Published in Proc Natl Acad Sci U S A on August 09, 2011
Genetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron (2011) 2.54
A survey of 6,300 genomic fragments for cis-regulatory activity in the imaginal discs of Drosophila melanogaster. Cell Rep (2012) 1.39
Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system. Proc Natl Acad Sci U S A (2015) 1.09
Cell-type-specific labeling of synapses in vivo through synaptic tagging with recombination. Neuron (2014) 1.02
Neuron hemilineages provide the functional ground plan for the Drosophila ventral nervous system. Elife (2015) 0.98
Vika/vox, a novel efficient and specific Cre/loxP-like site-specific recombination system. Nucleic Acids Res (2012) 0.92
Expanding the scope of site-specific recombinases for genetic and metabolic engineering. Biotechnol Bioeng (2013) 0.92
Motor control of Drosophila courtship song. Cell Rep (2013) 0.92
Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs. Elife (2016) 0.88
Captured segment exchange: a strategy for custom engineering large genomic regions in Drosophila melanogaster. Genetics (2012) 0.85
Genetic dissection of GABAergic neural circuits in mouse neocortex. Front Cell Neurosci (2014) 0.84
Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice. PLoS One (2014) 0.84
Lineage mapping identifies molecular and architectural similarities between the larval and adult Drosophila central nervous system. Elife (2016) 0.84
Enhanced and prolonged baculovirus-mediated expression by incorporating recombinase system and in cis elements: a comparative study. Nucleic Acids Res (2013) 0.83
Binary recombinase systems for high-resolution conditional mutagenesis. Nucleic Acids Res (2014) 0.83
Frazzled promotes growth cone attachment at the source of a Netrin gradient in the Drosophila visual system. Elife (2016) 0.82
SapTrap, a Toolkit for High-Throughput CRISPR/Cas9 Gene Modification in Caenorhabditis elegans. Genetics (2016) 0.82
A universal vector for high-efficiency multi-fragment recombineering of BACs and knock-in constructs. PLoS One (2013) 0.81
Identification of Inhibitory Premotor Interneurons Activated at a Late Phase in a Motor Cycle during Drosophila Larval Locomotion. PLoS One (2015) 0.79
The glia of the adult Drosophila nervous system. Glia (2017) 0.79
Generating customized transgene landing sites and multi-transgene arrays in Drosophila using phiC31 integrase. Genetics (2015) 0.78
Versatile genetic paintbrushes: Brainbow technologies. Wiley Interdiscip Rev Dev Biol (2014) 0.78
Strategies for designing transgenic DNA constructs. Methods Mol Biol (2013) 0.77
Generating mosaics for lineage analysis in flies. Wiley Interdiscip Rev Dev Biol (2013) 0.77
Genome engineering: Drosophila melanogaster and beyond. Wiley Interdiscip Rev Dev Biol (2015) 0.77
Novel Heterotypic Rox Sites for Combinatorial Dre Recombination Strategies. G3 (Bethesda) (2015) 0.77
Tissue-specific tagging of endogenous loci in Drosophila melanogaster. Biol Open (2015) 0.76
Connectomic Analysis of Brain Networks: Novel Techniques and Future Directions. Front Neuroanat (2016) 0.75
Efficient Genome Manipulation by Variants of Site-Specific Recombinases R and TD. J Mol Biol (2015) 0.75
Designed cell consortia as fragrance-programmable analog-to-digital converters. Nat Chem Biol (2017) 0.75
Bxb1 phage recombinase assists genome engineering in Drosophila melanogaster. Biotechniques (2017) 0.75
A Circuit Node that Integrates Convergent Input from Neuromodulatory and Social Behavior-Promoting Neurons to Control Aggression in Drosophila. Neuron (2017) 0.75
CRISPR/Cas9-loxP-Mediated Gene Editing as a Novel Site-Specific Genetic Manipulation Tool. Mol Ther Nucleic Acids (2017) 0.75
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene (1991) 38.64
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol (2004) 36.25
Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron (1999) 17.62
Analysis of genetic mosaics in developing and adult Drosophila tissues. Development (1993) 13.43
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet (2000) 11.80
Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci U S A (1988) 10.90
Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Genetics (2004) 9.98
The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome. Cell (1989) 8.93
Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections. Nat Neurosci (2007) 7.65
Nucleotide sequence of the yeast plasmid. Nature (1980) 7.64
