Published in Circ Res on February 18, 2000
Nitric oxide synthases: regulation and function. Eur Heart J (2011) 4.71
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov (2011) 3.08
Antioxidants in Translational Medicine. Antioxid Redox Signal (2015) 2.32
Nitric oxide and oxidative stress in vascular disease. Pflugers Arch (2010) 2.29
NADPH oxidases and angiotensin II receptor signaling. Mol Cell Endocrinol (2008) 2.22
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab (2010) 2.09
Chemistry and antihypertensive effects of tempol and other nitroxides. Pharmacol Rev (2008) 1.91
NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation. Circulation (2011) 1.68
eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. J Endocrinol (2011) 1.60
Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. Am J Pathol (2007) 1.52
T cell activation-induced mitochondrial hyperpolarization is mediated by Ca2+- and redox-dependent production of nitric oxide. J Immunol (2003) 1.39
Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia. Cancer Cell (2017) 1.38
Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow. Am J Pathol (2007) 1.28
Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (2003) 1.26
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Atherosclerosis (2007) 1.24
Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1. Circ Res (2008) 1.24
Early determinants of H2O2-induced endothelial dysfunction. Free Radic Biol Med (2006) 1.22
Beneficial effects of antioxidants and L-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress. Proc Natl Acad Sci U S A (2003) 1.16
NAD(P)H oxidase-derived peroxide mediates elevated basal and impaired flow-induced NO production in SHR mesenteric arteries in vivo. Am J Physiol Heart Circ Physiol (2008) 1.14
Oxidative stress in hypertension: role of the kidney. Antioxid Redox Signal (2013) 1.13
Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol. PLoS One (2011) 1.12
Exercise in the metabolic syndrome. Oxid Med Cell Longev (2012) 1.11
Activation of vascular endothelial nitric oxide synthase and heme oxygenase-1 expression by electrophilic nitro-fatty acids. Free Radic Biol Med (2009) 1.06
Reactive oxygen species and redox-regulation of skeletal muscle adaptations to exercise. Philos Trans R Soc Lond B Biol Sci (2005) 1.06
Tetrahydrobiopterin in cardiovascular health and disease. Antioxid Redox Signal (2014) 1.04
Ethanol metabolism and effects: nitric oxide and its interaction. Curr Clin Pharmacol (2007) 1.04
Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats. Cardiovasc Diabetol (2008) 1.03
Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity. Am J Physiol Lung Cell Mol Physiol (2008) 1.02
Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response. Free Radic Biol Med (2007) 1.00
Long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke. Mediators Inflamm (2013) 0.99
Hydrogen peroxide modulates the Kv1.5 channel expressed in a mammalian cell line. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.99
Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription. J Biol Chem (2008) 0.98
Serum amyloid A induces endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol (2008) 0.98
Natural antioxidants and hypertension: promise and challenges. Cardiovasc Ther (2010) 0.98
Hydrogen peroxide signaling in vascular endothelial cells. Redox Biol (2014) 0.97
The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages. Free Radic Res (2006) 0.97
Perspectives of Targeting mTORC1-S6K1 in Cardiovascular Aging. Front Physiol (2012) 0.97
20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt. Am J Physiol Lung Cell Mol Physiol (2010) 0.96
A novel role for caveolin-1 in regulating endothelial nitric oxide synthase activation in response to H2O2 and shear stress. Free Radic Biol Med (2010) 0.95
Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1. Free Radic Biol Med (2007) 0.95
Chronic ethanol ingestion increases nitric oxide production in the lung. Alcohol (2007) 0.93
Sexual dimorphism in reduced-size liver ischemia and reperfusion injury in mice: role of endothelial cell nitric oxide synthase. Proc Natl Acad Sci U S A (2003) 0.92
Critical role of endothelial hydrogen peroxide in post-ischemic neovascularization. PLoS One (2013) 0.92
Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1. Hypertension (2010) 0.91
Which NADPH oxidase isoform is relevant for ischemic stroke? The case for nox 2. Antioxid Redox Signal (2012) 0.91
PPARγ ligands regulate NADPH oxidase, eNOS, and barrier function in the lung following chronic alcohol ingestion. Alcohol Clin Exp Res (2011) 0.89
Hydrogen peroxide affects contractile activity and anti-oxidant enzymes in rat uterus. Br J Pharmacol (2009) 0.89
