Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice.

PubWeight™: 2.09‹?› | Rank: Top 2%

🔗 View Article (PMC 3020149)

Published in Cell Metab on May 05, 2010

Authors

Christian Rask-Madsen1, Qian Li, Bryn Freund, Danielle Feather, Roman Abramov, I-Hsien Wu, Kai Chen, Junko Yamamoto-Hiraoka, Jan Goldenbogen, Konstantinos B Sotiropoulos, Allen Clermont, Pedro Geraldes, Claudia Dall'Osso, Amy J Wagers, Paul L Huang, Mark Rekhter, Rosario Scalia, C Ronald Kahn, George L King

Author Affiliations

1: Research Division, Joslin Diabetes Center, Boston, MA 02215, USA.

Articles citing this

Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab (2011) 2.47

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Eur Heart J (2013) 2.02

Protein kinase C-β contributes to impaired endothelial insulin signaling in humans with diabetes mellitus. Circulation (2012) 1.88

Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms. J Endocrinol (2014) 1.76

Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab (2013) 1.51

Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature. Am J Physiol Endocrinol Metab (2011) 1.48

FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab (2012) 1.46

Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arterioscler Thromb Vasc Biol (2012) 1.28

Vascular effects of exercise: endothelial adaptations beyond active muscle beds. Physiology (Bethesda) (2011) 1.24

Variation in Type 2 Diabetes-Related Phenotypes among Apolipoprotein E-Deficient Mouse Strains. PLoS One (2015) 1.13

Insulin resistance: metabolic mechanisms and consequences in the heart. Arterioscler Thromb Vasc Biol (2012) 1.11

Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide. Rev Endocr Metab Disord (2013) 1.08

Targeting inflammation in diabetes: Newer therapeutic options. World J Diabetes (2014) 1.08

Opportunity "nox": a novel approach to preventing endothelial dysfunction in the context of insulin resistance. Diabetes (2013) 1.05

The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases. Endocr Rev (2012) 1.04

The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: an update. Basic Res Cardiol (2011) 1.03

Changing the way we think about endothelial cell insulin sensitivity, nitric oxide, and the pathophysiology of type 2 diabetes: the FoxO is loose. Diabetes (2013) 1.02

Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium. Circ Res (2013) 1.02

New perspectives on diabetic vascular complications: the loss of endogenous protective factors induced by hyperglycemia. Diabetes Metab J (2011) 0.98

Mechanisms of lipotoxicity in the cardiovascular system. Curr Hypertens Rep (2012) 0.98

Inflammation and oxidative stress in diabetic nephropathy: new insights on its inhibition as new therapeutic targets. J Diabetes Res (2013) 0.97

Enhanced inflammatory responses to toll-like receptor 2/4 stimulation in type 1 diabetic coronary artery endothelial cells: the effect of insulin. Cardiovasc Diabetol (2010) 0.97

Molecular Basis of Insulin Resistance: The Role of IRS and Foxo1 in the Control of Diabetes Mellitus and Its Complications. Drug Discov Today Dis Mech (2013) 0.97

Urinary miR-29 correlates with albuminuria and carotid intima-media thickness in type 2 diabetes patients. PLoS One (2013) 0.94

Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem (2011) 0.93

Insulin resistance, metabolic stress, and atherosclerosis. Front Biosci (Schol Ed) (2012) 0.93

Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol (2013) 0.92

Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1. Arterioscler Thromb Vasc Biol (2011) 0.91

Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice. Circ Res (2013) 0.91

Global gene expression profiling displays a network of dysregulated genes in non-atherosclerotic arterial tissue from patients with type 2 diabetes. Cardiovasc Diabetol (2012) 0.91

The endothelial cell: an "early responder" in the development of insulin resistance. Rev Endocr Metab Disord (2013) 0.90

Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene. J Biol Chem (2012) 0.90

Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance. Diabetes (2013) 0.89

Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials (2010) 0.88

Incretin hormones as immunomodulators of atherosclerosis. Front Endocrinol (Lausanne) (2012) 0.86

Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol (2012) 0.86

Insulin-regulated protein palmitoylation impacts endothelial cell function. Arterioscler Thromb Vasc Biol (2013) 0.86

PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates. Am J Physiol Cell Physiol (2011) 0.85

The endothelium in diabetes: its role in insulin access and diabetic complications. Rev Endocr Metab Disord (2013) 0.85

Protein kinase C inhibition ameliorates functional endothelial insulin resistance and vascular smooth muscle cell hypersensitivity to insulin in diabetic hypertensive rats. Cardiovasc Diabetol (2011) 0.84

Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin. Am J Physiol Endocrinol Metab (2013) 0.84

MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue. Circ Res (2016) 0.84

Clinical Update: Cardiovascular Disease in Diabetes Mellitus: Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes Mellitus - Mechanisms, Management, and Clinical Considerations. Circulation (2016) 0.84

Role of oxidative stress in endothelial insulin resistance. World J Diabetes (2015) 0.83

Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture. Diabetes (2016) 0.83

Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance. Atherosclerosis (2012) 0.83

Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis. Arterioscler Thromb Vasc Biol (2011) 0.83

Evidence stacks up that endothelial insulin resistance is a culprit in atherosclerosis. Circ Res (2013) 0.82

Uncomplicating the Macrovascular Complications of Diabetes: The 2014 Edwin Bierman Award Lecture. Diabetes (2015) 0.81

Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells. Diabetes (2016) 0.81

2013 Russell Ross memorial lecture in vascular biology: cellular and molecular mechanisms of diabetes mellitus-accelerated atherosclerosis. Arterioscler Thromb Vasc Biol (2014) 0.81

Ceacam1 deletion causes vascular alterations in large vessels. Am J Physiol Endocrinol Metab (2013) 0.81

Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. FASEB J (2014) 0.80

Insulin decreases atherosclerosis by inducing endothelin receptor B expression. JCI Insight (2016) 0.80

Possible role of fibroblast growth factor 21 on atherosclerosis via amelioration of endoplasmic reticulum stress-mediated apoptosis in apoE(-/-) mice. Heart Vessels (2014) 0.80

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol (2016) 0.80

Treating Diabetes with Exercise - Focus on the Microvasculature. J Diabetes Metab (2013) 0.80

Insulin Enhances Endothelial Function Throughout the Arterial Tree in Healthy But Not Metabolic Syndrome Subjects. J Clin Endocrinol Metab (2016) 0.80

Effect of PIP3 on adhesion molecules and adhesion of THP-1 monocytes to HUVEC treated with high glucose. Cell Physiol Biochem (2014) 0.79

Lysophosphatidic acid-induced vascular neointimal formation in mouse carotid arteries is mediated by the matricellular protein CCN1/Cyr61. Am J Physiol Cell Physiol (2016) 0.78

Endothelium-dependent delivery of insulin to muscle interstitium. Cell Metab (2011) 0.78

The dipeptidyl peptidase-4 inhibitor sitagliptin protects against dyslipidemia-related kidney injury in Apolipoprotein E knockout mice. Int J Mol Sci (2014) 0.78

Lipids and the endothelium: bidirectional interactions. Curr Atheroscler Rep (2013) 0.78

Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells. J Biol Chem (2015) 0.78

Vascular function, insulin action, and exercise: an intricate interplay. Trends Endocrinol Metab (2015) 0.77

Arterial insulin resistance in Yucatan micropigs with diet-induced obesity and metabolic syndrome. J Diabetes Complications (2013) 0.77

Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice. Arterioscler Thromb Vasc Biol (2012) 0.76

Role of habitual physical activity in modulating vascular actions of insulin. Exp Physiol (2015) 0.76

Endothelial Cell Surface Expressed Chemotaxis and Apoptosis Regulator (ECSCR) Regulates Lipolysis in White Adipocytes via the PTEN/AKT Signaling Pathway. PLoS One (2015) 0.75