Tissue- and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci U S A (1992) 6.94
Tools for neuroanatomy and neurogenetics in Drosophila. Proc Natl Acad Sci U S A (2008) 6.35
Cre recombinase: the universal reagent for genome tailoring. Genesis (2000) 6.29
The subcellular organization of neocortical excitatory connections. Nature (2009) 5.98
Organizing activity of wingless protein in Drosophila. Cell (1993) 5.65
Efficient gene transfer into the embryonic mouse brain using in vivo electroporation. Dev Biol (2001) 5.64
A phage integrase directs efficient site-specific integration in human cells. Proc Natl Acad Sci U S A (2000) 5.13
Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell (1996) 5.13
Refinement of tools for targeted gene expression in Drosophila. Genetics (2010) 4.53
Mechanisms of site-specific recombination. Annu Rev Biochem (2006) 4.29
Improved properties of FLP recombinase evolved by cycling mutagenesis. Nat Biotechnol (1998) 4.14
Rapid redistribution of synaptic PSD-95 in the neocortex in vivo. PLoS Biol (2006) 4.12
Site-specific transformation of Drosophila via phiC31 integrase-mediated cassette exchange. Genetics (2006) 3.94
Site-specific recombination between homologous chromosomes in Drosophila. Science (1991) 3.70
Vagaries of conditional gene targeting. Nat Immunol (2007) 3.51
Transgene Coplacement and high efficiency site-specific recombination with the Cre/loxP system in Drosophila. Genetics (1996) 3.43
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc Natl Acad Sci U S A (2000) 2.71
Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps. Neuron (2006) 2.18
Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice. Dis Model Mech (2009) 1.97
Flybow: genetic multicolor cell labeling for neural circuit analysis in Drosophila melanogaster. Nat Methods (2011) 1.96
Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet (2003) 1.95
Molecular neuroanatomy's "Three Gs": a primer. Neuron (2007) 1.91
High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. J Neurosci (2006) 1.89
DNA recombination with a heterospecific Cre homolog identified from comparison of the pac-c1 regions of P1-related phages. Nucleic Acids Res (2004) 1.63
The FLP protein of the 2-micron plasmid of yeast. Purification of the protein from Escherichia coli cells expressing the cloned FLP gene. J Biol Chem (1985) 1.59
Molecular and functional organization of yeast plasmid pSR1. J Mol Biol (1985) 1.58
The C terminus of mouse ornithine decarboxylase confers rapid degradation on dihydrofolate reductase. Support for the pest hypothesis. J Biol Chem (1991) 1.44
Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges. J Mol Biol (2011) 1.38
Neuron-specific expression of therapeutic proteins: evaluation of different cellular promoters in recombinant adenoviral vectors. Mol Cell Neurosci (2001) 1.35
Operation of an efficient site-specific recombination system of Zygosaccharomyces rouxii in tobacco cells. Nucleic Acids Res (1991) 1.27
Site-specific recombinases for manipulation of the mouse genome. Methods Mol Biol (2009) 1.23
Yeast plasmids resembling 2 micron DNA: regional similarities and diversities at the molecular level. J Bacteriol (1987) 1.17
Reduction of Cre recombinase toxicity in proliferating Drosophila cells by estrogen-dependent activity regulation. Dev Genes Evol (2001) 1.16
Stepwise manipulation of DNA specificity in Flp recombinase: progressively adapting Flp to individual and combinatorial mutations in its target site. J Mol Biol (2003) 1.15
Site-specific recombinase, R, encoded by yeast plasmid pSR1. J Mol Biol (1992) 1.14
Mammalian genome targeting using site-specific recombinases. Front Biosci (2006) 1.12
The structure of the human synapsin I gene and protein. J Biol Chem (1990) 1.11
Sequence organization of the circular plasmid pKD1 from the yeast Kluyveromyces drosophilarum. Nucleic Acids Res (1986) 1.11
Combinatorial methods for refined neuronal gene targeting. Curr Opin Neurobiol (2007) 1.11
Deoxyribonucleic acid plasmids in yeasts. Microbiol Rev (1989) 1.09
VCre/VloxP and SCre/SloxP: new site-specific recombination systems for genome engineering. Nucleic Acids Res (2011) 1.08
Physical and functional structure of a yeast plasmid, pSB3, isolated from Zygosaccharomyces bisporus. Nucleic Acids Res (1985) 1.02
A circular plasmid from the yeast Torulaspora delbrueckii. Plasmid (1997) 1.02
Plasmids resembling 2-micrometers DNA in the osmotolerant yeasts Saccharomyces bailii and Saccharomyces bisporus. J Gen Microbiol (1984) 0.96