Piper sarmentosum increases nitric oxide production in oxidative stress: a study on human umbilical vein endothelial cells. Clinics (Sao Paulo) (2010) 0.88
Oxygen cycling in conjunction with stem cell transplantation induces NOS3 expression leading to attenuation of fibrosis and improved cardiac function. Cardiovasc Res (2011) 0.88
Abnormal nitric oxide production in aged rat mesenteric arteries is mediated by NAD(P)H oxidase-derived peroxide. Am J Physiol Heart Circ Physiol (2009) 0.87
Chronic ethanol ingestion increases aortic endothelial nitric oxide synthase expression and nitric oxide production in the rat. Alcohol Clin Exp Res (2007) 0.87
Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension. Am J Physiol Heart Circ Physiol (2012) 0.86
Impaired regulation of neuronal nitric oxide synthase and heart rate during exercise in mice lacking one nNOS allele. J Physiol (2004) 0.85
Salidroside exerts angiogenic and cytoprotective effects on human bone marrow-derived endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK signalling pathways. Br J Pharmacol (2014) 0.85
Aberrant production of extracellular matrix proteins and dysfunction in kidney endothelial cells with a short duration of diabetes. Am J Physiol Renal Physiol (2012) 0.84
NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice. Eur Heart J (2015) 0.84
Chronic cadmium treatment promotes oxidative stress and endothelial damage in isolated rat aorta. PLoS One (2013) 0.84
Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity. DNA Cell Biol (2009) 0.83
Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction. Biomed Res Int (2014) 0.83
NADPH oxidase-derived reactive oxygen species contribute to impaired cutaneous microvascular function in chronic kidney disease. Am J Physiol Renal Physiol (2014) 0.83
Exercise and the cardiovascular system. Cardiol Res Pract (2012) 0.83
Pharmacological induction of vascular extracellular superoxide dismutase expression in vivo. J Cell Mol Med (2008) 0.81
Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42). PLoS One (2013) 0.81
Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice. J Neurochem (2015) 0.81
NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species. Oxid Med Cell Longev (2015) 0.80
Nox2 and p47(phox) modulate compensatory growth of primary collateral arteries. Am J Physiol Heart Circ Physiol (2014) 0.80
Exercise and the aging endothelium. J Diabetes Res (2013) 0.80
Comparisons between perivascular adipose tissue and the endothelium in their modulation of vascular tone. Br J Pharmacol (2016) 0.80
Role of rutin on nitric oxide synthesis in human umbilical vein endothelial cells. ScientificWorldJournal (2014) 0.79
Endothelial nitric oxide synthase in the microcirculation. Cell Mol Life Sci (2015) 0.79
Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices. Exp Cell Res (2012) 0.79
Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress. Am J Physiol Heart Circ Physiol (2015) 0.79
Altered Nitric Oxide System in Cardiovascular and Renal Diseases. Chonnam Med J (2016) 0.79
Exercise and NO production: relevance and implications in the cardiopulmonary system. Front Cell Dev Biol (2015) 0.78
Different impacts of cardiovascular risk factors on oxidative stress. Int J Mol Sci (2011) 0.78
The antihypertensive effect of cysteine. Int J Angiol (2009) 0.77
Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress. J Biol Chem (2016) 0.77
Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167. Free Radic Biol Med (2013) 0.77
Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension. Int J Biol Sci (2014) 0.77
Redox-sensitive up-regulation of eNOS by purple grape juice in endothelial cells: role of PI3-kinase/Akt, p38 MAPK, JNK, FoxO1 and FoxO3a. PLoS One (2013) 0.77
PGC-1α dictates endothelial function through regulation of eNOS expression. Sci Rep (2016) 0.77
Variations in Antioxidant Genes and Male Infertility. Biomed Res Int (2015) 0.77
Oxidative Stress and Hypertensive Diseases. Med Clin North Am (2016) 0.75
The Contrary Impact Of Diabetes And Exercise On Endothelial Nitric Oxide Synthase Function. Webmedcentral (2010) 0.75
Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity. Physiol Rep (2015) 0.75
Application of a nitric oxide sensor in biomedicine. Biosensors (Basel) (2014) 0.75
The role of nitric oxide in Doxorubicin-induced cardiotoxicity: experimental study. Turk J Haematol (2014) 0.75
Endothelial mechanotransduction proteins and vascular function are altered by dietary sucrose supplementation in healthy young male subjects. J Physiol (2017) 0.75
Regulation of iNOS-Derived ROS Generation by HSP90 and Cav-1 in Porcine Reproductive and Respiratory Syndrome Virus-Infected Swine Lung Injury. Inflammation (2017) 0.75
