A novel role for caveolin-1 in regulating endothelial nitric oxide synthase activation in response to H2O2 and shear stress.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMC 3815623)

Published in Free Radic Biol Med on March 29, 2010

Authors

Jing Tian1, Yali Hou, Qing Lu, Dean A Wiseman, Fabio Vasconcelos Fonsesca, Shawn Elms, David J Fulton, Stephen M Black

Author Affiliations

1: Pulmonary Vascular Disease Program, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA.

Articles citing this

eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. J Endocrinol (2011) 1.60

Apolipoprotein E enhances endothelial-NO production by modulating caveolin 1 interaction with endothelial NO synthase. Hypertension (2012) 1.49

Role of reactive oxygen and nitrogen species in the vascular responses to inflammation. Free Radic Biol Med (2011) 1.17

Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow. Antioxid Redox Signal (2013) 0.94

Asymmetric dimethylarginine induces endothelial nitric-oxide synthase mitochondrial redistribution through the nitration-mediated activation of Akt1. J Biol Chem (2012) 0.92

Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase. Am J Respir Cell Mol Biol (2014) 0.90

Placenta growth factor expression is regulated by hydrogen peroxide in vascular smooth muscle cells. Am J Physiol Cell Physiol (2010) 0.80

Specific visualization of nitric oxide in the vasculature with two-photon microscopy using a copper based fluorescent probe. PLoS One (2013) 0.79

Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb. Trends Cardiovasc Med (2010) 0.78

Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167. Free Radic Biol Med (2013) 0.77

Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells. Am J Respir Cell Mol Biol (2016) 0.75

Orthostatic Challenge Shifts the Hemostatic System of Patients Recovered from Stroke toward Hypercoagulability. Front Physiol (2017) 0.75

Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells. Sci Rep (2015) 0.75

Articles cited by this

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (1987) 35.44

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A (1987) 14.22

Flow-mediated endothelial mechanotransduction. Physiol Rev (1995) 10.13

Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science (2001) 8.53

The multiple faces of caveolae. Nat Rev Mol Cell Biol (2007) 6.85

Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev (2008) 5.74

Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol (1999) 4.70

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem (1997) 4.12

TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol (2005) 3.92

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A (1996) 3.83

Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem (1997) 3.80

Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae. J Biol Chem (1996) 3.75

Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann N Y Acad Sci (2000) 3.70

Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem (1996) 3.62

Caveolae: where incoming and outgoing messengers meet. Proc Natl Acad Sci U S A (1993) 3.53

In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nat Med (2000) 3.37

Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol (2004) 3.27

VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro. Mol Biol Cell (1995) 3.05

Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J Biol Chem (1996) 3.01

Tyrosine phosphorylation of a 22-kDa protein is correlated with transformation by Rous sarcoma virus. J Biol Chem (1989) 2.86

Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences. Cardiovasc Res (2005) 2.80

Regulation of endothelial nitric oxide synthase: location, location, location. Annu Rev Physiol (2002) 2.79

Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin. J Biol Chem (1997) 2.76

The Caveolin genes: from cell biology to medicine. Ann Med (2004) 2.68

Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. J Clin Invest (2006) 2.47

Caveolin regulation of endothelial function. Am J Physiol Lung Cell Mol Physiol (2003) 2.22

Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue. Am J Physiol Cell Physiol (2003) 2.06

Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases. Am J Physiol Cell Physiol (2003) 2.00

Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res (2000) 1.99

Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem (2001) 1.99

The endothelial nitric-oxide synthase-caveolin regulatory cycle. J Biol Chem (1998) 1.91

Cholesterol and fatty acids regulate dynamic caveolin trafficking through the Golgi complex and between the cell surface and lipid bodies. Mol Biol Cell (2005) 1.86

Cellular regulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol (2001) 1.77

Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proc Natl Acad Sci U S A (2004) 1.75

Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation. J Biol Chem (1999) 1.66

Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro. Am J Physiol Heart Circ Physiol (2003) 1.47

Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1. J Biol Chem (2003) 1.46

Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells. Am J Physiol Heart Circ Physiol (2003) 1.43

Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide. Am J Physiol Lung Cell Mol Physiol (2004) 1.42

Endothelium-derived nitric oxide and vascular physiology and pathology. Cell Mol Life Sci (1999) 1.41

Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide. Mol Pharmacol (2003) 1.41

Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein. Circ Res (1993) 1.38

Subcellular targeting and trafficking of nitric oxide synthases. Biochem J (2006) 1.37

Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction. Am J Physiol Cell Physiol (2008) 1.35

Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90. Am J Physiol Lung Cell Mol Physiol (2007) 1.35

Shear stress induction of the tissue factor gene. J Clin Invest (1997) 1.35

Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem (2003) 1.22

Altered endothelial nitric oxide synthase targeting and conformation and caveolin-1 expression in the diabetic kidney. Diabetes (2006) 1.22

Induction of endothelial NO synthase by hydrogen peroxide via a Ca(2+)/calmodulin-dependent protein kinase II/janus kinase 2-dependent pathway. Arterioscler Thromb Vasc Biol (2001) 1.18

Exercise, vascular wall and cardiovascular diseases: an update (Part 1). Sports Med (2008) 1.15

Aberrant dysferlin trafficking in cells lacking caveolin or expressing dystrophy mutants of caveolin-3. Hum Mol Genet (2005) 1.14

Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting. Proc Natl Acad Sci U S A (1995) 1.10

The double regulation of endothelial nitric oxide synthase by caveolae and caveolin: a paradox solved through the study of angiogenesis. Trends Cardiovasc Med (2005) 1.08

Caveolin-dependent angiotensin II type 1 receptor signaling in vascular smooth muscle. Hypertension (2006) 1.07

The caveolar paradox: suppressing, inducing, and terminating eNOS signaling. Circ Res (2001) 1.06

Endothelial nitric oxide synthase activity is linked to its presence at cell-cell contacts. Biochem J (2002) 1.05

Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity. Am J Physiol Lung Cell Mol Physiol (2008) 1.02

Disruption of endothelial caveolae is associated with impairment of both NO- as well as EDHF in acetylcholine-induced relaxation depending on their relative contribution in different vascular beds. Life Sci (2007) 0.87

Myristoylation of endothelial cell nitric oxide synthase is important for extracellular release of nitric oxide. Mol Cell Biochem (1995) 0.86

Role of caveolin-1 in the regulation of the vascular shear stress response. J Clin Invest (2006) 0.84

Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity. DNA Cell Biol (2009) 0.83

Articles by these authors

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev (2011) 3.15

Choosing an optimal method to combine P-values. Stat Med (2009) 3.15

Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80

The clinical value of diffusion-weighted imaging in combination with T2-weighted imaging in diagnosing prostate carcinoma: a systematic review and meta-analysis. AJR Am J Roentgenol (2012) 2.51

Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function. Endocrinology (2014) 2.17

Analysis of copy number variations among diverse cattle breeds. Genome Res (2010) 2.02

Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase. Circ Res (2003) 2.01

Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency. Blood (2002) 1.96

Regulators of endothelial and epithelial barrier integrity and function in acute lung injury. Biochem Pharmacol (2009) 1.85

Vascular disease in mice with a dysfunctional circadian clock. Circulation (2009) 1.82

S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity. Proc Natl Acad Sci U S A (2004) 1.79

The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation. Crit Care Med (2010) 1.78

Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury. Circulation (2012) 1.78

Loss of methyl-CpG-binding domain protein 2 enhances endothelial angiogenesis and protects mice against hind-limb ischemic injury. Circulation (2011) 1.74

Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. Circulation (2009) 1.70

Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am J Physiol Lung Cell Mol Physiol (2006) 1.64

