BMP receptor signaling is required for postnatal maintenance of articular cartilage.

A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis. Dev Biol (2008) 2.09

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell (2009) 1.67

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res (2010) 1.54

Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass. J Bone Miner Res (2008) 1.54

Joint morphogenetic cells in the adult mammalian synovium. Nat Commun (2017) 1.46

Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury. Arthritis Res Ther (2006) 1.31

Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms. Dev Biol (2007) 1.30

Vertebrate skeletogenesis. Curr Top Dev Biol (2010) 1.30

Genetic control of programmed cell death during animal development. Annu Rev Genet (2009) 1.24

The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling. J Clin Invest (2007) 1.19

Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb. Development (2009) 1.18

Identification of a Prg4-expressing articular cartilage progenitor cell population in mice. Arthritis Rheumatol (2015) 1.13

Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells. Lab Invest (2011) 1.13

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. EMBO J (2009) 1.13

Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling. Arthritis Res Ther (2007) 1.12

Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol (2010) 1.08

TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. J Bone Miner Res (2010) 1.08

Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling. Ann N Y Acad Sci (2007) 1.01

Gene expression analyses of subchondral bone in early experimental osteoarthritis by microarray. PLoS One (2012) 1.00

A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis. Biomaterials (2011) 0.99

BMP signalling in skeletal development, disease and repair. Nat Rev Endocrinol (2016) 0.97

Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. Dev Biol (2010) 0.96

Distinct roles and regulations for HoxD genes in metanephric kidney development. PLoS Genet (2007) 0.96

BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures. J Cell Physiol (2008) 0.95

Col2a1 lineage tracing reveals that the meniscus of the knee joint has a complex cellular origin. J Anat (2008) 0.94

Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis. Dev Biol (2015) 0.93

Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation. Development (2015) 0.92

New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies. Biofactors (2011) 0.91

Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses. Dev Biol (2013) 0.91

Genesis and morphogenesis of limb synovial joints and articular cartilage. Matrix Biol (2014) 0.89

BMPRIA mediated signaling is essential for temporomandibular joint development in mice. PLoS One (2014) 0.88

Lineage tracing of resident tendon progenitor cells during growth and natural healing. PLoS One (2014) 0.88

TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone Res (2016) 0.88

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors. Arthritis Res Ther (2013) 0.87

Hox11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements. Development (2010) 0.87

Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice. FASEB J (2016) 0.87

Bone morphogenetic proteins in destructive and remodeling arthritis. Arthritis Res Ther (2007) 0.86

TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. J Cell Sci (2013) 0.86

Genetic evidence of the regulatory role of parathyroid hormone-related protein in articular chondrocyte maintenance in an experimental mouse model. Arthritis Rheum (2011) 0.86

Toward regeneration of articular cartilage. Birth Defects Res C Embryo Today (2013) 0.85

Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys? Arthritis Res Ther (2015) 0.83

Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy: implications for joint remodeling in AS. Arthritis Res Ther (2015) 0.83

Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin. Dev Biol (2014) 0.82

Differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein. Matrix Biol (2007) 0.81

GDF-5 can act as a context-dependent BMP-2 antagonist. BMC Biol (2015) 0.81

Resident mesenchymal progenitors of articular cartilage. Matrix Biol (2014) 0.81

Differential gene expression associated with postnatal equine articular cartilage maturation. BMC Musculoskelet Disord (2008) 0.81

Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development. Histochem Cell Biol (2012) 0.81

Identification of fibroblast growth factor-18 as a molecule to protect adult articular cartilage by gene expression profiling. J Biol Chem (2014) 0.80

Articular Cartilage: Structural and Developmental Intricacies and Questions. Curr Osteoporos Rep (2015) 0.79

Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage. Osteoarthritis Cartilage (2015) 0.79

Correlation of bone morphogenetic protein-2 levels in serum and synovial fluid with disease severity of knee osteoarthritis. Med Sci Monit (2015) 0.78

Dynamics and cellular localization of Bmp2, Bmp4, and Noggin transcription in the postnatal mouse skeleton. J Bone Miner Res (2015) 0.78

Joint Development Involves a Continuous Influx of Gdf5-Positive Cells. Cell Rep (2016) 0.77

Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Ann Rheum Dis (2015) 0.77

How to build an inducible cartilage-specific transgenic mouse. Arthritis Res Ther (2014) 0.77

Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis. J Clin Invest (2016) 0.76

The biological function of type I receptors of bone morphogenetic protein in bone. Bone Res (2016) 0.76