Microvascular management of systemic insulin sensitivity. Circ Res (2012) 0.75

Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance. Diabetes (2016) 0.75

Cardiac aging and insulin resistance: could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target? Curr Pharm Des (2013) 0.75

Overweight status is associated with extensive signs of microvascular dysfunction and cardiovascular risk. Sci Rep (2016) 0.75

Letter by Rask-Madsen et al Regarding Article, "Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop". Circ Res (2017) 0.75

Selective Insulin Resistance in the Kidney. Biomed Res Int (2016) 0.75

Hemodynamic actions of insulin: beyond the endothelium. Front Physiol (2013) 0.75

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE(-/-) mouse model of atherosclerosis with alterations in IL10/AMPKα pathway. Mol Metab (2017) 0.75

Insulin resistance in vascular endothelial cells promotes intestinal tumour formation. Oncogene (2017) 0.75

Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice. Proc Natl Acad Sci U S A (2017) 0.75

Articles cited by this

Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol (2001) 10.32

Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem (1999) 5.66

Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med (1996) 5.20

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest (1995) 5.09

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest (1996) 4.98

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem (1999) 3.95

Insulin sensitivity and atherosclerosis. The Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Circulation (1996) 3.88

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest (1994) 3.49

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest (1999) 3.18

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab (2006) 3.14

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest (1996) 2.82

Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab (2007) 2.53

Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab (2007) 2.48

Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest (2006) 2.40

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation (2000) 2.18

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest (2003) 2.11

Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest (2007) 2.03

Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res (2000) 1.99

Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J Immunol (2007) 1.79

Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. Am J Physiol (1999) 1.72

Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes (2006) 1.71

Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells. Circ Res (1996) 1.70

The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest (2007) 1.67

Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci U S A (1996) 1.64

Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res (2009) 1.60

Effect of endothelium-specific insulin resistance on endothelial function in vivo. Diabetes (2008) 1.52

Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells. Arterioscler Thromb Vasc Biol (2000) 1.50

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab (2006) 1.50

Insulin stimulates both endothelin and nitric oxide activity in the human forearm. Circulation (1999) 1.48

Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses. J Cell Biol (1998) 1.43

Stimulation of endothelin-1 gene expression by insulin in endothelial cells. J Biol Chem (1991) 1.34

Simvastatin exerts both anti-inflammatory and cardioprotective effects in apolipoprotein E-deficient mice. Circulation (2001) 1.34

Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study. Diabetes (2000) 1.27

Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease. Diabetes (2001) 1.25

Elevated ambient glucose induces acute inflammatory events in the microvasculature: effects of insulin. Am J Physiol Endocrinol Metab (2001) 1.23

A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression. J Biol Chem (2006) 1.10

Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem (2008) 1.05

Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J Clin Endocrinol Metab (2000) 1.05

Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen-activated protein-kinase. Diabetologia (2004) 1.04

Molecular mechanisms of atherosclerosis in metabolic syndrome: role of reduced IRS2-dependent signaling. Arterioscler Thromb Vasc Biol (2008) 0.95

Chemical analysis of atherosclerotic plaque cholesterol combined with histology of the same tissue. J Lipid Res (2008) 0.94

Atherosclerosis in diabetes and insulin resistance. Diabetes Obes Metab (2007) 0.93

High insulin exacerbates neutrophil-endothelial cell adhesion through endothelial surface expression of intercellular adhesion molecule-1 via activation of protein kinase C and mitogen-activated protein kinase. Diabetologia (2002) 0.91

Augmentation of arterial endothelial cell expression of the plasminogen activator inhibitor type-1 (PAI-1) gene by proinsulin and insulin in vivo. J Mol Cell Cardiol (1998) 0.89

Genotype-specific transcriptional regulation of PAI-1 gene by insulin, hypertriglyceridemic VLDL, and Lp(a) in transfected, cultured human endothelial cells. Arterioscler Thromb Vasc Biol (1998) 0.86

Articles by these authors

Identification and importance of brown adipose tissue in adult humans. N Engl J Med (2009) 20.57