Cre recombinase expression can result in phenotypic aberrations in plants. Plant Mol Biol (2003) 0.90
Generality of the shared active site among yeast family site-specific recombinases. The R site-specific recombinase follows the Flp paradigm [corrected]. J Biol Chem (1994) 0.90
Functions encoded by the yeast plasmid pSB3 isolated from Zygosaccharomyces rouxii IFO 1730 (formerly Saccharomyces bisporus var. mellis). J Gen Microbiol (1986) 0.82
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat Methods (2009) 13.39
Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature (2013) 12.01
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature (2002) 11.85
Computational identification of Drosophila microRNA genes. Genome Biol (2003) 9.86
Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Science (2002) 9.43
Evidence for large domains of similarly expressed genes in the Drosophila genome. J Biol (2002) 9.31
Systematic determination of patterns of gene expression during Drosophila embryogenesis. Genome Biol (2002) 8.89
Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. Genome Biol (2002) 8.59
ScanImage: flexible software for operating laser scanning microscopes. Biomed Eng Online (2003) 8.59
Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome. Proc Natl Acad Sci U S A (2002) 8.56
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics (2004) 8.40
Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence. Genome Biol (2002) 8.07
Genetic dissection of neural circuits. Neuron (2008) 7.97
Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections. Nat Neurosci (2007) 7.65
Experience-dependent structural synaptic plasticity in the mammalian brain. Nat Rev Neurosci (2009) 7.54
The Drosophila gene collection: identification of putative full-length cDNAs for 70% of D. melanogaster genes. Genome Res (2002) 6.61
Tools for neuroanatomy and neurogenetics in Drosophila. Proc Natl Acad Sci U S A (2008) 6.35
Transient and persistent dendritic spines in the neocortex in vivo. Neuron (2005) 6.30
Global analysis of patterns of gene expression during Drosophila embryogenesis. Genome Biol (2007) 6.27
Structure and function of dendritic spines. Annu Rev Physiol (2002) 6.17
Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci (2012) 6.09
Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice. Nature (2008) 6.08
The subcellular organization of neocortical excitatory connections. Nature (2009) 5.98
The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective. Genome Biol (2002) 5.80
Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. Genes Dev (2005) 5.78
Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nat Protoc (2009) 5.68
Experience-dependent and cell-type-specific spine growth in the neocortex. Nature (2006) 5.63
Computational analysis of core promoters in the Drosophila genome. Genome Biol (2002) 5.60
Heterochromatic sequences in a Drosophila whole-genome shotgun assembly. Genome Biol (2002) 5.09
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci (2012) 4.87
A GAL4-driver line resource for Drosophila neurobiology. Cell Rep (2012) 4.67
The Toll and Imd pathways are the major regulators of the immune response in Drosophila. EMBO J (2002) 4.63
Refinement of tools for targeted gene expression in Drosophila. Genetics (2010) 4.53
The life cycle of Ca(2+) ions in dendritic spines. Neuron (2002) 4.52
Locally dynamic synaptic learning rules in pyramidal neuron dendrites. Nature (2007) 4.48
Targeted mutagenesis by homologous recombination in D. melanogaster. Genes Dev (2002) 4.21
Rapid redistribution of synaptic PSD-95 in the neocortex in vivo. PLoS Biol (2006) 4.12
A visual motion detection circuit suggested by Drosophila connectomics. Nature (2013) 3.94
A Drosophila full-length cDNA resource. Genome Biol (2002) 3.67
Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex. Neuron (2003) 3.65
Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex. Neuron (2006) 3.61
Spine growth precedes synapse formation in the adult neocortex in vivo. Nat Neurosci (2006) 3.57
Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura. Genome Biol (2004) 3.36
Geometric and functional organization of cortical circuits. Nat Neurosci (2005) 3.22
Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice. Nature (2010) 3.18
The Drosophila melanogaster genome. Annu Rev Genomics Hum Genet (2003) 3.18
