Published in Genesis on February 01, 2000
A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res (2003) 12.94
Genetic dissection of neural circuits. Neuron (2008) 7.97
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development (2002) 5.09
Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res (2005) 4.08
Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes. Proc Natl Acad Sci U S A (2002) 3.01
Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia. Dev Biol (2007) 2.48
Enhanced efficiency through nuclear localization signal fusion on phage PhiC31-integrase: activity comparison with Cre and FLPe recombinase in mammalian cells. Nucleic Acids Res (2002) 2.14
IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A (2004) 2.12
Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest (2011) 2.09
In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis (2005) 2.08
BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biol (2004) 2.05
Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. J Clin Invest (2007) 2.04
Molecular neuroanatomy's "Three Gs": a primer. Neuron (2007) 1.91
Dissecting neural function using targeted genome engineering technologies. ACS Chem Neurosci (2012) 1.89
Directed evolution of the site specificity of Cre recombinase. Proc Natl Acad Sci U S A (2002) 1.77
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest (2008) 1.76
MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol (2010) 1.75
Cre-lox-based system for multiple gene deletions and selectable-marker removal in Lactobacillus plantarum. Appl Environ Microbiol (2006) 1.70
Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development. Dev Biol (2007) 1.67
Long-term survival of influenza virus infected club cells drives immunopathology. J Exp Med (2014) 1.64
Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function. J Neurosci (2011) 1.60
Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis. Am J Physiol Cell Physiol (2013) 1.57
Regulation of Cre recombinase by ligand-induced complementation of inactive fragments. Nucleic Acids Res (2003) 1.57
Strategies to achieve conditional gene mutation in mice. Cold Spring Harb Protoc (2014) 1.54
Telomere length influences cancer cell differentiation in vivo. Mol Cell Biol (2013) 1.52
Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep (2000) 1.44
Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Res (2005) 1.41
Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination. Mol Cell Biol (2004) 1.40
Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus Macaques. Cell (2016) 1.39
Analysis of kinesin-2 function in photoreceptor cells using synchronous Cre-loxP knockout of Kif3a with RHO-Cre. Invest Ophthalmol Vis Sci (2006) 1.38
Chimeric recombinases with designed DNA sequence recognition. Proc Natl Acad Sci U S A (2003) 1.35
Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice. J Clin Invest (2010) 1.30
Live-imaging fluorescent proteins in mouse embryos: multi-dimensional, multi-spectral perspectives. Trends Biotechnol (2009) 1.25
c-Kit-mediated functional positioning of stem cells to their niches is essential for maintenance and regeneration of adult hematopoiesis. PLoS One (2011) 1.24
Multiple new site-specific recombinases for use in manipulating animal genomes. Proc Natl Acad Sci U S A (2011) 1.23
Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance. Bone (2009) 1.23
Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production. Am J Physiol Heart Circ Physiol (2009) 1.22
Cre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles. Nucleic Acids Res (2003) 1.21
Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells. Proc Natl Acad Sci U S A (2008) 1.21
Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by exercise to facilitate nerve regeneration. J Neurosci (2012) 1.19
Split-cre complementation indicates coincident activity of different genes in vivo. PLoS One (2009) 1.19
Inducible gene inactivation in neurons of the adult mouse forebrain. BMC Neurosci (2007) 1.19
Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development. Int J Biol Sci (2006) 1.18
The order of strand exchanges in Cre-LoxP recombination and its basis suggested by the crystal structure of a Cre-LoxP Holliday junction complex. J Mol Biol (2002) 1.16
Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi. BMC Dev Biol (2005) 1.16
A practical approach to using mice in atherosclerosis research. Clin Biochem Rev (2004) 1.16
Androgens and spermatogenesis: lessons from transgenic mouse models. Philos Trans R Soc Lond B Biol Sci (2010) 1.16
Moderate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death. Dis Model Mech (2013) 1.16
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest (2010) 1.15
Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle. Dev Biol (2012) 1.15