Endothelial dysfunction in cardiovascular disease and Flammer syndrome-similarities and differences. EPMA J (2017) 0.75
The influence of vitamin C on the interaction between acute mental stress and endothelial function. Eur J Appl Physiol (2017) 0.75
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res (2000) 10.95
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest (1996) 6.38
Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest (1993) 4.70
Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature (1990) 4.28
Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res (2001) 3.89
Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell (1993) 3.68
Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest (1996) 3.64
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation (2001) 3.54
Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation (1997) 3.28
Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1. Mol Cell Biol (1997) 2.99
Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance. J Clin Invest (1995) 2.94
Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy. Hypertension (1998) 2.70
Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res (1996) 2.43
Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol Cell Biol (1990) 2.42
Does visual interpretation of the coronary arteriogram predict the physiologic importance of a coronary stenosis? N Engl J Med (1984) 2.34
Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates. Circ Res (1986) 2.11
Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest (1992) 2.10
Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. Circulation (1999) 2.05
p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ Res (1997) 2.04
Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest (1990) 1.99
The calcium content of human erythrocytes. J Physiol (1968) 1.97
Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. Arterioscler Thromb Vasc Biol (1997) 1.96
Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol (1995) 1.93
Transcription initiation by RNA polymerase II in vitro. Properties of preinitiation, initiation, and elongation complexes. J Biol Chem (1987) 1.93
Simulation of enzyme-substrate encounter with gated active sites. Nat Struct Biol (1994) 1.93
Conversion of a dorsal-dependent silencer into an enhancer: evidence for dorsal corepressors. EMBO J (1993) 1.88
Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress. Circ Res (2001) 1.87
Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt. Circulation (2000) 1.87
Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli. Proc Natl Acad Sci U S A (1995) 1.85
Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. Circ Res (1991) 1.83
Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training. J Clin Invest (2000) 1.81
Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required. Biochem Pharmacol (1991) 1.81
Gating of the active site of triose phosphate isomerase: Brownian dynamics simulations of flexible peptide loops in the enzyme. Biophys J (1993) 1.80
A first-generation whole genome-radiation hybrid map spanning the mouse genome. Genome Res (1997) 1.73
Experimental studies, old and new, on menstrual toxin. J Comp Psychol (1934) 1.72
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J Biol Chem (2001) 1.67
Diffusion-controlled enzymatic reactions. Methods Enzymol (1991) 1.66
THE RESUSCITATION OF NEWLY-BORN BABIES SHOWING NARCOSIS. Can Med Assoc J (1933) 1.66
Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci U S A (1996) 1.64
Posttranscriptional regulation of endothelial nitric oxide synthase during cell growth. Circ Res (1999) 1.60
Estrogens and the aging process. The detection, prevention, and retardation of osteoporosis. JAMA (1966) 1.57
A QRS scoring system for assessing left ventricular function after myocardial infarction. N Engl J Med (1982) 1.55
Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: contributions of NOS isoforms to blood pressure and heart rate control. Cardiovasc Res (1999) 1.54
Rethrombosis after reperfusion with streptokinase: importance of geometry of residual lesions. Circulation (1984) 1.51
Transcription initiation by RNA polymerase II in vitro. At least two nucleotides must be added to form a stable ternary complex. J Biol Chem (1987) 1.49
Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol. Oncogene (1992) 1.48
The clinical use of oral basal temperatures. J Am Med Assoc (1946) 1.47
Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug. J Clin Invest (1996) 1.46
New class of polymers for the delivery of macromolecular therapeutics. Bioconjug Chem (2000) 1.43
Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity. Am J Physiol (1991) 1.43
Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature: A potential link between the renin-angiotensin system and atherosclerosis. Circulation (1999) 1.40
The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17. Mol Cell Biol (1993) 1.39
Late glacial stage and holocene tropical ice core records from huascaran, peru. Science (1995) 1.39
The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells. Leukemia (2004) 1.38
The L-isoaspartyl protein repair methyltransferase enhances survival of aging Escherichia coli subjected to secondary environmental stresses. J Bacteriol (1998) 1.37
Visual estimates of percent diameter coronary stenosis: "a battered gold standard". J Am Coll Cardiol (1988) 1.36
Activated c-Ha-ras oncogene with a guanine to thymine transversion at the twelfth codon in a human stomach cancer cell line. Cancer Res (1987) 1.35
Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways. Circ Res (2001) 1.34
Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation. Cell Mol Life Sci (2006) 1.32
Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota. Gut (2010) 1.31
Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells. Circ Res (1996) 1.29
Epidemiology of systemic lupus erythematosus in rural Wisconsin. Lupus (2005) 1.27
Alterations in the coronary circulation in hypertrophied ventricles. Circulation (1987) 1.25
Vascular expression of extracellular superoxide dismutase in atherosclerosis. J Clin Invest (1998) 1.25
Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability. J Clin Invest (1995) 1.25
Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension. Circ Res (1999) 1.24
Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates. Nucleic Acids Res (1998) 1.23
Base mispair extension kinetics. Binding of avian myeloblastosis reverse transcriptase to matched and mismatched base pair termini. J Biol Chem (1992) 1.22
Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide production. Biochem Biophys Res Commun (1999) 1.22
Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women. J Med Genet (2008) 1.22
Oxidation of indole by cytochrome P450 enzymes. Biochemistry (2000) 1.21
hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations. Br J Cancer (2010) 1.19
Electron spin resonance characterization of the NAD(P)H oxidase in vascular smooth muscle cells. Free Radic Biol Med (2001) 1.19
Induction of endothelial NO synthase by hydrogen peroxide via a Ca(2+)/calmodulin-dependent protein kinase II/janus kinase 2-dependent pathway. Arterioscler Thromb Vasc Biol (2001) 1.18
Poisson-Boltzmann analysis of the lambda repressor-operator interaction. Biophys J (1992) 1.17
Annually resolved ice core records of tropical climate variability over the past ~1800 years. Science (2013) 1.17
Role for endothelin-1 in angiotensin II-mediated hypertension. Hypertension (1997) 1.17
Identification, characterization, and comparison of the calmodulin-binding domains of the endothelial and inducible nitric oxide synthases. J Biol Chem (1996) 1.15
Molecular regulation of the bovine endothelial cell nitric oxide synthase by transforming growth factor-beta 1. Arterioscler Thromb Vasc Biol (1995) 1.15
Chemical stability of artesunate injection and proposal for its administration by intravenous infusion. J Pharm Pharmacol (1996) 1.15
Release of NO and EDRF from cultured bovine aortic endothelial cells. Am J Physiol (1989) 1.15
Fast-track surgery improves postoperative recovery in patients undergoing partial hepatectomy for primary liver cancer: A prospective randomized controlled trial. Eur J Surg Oncol (2013) 1.13
Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance. Proc Natl Acad Sci U S A (1995) 1.11
Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy. Cell Death Differ (2009) 1.10
Effects of structure of beta-cyclodextrin-containing polymers on gene delivery. Bioconjug Chem (2001) 1.10
L-arginine does not restore endothelial dysfunction in atherosclerotic rabbit aorta in vitro. Blood Vessels (1991) 1.09
Regulation of endothelial nitric oxide synthase mRNA, protein, and activity during cell growth. Am J Physiol (1994) 1.09
Role of the enzyme calmodulin-binding domain in membrane association and phospholipid inhibition of endothelial nitric oxide synthase. J Biol Chem (1995) 1.09
Hemodynamics and vascular endothelial biology. J Cardiovasc Pharmacol (1993) 1.08
Holocene--late pleistocene climatic ice core records from qinghai-tibetan plateau. Science (1989) 1.07
Dysfunctional regulation of endothelial nitric oxide synthase (eNOS) expression in response to exercise in mice lacking one eNOS gene. Circulation (2001) 1.06