Copy number variation of individual cattle genomes using next-generation sequencing. Genome Res (2012) 1.62

eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. J Endocrinol (2011) 1.60

A long noncoding RNA regulates photoperiod-sensitive male sterility, an essential component of hybrid rice. Proc Natl Acad Sci U S A (2012) 1.59

Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study. Am J Hypertens (2012) 1.51

Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs. Pediatr Crit Care Med (2004) 1.48

Endothelial nitric oxide (NO) and its pathophysiologic regulation. Vascul Pharmacol (2008) 1.45

Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide. Am J Physiol Lung Cell Mol Physiol (2004) 1.42

Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes. Hum Hered (2006) 1.41

Left ventricular apical aneurysm associated with normal coronary arteries following cardiac surgery: echocardiographic features and differential diagnosis. Int J Cardiol (2013) 1.39

Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol (2005) 1.37

Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction. Am J Physiol Cell Physiol (2008) 1.35

Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90. Am J Physiol Lung Cell Mol Physiol (2007) 1.35

Regional homogeneity in depression and its relationship with separate depressive symptom clusters: a resting-state fMRI study. J Affect Disord (2008) 1.35

HISTONE DEACETYLASE6 interacts with FLOWERING LOCUS D and regulates flowering in Arabidopsis. Plant Physiol (2011) 1.30

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest (2014) 1.26

Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1. Am J Physiol Lung Cell Mol Physiol (2003) 1.25

Anatomic and functional evaluation of the lymphatics and lymph nodes in diagnosis of lymphatic circulation disorders with contrast magnetic resonance lymphangiography. J Vasc Surg (2009) 1.25

Alterations in zinc homeostasis underlie endothelial cell death induced by oxidative stress from acute exposure to hydrogen peroxide. Am J Physiol Lung Cell Mol Physiol (2006) 1.24

Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2007) 1.20

Pseudoaneurysm of the mitral-aortic intervalvular fibrosa. Int J Cardiol (2012) 1.19

Endothelial response to stress from exogenous Zn2+ resembles that of NO-mediated nitrosative stress, and is protected by MT-1 overexpression. Am J Physiol Cell Physiol (2006) 1.16

Activation of constitutive nitric-oxide synthase activity is an early signaling event induced by ionizing radiation. J Biol Chem (2002) 1.15

Pressed for time: the circadian clock and hypertension. J Appl Physiol (1985) (2009) 1.15

A randomized control trial on interruption of HBV transmission in uterus. Chin Med J (Engl) (2003) 1.15

Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain. Proc Natl Acad Sci U S A (2011) 1.15

The Arabidopsis BRAHMA chromatin-remodeling ATPase is involved in repression of seed maturation genes in leaves. Plant Physiol (2008) 1.13

Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation. J Biol Chem (2005) 1.13

Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone. Circ Res (2009) 1.13

Cytokeratin 10 and cytokeratin 19: predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection. Clin Cancer Res (2008) 1.13

Detecting genetic interactions for quantitative traits with U-statistics. Genet Epidemiol (2011) 1.13

eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally. Am J Physiol Lung Cell Mol Physiol (2005) 1.11

Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. Am J Physiol Lung Cell Mol Physiol (2008) 1.10

Role of reactive oxygen species in vascular remodeling associated with pulmonary hypertension. Antioxid Redox Signal (2003) 1.10

HD2C interacts with HDA6 and is involved in ABA and salt stress response in Arabidopsis. J Exp Bot (2012) 1.09

Transcriptional profiling of mammary gland in Holstein cows with extremely different milk protein and fat percentage using RNA sequencing. BMC Genomics (2014) 1.09

Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia. PLoS One (2011) 1.09

Hydrogen sulphide regulates calcium homeostasis in microglial cells. Glia (2006) 1.09

