Published in Nature on November 22, 1985
Correcting single channel data for missed events. Biophys J (1986) 6.06
Quantitative description of three modes of activity of fast chloride channels from rat skeletal muscle. J Physiol (1986) 5.52
Allosteric gating of a large conductance Ca-activated K+ channel. J Gen Physiol (1997) 3.57
Intrinsic voltage dependence and Ca2+ regulation of mslo large conductance Ca-activated K+ channels. J Gen Physiol (1997) 3.54
Kinetic states and modes of single large-conductance calcium-activated potassium channels in cultured rat skeletal muscle. J Physiol (1988) 3.48
Accounting for the Ca(2+)-dependent kinetics of single large-conductance Ca(2+)-activated K+ channels in rat skeletal muscle. J Physiol (1991) 2.95
Voltage and Ca2+ activation of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism. J Gen Physiol (2000) 2.41
Estimating kinetic parameters for single channels with simulation. A general method that resolves the missed event problem and accounts for noise. Biophys J (1990) 2.36
Gating kinetics of single large-conductance Ca2+-activated K+ channels in high Ca2+ suggest a two-tiered allosteric gating mechanism. J Gen Physiol (1999) 2.35
Gating mechanism of BK (Slo1) channels: so near, yet so far. J Gen Physiol (2003) 2.31
Activation of N-methyl-D-aspartate receptors by L-glutamate in cells dissociated from adult rat hippocampus. J Physiol (1992) 2.24
Testing for microscopic reversibility in the gating of maxi K+ channels using two-dimensional dwell-time distributions. Biophys J (1994) 2.16
Fractal models are inadequate for the kinetics of four different ion channels. Biophys J (1988) 2.06
Divalent cation activation and inhibition of single calcium release channels from sheep cardiac sarcoplasmic reticulum. J Gen Physiol (1990) 2.02
Kinetic time constants independent of previous single-channel activity suggest Markov gating for a large conductance Ca-activated K channel. J Gen Physiol (1989) 1.81
Glutamate receptor channel kinetics: the effect of glutamate concentration. Biophys J (1988) 1.79
Kinetic structure of large-conductance Ca2+-activated K+ channels suggests that the gating includes transitions through intermediate or secondary states. A mechanism for flickers. J Gen Physiol (1998) 1.74
Gating kinetics of batrachotoxin-modified Na+ channels in the squid giant axon. Voltage and temperature effects. Biophys J (1992) 1.44
Adjacent interval analysis distinguishes among gating mechanisms for the fast chloride channel from rat skeletal muscle. J Physiol (1989) 1.40
Intra- and intersubunit cooperativity in activation of BK channels by Ca2+. J Gen Physiol (2006) 1.39
Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound. J Gen Physiol (2002) 1.22
Single ion channel models incorporating aggregation and time interval omission. Biophys J (1993) 1.17
Continuum model of voltage-dependent gating. Macroscopic conductance, gating current, and single-channel behavior. Biophys J (1989) 1.13
Single-channel autocorrelation functions: the effects of time interval omission. Biophys J (1988) 1.12
Two-dimensional components and hidden dependencies provide insight into ion channel gating mechanisms. Biophys J (1997) 1.11
What can one learn from two-state single-molecule trajectories? Biophys J (2005) 1.11
Markovian models of low and high activity levels of cardiac ryanodine receptors. Biophys J (2001) 1.04
Markov, fractal, diffusion, and related models of ion channel gating. A comparison with experimental data from two ion channels. Biophys J (1989) 1.04
The use of dwell time cross-correlation functions to study single-ion channel gating kinetics. Biophys J (1988) 1.02
Fractal models, Markov models, and channel kinetics. Biophys J (1989) 1.01
Glutamate receptor-channel gating. Maximum likelihood analysis of gigaohm seal recordings from locust muscle. Biophys J (1990) 0.97
Gbetagamma binding increases the open time of IKACh: kinetic evidence for multiple Gbetagamma binding sites. Biophys J (1999) 0.96
