Published in J Biol Chem on March 10, 2000
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The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis. Proc Natl Acad Sci U S A (2003) 0.91
Loss of canonical insulin signaling accelerates vascular smooth muscle cell proliferation and migration through changes in p27Kip1 regulation. Endocrinology (2010) 0.91
Intracellular signaling pathways regulating net protein balance following diaphragm muscle denervation. Am J Physiol Cell Physiol (2010) 0.90
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Activating mutations in TOR are in similar structures as oncogenic mutations in PI3KCalpha. ACS Chem Biol (2009) 0.89
Identification of mTORC2 as a necessary component of HRG/ErbB2-dependent cellular transformation. Mol Cancer Res (2014) 0.89
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Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells. Oncotarget (2014) 0.88
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Glucocorticoids attenuate the central sympathoexcitatory actions of insulin. J Neurophysiol (2014) 0.87
β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway. J Neurochem (2010) 0.85
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Modulation of type-1 Ins(1,4,5)P3 receptor channels by the FK506-binding protein, FKBP12. Biochem J (2002) 0.85
Structural basis for the association of the redox-sensitive target of rapamycin FATC domain with membrane-mimetic micelles. J Biol Chem (2009) 0.84
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Leucine and histidine independently regulate milk protein synthesis in bovine mammary epithelial cells via mTOR signaling pathway. J Zhejiang Univ Sci B (2015) 0.79
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mTOR complex 2 mediates Akt phosphorylation that requires PKCε in adult cardiac muscle cells. Cell Signal (2013) 0.79
A new functional role for mechanistic/mammalian target of rapamycin complex 1 (mTORC1) in the circadian regulation of L-type voltage-gated calcium channels in avian cone photoreceptors. PLoS One (2013) 0.77
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Aspirin-induced gastrointestinal damage is associated with an inhibition of epithelial cell autophagy. J Gastroenterol (2015) 0.77
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Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation. Pharmacol Res (2017) 0.76
Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation. J Immunol (2014) 0.76
Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioning. J Neurochem (2015) 0.76
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Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival. Genes Dev (2016) 0.76
Growth factor progranulin promotes tumorigenesis of cervical cancer via PI3K/Akt/mTOR signaling pathway. Oncotarget (2016) 0.76
Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Sci Rep (2016) 0.76
Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes. J Cell Biol (2015) 0.76
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Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas. Leukemia (2015) 0.75
Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes. Oxid Med Cell Longev (2017) 0.75
P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy. Cell Death Dis (2016) 0.75
Mammalian target of rapamycin (mTOR) as a potential therapeutic target in various diseases. Inflammopharmacology (2017) 0.75
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