Published in Neuron on January 01, 2000
Identification of SLEEPLESS, a sleep-promoting factor. Science (2008) 4.56
Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila. Science (2009) 3.07
Control of sleep and wakefulness. Physiol Rev (2012) 3.06
Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. Cell (2011) 2.71
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain. Proc Natl Acad Sci U S A (2008) 2.43
Circadian organization of behavior and physiology in Drosophila. Annu Rev Physiol (2010) 2.36
Is sleep essential? PLoS Biol (2008) 2.33
A Drosophila model for age-associated changes in sleep:wake cycles. Proc Natl Acad Sci U S A (2006) 2.27
Genetics of sleep and sleep disorders. Cell (2011) 2.26
Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting. Cell (2015) 2.20
Sleep and synaptic homeostasis: structural evidence in Drosophila. Science (2011) 2.07
Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila. Nat Neurosci (2008) 2.01
Inducing sleep by remote control facilitates memory consolidation in Drosophila. Science (2011) 1.98
The genetic and molecular regulation of sleep: from fruit flies to humans. Nat Rev Neurosci (2009) 1.82
A role for cryptochromes in sleep regulation. BMC Neurosci (2002) 1.81
Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila. Curr Biol (2012) 1.79
Identification of a dopamine pathway that regulates sleep and arousal in Drosophila. Nat Neurosci (2012) 1.76
A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. PLoS One (2010) 1.72
D1 receptor activation in the mushroom bodies rescues sleep-loss-induced learning impairments in Drosophila. Curr Biol (2008) 1.71
Unearthing the phylogenetic roots of sleep. Curr Biol (2008) 1.71
Octopamine regulates sleep in drosophila through protein kinase A-dependent mechanisms. J Neurosci (2008) 1.66
A video method to study Drosophila sleep. Sleep (2008) 1.64
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila. Elife (2014) 1.62
Conservation of sleep: insights from non-mammalian model systems. Trends Neurosci (2008) 1.62
Calcitonin gene-related peptide neurons mediate sleep-specific circadian output in Drosophila. Curr Biol (2014) 1.61
Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep. Nat Genet (2009) 1.59
Clock and cycle limit starvation-induced sleep loss in Drosophila. Curr Biol (2010) 1.55
Identification of Neurons with a Privileged Role in Sleep Homeostasis in Drosophila melanogaster. Curr Biol (2015) 1.51
The energy hypothesis of sleep revisited. Prog Neurobiol (2008) 1.47
pySolo: a complete suite for sleep analysis in Drosophila. Bioinformatics (2009) 1.47
Interaction between sleep and the immune response in Drosophila: a role for the NFkappaB relish. Sleep (2007) 1.45
A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila. Sleep (2008) 1.45
Computer automated movement detection for the analysis of behavior. J Neurosci Methods (2007) 1.43
Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female. Proc Biol Sci (2009) 1.41
Sleep and wakefulness in Drosophila melanogaster. Ann N Y Acad Sci (2008) 1.39
Sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in rats. J Physiol (2003) 1.39
Synaptic plasticity in sleep: learning, homeostasis and disease. Trends Neurosci (2011) 1.37
Identification of a biomarker for sleep drive in flies and humans. Proc Natl Acad Sci U S A (2006) 1.32
High-resolution positional tracking for long-term analysis of Drosophila sleep and locomotion using the "tracker" program. PLoS One (2012) 1.30
The perilipin homologue, lipid storage droplet 2, regulates sleep homeostasis and prevents learning impairments following sleep loss. PLoS Biol (2010) 1.30
Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila. Curr Biol (2011) 1.30
Imaging analysis of clock neurons reveals light buffers the wake-promoting effect of dopamine. Nat Neurosci (2011) 1.29
Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders. Sleep Med Rev (2009) 1.27
Assaying locomotor activity to study circadian rhythms and sleep parameters in Drosophila. J Vis Exp (2010) 1.27
SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker. Nat Neurosci (2009) 1.27
Genetic analysis of sleep. Genes Dev (2010) 1.26
Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. J Neurosci (2008) 1.26
Dopamine in Drosophila: setting arousal thresholds in a miniature brain. Proc Biol Sci (2011) 1.26
A dynamic deep sleep stage in Drosophila. J Neurosci (2013) 1.24
insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila. Neuron (2011) 1.23
What are microarrays teaching us about sleep? Trends Mol Med (2009) 1.22
The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor. J Neurosci (2009) 1.21
The Drosophila ARC homolog regulates behavioral responses to starvation. Mol Cell Neurosci (2007) 1.20
Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly. Mol Psychiatry (2008) 1.18