Voltage- and cold-dependent gating of single TRPM8 ion channels. J Gen Physiol (2011) 0.95
Time-dependent molecular memory in single voltage-gated sodium channel. J Membr Biol (2007) 0.95
G-protein-gated TRP-like cationic channel activated by muscarinic receptors: effect of potential on single-channel gating. J Gen Physiol (2004) 0.93
Mechanism of maxi-K channel activation by dehydrosoyasaponin-I. J Gen Physiol (1998) 0.91
Single-channel kinetics of BK (Slo1) channels. Front Physiol (2015) 0.82
Periodic forcing of a K+ channel at various temperatures. Biophys J (1994) 0.81
Quinine blockade of currents through Ca2+-activated K+ channels in bovine chromaffin cells. J Physiol (1988) 0.80
Properties of single NMDA receptor channels in human dentate gyrus granule cells. J Physiol (1999) 0.76
Non-markovian gating of ca(2+)-activated k(+) channels in cultured kidney cells vero. Rescaled range analysis. J Biol Phys (1999) 0.75
A quantitative description of end-plate currents. J Physiol (1972) 11.27
Properties of single calcium-activated potassium channels in cultured rat muscle. J Physiol (1982) 8.59
The effect of voltage on the time course of end-plate currents. J Physiol (1972) 8.24
Correcting single channel data for missed events. Biophys J (1986) 6.06
Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture. Nature (1981) 5.65
Quantitative description of three modes of activity of fast chloride channels from rat skeletal muscle. J Physiol (1986) 5.52
Calcium dependence of open and shut interval distributions from calcium-activated potassium channels in cultured rat muscle. J Physiol (1983) 4.70
Ion conductance and selectivity of single calcium-activated potassium channels in cultured rat muscle. J Gen Physiol (1984) 3.94
Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle. Nature (1986) 3.91
Sampling, log binning, fitting, and plotting durations of open and shut intervals from single channels and the effects of noise. Pflugers Arch (1987) 3.67
Burst kinetics of single calcium-activated potassium channels in cultured rat muscle. J Physiol (1983) 3.62
Kinetic states and modes of single large-conductance calcium-activated potassium channels in cultured rat skeletal muscle. J Physiol (1988) 3.48
Accounting for the Ca(2+)-dependent kinetics of single large-conductance Ca(2+)-activated K+ channels in rat skeletal muscle. J Physiol (1991) 2.95
Factors affecting the time course of decay of end-plate currents: a possible cooperative action of acetylcholine on receptors at the frog neuromuscular junction. J Physiol (1975) 2.68
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry (1994) 2.51
Voltage and Ca2+ activation of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism. J Gen Physiol (2000) 2.41
Gating kinetics of single large-conductance Ca2+-activated K+ channels in high Ca2+ suggest a two-tiered allosteric gating mechanism. J Gen Physiol (1999) 2.35
High-conductance calcium-activated potassium channels; structure, pharmacology, and function. J Bioenerg Biomembr (1996) 2.31
Testing for microscopic reversibility in the gating of maxi K+ channels using two-dimensional dwell-time distributions. Biophys J (1994) 2.16
Fractal models are inadequate for the kinetics of four different ion channels. Biophys J (1988) 2.06
A study of desensitization of acetylcholine receptors using nerve-released transmitter in the frog. J Physiol (1981) 1.88
The effect of repetitive stimulation on facilitation of transmitter release at the frog neuromuscular junction. J Physiol (1973) 1.88
Kinetic time constants independent of previous single-channel activity suggest Markov gating for a large conductance Ca-activated K channel. J Gen Physiol (1989) 1.81
Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J Immunol (1997) 1.80
The beta subunit increases the Ca2+ sensitivity of large conductance Ca2+-activated potassium channels by retaining the gating in the bursting states. J Gen Physiol (1999) 1.80
Single voltage-dependent chloride-selective channels of large conductance in cultured rat muscle. Biophys J (1983) 1.78