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10

Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature (2005) 11.23

Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol (2006) 10.67

Ferroelectric metal-organic framework with a high dielectric constant. J Am Chem Soc (2006) 9.51

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24

Developmental origin of fat: tracking obesity to its source. Cell (2007) 8.80

Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature (2004) 8.36

Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab (2008) 7.97

Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol (2002) 7.78

In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat Nanotechnol (2006) 6.93

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature (2008) 6.82

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48

Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell (2013) 6.35

Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A (2005) 6.32

Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med (2005) 5.68

Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett (2006) 5.63

Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc Natl Acad Sci U S A (2007) 5.36

Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Cell (2004) 5.20

Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A (2009) 5.19

Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell (2007) 5.17

Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab (2008) 5.07

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell (2002) 5.01

Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. Cell (2008) 4.92

Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci U S A (2006) 4.81

Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature (2009) 4.68

Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature (2012) 4.64

From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol (2006) 4.58

Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci U S A (2003) 4.41

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35

Retinopathy in diabetes. Diabetes Care (2004) 4.25

Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov (2010) 4.23

Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA (2002) 4.18

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature (2002) 3.92

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82

A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol (2004) 3.79

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab (2007) 3.69

Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med (2008) 3.66

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci U S A (2010) 3.54

Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell (2005) 3.52

Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Cell (2012) 3.50

miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med (2010) 3.50

Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res (2008) 3.47

No place like home: anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol (2008) 3.46

Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci U S A (2007) 3.40

Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science (2014) 3.37

Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab (2006) 3.34

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33

Endocrine regulation of ageing. Nat Rev Mol Cell Biol (2007) 3.28

Roundup: a multi-genome repository of orthologs and evolutionary distances. Bioinformatics (2006) 3.28

Retracted Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Nature (2010) 3.21

Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol (2004) 3.18

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci U S A (2010) 3.16

US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. Radiology (2008) 3.15

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science (2014) 3.14

A special population of regulatory T cells potentiates muscle repair. Cell (2013) 3.09

Retracted Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J Biol Chem (2003) 3.06

Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metab (2010) 3.05

Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations. J Immunol (2008) 3.04

Nitrolinoleic acid: an endogenous peroxisome proliferator-activated receptor gamma ligand. Proc Natl Acad Sci U S A (2005) 3.03

Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med (2002) 2.96

Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes (2010) 2.94

Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell (2012) 2.91

The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells. Cell Stem Cell (2008) 2.88

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest (2003) 2.87

Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res (2010) 2.87

Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature. J Nucl Med (2007) 2.86

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med (2012) 2.86

Retracted Osteolineage niche cells initiate hematopoietic stem cell mobilization. Blood (2008) 2.84

Prevalence of calcidiol deficiency in CKD: a cross-sectional study across latitudes in the United States. Am J Kidney Dis (2005) 2.82

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab (2006) 2.82

Decoy state quantum key distribution. Phys Rev Lett (2005) 2.77

PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. J Nucl Med (2008) 2.77

The emerging genetic architecture of type 2 diabetes. Cell Metab (2008) 2.77

Dysregulation of HSG triggers vascular proliferative disorders. Nat Cell Biol (2004) 2.75

Adiponectin: A novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab (2004) 2.74

Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes (2005) 2.72

Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol (2005) 2.68

Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics (2012) 2.66

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest (2002) 2.65

In vivo imaging of proteolytic activity in atherosclerosis. Circulation (2002) 2.62

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest (2004) 2.56

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci U S A (2004) 2.54

Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes (2004) 2.54

Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A (2004) 2.54

Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nat Med (2007) 2.54

Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest (2002) 2.53

(64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression. J Nucl Med (2007) 2.50

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A (2001) 2.49

Phlorizin: a review. Diabetes Metab Res Rev (2005) 2.48

Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab (2007) 2.48

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell (2013) 2.46

Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction. Circulation (2005) 2.45

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab (2012) 2.43