Published in J Exp Med on March 06, 2000
The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat Rev Immunol (2010) 4.26
Identification and characterization of circulating human transitional B cells. Blood (2005) 3.62
Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion. Springer Semin Immunopathol (2005) 2.76
Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J Clin Invest (2001) 2.26
B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleen. J Exp Med (2002) 2.01
The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome. Proc Natl Acad Sci U S A (2009) 1.28
Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lymphoproliferative autoimmunity. J Exp Med (2002) 1.22
BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. EMBO J (2002) 1.21
Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. J Exp Med (2003) 1.16
Decreased CD5⁺ B cells in active ANCA vasculitis and relapse after rituximab. Clin J Am Soc Nephrol (2013) 1.12
The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease. Curr Opin Immunol (2011) 1.05
Loss of the proapoptotic protein, Bim, breaks B cell anergy. J Exp Med (2006) 1.01
Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells. Mol Immunol (2009) 0.99
Programmed cell death 1 suppresses B-1b cell expansion and long-lived IgG production in response to T cell-independent type 2 antigens. J Immunol (2011) 0.97
The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus. Arthritis Res Ther (2011) 0.97
CD5 expression by B lymphocytes and its regulation upon Epstein-Barr virus transformation. Proc Natl Acad Sci U S A (2001) 0.96
CD40 signaling synergizes with TLR-2 in the BCR independent activation of resting B cells. PLoS One (2011) 0.95
Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction. J Immunol (2015) 0.93
Multiple regulatory mechanisms control B-1 B cell activation. Front Immunol (2012) 0.92
Modulation of peripheral B cell tolerance by CD72 in a murine model. Arthritis Rheum (2008) 0.92
Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Lab Invest (2008) 0.91
Primate B-1 cells generate antigen-specific B cell responses to T cell-independent type 2 antigens. J Immunol (2013) 0.90
B lymphocytes: development, tolerance, and their role in autoimmunity-focus on systemic lupus erythematosus. Autoimmune Dis (2013) 0.90
CD5-positive and CD5-negative human B cells converge to an indistinguishable population on signalling through B-cell receptors and CD40. Immunology (2000) 0.89
The modulatory effects of lipopolysaccharide-stimulated B cells on differential T-cell polarization. Immunology (2008) 0.89
Immunological aspects in chronic lymphocytic leukemia (CLL) development. Ann Hematol (2012) 0.88
Accelerated progression of chronic lymphocytic leukemia in Eμ-TCL1 mice expressing catalytically inactive RAG1. Blood (2013) 0.83
Characteristics of natural antibody-secreting cells. Ann N Y Acad Sci (2015) 0.83
CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes. Mol Immunol (2009) 0.82
CD5 sweetens lymphocyte responses. Proc Natl Acad Sci U S A (2009) 0.81
Age-dependent increase of peritoneal B-1b B cells in SCID mice. Immunology (2002) 0.81
Analysis of ancestral and functionally relevant CD5 variants in systemic lupus erythematosus patients. PLoS One (2014) 0.81
Perspectives on fetal derived CD5(+) B1 B cells. Eur J Immunol (2015) 0.80
B-1 lymphocytes in mice and nonhuman primates. Ann N Y Acad Sci (2015) 0.78
Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus. Arthritis Res Ther (2015) 0.78
B-cell-mediated strategies to fight chronic allograft rejection. Front Immunol (2013) 0.77
A conserved enhancer element differentially regulates developmental expression of CD5 in B and T cells. J Immunol (2010) 0.77
EndoU is a novel regulator of AICD during peripheral B cell selection. J Exp Med (2013) 0.76
Increased susceptibility of cord blood B lymphocytes to undergo spontaneous apoptosis. Clin Exp Immunol (2006) 0.76
CD5+ B lymphocytes in systemic lupus erythematosus patients: relation to disease activity. Clin Rheumatol (2017) 0.75
Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. J Exp Med (1975) 17.16
Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature (1997) 9.99
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature (1988) 9.17
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet (1998) 8.20
T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J Exp Med (1980) 6.62
The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice. J Exp Med (1983) 5.74
Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature (1994) 4.36
Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell (1993) 4.06
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature (1991) 4.04
Induction of self-tolerance in mature peripheral B lymphocytes. Nature (1989) 4.02
Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity. Nat Med (1999) 3.88
CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J Exp Med (1998) 3.82
The Ly-1 B cell lineage. Immunol Rev (1986) 3.59
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science (1995) 3.24
Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet (1993) 3.11
Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell (1993) 3.09
Positive selection of natural autoreactive B cells. Science (1999) 2.91
A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science (1995) 2.84
Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells. J Exp Med (1985) 2.81
Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity (1998) 2.42
Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity (1997) 2.34
Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci U S A (1996) 2.34
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med (1994) 2.23
Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen. Science (1991) 1.97
Treatment of murine CD5- B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways. Int Immunol (1991) 1.90
Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity (1995) 1.88
CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. Science (1996) 1.84
Quantitative analysis of the T cell repertoire that escapes negative selection. Immunity (1999) 1.61
Distinctive developmental origins and specificities of murine CD5+ B cells. Immunol Rev (1994) 1.45
CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1. Mol Cell Biol (1999) 1.37
Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J Exp Med (1996) 1.34
Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. Immunity (1998) 1.30
CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. J Exp Med (1997) 1.26
Lymphocyte populations and immune responses in CD5-deficient mice. Eur J Immunol (1994) 1.25
Secondary V(D)J recombination in B-1 cells. Nature (1999) 1.06
Preliminary crystallographic study of the complex between the Fab fragment of a monoclonal anti-lysozyme antibody and its antigen. J Mol Biol (1983) 0.96
Production of multiple lymphokines by the A20.1 B cell lymphoma after cross-linking of membrane Ig by immobilized anti-Ig. J Immunol (1989) 0.95
Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice. Curr Biol (1994) 0.92
CD5 B cells in autoimmunity. Ann N Y Acad Sci (1992) 0.86
B-chronic lymphocytic leukemia, small lymphocytic lymphoma, and lymphoplasmacytic lymphoma, including Waldenström's macroglobulinemia: a clinical, morphologic, and biologic spectrum of similar disorders. Semin Hematol (1999) 0.85
Delineating the genetic basis of systemic lupus erythematosus. Immunity (2001) 4.02
A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proc Natl Acad Sci U S A (1998) 2.31
Review of recent genome-wide association scans in lupus. J Intern Med (2009) 2.07
The genetics of human systemic lupus erythematosus. Curr Opin Immunol (1998) 1.85
Expression levels for many genes in human peripheral blood cells are highly sensitive to ex vivo incubation. Genes Immun (2004) 1.77
Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families. Am J Hum Genet (2000) 1.72
Peripheral blood gene expression profiling in rheumatoid arthritis. Genes Immun (2005) 1.66
Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus. Genes Immun (2006) 1.54
Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene. Immunity (1996) 1.54
Genome scan of human systemic lupus erythematosus by regression modeling: evidence of linkage and epistasis at 4p16-15.2. Am J Hum Genet (2000) 1.47
Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. J Exp Med (1999) 1.44
Familial aggregation and linkage analysis of autoantibody traits in pedigrees multiplex for systemic lupus erythematosus. Genes Immun (2006) 1.39
c-Rel is required for the protection of B cells from antigen receptor-mediated, but not Fas-mediated, apoptosis. J Immunol (2001) 1.35
Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. Immunity (1998) 1.30
Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus. Arthritis Res (2001) 1.28
Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes. J Immunol (1994) 1.25
Genomic view of systemic autoimmunity in MRLlpr mice. Genes Immun (2006) 1.18
Two novel routes of transporter associated with antigen processing (TAP)-independent major histocompatibility complex class I antigen processing. J Exp Med (1997) 1.17
Differential regulation of bcl-2 and bcl-x by CD3, CD28, and the IL-2 receptor in cloned CD4+ helper T cells. A model for the long-term survival of memory cells. J Immunol (1996) 1.12
PARP alleles and SLE: failure to confirm association with disease susceptibility. J Clin Invest (2000) 1.04
Bcl-xL rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli. J Immunol (1995) 1.01
Microsatellite typing for DRB1 alleles: application to the analysis of HLA associations with rheumatoid arthritis. Genes Immun (2006) 0.99
Ig light chain receptor editing in anergic B cells. J Immunol (2000) 0.97
Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells. J Exp Med (1998) 0.91
Renal oxidant injury and oxidant response induced by mercury. Kidney Int (1996) 0.90
A distinct inflammatory gene expression profile in patients with psoriatic arthritis. Genes Immun (2006) 0.90
TAP-independent delivery of antigenic peptides to the endoplasmic reticulum: therapeutic potential and insights into TAP-dependent antigen processing. J Immunother (1998) 0.88
European population substructure correlates with systemic lupus erythematosus endophenotypes in North Americans of European descent. Genes Immun (2009) 0.88
The role of the clinical rheumatologist in the establishment of a large sibling pair resource for systemic lupus erythematosus. J Rheumatol (1998) 0.88
Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE. Genes Immun (2009) 0.86
Promiscuous liberation of MHC-class I-binding peptides from the C termini of membrane and soluble proteins in the secretory pathway. Eur J Immunol (1998) 0.85
CD40 inhibits B cell apoptosis by upregulating bcl-xL expression and blocking oxidant accumulation. Am J Physiol (1997) 0.82
Modulation of apoptosis-associated genes bcl-2, bcl-x, and bax during rat liver regeneration. Cell Growth Differ (1996) 0.82
The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus. Genes Immun (2011) 0.81
The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus. Genes Immun (2006) 0.80
Fine mapping chromosome 16q12 in a collection of 231 systemic lupus erythematosus sibpair and multiplex families. Genes Immun (2005) 0.79
Left ventricular diastolic properties and filling characteristics during spontaneous angina pectoris at rest. Am J Cardiol (1983) 0.75