Kinetic structure of large-conductance Ca2+-activated K+ channels suggests that the gating includes transitions through intermediate or secondary states. A mechanism for flickers. J Gen Physiol (1998) 1.74
Functional coupling of the beta(1) subunit to the large conductance Ca(2+)-activated K(+) channel in the absence of Ca(2+). Increased Ca(2+) sensitivity from a Ca(2+)-independent mechanism. J Gen Physiol (2000) 1.67
Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology (1996) 1.64
Gating scheme for single GABA-activated Cl- channels determined from stability plots, dwell-time distributions, and adjacent-interval durations. J Neurosci (1989) 1.60
Augmentation: A process that acts to increase transmitter release at the frog neuromuscular junction. J Physiol (1976) 1.59
A quantitative description of tetanic and post-tetanic potentiation of transmitter release at the frog neuromuscular junction. J Physiol (1975) 1.58
Opening and closing transitions for BK channels often occur in two steps via sojourns through a brief lifetime subconductance state. Biophys J (1993) 1.55
Oxidative regulation of large conductance calcium-activated potassium channels. J Gen Physiol (2001) 1.54
Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle. J Biol Chem (1994) 1.54
Single chloride-selective channels active at resting membrane potentials in cultured rat skeletal muscle. Biophys J (1985) 1.46
Testing for detailed balance (microscopic reversibility in ion channel gating. Biophys J (2001) 1.41
Adjacent interval analysis distinguishes among gating mechanisms for the fast chloride channel from rat skeletal muscle. J Physiol (1989) 1.40
Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle. Biochemistry (1992) 1.40
A dual effect of repetitive stimulation on post-tetanic potentiation of transmitter release at the frog neuromuscular junction. J Physiol (1975) 1.39
The effect of tetanic and post-tetanic potentiation on facilitation of transmitter release at the frog neuromuscular junction. J Physiol (1973) 1.38
Augmentation and facilitation of transmitter release. A quantitative description at the frog neuromuscular junction. J Gen Physiol (1982) 1.34
Changes in miniature endplate potential frequency during repetitive nerve stimulation in the presence of Ca2+, Ba2+, and Sr2+ at the frog neuromuscular junction. J Gen Physiol (1981) 1.30
Differential effects of Ba2+, Sr2+, and Ca2+ on stimulation-induced changes in transmitter release at the frog neuromuscular junction. J Gen Physiol (1980) 1.27
Nickel and calcium ions modify the characteristics of the acetylcholine receptor-channel complex at the frog neuromuscular junction. J Physiol (1980) 1.22
High Ca2+ concentrations induce a low activity mode and reveal Ca2(+)-independent long shut intervals in BK channels from rat muscle. J Physiol (1996) 1.22
Wanderlust kinetics and variable Ca(2+)-sensitivity of Drosophila, a large conductance Ca(2+)-activated K+ channel, expressed in oocytes. Biophys J (1996) 1.21
Long term changes in augmentation, potentiation, and depression of transmitter release as a function of repeated synaptic activity at the frog neuromuscular junction. J Physiol (1976) 1.21
A quantitative description of stimulation-induced changes in transmitter release at the frog neuromuscular junction. J Gen Physiol (1982) 1.19
Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels. Cell Immunol (1999) 1.19
The effect of (+)-tubocurarine on neuromuscular transmission during repetitive stimulation in the rat, mouse, and frog. J Physiol (1981) 1.19
Synthetic charybdotoxin-iberiotoxin chimeric peptides define toxin binding sites on calcium-activated and voltage-dependent potassium channels. Biochemistry (1993) 1.17
Facilitation, augmentation, and potentiation of synaptic transmission at the superior cervical ganglion of the rabbit. J Gen Physiol (1980) 1.13
Voltage-dependent gating mechanism for single fast chloride channels from rat skeletal muscle. J Physiol (1992) 1.12
