High-conductance calcium-activated potassium channels; structure, pharmacology, and function.

PubWeight™: 2.31‹?› | Rank: Top 2%

🔗 View Article (PMID 8807400)

Published in J Bioenerg Biomembr on June 01, 1996

Authors

G J Kaczorowski1, H G Knaus, R J Leonard, O B McManus, M L Garcia

Author Affiliations

1: Merck Research Laboratories, Rahway, New Jersey 07065, USA.

Articles citing this

How neutrophils kill microbes. Annu Rev Immunol (2005) 6.87

Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science (2010) 3.03

Voltage and Ca2+ activation of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism. J Gen Physiol (2000) 2.41

The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems. Biochim Biophys Acta (2004) 2.39

Gating mechanism of BK (Slo1) channels: so near, yet so far. J Gen Physiol (2003) 2.31

Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature (2010) 2.00

Retracted The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Nature (2004) 1.85

The beta subunit increases the Ca2+ sensitivity of large conductance Ca2+-activated potassium channels by retaining the gating in the bursting states. J Gen Physiol (1999) 1.80

Functional coupling of the beta(1) subunit to the large conductance Ca(2+)-activated K(+) channel in the absence of Ca(2+). Increased Ca(2+) sensitivity from a Ca(2+)-independent mechanism. J Gen Physiol (2000) 1.67

Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain. Cell Mol Life Sci (2008) 1.67

Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel. Nature (2011) 1.60

Oxidative regulation of large conductance calcium-activated potassium channels. J Gen Physiol (2001) 1.54

Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery. Br J Pharmacol (2009) 1.46

Elevated subsarcolemmal Ca2+ in mdx mouse skeletal muscle fibers detected with Ca2+-activated K+ channels. Proc Natl Acad Sci U S A (2000) 1.46

Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+. Proc Natl Acad Sci U S A (2002) 1.41

Intra- and intersubunit cooperativity in activation of BK channels by Ca2+. J Gen Physiol (2006) 1.39

Rat supraoptic magnocellular neurones show distinct large conductance, Ca2+-activated K+ channel subtypes in cell bodies versus nerve endings. J Physiol (1999) 1.32

Role of gap junctions and EETs in endothelium-dependent hyperpolarization of porcine coronary artery. Br J Pharmacol (2000) 1.30

Effects of intracellular stores and extracellular Ca(2+) on Ca(2+)-activated K(+) currents in mature mouse inner hair cells. J Physiol (2004) 1.29

An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating. J Gen Physiol (2006) 1.26

CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels. Nat Neurosci (2005) 1.25

Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. Proc Natl Acad Sci U S A (2008) 1.24

The role of Ca2+-activated K+ channel spliced variants in the tonotopic organization of the turtle cochlea. J Physiol (1999) 1.22

The beta subunit of the high-conductance calcium-activated potassium channel contributes to the high-affinity receptor for charybdotoxin. Proc Natl Acad Sci U S A (1997) 1.20

Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity. Cell Death Dis (2013) 1.17

Functional effects of auxiliary beta4-subunit on rat large-conductance Ca(2+)-activated K(+) channel. Biophys J (2004) 1.13

Molecular determinants of Ca2+-dependent K+ channel function in rat dorsal vagal neurones. J Physiol (2000) 1.10

BKCa channels activating at resting potential without calcium in LNCaP prostate cancer cells. J Membr Biol (2006) 1.10

BK channel β1 subunits regulate airway contraction secondary to M2 muscarinic acetylcholine receptor mediated depolarization. J Physiol (2011) 1.06

Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of BK channels. Am J Physiol Heart Circ Physiol (2010) 1.06

K(Ca)3.1 channels facilitate K+ secretion or Na+ absorption depending on apical or basolateral P2Y receptor stimulation. J Physiol (2011) 1.03

Slo1 is the principal potassium channel of human spermatozoa. Elife (2013) 1.00

Gating and conductance properties of BK channels are modulated by the S9-S10 tail domain of the alpha subunit. A study of mSlo1 and mSlo3 wild-type and chimeric channels. J Gen Physiol (2001) 0.99

Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy. Brain Res (2008) 0.99

Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol. Pharmacol Ther (2012) 0.96

An extracellular domain of the accessory β1 subunit is required for modulating BK channel voltage sensor and gate. J Gen Physiol (2011) 0.96

NFATc3 regulates BK channel function in murine urinary bladder smooth muscle. Am J Physiol Cell Physiol (2008) 0.94

Nitric oxide and sodium nitroprusside-induced relaxation of the human umbilical artery. Br J Pharmacol (2000) 0.94

Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease. Pflugers Arch (2009) 0.92

Ca(2+) influx and opening of Ca(2+)-activated K(+) channels in muscle fibers from control and mdx mice. Biophys J (2002) 0.91

WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism. Am J Physiol Renal Physiol (2011) 0.91

Activation of Ca2+-activated K+ channels by an increase in intracellular Ca2+ induced by depolarization of mouse skeletal muscle fibres. J Physiol (1998) 0.91

BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic β-cells. J Physiol (2010) 0.90

Pregnancy switches adrenergic signal transduction in rat and human uterine myocytes as probed by BKCa channel activity. J Physiol (2000) 0.90

Analysis of Maxi-K alpha subunit splice variants in human myometrium. Reprod Biol Endocrinol (2004) 0.88

Mechanism of generation of spontaneous miniature outward currents (SMOCs) in retinal amacrine cells. J Gen Physiol (2002) 0.88

Ion channels and receptor as targets for the control of parasitic nematodes. Int J Parasitol Drugs Drug Resist (2011) 0.87

Positions of β2 and β3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel. J Gen Physiol (2013) 0.87

Ginsenoside Rg3 enhances large conductance Ca2+-activated potassium channel currents: a role of Tyr360 residue. Mol Cells (2010) 0.86

Habituation of reflexive and motivated behavior in mice with deficient BK channel function. Front Integr Neurosci (2013) 0.85

Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin) (2009) 0.84

WNK1 activates large-conductance Ca2+-activated K+ channels through modulation of ERK1/2 signaling. J Am Soc Nephrol (2014) 0.84

Renin-angiotensin system expression and secretory function in cultured human ciliary body non-pigmented epithelium. Br J Ophthalmol (2002) 0.84

A voltage- and Ca2+-dependent big conductance K channel in cochlear spiral ligament fibrocytes. Pflugers Arch (2003) 0.84

Molecular mechanisms of large-conductance ca (2+) -activated potassium channel activation by ginseng gintonin. Evid Based Complement Alternat Med (2013) 0.84

Kinetic gating mechanisms for BK channels: when complexity leads to simplicity. J Gen Physiol (2001) 0.83

KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis. Arthritis Rheumatol (2015) 0.82

Large conductance Ca2+-activated K+ channels contribute to vascular function in nonpregnant human uterine arteries. Reprod Sci (2008) 0.82

Stimulation of the BK(Ca) channel in cultured smooth muscle cells of human trachea by magnolol. Thorax (2002) 0.81

DiBAC₄(3) hits a "sweet spot" for the activation of arterial large-conductance Ca²⁺-activated potassium channels independently of the β₁-subunit. Am J Physiol Heart Circ Physiol (2013) 0.81

N-salicyloyltryptamine, a new anticonvulsant drug, acts on voltage-dependent Na+, Ca2+, and K+ ion channels. Br J Pharmacol (2003) 0.81

Regulatory effect of sulphatides on BKCa channels. Br J Pharmacol (2006) 0.81

Peptide toxins and small-molecule blockers of BK channels. Acta Pharmacol Sin (2016) 0.80

Relaxation to authentic nitric oxide and SIN-1 in rat isolated mesenteric arteries: variable role for smooth muscle hyperpolarization. Br J Pharmacol (2001) 0.80

A-272651, a nonpeptidic blocker of large-conductance Ca2+-activated K+ channels, modulates bladder smooth muscle contractility and neuronal action potentials. Br J Pharmacol (2007) 0.79

125I-Labelled mapacalcine: a specific tool for a pharmacological approach to a receptor associated with a new calcium channel on mouse intestinal membranes. Biochem J (1998) 0.79

Synthesis of an iberiotoxin derivative by chemical ligation: a method for improved yields of cysteine-rich scorpion toxin peptides. Peptides (2009) 0.79

Current understanding of iberiotoxin-resistant BK channels in the nervous system. Front Physiol (2014) 0.79

Morphine induces preconditioning via activation of mitochondrial K(Ca) channels. Can J Anaesth (2010) 0.79

Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy. Neurosci Res (2010) 0.78

Relaxation to bradykinin in bovine pulmonary supernumerary arteries can be mediated by both a nitric oxide-dependent and -independent mechanism. Br J Pharmacol (2002) 0.77

Ability of naringenin, a bioflavonoid, to activate M-type potassium current in motor neuron-like cells and to increase BKCa-channel activity in HEK293T cells transfected with α-hSlo subunit. BMC Neurosci (2014) 0.77

Effects of nitric oxide on expressions of nitrosocysteine and calcium-activated potassium channels in the supraoptic nuclei and neural lobe of dehydrated rats. Neurosci Lett (2006) 0.76

Energy imbalance alters Ca(2+) handling and excitability of POMC neurons. Elife (2017) 0.75

On benzofuroindole analogues as smooth muscle relaxants. J Biomed Biotechnol (2011) 0.75