Tamoxifen-dependent, inducible Bmp2CreER drives selective recombinase activity in early interdigital mesenchyme and digit collateral ligaments. PLoS One (2015) 0.76

Prg4-expressing cells: articular stem cells or differentiated progeny in the articular chondrocyte lineage? Arthritis Rheumatol (2015) 0.76

Heads, Shoulders, Elbows, Knees, and Toes: Modular Gdf5 Enhancers Control Different Joints in the Vertebrate Skeleton. PLoS Genet (2016) 0.75

BMP-2 shows characteristic extracellular patterns in osteoarthritic cartilage: a preliminary report. GMS Interdiscip Plast Reconstr Surg DGPW (2013) 0.75

Gremlin-1 Concentrations Are Correlated with the Severity of Knee Osteoarthritis. Med Sci Monit (2016) 0.75

Atypical molecular profile for joint development in the avian costal joint. Dev Dyn (2010) 0.75

Aging, osteoarthritis and transforming growth factor-beta signaling in cartilage. Arthritis Res Ther (2006) 0.75

Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints. PLoS One (2016) 0.75

Signaling networks in joint development. Dev Dyn (2016) 0.75

Regenerative medicine: Cartilage stem cells identified, but can they heal? Nat Rev Rheumatol (2017) 0.75

The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications. Pharmaceuticals (Basel) (2017) 0.75

The human genome browser at UCSC. Genome Res (2002) 168.23

Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science (1996) 8.14

Sox9 is required for cartilage formation. Nat Genet (1999) 7.89

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev (1995) 7.13

Z/AP, a double reporter for cre-mediated recombination. Dev Biol (1999) 6.88

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet (2001) 6.36

Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome. Nat Biotechnol (1997) 6.29

Cre recombinase: the universal reagent for genome tailoring. Genesis (2000) 6.29

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol (1997) 5.72

A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J (1998) 5.15

SOX9 directly regulates the type-II collagen gene. Nat Genet (1997) 4.88

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev (1995) 4.23

The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell (2001) 4.11

Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature (1994) 3.99

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development (1996) 3.91

Genetic influences on osteoarthritis in women: a twin study. BMJ (1996) 3.70

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem (1994) 3.49

Requirement for BMP signaling in interdigital apoptosis and scale formation. Science (1996) 3.40

TGFbeta signaling: receptors, transducers, and Mad proteins. Cell (1996) 3.31

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol (2001) 3.22

SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6. J Biol Chem (2000) 3.20

Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat Genet (1996) 3.11

Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton. Cell (2001) 3.06

Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol (1997) 2.72

Generation of Bmpr/Alk3 conditional knockout mice. Genesis (2002) 2.71

Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev (1997) 2.59

The economic cost and social and psychological impact of musculoskeletal conditions. National Arthritis Data Work Groups. Arthritis Rheum (1995) 2.58

Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc Natl Acad Sci U S A (1996) 2.53

Collagen of articular cartilage. Arthritis Res (2001) 2.47

Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study. Arthritis Rheum (1998) 2.45

Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest (1997) 2.42

Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development (1996) 2.39

The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development (2000) 2.30

The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell (1992) 2.21

Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol (2003) 2.17

Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol Cell Biol (1994) 2.16

Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis. Endocrinology (1995) 2.12

Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. EMBO J (1986) 2.10

Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. J Biol Chem (1994) 2.03

Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Am J Hum Genet (2001) 1.81

BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Development (2001) 1.79

Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene. Nature (1992) 1.74

Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J Biol Chem (1996) 1.72

Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling. Dev Biol (2003) 1.72

Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs. Biochim Biophys Acta (1991) 1.67

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat Genet (1999) 1.67

Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol (2000) 1.63

Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity. Development (2000) 1.62

BMP-2/-4 mediate programmed cell death in chicken limb buds. Development (1996) 1.36

Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: evidence for a locus on 2q. Am J Hum Genet (1999) 1.35

Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes. J Cell Biol (1998) 1.34

Development of the diarthrodial joints in the rat embryo. Am J Anat (1978) 1.34

A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol (2001) 1.27

Familial aggregation of osteoarthritis: data from the Baltimore Longitudinal Study on Aging. Arthritis Rheum (1998) 1.27

Human articular chondrocytes express osteogenic protein-1. J Histochem Cytochem (2000) 1.27

In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb. Dev Biol (2002) 1.27

Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10. Eur J Biochem (1992) 1.23