Homozygous carnitine palmitoyltransferase 1b (muscle isoform) deficiency is lethal in the mouse. Mol Genet Metab (2007) 1.15
Exploiting the keratin 17 gene promoter to visualize live cells in epithelial appendages of mice. Mol Cell Biol (2005) 1.14
Completion of the swine genome will simplify the production of swine as a large animal biomedical model. BMC Med Genomics (2012) 1.14
Loops in DNA: an overview of experimental and theoretical approaches. Eur Phys J E Soft Matter (2006) 1.13
Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol (2009) 1.12
Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J Immunol Methods (2014) 1.11
Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience (2009) 1.11
Genetic mouse models for bone studies--strengths and limitations. Bone (2011) 1.10
Constitutive turnover of cyclin E by Cul3 maintains quiescence. Mol Cell Biol (2007) 1.10
ARS2 is a conserved eukaryotic gene essential for early mammalian development. Mol Cell Biol (2007) 1.10
Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system. Nucleic Acids Res (2004) 1.08
Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform. Proc Natl Acad Sci U S A (2002) 1.08
The a"MAZE"ing world of lung-specific transgenic mice. Am J Respir Cell Mol Biol (2011) 1.07
Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping. PLoS One (2007) 1.07
Silencing inhibits Cre-mediated recombination of the Z/AP and Z/EG reporters in adult cells. PLoS One (2009) 1.05
Tamoxifen-dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbud. Dev Dyn (2009) 1.05
CRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei. Mol Biochem Parasitol (2007) 1.05
Enhanced cell-permeant Cre protein for site-specific recombination in cultured cells. BMC Biotechnol (2004) 1.04
Genetic inactivation of the vesicular glutamate transporter 2 (VGLUT2) in the mouse: what have we learnt about functional glutamatergic neurotransmission? Ups J Med Sci (2010) 1.03
Imaging mouse development with confocal time-lapse microscopy. Methods Enzymol (2010) 1.03
Use of Cre-adenovirus and CAR transgenic mice for efficient deletion of genes in post-thymic T cells. J Immunol Methods (2007) 1.02
The embryonic mouse hindbrain as a qualitative and quantitative model for studying the molecular and cellular mechanisms of angiogenesis. Nat Protoc (2013) 1.02
Generation of a floxed allele of the mouse Endoglin gene. Genesis (2007) 1.02
Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward. Nat Neurosci (2014) 1.02
Tamoxifen-inducible podocyte-specific iCre recombinase transgenic mouse provides a simple approach for modulation of podocytes in vivo. Genesis (2010) 1.01
High-efficient FLPo deleter mice in C57BL/6J background. PLoS One (2009) 1.01
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice. J Clin Invest (2011) 1.00
Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo. RNA (2004) 1.00
Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons. PLoS One (2009) 1.00
Tracking cells in their native habitat: lineage tracing in epithelial neoplasia. Nat Rev Cancer (2013) 1.00
Notch signaling during vascular development. Proc Natl Acad Sci U S A (2001) 0.99
A method for the generation of conditional gene repair mutations in mice. Nucleic Acids Res (2001) 0.99
Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes (2012) 0.99
Conditional transgenesis using Dimerizable Cre (DiCre). PLoS One (2007) 0.98
Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism. Dev Biol (2009) 0.98
Adenovirus-mediated gene delivery into mouse spermatogonial stem cells. Proc Natl Acad Sci U S A (2007) 0.98
15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse. Neuropharmacology (2013) 0.97
Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis. J Biol Chem (2015) 0.97
Promises and pitfalls of a Pannexin1 transgenic mouse line. Front Pharmacol (2013) 0.97
Developmental impact of a familial GABAA receptor epilepsy mutation. Ann Neurol (2008) 0.97
Genetic methods to identify and manipulate newly born neurons in the adult brain. Front Neurosci (2011) 0.97
Pex13 inactivation in the mouse disrupts peroxisome biogenesis and leads to a Zellweger syndrome phenotype. Mol Cell Biol (2003) 0.95
Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse. Am J Pathol (2012) 0.94
Inducible gene trapping with drug-selectable markers and Cre/loxP to identify developmentally regulated genes. Mol Cell Biol (2004) 0.94
Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis (2008) 0.94
Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice. Neurophotonics (2015) 0.94
Bacterial delivery of nuclear proteins into pluripotent and differentiated cells. PLoS One (2011) 0.93
Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes. BMC Biotechnol (2016) 0.93
Expanding the scope of site-specific recombinases for genetic and metabolic engineering. Biotechnol Bioeng (2013) 0.92