Two-dimensional components and hidden dependencies provide insight into ion channel gating mechanisms. Biophys J (1997) 1.11
Preventing errors when estimating single channel properties from the analysis of current fluctuations. Biophys J (1993) 1.10
Is the quantum of transmitter release composed of subunits? A critical analysis in the mouse and frog. J Physiol (1981) 1.06
Automated electrophysiology in drug discovery. Curr Pharm Des (2007) 1.05
Membrane-pipette interactions underlie delayed voltage activation of mechanosensitive channels in Xenopus oocytes. Biophys J (1999) 1.04
Voltage-induced membrane displacement in patch pipettes activates mechanosensitive channels. Proc Natl Acad Sci U S A (1999) 1.03
Fractal models, Markov models, and channel kinetics. Biophys J (1989) 1.01
Gating and conductance properties of BK channels are modulated by the S9-S10 tail domain of the alpha subunit. A study of mSlo1 and mSlo3 wild-type and chimeric channels. J Gen Physiol (2001) 0.99
Potassium channels: from scorpion venoms to high-resolution structure. Toxicon (2001) 0.99
Ion channels. Preventing artifacts and reducing errors in single-channel analysis. Methods Enzymol (1992) 0.99
Voltage-induced slow activation and deactivation of mechanosensitive channels in Xenopus oocytes. J Physiol (1997) 0.98
Transmitter release during repetitive stimulation: selective changes produced by Sr2+ and Ba2+. Science (1977) 0.98
Facilitation, augmentation, and potentiation of transmitter release. Prog Brain Res (1979) 0.93
Voltage dependence and stability of the gating kinetics of the fast chloride channel from rat skeletal muscle. J Physiol (1990) 0.92
Time-irreversible subconductance gating associated with Ba2+ block of large conductance Ca2+-activated K+ channels. J Gen Physiol (1998) 0.91
Wanderlust kinetics and variable Ca(2+)-sensitivity of dSlo [correction of Drosophila], a large conductance CA(2+)-activated K+ channel, expressed in oocytes. Biophys J (1996) 0.91
Mechanism of maxi-K channel activation by dehydrosoyasaponin-I. J Gen Physiol (1998) 0.91
Asymmetric proton block of inward rectifier K channels in skeletal muscle. Pflugers Arch (1984) 0.91
Is the quantum of transmitter release composed of subunits? Nature (1978) 0.91
Two-dimensional kinetic analysis suggests nonsequential gating of mechanosensitive channels in Xenopus oocytes. Biophys J (2001) 0.88
Ca2+-dependent gating mechanisms for dSlo, a large-conductance Ca2+-activated K+ (BK) channel. Biophys J (1999) 0.88
Molecular analysis of two cytochrome P450 monooxygenase genes required for paxilline biosynthesis in Penicillium paxilli, and effects of paxilline intermediates on mammalian maxi-K ion channels. Mol Genet Genomics (2003) 0.88
Recording from calcium-activated potassium channels. Methods Enzymol (1992) 0.87
Investigating single-channel gating mechanisms through analysis of two-dimensional dwell-time distributions. Methods Enzymol (1998) 0.85
Peptides isolated from the venom of Conus geographus block neuromuscular transmission. Neurosci Lett (1981) 0.85
Block of neuronal fast chloride channels by internal tetraethylammonium ions. J Gen Physiol (1994) 0.83
Stimulation-induced factors which affect augmentation and potentiation of trasmitter release at the neuromuscular junction. J Physiol (1976) 0.83
Voltage-dependent block of fast chloride channels from rat cortical neurons by external tetraethylammonium ion. J Gen Physiol (1992) 0.83
Block of neuronal chloride channels by tetraethylammonium ion derivatives. J Gen Physiol (1995) 0.80
Postsynaptic block of frog neuromuscular transmission by conotoxin GI. J Neurosci (1985) 0.77
Beating the odds with Big K. Science (1999) 0.76
Subtypes of substantia nigra dopaminergic neurons revealed by apamin: autoradiographic and electrophysiological studies. Brain Res Bull (1992) 0.76
Purification and functional reconstitution of high-conductance calcium-activated potassium channel from smooth muscle. Methods Enzymol (1999) 0.75