the United States and the United Kingdom. Fam Med (2001) 4.54
Comparison of standards in training and non-training practices. J R Coll Gen Pract (1985) 4.44
Qualitative methods in research on healthcare quality. Qual Saf Health Care (2002) 4.42
The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J Immunol (1989) 4.30
Further observations on the vaso-motor reflexes and associated phenomena. J Physiol (1928) 4.21
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med (1997) 4.12
The peritoneal exudate lymphocyte. I. Differences in antigen responsiveness between peritoneal exudate and lymph node lymphocytes from immunized guinea pigs. J Exp Med (1971) 3.81
THE IMMEDIATE AND END-RESULTS OF CHOLECYSTECTOMY. Ann Surg (1940) 3.65
Aircraft and road traffic noise and children's cognition and health: a cross-national study. Lancet (2005) 3.64
Genetic evidence for Near-Eastern origins of European cattle. Nature (2001) 3.60
What do we know about how to do audit and feedback? Pitfalls in applying evidence from a systematic review. BMC Health Serv Res (2005) 3.51
The pharmacodynamical action of chloralose. J Physiol (1928) 3.30
Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. J Immunol (1990) 3.29
Impact of the population at risk of diabetes on projections of diabetes burden in the United States: an epidemic on the way. Diabetologia (2006) 3.28
Changing the clinical behavior of doctors: a psychological framework. Qual Health Care (1996) 3.22
Electrotonic coupling between neurons in cat inferior olive. J Neurophysiol (1974) 3.20
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A (1990) 3.13
Isolation of virus related to SV40 from patients with progressive multifocal leukoencephalopathy. N Engl J Med (1972) 3.09
The association between air pollution and heart failure, arrhythmia, embolism, thrombosis, and other cardiovascular causes of death in a time series study. Epidemiology (2001) 3.07
Model for directly assessing and improving clinical competence and performance in revalidation of clinicians. BMJ (2001) 3.05
Features of primary care associated with variations in process and outcome of care of people with diabetes. Br J Gen Pract (2001) 2.95
Adrenin and the splanchnic nerve. J Physiol (1927) 2.95
Results of systematic second-look surgery plus HIPEC in asymptomatic patients presenting a high risk of developing colorectal peritoneal carcinomatosis. Ann Surg (2011) 2.91
Determinant selection is a macrophage dependent immune response gene function. Nature (1977) 2.85
Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP. Proc Natl Acad Sci U S A (1979) 2.81
Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc Natl Acad Sci U S A (1996) 2.81
The Haemolymph Glands of some Vertebrates. J Anat Physiol (1897) 2.71
Clozapine for the treatment of adolescents with schizophrenia. J Am Acad Child Adolesc Psychiatry (1992) 2.68
Microsatellite DNA variation and the evolution, domestication and phylogeography of taurine and zebu cattle (Bos taurus and Bos indicus). Genetics (1997) 2.65
Long-term symptomless HIV-1 infection in recipients of blood products from a single donor. Lancet (1992) 2.60
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry (1994) 2.51
Prevalence, incidence, and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIV-negative women. J Infect Dis (2001) 2.51
Traffic-related air pollution and respiratory health during the first 2 yrs of life. Eur Respir J (2002) 2.50
Barium enemas in the frail elderly. Am J Med (1992) 2.50
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br J Pharmacol (1992) 2.50
Inverse relationship of the durations of adjacent open and shut intervals for C1 and K channels. Nature (1985) 2.48
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A (1996) 2.48
Tailored interventions to overcome identified barriers to change: effects on professional practice and health care outcomes. Cochrane Database Syst Rev (2005) 2.46
Immunologic relatedness of papillomaviruses from different species. J Natl Cancer Inst (1980) 2.44
Differentiating between audit and research: postal survey of health authorities' views. BMJ (1999) 2.41
Quality improvement research: understanding the science of change in health care. Qual Saf Health Care (2002) 2.41
Differentiation of atypical atrioventricular node re-entrant tachycardia from orthodromic reciprocating tachycardia using a septal accessory pathway by the response to ventricular pacing. J Am Coll Cardiol (2001) 2.40
