SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker.

PubWeight™: 1.27‹?› | Rank: Top 10%

🔗 View Article (PMC 2842941)

Published in Nat Neurosci on December 13, 2009

Authors

Mark N Wu1, William J Joiner, Terry Dean, Zhifeng Yue, Corinne J Smith, Dechun Chen, Toshinori Hoshi, Amita Sehgal, Kyunghee Koh

Author Affiliations

1: Division of Sleep Medicine, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Articles citing this

About sleep's role in memory. Physiol Rev (2013) 3.35

Control of sleep and wakefulness. Physiol Rev (2012) 3.06

Genetics of sleep and sleep disorders. Cell (2011) 2.26

Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila. Curr Biol (2012) 1.79

100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future. Nat Rev Neurosci (2010) 1.76

Genetic analysis of sleep. Genes Dev (2010) 1.26

insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila. Neuron (2011) 1.23

Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes. J Biol Chem (2010) 1.06

Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons. J Biol Chem (2011) 1.05

Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons. J Neurosci (2010) 1.04

Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila. PLoS Genet (2012) 1.02

Function and mechanism of axonal targeting of voltage-sensitive potassium channels. Prog Neurobiol (2011) 1.01

Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genet (2013) 0.96

Sleep, aging, and lifespan in Drosophila. BMC Neurosci (2010) 0.96

From genetics to structure to function: exploring sleep in Drosophila. Int Rev Neurobiol (2011) 0.95

The genetic analysis of functional connectomics in Drosophila. Adv Genet (2012) 0.95

Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization. J Biol Chem (2012) 0.94

Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount. Elife (2014) 0.93

SLEEPLESS is a bifunctional regulator of excitability and cholinergic synaptic transmission. Curr Biol (2014) 0.91

Sleep interacts with aβ to modulate intrinsic neuronal excitability. Curr Biol (2015) 0.90

Tethering toxins and peptide ligands for modulation of neuronal function. Curr Opin Neurobiol (2011) 0.89

Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels. J Neurosci (2011) 0.88

dyschronic, a Drosophila homolog of a deaf-blindness gene, regulates circadian output and Slowpoke channels. PLoS Genet (2012) 0.84

A neuron-glia interaction involving GABA transaminase contributes to sleep loss in sleepless mutants. Mol Psychiatry (2014) 0.83

Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States. J Neurosci (2015) 0.82

Ly6h regulates trafficking of alpha7 nicotinic acetylcholine receptors and nicotine-induced potentiation of glutamatergic signaling. J Neurosci (2015) 0.82

The Ly6 protein coiled is required for septate junction and blood brain barrier organisation in Drosophila. PLoS One (2011) 0.81

TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila. Curr Biol (2015) 0.80

Modeling the genetic basis for human sleep disorders in Drosophila. Commun Integr Biol (2013) 0.79

Short toxin-like proteins attack the defense line of innate immunity. Toxins (Basel) (2013) 0.79

Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors. PLoS One (2015) 0.77

Multispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Family. Mol Biol Evol (2015) 0.76

Cell-specific fine-tuning of neuronal excitability by differential expression of modulator protein isoforms. J Neurosci (2013) 0.76

Structural Analysis and Deletion Mutagenesis Define Regions of QUIVER/SLEEPLESS that Are Responsible for Interactions with Shaker-Type Potassium Channels and Nicotinic Acetylcholine Receptors. PLoS One (2016) 0.76

Unraveling the Evolutionary Determinants of Sleep. Curr Biol (2016) 0.76

Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis. Proc Natl Acad Sci U S A (2014) 0.76

KChIP-like auxiliary subunits of Kv4 channels regulate excitability of muscle cells and control male turning behavior during mating in Caenorhabditis elegans. J Neurosci (2015) 0.75

Circadian Rhythms and Sleep in Drosophila melanogaster. Genetics (2017) 0.75

Quasimodo mediates daily and acute light effects on Drosophila clock neuron excitability. Proc Natl Acad Sci U S A (2016) 0.75

Identification of a Ly-6 superfamily gene expressed in lateral line neuromasts in zebrafish. Dev Genes Evol (2015) 0.75

Articles cited by this

Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc (2009) 32.64

Hypothalamic regulation of sleep and circadian rhythms. Nature (2005) 8.23

Correlates of sleep and waking in Drosophila melanogaster. Science (2000) 5.89

Rest in Drosophila is a sleep-like state. Neuron (2000) 5.72

Identification of SLEEPLESS, a sleep-promoting factor. Science (2008) 4.56

Dopamine is a regulator of arousal in the fruit fly. J Neurosci (2005) 3.65

Sleep in Drosophila is regulated by adult mushroom bodies. Nature (2006) 3.36

Dopaminergic modulation of arousal in Drosophila. Curr Biol (2005) 3.09

Reduced sleep in Drosophila Shaker mutants. Nature (2005) 3.07

PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. Neuron (2008) 2.81

A dynamic role for the mushroom bodies in promoting sleep in Drosophila. Nature (2006) 2.79

Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. Nat Neurosci (2007) 2.64

The behavior of four neurological mutants of Drosophila. Genetics (1969) 2.63

Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain. Proc Natl Acad Sci U S A (2008) 2.43

Large ventral lateral neurons modulate arousal and sleep in Drosophila. Curr Biol (2008) 2.26

A sleep-promoting role for the Drosophila serotonin receptor 1A. Curr Biol (2006) 2.26

A modified minimal hemolymph-like solution, HL3.1, for physiological recordings at the neuromuscular junctions of normal and mutant Drosophila larvae. J Neurogenet (2005) 2.13