Time to be SHY? Some comments on sleep and synaptic homeostasis. Neural Plast (2012) 1.18
Operation of a homeostatic sleep switch. Nature (2016) 1.16
Drosophila D1 dopamine receptor mediates caffeine-induced arousal. Proc Natl Acad Sci U S A (2008) 1.13
The origin of behavioral bursts in decision-making circuitry. PLoS Comput Biol (2011) 1.12
The microarchitecture of C. elegans behavior during lethargus: homeostatic bout dynamics, a typical body posture, and regulation by a central neuron. Sleep (2013) 1.11
Genome-wide association study of sleep in Drosophila melanogaster. BMC Genomics (2013) 1.11
Short neuropeptide F is a sleep-promoting inhibitory modulator. Neuron (2013) 1.10
Quantitative genetic analysis of sleep in Drosophila melanogaster. Genetics (2008) 1.09
The steroid molting hormone Ecdysone regulates sleep in adult Drosophila melanogaster. Genetics (2010) 1.08
Sleep triggered by an immune response in Drosophila is regulated by the circadian clock and requires the NFkappaB Relish. BMC Neurosci (2010) 1.07
Caenorhabditis-in-drop array for monitoring C. elegans quiescent behavior. Sleep (2013) 1.07
The dynamics of sleep-like behaviour in honey bees. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2003) 1.06
Dietary modulation of Drosophila sleep-wake behaviour. PLoS One (2010) 1.05
Time-restricted feeding attenuates age-related cardiac decline in Drosophila. Science (2015) 1.05
Drosophila aging 2006/2007. Exp Gerontol (2007) 1.05
Circadian modulation of short-term memory in Drosophila. Learn Mem (2008) 1.05
Video tracking and analysis of sleep in Drosophila melanogaster. Nat Protoc (2012) 1.04
Sleep deprivation specifically impairs short-term olfactory memory in Drosophila. Sleep (2009) 1.03
A critical period of sleep for development of courtship circuitry and behavior in Drosophila. Science (2014) 1.03
Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality. PLoS Genet (2012) 1.02
Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans. J Biol Chem (2008) 1.02
Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila. PLoS Genet (2012) 1.02
Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila. Cell Rep (2012) 1.02
Understanding the neurogenetics of sleep: progress from Drosophila. Trends Genet (2009) 1.02
Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster. PLoS One (2012) 1.01
Control of sleep by cyclin A and its regulator. Science (2012) 1.01
Sleep fragmentation and motor restlessness in a Drosophila model of Restless Legs Syndrome. Curr Biol (2012) 1.01
Sleep deprivation during early-adult development results in long-lasting learning deficits in adult Drosophila. Sleep (2011) 0.99
Sleep deprivation impairs precision of waggle dance signaling in honey bees. Proc Natl Acad Sci U S A (2010) 0.98
Dopamine modulates metabolic rate and temperature sensitivity in Drosophila melanogaster. PLoS One (2012) 0.97
Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster. Genet Res (Camb) (2009) 0.96
Sleep, aging, and lifespan in Drosophila. BMC Neurosci (2010) 0.96
From genetics to structure to function: exploring sleep in Drosophila. Int Rev Neurobiol (2011) 0.95
Circadian rhythm of temperature preference and its neural control in Drosophila. Curr Biol (2012) 0.95
Tolerance in Drosophila. J Neurogenet (2009) 0.94
Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body. Curr Biol (2015) 0.94
Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling. Sleep (2014) 0.93
A conserved long noncoding RNA affects sleep behavior in Drosophila. Genetics (2011) 0.92
A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. Elife (2015) 0.92
The Drosophila circadian pacemaker circuit: Pas De Deux or Tarantella? Crit Rev Biochem Mol Biol (2008) 0.92
In vivo circadian oscillation of dCREB2 and NF-κB activity in the Drosophila nervous system. PLoS One (2012) 0.91
Call it Worm Sleep. Trends Neurosci (2015) 0.91
A homeostatic sleep-stabilizing pathway in Drosophila composed of the sex peptide receptor and its ligand, the myoinhibitory peptide. PLoS Biol (2014) 0.91
Cross-translational studies in human and Drosophila identify markers of sleep loss. PLoS One (2013) 0.91
Sleep interacts with aβ to modulate intrinsic neuronal excitability. Curr Biol (2015) 0.90
Drosophila ATF-2 regulates sleep and locomotor activity in pacemaker neurons. Mol Cell Biol (2008) 0.90
Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night. Sleep (1997) 5.82
Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea. Am Rev Respir Dis (1993) 5.82
Hours, volume, and type of work of preregistration house officers. BMJ (1990) 5.68
Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol (1994) 5.66
Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhoea. Br Med J (1978) 4.99
Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity. Am J Trop Med Hyg (1993) 4.75