The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol (2007) 1.08

Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther (2010) 1.08

Nitric oxide decreases endothelin-1 secretion through the activation of soluble guanylate cyclase. Am J Physiol Lung Cell Mol Physiol (2003) 1.07

A regularized regression approach for dissecting genetic conflicts that increase disease risk in pregnancy. Stat Appl Genet Mol Biol (2009) 1.07

Developmental changes in murine brain antioxidant enzymes. Pediatr Res (2003) 1.06

Reactive oxygen species in pulmonary vascular remodeling. Compr Physiol (2013) 1.06

Tyrosine nitration of IkappaBalpha: a novel mechanism for NF-kappaB activation. Biochemistry (2007) 1.05

The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition. Vascul Pharmacol (2010) 1.04

PKCdelta regulates endothelial basal barrier function through modulation of RhoA GTPase activity. Exp Cell Res (2005) 1.03

Pharmacology and signaling properties of epidermal growth factor receptor isoforms studied by bioluminescence resonance energy transfer. Mol Pharmacol (2006) 1.03

Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension. Physiol Genomics (2009) 1.02

Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation. Free Radic Biol Med (2012) 1.02

SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases. Arterioscler Thromb Vasc Biol (2011) 1.02

Comparative study of the anatomy, CT and MR images of the lateral collateral ligaments of the ankle joint. Surg Radiol Anat (2008) 1.02

Increased NADPH oxidase-derived superoxide is involved in the neuronal cell death induced by hypoxia-ischemia in neonatal hippocampal slice cultures. Free Radic Biol Med (2012) 1.02

Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-beta1 and reactive oxygen species: a requirement for NAD(P)H oxidase. Am J Physiol Lung Cell Mol Physiol (2005) 1.02

Gene expression in archived newborn blood spots distinguishes infants who will later develop cerebral palsy from matched controls. Pediatr Res (2012) 1.02

Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity. Am J Physiol Lung Cell Mol Physiol (2008) 1.02

Real-time 3-dimensional echocardiography in assessing atrial and ventricular septal defects: an echocardiographic-surgical correlative study. Am Heart J (2004) 1.01

SPARC ameliorates ovarian cancer-associated inflammation. Neoplasia (2008) 1.01

SPARC inhibits LPA-mediated mesothelial-ovarian cancer cell crosstalk. Neoplasia (2007) 1.01

Model for mapping imprinted quantitative trait loci in an inbred F2 design. Genomics (2006) 1.01

Harvesting, identification and barrier function of human lung microvascular endothelial cells. Vascul Pharmacol (2010) 1.01

Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2003) 1.00

Detection in 2009 of the swine origin influenza A (H1N1) virus by a subtyping microarray. J Clin Microbiol (2009) 1.00

Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb. Am J Physiol Lung Cell Mol Physiol (2005) 1.00

The affected-/discordant-sib-pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibrium. Am J Hum Genet (2006) 1.00

Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2003) 1.00

Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. Mol Biol Cell (2003) 0.99

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Am J Respir Cell Mol Biol (2012) 0.99

Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice. Circ Res (2012) 0.99

Cutaneous angiosarcoma of the head and neck: a case presentation and review of the literature. Ear Nose Throat J (2006) 0.99

High-density lipoprotein increases the abundance of eNOS protein in human vascular endothelial cells by increasing its half-life. J Am Coll Cardiol (2003) 0.98

Methylation signature of lymph node metastases in breast cancer patients. BMC Cancer (2012) 0.98

Modeling extent and distribution of zygotic disequilibrium: implications for a multigenerational canine pedigree. Genetics (2006) 0.97

Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis. Proc Natl Acad Sci U S A (2011) 0.97

Calcium/calmodulin-dependent kinase II mediates the phosphorylation and activation of NADPH oxidase 5. Mol Pharmacol (2011) 0.97

A non-parametric method for building predictive genetic tests on high-dimensional data. Hum Hered (2011) 0.96