BMP/GDF-signalling interactions during synovial joint development. Cell Tissue Res (1999) 1.21

Bone morphogenetic proteins in the development and healing of synovial joints. Semin Arthritis Rheum (2001) 1.17

JunB is involved in the inhibition of myogenic differentiation by bone morphogenetic protein-2. J Biol Chem (1998) 1.11

Regulation of osteogenic proteins by chondrocytes. Int J Biochem Cell Biol (2003) 1.10

Molecular structure, processing, and tissue distribution of matrilin-4. J Biol Chem (2001) 1.10

Function of bone morphogenetic protein signaling during mouse development. Front Biosci (2003) 1.09

Association of two loci on chromosome 2q with nodal osteoarthritis. Ann Rheum Dis (1996) 1.08

The effect of osteoarthritis on disability and health care use in Canada. J Rheumatol Suppl (1995) 1.05

Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro. Arthritis Rheum (1998) 1.04

Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis. Osteoarthritis Cartilage (2002) 1.04

Activation of protein kinase A is a pivotal step involved in both BMP-2- and cyclic AMP-induced chondrogenesis. J Cell Physiol (1997) 1.02

Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro. Arthritis Rheum (2003) 1.01

Induction of the Sry-related factor SOX6 contributes to bone morphogenetic protein-2-induced chondroblastic differentiation of C3H10T1/2 cells. Mol Endocrinol (2003) 0.99

Internucleosomal DNA fragmentation and programmed cell death (apoptosis) in the interdigital tissue of the embryonic chick leg bud. J Cell Sci (1993) 0.98

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem Biophys Res Commun (1994) 0.94

Finer linkage mapping of a primary hip osteoarthritis susceptibility locus on chromosome 6. Eur J Hum Genet (2002) 0.93

Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes but not up-regulated or down-regulated in osteoarthritic cartilage. J Bone Miner Res (2002) 0.91

Immunohistochemical localization of osteogenetic protein (OP-1) and its receptors in rabbit articular cartilage. J Histochem Cytochem (2002) 0.89

Identification of the haematopoietic stem cell niche and control of the niche size. Nature (2003) 18.17

Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles. Science (2005) 10.46

Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A (2003) 7.87

Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. Nature (2004) 7.62

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet (2004) 7.37

Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer. Science (2009) 5.64

The genomic basis of adaptive evolution in threespine sticklebacks. Nature (2012) 5.20

BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med (2008) 4.20

Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol (2008) 4.07

Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet (2013) 3.87

cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebacks and humans. Cell (2007) 3.72

The genetic architecture of parallel armor plate reduction in threespine sticklebacks. PLoS Biol (2004) 3.46

Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46

Human-specific loss of regulatory DNA and the evolution of human-specific traits. Nature (2011) 3.30

Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. J Biol Chem (2004) 3.21

Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proc Natl Acad Sci U S A (2002) 2.99

Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor. Circulation (2007) 2.93

The master sex-determination locus in threespine sticklebacks is on a nascent Y chromosome. Curr Biol (2004) 2.90

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A (2005) 2.82

Evidence for ecology's role in speciation. Nature (2004) 2.78

Rapid generation of inducible mouse mutants. Nucleic Acids Res (2003) 2.77

Requirement of Bmpr1a for Müllerian duct regression during male sexual development. Nat Genet (2002) 2.75

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature (2013) 2.70

Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. J Biol Chem (2004) 2.70

Nongenetic method for purifying stem cell-derived cardiomyocytes. Nat Methods (2009) 2.64

Distinct functions for Bmp signaling in lip and palate fusion in mice. Development (2005) 2.46

Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists. Nat Med (2011) 2.40

BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion. Cell Metab (2007) 2.39

BMP signaling and early embryonic patterning. Cytokine Growth Factor Rev (2005) 2.25

BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A (2004) 2.25

Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells. Cell Stem Cell (2013) 2.23

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature (2016) 2.21

Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia. Gastroenterology (2006) 2.21

Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature (2007) 2.21

Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol (2003) 2.17

The genetics of adaptive shape shift in stickleback: pleiotropy and effect size. Evolution (2007) 2.15

Muscle contraction is necessary to maintain joint progenitor cell fate. Dev Cell (2009) 2.09

Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells (2006) 2.09

A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis. Dev Biol (2008) 2.09

Three periods of regulatory innovation during vertebrate evolution. Science (2011) 2.09

Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage. Gastroenterology (2007) 2.07