An instrument to measure functional status outcomes for disorders of excessive sleepiness. Sleep (1997) 4.40
Pattern formation and eyespot determination in butterfly wings. Science (1994) 3.98
Expression and structure of the human NGF receptor. Cell (1986) 3.82
Upper airway and soft tissue anatomy in normal subjects and patients with sleep-disordered breathing. Significance of the lateral pharyngeal walls. Am J Respir Crit Care Med (1995) 3.15
Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL. Science (1995) 2.87
A survey screen for prediction of apnea. Sleep (1995) 2.84
Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. J Clin Invest (1985) 2.64
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell (2001) 2.59
Night-to-night variability in CPAP use over the first three months of treatment. Sleep (1997) 2.56
Indications for positive airway pressure treatment of adult obstructive sleep apnea patients: a consensus statement. Chest (1999) 2.46
Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron (2001) 2.45
Delayed reinforcement as an indiscriminable contingency in verbal/nonverbal correspondence training. J Appl Behav Anal (1984) 2.43
Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit. Am J Respir Crit Care Med (2001) 2.42
Block in nuclear localization of period protein by a second clock mutation, timeless. Science (1994) 2.37
Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell (1996) 2.35
Effects of one night without nasal CPAP treatment on sleep and sleepiness in patients with obstructive sleep apnea. Am Rev Respir Dis (1993) 2.33
Origin and evolution of high throughput screening. Br J Pharmacol (2007) 2.28
Positional cloning and sequence analysis of the Drosophila clock gene, timeless. Science (1995) 2.28
A role for the proteasome in the light response of the timeless clock protein. Science (1999) 2.21
Pancreatic acinar cells: acetylcholine-induced membrane depolarization, calcium efflux and amylase release. J Physiol (1973) 2.12
Differential susceptibility of plasma proteins to oxidative modification: examination by western blot immunoassay. Free Radic Biol Med (1994) 2.03
Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science (1986) 2.00
Possible role of microtubules in thyroid secretion. Proc Natl Acad Sci U S A (1970) 2.00
A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis. Nat Neurosci (2001) 1.95
Gene transfer and molecular cloning of the human NGF receptor. Science (1986) 1.91
The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias. Proc Natl Acad Sci U S A (1986) 1.91
Liver disease in Crohn's disease. A study of 100 consecutive patients. Scand J Gastroenterol (1971) 1.89
U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells. J Biol Chem (1992) 1.83
Action of secretagogues on a new preparation of functionally intact, isolated pancreatic acini. Am J Physiol (1978) 1.80
Survival of patients with metastases from uveal melanoma. Ophthalmology (1991) 1.80
Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol. Gastroenterology (1984) 1.79
The current use of vagotomy in the treatment of peptic ulceration. Br J Surg (1969) 1.79
Molecular components of the circadian system in Drosophila. Annu Rev Physiol (2001) 1.78
Screening for cervical cancer by direct inspection. BMJ (1992) 1.78
Magnetic resonance imaging of the upper airway structure of children with obstructive sleep apnea syndrome. Am J Respir Crit Care Med (2001) 1.77
Evaluation of two commercial systems for identification of coagulase-negative staphylococci to species level. Diagn Microbiol Infect Dis (1994) 1.71
Glucocorticoids increase amylase mRNA levels, secretory organelles, and secretion in pancreatic acinar AR42J cells. J Cell Biol (1985) 1.68
Post-gastrectomy bile vomiting. Lancet (1965) 1.68
Dynamic upper airway imaging during awake respiration in normal subjects and patients with sleep disordered breathing. Am Rev Respir Dis (1993) 1.68
HSP27 expression regulates CCK-induced changes of the actin cytoskeleton in CHO-CCK-A cells. Am J Physiol (1999) 1.67
Management of internal haemorrhoids by rubber-band ligation. Br J Surg (1971) 1.65
Antibodies to recombinant Clostridium difficile toxins A and B are an effective treatment and prevent relapse of C. difficile-associated disease in a hamster model of infection. Infect Immun (1998) 1.63
Response-reinforcer relationships and improved learning in autistic children. J Appl Behav Anal (1981) 1.63
Direct versus indirect response-reinforcer relationships in teaching autistic children. J Abnorm Child Psychol (1980) 1.62
A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK. Science (2001) 1.61
Upper airway and soft tissue structural changes induced by CPAP in normal subjects. Am J Respir Crit Care Med (1996) 1.61
The articular scan in patients with rheumatoid arthritis: a possible method of quantitating joint inflammation using radio-technetium. Clin Sci (1968) 1.60