Role of EDHF in the vasodilatory effect of loop diuretics in guinea-pig mesenteric resistance arteries. Br J Pharmacol (2000) 0.75

Activation of lysophosphatidic Acid receptor is coupled to enhancement of ca(2+)-activated potassium channel currents. Korean J Physiol Pharmacol (2013) 0.75

Properties and physiological function of Ca2+-dependent K+ currents in uniglomerular olfactory projection neurons. J Neurophysiol (2016) 0.75

Articles by these authors

Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science (2003) 6.35

Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J Biol Chem (1990) 3.98

Functional role of the beta subunit of high conductance calcium-activated potassium channels. Neuron (1995) 3.75

Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci U S A (1996) 3.39

Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release. Neuron (1993) 3.07

A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends Pharmacol Sci (1999) 2.71

Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle. J Biol Chem (1994) 2.62

Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry (1994) 2.51

Inverse relationship of the durations of adjacent open and shut intervals for C1 and K channels. Nature (1985) 2.48

Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release. J Neurosci (2001) 2.48

Missteps and masquerade in American medical academe: clinical anatomists call for action. Clin Anat (1999) 2.27

Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. Receptors Channels (1995) 2.24

Molecular constituents of maxi KCa channels in human coronary smooth muscle: predominant alpha + beta subunit complexes. J Physiol (1997) 2.23

An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetylcholine receptor. Neuron (1990) 2.06

Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3. Science (2000) 1.97

Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels. J Biol Chem (1993) 1.94

Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels. Proc Natl Acad Sci U S A (1988) 1.92

Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels. J Biol Chem (1994) 1.89

Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel. Biophys J (1992) 1.86

Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle. J Pharmacol Exp Ther (1989) 1.82

Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J Immunol (1997) 1.80

Oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX6). GERCOR. Eur J Cancer (1999) 1.72

Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals. J Neurosci (1996) 1.71

Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation. J Exp Med (1993) 1.67

Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin. Proc Natl Acad Sci U S A (1992) 1.65

Timing of events in normal swallowing: a videofluoroscopic study. Dysphagia (2000) 1.64

Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology (1996) 1.64

Enhancement of neutrophils function as a result of prior exposure to chemotactic factor. J Clin Invest (1980) 1.64

Active transport in membrane vesicles from Escherichia coli: the electrochemical proton gradient alters the distribution of the lac carrier between two different kinetic states. Biochemistry (1980) 1.60

Anomalous fluorescence enhancement of Cy3 and cy3.5 versus anomalous fluorescence loss of Cy5 and Cy7 upon covalent linking to IgG and noncovalent binding to avidin. Bioconjug Chem (2000) 1.56

Opening and closing transitions for BK channels often occur in two steps via sojourns through a brief lifetime subconductance state. Biophys J (1993) 1.55

An activator of calcium-dependent potassium channels isolated from a medicinal herb. Biochemistry (1993) 1.55

Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle. J Biol Chem (1994) 1.54

Oxidative regulation of large conductance calcium-activated potassium channels. J Gen Physiol (2001) 1.54

Acetylcholine raises excitability by inhibiting the fast transient potassium current in cultured hippocampal neurons. Proc Natl Acad Sci U S A (1986) 1.47

Purified reconstituted lac carrier protein from Escherichia coli is fully functional. Proc Natl Acad Sci U S A (1984) 1.40

Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle. Biochemistry (1992) 1.40

Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. 1. Effect of pH and imposed membrane potential on efflux, exchange, and counterflow. Biochemistry (1983) 1.37

Charybdotoxin and its effects on potassium channels. Am J Physiol (1995) 1.35

Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology. J Biol Chem (1997) 1.35

Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3. Biochemistry (1999) 1.34

Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin. J Biol Chem (1988) 1.31

Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea pig smooth muscle tissues. J Pharmacol Exp Ther (1991) 1.31

Pharmacology of voltage-gated and calcium-activated potassium channels. Curr Opin Chem Biol (1999) 1.30

Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1. Clin Infect Dis (1995) 1.29

Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. 2. Deuterium solvent isotope effects. Biochemistry (1983) 1.28

Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor. J Pharmacol Exp Ther (1990) 1.27

Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations. J Biol Chem (1987) 1.25

Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom. J Biol Chem (1988) 1.23

Functional reconstitution of the large-conductance, calcium-activated potassium channel purified from bovine aortic smooth muscle. Biochemistry (1995) 1.20

The beta subunit of the high-conductance calcium-activated potassium channel contributes to the high-affinity receptor for charybdotoxin. Proc Natl Acad Sci U S A (1997) 1.20

Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels. Cell Immunol (1999) 1.19

Synthetic charybdotoxin-iberiotoxin chimeric peptides define toxin binding sites on calcium-activated and voltage-dependent potassium channels. Biochemistry (1993) 1.17