Measles virus structural components are enriched into lipid raft microdomains: a potential cellular location for virus assembly. J Virol (2000) 2.40
Left in limbo: patients' views on care across the primary/secondary interface. Qual Health Care (1999) 2.38
The effect of hyper-respiration on the blood-pressure in man. J Physiol (1928) 2.37
Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol (1998) 2.36
High-conductance calcium-activated potassium channels; structure, pharmacology, and function. J Bioenerg Biomembr (1996) 2.31
Imaging findings of extraventricular neurocytoma: report of 3 cases and review of the literature. AJNR Am J Neuroradiol (2008) 2.30
Widespread expression of Huntington's disease gene (IT15) protein product. Neuron (1995) 2.29
Birth weight and cognitive function in young adult life: historical cohort study. BMJ (1997) 2.29
Jumonji, a nuclear protein that is necessary for normal heart development. Circ Res (2000) 2.26
Laparoscopic kidney transplantation: an initial experience. Am J Transplant (2011) 2.24
Depletion of antibody-forming cells and their precursors from complex lymphoid cell populations. J Immunol (1972) 2.24
Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients. Neurosci Lett (1993) 2.16
A split binding site for transcription factor tau on the tRNA3Glu gene. EMBO J (1985) 2.16
ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nat Cell Biol (2001) 2.14
In vivo intracellular recording and perturbation of persistent activity in a neural integrator. Nat Neurosci (2001) 2.13
Arterial embolization is a rapid and effective technique for controlling pelvic fracture hemorrhage. J Trauma (1997) 2.12
The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells. J Immunol (1990) 2.11
A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling. Nature (1994) 2.11
Effectiveness of screening and monitoring tests for diabetic retinopathy--a systematic review. Diabet Med (2000) 2.10
Pulse-length dependence of cellular response to intense near-infrared laser pulses in multiphoton microscopes. Opt Lett (1999) 2.10
Metastatic malignant mesothelioma presenting as colonic polyps. Hum Pathol (1997) 2.09
Exposure to traffic related air pollutants: self reported traffic intensity versus GIS modelled exposure. Occup Environ Med (2005) 2.07
Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q. Genes Chromosomes Cancer (1997) 2.06
Estimation of long-term average exposure to outdoor air pollution for a cohort study on mortality. J Expo Anal Environ Epidemiol (2002) 2.04
General practitioners' reasons for not attending a higher professional education course. Br J Gen Pract (1994) 2.03
Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology. J Gen Physiol (1997) 1.99
Unnatural ligands for engineered proteins: new tools for chemical genetics. Annu Rev Biophys Biomol Struct (2000) 1.99
Human papillomaviruses in women with a history of abnormal Papanicolaou smears and in their male partners. Obstet Gynecol (1987) 1.97
Dioxygenolytic cleavage of aryl ether bonds: 1,10-dihydro-1,10-dihydroxyfluoren-9-one, a novel arene dihydrodiol as evidence for angular dioxygenation of dibenzofuran. FEMS Microbiol Lett (1989) 1.97
Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes. Genes Dev (1998) 1.97
Teicoplanin-resistant Staphylococcus aureus expresses a novel membrane protein and increases expression of penicillin-binding protein 2 complex. Antimicrob Agents Chemother (1993) 1.95
Effects of treatment with formoterol on bronchoprotection against methacholine. Am J Med (1998) 1.94
Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stage. J Infect Dis (1997) 1.90
Features of primary health care teams associated with successful quality improvement of diabetes care: a qualitative study. Fam Pract (2001) 1.84
Severe community-acquired pneumonia. Risk factors and follow-up epidemiology. Am J Respir Crit Care Med (1999) 1.83
3-(2-hydroxyphenyl)catechol as substrate for proximal meta ring cleavage in dibenzofuran degradation by Brevibacterium sp. strain DPO 1361. J Bacteriol (1991) 1.82
Engineering Src family protein kinases with unnatural nucleotide specificity. Chem Biol (1998) 1.81
Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J Immunol (1997) 1.80
The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities. J Immunol (1985) 1.78
Human exposure to SV40: review and comment. Am J Epidemiol (1976) 1.77