Identification of a Chlamydia trachomatis serovar E urogenital isolate which lacks the cryptic plasmid. Infect Immun (1998) 1.56
Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via phosphatidylinositol 3-kinase- and AKT-dependent pathways. Cancer Res (2000) 1.56
Control of pancreatic amylase release in vitro: effects of ions, cyclic AMP, and colchicine. Br J Pharmacol (1972) 1.56
Outpatient operations. I. The surgeon's view. Br Med J (1969) 1.55
Magnetic resonance imaging of the upper airway in children with Down syndrome. Am J Respir Crit Care Med (2001) 1.54
Addressing the ethical problems of randomized and placebo-controlled trials of CPAP. Am J Respir Crit Care Med (2001) 1.54
Photic signaling by cryptochrome in the Drosophila circadian system. Mol Cell Biol (2001) 1.54
Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations. Clin Pharmacol Ther (2008) 1.53
Cytochalasin B inhibits thyroid secretion. Biochem Biophys Res Commun (1971) 1.53
Psychosocial disorders in women undergoing postoperative radiation and chemotherapy for breast cancer in India. Indian J Cancer (2010) 1.53
The effects of diversion of intestinal contents on the progress of Crohn's disease of the large bowel. Gut (1971) 1.53
The scope and nature of the drowsy driving problem in New York State. Accid Anal Prev (1996) 1.50
Resistance plasmids in Pseudomonas cepacia 4G9. J Bacteriol (1979) 1.50
Role of male behavior in cervical carcinogenesis among women with one lifetime sexual partner. Cancer (1993) 1.48
Polydioxanone (PDS), a novel monofilament synthetic absorbable suture. Surg Gynecol Obstet (1981) 1.47
Determination of carbonyl groups in oxidized proteins. Methods Mol Biol (2000) 1.47
Origin of transmembrane potentials in non-excitable cells. J Theor Biol (1970) 1.45
Role of the diaphragm in the genesis of lower esophageal sphincter pressure in the cat. Gastroenterology (1985) 1.44
Intracellular free calcium concentrations in isolated pancreatic acini; effects of secretagogues. Biochem Biophys Res Commun (1983) 1.43
The insulin-pancreatic acinar axis. Diabetes (1985) 1.42
Good outcome from surgery for ampullary tumour. Aust N Z J Surg (1999) 1.41
Binding of cholecystokinin to high affinity receptors on isolated rat pancreatic acini. J Biol Chem (1980) 1.41
Herbal medicines--harmless or harmful? Anaesthesia (2002) 1.41
Colchicine-binding protein and the secretion of thyroid hormone. J Cell Biol (1972) 1.40
Regulation of pancreatic acinar cell function by intracellular calcium. Am J Physiol (1980) 1.40
The need for a simple animal model to understand sleep. Prog Neurobiol (2000) 1.39
The fate of ileorectal anastomosis in Crohn's disease. Gut (1971) 1.39
The incidence of recurrence in Crohn's disease. Surg Gynecol Obstet (1972) 1.38
Response of the timeless protein to light correlates with behavioral entrainment and suggests a nonvisual pathway for circadian photoreception. Neuron (1998) 1.38
A biologic comparison of polyglactin 910 and polyglycolic acid synthetic absorbable sutures. Surg Gynecol Obstet (1975) 1.38
Serotonergic excitatory drive to hypoglossal motoneurons in the decerebrate cat. Neurosci Lett (1992) 1.38
Intracellular divalent cation release in pancreatic acinar cells during stimulus-secretion coupling. I. Use of chlorotetracycline as fluorescent probe. J Cell Biol (1978) 1.37
Effect of selective and proximal gastric vagotomy on serum gastrin. Gastroenterology (1974) 1.36
Hip fracture outcomes: quality of life and functional status in older adults living in the community. Aust N Z J Med (2000) 1.36
Crohn's disease involving the colon: an audit of clinical management. Gastroenterology (1977) 1.36
Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2. Proc Natl Acad Sci U S A (1996) 1.34
Partial gastrectomy: the value of permanent vitamin-B-12 therapy. Lancet (1966) 1.32
Effects of ouabain and diphenylhydantoin on transmembrane potentials, intracellular electrolytes, and cell pH of rat muscle and liver in vivo. J Physiol (1971) 1.32
Comparison of airway responses following tracheal or esophageal acidification in the cat. Gastroenterology (1984) 1.32
Regulation of gastric emptying in humans by cholecystokinin. J Clin Invest (1986) 1.31
Pancreatic acinar cells in monolayer culture: direct trophic effects of caerulein in vitro. Am J Physiol (1986) 1.29
An algorithm to stratify sleep apnea risk in a sleep disorders clinic population. Am J Respir Crit Care Med (2001) 1.29
Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines. Antimicrob Agents Chemother (1995) 1.28
Development of a diurnal resting box to collect Culiseta melanura (COQ.). Am J Trop Med Hyg (1968) 1.28
Luminescence imaging microscopy and lifetime mapping using kinetically stable lanthanide(III) complexes. J Photochem Photobiol B (2000) 1.27