A role for a neo-sex chromosome in stickleback speciation. Nature (2009) 2.06

SDIR1 is a RING finger E3 ligase that positively regulates stress-responsive abscisic acid signaling in Arabidopsis. Plant Cell (2007) 2.02

MicroRNA 23b regulates autophagy associated with radioresistance of pancreatic cancer cells. Gastroenterology (2013) 2.00

Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation. Microbiome (2013) 1.98

Parallel genetic origins of pelvic reduction in vertebrates. Proc Natl Acad Sci U S A (2006) 1.96

BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. Development (2004) 1.93

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development (2008) 1.86

Highly specific gene silencing by artificial miRNAs in rice. PLoS One (2008) 1.85

Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. Dev Biol (2006) 1.83

Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells. Ann N Y Acad Sci (2004) 1.80

Thymosin alpha1- and ulinastatin-based immunomodulatory strategy for sepsis arising from intra-abdominal infection due to carbapenem-resistant bacteria. J Infect Dis (2008) 1.78

Simultaneous determination of catechins, caffeine and gallic acids in green, Oolong, black and pu-erh teas using HPLC with a photodiode array detector. Talanta (2002) 1.78

ALK1 signaling regulates early postnatal lymphatic vessel development. Blood (2009) 1.76

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family. Mol Cell Biol (2004) 1.73

Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2. Genesis (2006) 1.67

GPR30 does not mediate estrogenic responses in reproductive organs in mice. Biol Reprod (2008) 1.67

Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest. Am J Physiol Heart Circ Physiol (2009) 1.66

Mutations in ANKH cause chondrocalcinosis. Am J Hum Genet (2002) 1.63

Adenovirus-mediated small-interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain. Hypertension (2005) 1.60

BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development (2006) 1.59

Biochemical and genetic analysis of ANK in arthritis and bone disease. Am J Hum Genet (2006) 1.56

Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development (2006) 1.56

Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev (2003) 1.55

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res (2010) 1.54

Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass. J Bone Miner Res (2008) 1.54

Obesity-related glomerulopathy: body mass index and proteinuria. Clin J Am Soc Nephrol (2010) 1.54

A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli. Nat Methods (2007) 1.54

Retroperitoneal laparoscopic anatrophic nephrolithotomy for large staghorn calculi. Int J Urol (2010) 1.53

Role of splanchnic hemodynamics in liver regeneration after living donor liver transplantation. Liver Transpl (2009) 1.53

Expression of PTEN and mTOR in sacral chordoma and association with poor prognosis. Med Oncol (2014) 1.50

Identification of SOX3 as an XX male sex reversal gene in mice and humans. J Clin Invest (2010) 1.50

A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence in sticklebacks. Curr Biol (2011) 1.50

BMP signalling inhibits premature neural differentiation in the mouse embryo. Development (2007) 1.49

BMP signaling is required locally to pattern the dorsal telencephalic midline. Neuron (2002) 1.49

A general approach for identifying distant regulatory elements applied to the Gdf6 gene. Genome Res (2003) 1.49

Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus. Circ Res (2005) 1.48

Integrative genetic analysis of transcription modules: towards filling the gap between genetic loci and inherited traits. Hum Mol Genet (2005) 1.46

Microfluidic chip for low-flow push-pull perfusion sampling in vivo with on-line analysis of amino acids. Anal Chem (2005) 1.45

In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun (2009) 1.44

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci (2011) 1.44

Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism. Proc Natl Acad Sci U S A (2002) 1.42

Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia development by concerted actions of BMP signaling [corrected]. Development (2003) 1.38

SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes. Matrix Biol (2003) 1.37

Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Development (2011) 1.37

Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts. Dev Biol (2006) 1.37

Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. Biomaterials (2011) 1.36

BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling. Development (2007) 1.35

FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development (2009) 1.35

Endothelial cell migration directs testis cord formation. Dev Biol (2008) 1.35

Disruption of a long distance regulatory region upstream of SOX9 in isolated disorders of sex development. J Med Genet (2011) 1.34

The Reference Genome of the Halophytic Plant Eutrema salsugineum. Front Plant Sci (2013) 1.34

Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development (2005) 1.33

M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proc Natl Acad Sci U S A (2012) 1.32

Copy number variation in patients with disorders of sex development due to 46,XY gonadal dysgenesis. PLoS One (2011) 1.32

Identification of amyloid fibril-forming segments based on structure and residue-based statistical potential. Bioinformatics (2007) 1.28

The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation. Dev Biol (2009) 1.25

BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci (2010) 1.22