Neural activity in barrel cortex underlying vibrissa-based object localization in mice. Neuron (2010) 3.16
A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo. J Neurosci (2012) 3.13
Facilitation at single synapses probed with optical quantal analysis. Nat Neurosci (2002) 3.13
Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genome. Genome Biol (2002) 3.09
ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos. Proc Natl Acad Sci U S A (2002) 3.09
Interdigitated paralemniscal and lemniscal pathways in the mouse barrel cortex. PLoS Biol (2006) 2.89
A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS Comput Biol (2009) 2.88
The spread of Ras activity triggered by activation of a single dendritic spine. Science (2008) 2.87
Laminar and columnar organization of ascending excitatory projections to layer 2/3 pyramidal neurons in rat barrel cortex. J Neurosci (2005) 2.81
Imaging calcium concentration dynamics in small neuronal compartments. Sci STKE (2004) 2.80
Monitoring neural activity and [Ca2+] with genetically encoded Ca2+ indicators. J Neurosci (2004) 2.80
Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol Cell Biol (2004) 2.75
Vibrissa-based object localization in head-fixed mice. J Neurosci (2010) 2.69
Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. Neuron (2004) 2.68
Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging. Nat Neurosci (2006) 2.66
NMDA receptor subunit-dependent [Ca2+] signaling in individual hippocampal dendritic spines. J Neurosci (2005) 2.65
The functional microarchitecture of the mouse barrel cortex. PLoS Biol (2007) 2.64
Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proc Natl Acad Sci U S A (2005) 2.62
Nonlinear dendritic integration of sensory and motor input during an active sensing task. Nature (2012) 2.56
A directional tuning map of Drosophila elementary motion detectors. Nature (2013) 2.53
A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics (2009) 2.45
Stereotyped odor-evoked activity in the mushroom body of Drosophila revealed by green fluorescent protein-based Ca2+ imaging. J Neurosci (2004) 2.44
Large-scale trends in the evolution of gene structures within 11 animal genomes. PLoS Comput Biol (2006) 2.42
A genetically encoded fluorescent sensor of ERK activity. Proc Natl Acad Sci U S A (2008) 2.34
Experience strengthening transmission by driving AMPA receptors into synapses. Science (2003) 2.34
Characterization and subcellular targeting of GCaMP-type genetically-encoded calcium indicators. PLoS One (2008) 2.31
Identification of putative noncoding polyadenylated transcripts in Drosophila melanogaster. Proc Natl Acad Sci U S A (2005) 2.30
Rapid and reversible chemical inactivation of synaptic transmission in genetically targeted neurons. Neuron (2005) 2.26
Diverse modes of axon elaboration in the developing neocortex. PLoS Biol (2005) 2.26
Activity in motor-sensory projections reveals distributed coding in somatosensation. Nature (2012) 2.24
Rapid functional maturation of nascent dendritic spines. Neuron (2009) 2.21
Long-range neuronal circuits underlying the interaction between sensory and motor cortex. Neuron (2011) 2.20
A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature (2012) 2.20
Myosin-dependent targeting of transmembrane proteins to neuronal dendrites. Nat Neurosci (2009) 2.14
Ephus: multipurpose data acquisition software for neuroscience experiments. Front Neural Circuits (2010) 2.12
Using translational enhancers to increase transgene expression in Drosophila. Proc Natl Acad Sci U S A (2012) 1.98
Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. Dev Cell (2003) 1.88
The number of glutamate receptors opened by synaptic stimulation in single hippocampal spines. J Neurosci (2004) 1.83
Plasticity of calcium channels in dendritic spines. Nat Neurosci (2003) 1.82
Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development. Curr Biol (2003) 1.76
Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice. J Neurosci (2008) 1.72
Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas. PLoS Biol (2011) 1.71
Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. Nat Neurosci (2004) 1.65
Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes. RNA (2004) 1.63
A resource for manipulating gene expression and analyzing cis-regulatory modules in the Drosophila CNS. Cell Rep (2012) 1.62
Nurturing interdisciplinary research. Nat Struct Mol Biol (2004) 1.61
Reverse engineering the mouse brain. Nature (2009) 1.58