Calcium channels from Cyprinus carpio skeletal muscle. Proc Natl Acad Sci U S A (1991) 1.17

Computer-assisted design of an implantable, intrathoracic artificial lung. Artif Organs (1994) 1.17

Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom. J Biol Chem (1998) 1.15

Direct measurement of lactose/proton symport in Escherichia coli membrane vesicles: further evidence for the involvement of histidine residue(s). Biochemistry (1982) 1.15

Lactose-proton symport by purified lac carrier protein. Biochemistry (1982) 1.14

Covalent attachment of charybdotoxin to the beta-subunit of the high conductance Ca(2+)-activated K+ channel. Identification of the site of incorporation and implications for channel topology. J Biol Chem (1994) 1.14

Characterization of the Na+/H+ antiporter of alkalophilic bacilli in vivo: delta psi-dependent 22Na+ efflux from whole cells. J Bacteriol (1983) 1.13

Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel. FEBS Lett (1987) 1.13

Characterization of high affinity binding sites for charybdotoxin in human T lymphocytes. Evidence for association with the voltage-gated K+ channel. J Biol Chem (1991) 1.12

Characterization of tissue-expressed alpha subunits of the high conductance Ca(2+)-activated K+ channel. J Biol Chem (1995) 1.12

High-conductance calcium-activated potassium channels in rat brain: pharmacology, distribution, and subunit composition. Biochemistry (1999) 1.11

Hyoid movement during swallowing in older patients with dysphagia. Arch Otolaryngol Head Neck Surg (2001) 1.11

A comment on recent teaching of human anatomy in the United States. Surg Radiol Anat (2000) 1.09

Potassium channels regulate tone in rat pulmonary veins. Am J Physiol Lung Cell Mol Physiol (2001) 1.09

Differential development of two classes of acetylcholine receptors in Xenopus muscle in culture. Science (1984) 1.08

Pancreatic islet transplantation. Effects on the glomerular lesions of experimental diabetes in the rat. Diabetes (1974) 1.07

The beta subunit of the high conductance calcium-activated potassium channel. Identification of residues involved in charybdotoxin binding. J Biol Chem (1998) 1.06

Binding of correolide to K(v)1 family potassium channels. Mapping the domains of high affinity interaction. J Biol Chem (1999) 1.05

Increased expression of Ca2+-sensitive K+ channels in the cerebral microcirculation of genetically hypertensive rats: evidence for their protection against cerebral vasospasm. Circ Res (1998) 1.05

Automated electrophysiology in drug discovery. Curr Pharm Des (2007) 1.05

Increased expression of Ca2+-sensitive K+ channels in aorta of hypertensive rats. Hypertension (1997) 1.03

Incorporation of calcium channels from cardiac sarcolemmal membrane vesicles into planar lipid bilayers. Proc Natl Acad Sci U S A (1986) 1.03

Binding of correolide to the K(v)1.3 potassium channel: characterization of the binding domain by site-directed mutagenesis. Biochemistry (2001) 1.02

Characterization of high affinity binding sites for charybdotoxin in sarcolemmal membranes from bovine aortic smooth muscle. Evidence for a direct association with the high conductance calcium-activated potassium channel. J Biol Chem (1989) 1.01

Synthesis and structural characterization of charybdotoxin, a potent peptidyl inhibitor of the high conductance Ca2(+)-activated K+ channel. J Biol Chem (1990) 1.01

Potassium channels: from scorpion venoms to high-resolution structure. Toxicon (2001) 0.99

Binding of Ca2+ entry blockers to cardiac sarcolemmal membrane vesicles. Characterization of diltiazem-binding sites and their interaction with dihydropyridine and aralkylamine receptors. J Biol Chem (1986) 0.99

Glucocorticoid regulation of calcium-activated potassium channels mediated by serine/threonine protein phosphatase. J Biol Chem (1998) 0.98

Pharyngeal constriction in elderly dysphagic patients compared with young and elderly nondysphagic controls. Dysphagia (2001) 0.98

The role of sodium-calcium exchange in excitable cells. Biochem Soc Trans (1988) 0.97

Pharmacology of potassium channels. Adv Pharmacol (1997) 0.97

High affinity interaction of mibefradil with voltage-gated calcium and sodium channels. Br J Pharmacol (2000) 0.97

Mechanism of lactose transport in Escherichia coli membrane vesicles: evidence for the involvement of histidine residue(s) in the response of the lac carrier to the proton electrochemical gradient. Biochemistry (1982) 0.97

A light stabilizer (Tinuvin 770) that elutes from polypropylene plastic tubes is a potent L-type Ca(2+)-channel blocker. Proc Natl Acad Sci U S A (1993) 0.97