Inherited neuronal ion channelopathies: new windows on complex neurological diseases. J Neurosci (2008) 2.04

lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS. Neuron (1999) 1.98

Modeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles. Biophys J (2002) 1.98

Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. J Biol Rhythms (2003) 1.85

Structure of human urokinase plasminogen activator in complex with its receptor. Science (2006) 1.84

Snake venom alpha-neurotoxins and other 'three-finger' proteins. Eur J Biochem (1999) 1.83

Electrophysiological correlates of rest and activity in Drosophila melanogaster. Curr Biol (2002) 1.80

T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites. Nat Neurosci (2008) 1.79

Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A (2005) 1.77

Octopamine regulates sleep in drosophila through protein kinase A-dependent mechanisms. J Neurosci (2008) 1.66

Abnormal action potentials associated with the Shaker complex locus of Drosophila. Proc Natl Acad Sci U S A (1981) 1.60

Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron (2002) 1.56

Drosophila Hyperkinetic mutants have reduced sleep and impaired memory. J Neurosci (2007) 1.54

Twenty years of dendrotoxins. Toxicon (2001) 1.51

The GAL4 system : a versatile system for the expression of genes. Methods Mol Biol (2008) 1.48

Tissue expression, structure and function of the murine Ly-6 family of molecules. Immunol Cell Biol (1995) 1.48

A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila. Sleep (2008) 1.45

The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila. Curr Biol (2009) 1.43

Sleep in Kcna2 knockout mice. BMC Biol (2007) 1.42

FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proc Natl Acad Sci U S A (2007) 1.37

Determinants of voltage-gated potassium channel surface expression and localization in Mammalian neurons. Crit Rev Biochem Mol Biol (2004) 1.28

Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase. Nat Struct Biol (1999) 1.27

Voltage-gated potassium channels: regulation by accessory subunits. Neuroscientist (2006) 1.23

Slob, a novel protein that interacts with the Slowpoke calcium-dependent potassium channel. Neuron (1998) 1.21

Ablation of Kv3.1 and Kv3.3 potassium channels disrupts thalamocortical oscillations in vitro and in vivo. J Neurosci (2008) 1.15

A novel leg-shaking Drosophila mutant defective in a voltage-gated K(+)current and hypersensitive to reactive oxygen species. J Neurosci (2000) 1.10

Structural basis for EGFR ligand sequestration by Argos. Nature (2008) 1.08

Increased motor drive and sleep loss in mice lacking Kv3-type potassium channels. Genes Brain Behav (2004) 1.03

Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs). Mol Interv (2001) 1.02

Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K. FASEB J (2006) 0.96

NMR and restrained molecular dynamics study of the three-dimensional solution structure of toxin FS2, a specific blocker of the L-type calcium channel, isolated from black mamba venom. Biochemistry (1995) 0.93

Diverse expression and distribution of Shaker potassium channels during the development of the Drosophila nervous system. J Neurosci (1997) 0.90

Genetic basis of ventricular arrhythmias. Cardiol Clin (2008) 0.84

Articles by these authors

Identification of SLEEPLESS, a sleep-promoting factor. Science (2008) 4.56

Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome. Neuron (2005) 4.11

The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron (2002) 4.11

Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. Nature (2002) 3.96

Sleep in Drosophila is regulated by adult mushroom bodies. Nature (2006) 3.36

High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Proc Natl Acad Sci U S A (2002) 2.85

Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. Cell Metab (2008) 2.85

Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function. Arch Biochem Biophys (2002) 2.76

Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell (2004) 2.62

A Drosophila model for age-associated changes in sleep:wake cycles. Proc Natl Acad Sci U S A (2006) 2.27

A sleep-promoting role for the Drosophila serotonin receptor 1A. Curr Biol (2006) 2.26

Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse. Sleep Med (2005) 2.22

JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science (2006) 2.13

Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. J Neurosci (2003) 2.05

Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Neuron (2002) 2.03

AKT and TOR signaling set the pace of the circadian pacemaker. Curr Biol (2010) 1.97

The circadian clock interacts with metabolic physiology to influence reproductive fitness. Cell Metab (2011) 1.96

Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. J Biol Rhythms (2003) 1.85

Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature (2003) 1.84

Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior. Neuron (2010) 1.75

An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. J Neurosci (2003) 1.73

A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. PLoS One (2010) 1.72

Octopamine regulates sleep in drosophila through protein kinase A-dependent mechanisms. J Neurosci (2008) 1.66

Cognitive deficits associated with restless legs syndrome (RLS). Sleep Med (2005) 1.60

Drosophila melanogaster: an insect model for fundamental studies of sleep. Methods Enzymol (2005) 1.59

Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing. Nat Struct Mol Biol (2004) 1.57

Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation. Proc Natl Acad Sci U S A (2004) 1.54

Serotonin modulates circadian entrainment in Drosophila. Neuron (2005) 1.51

Interaction between sleep and the immune response in Drosophila: a role for the NFkappaB relish. Sleep (2007) 1.45

A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila. Sleep (2008) 1.45

Circadian control of eclosion: interaction between a central and peripheral clock in Drosophila melanogaster. Curr Biol (2003) 1.40

Modulation of BKCa channel gating by endogenous signaling molecules. Physiology (Bethesda) (2009) 1.38

Probing the relative importance of molecular oscillations in the circadian clock. Genetics (2008) 1.38

FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proc Natl Acad Sci U S A (2007) 1.37

Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins. FASEB J (2002) 1.35

Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1). Genes Dev (2007) 1.33

Heme regulates allosteric activation of the Slo1 BK channel. J Gen Physiol (2005) 1.32

The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice. J Biol Rhythms (2008) 1.30

Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit. Cell (2012) 1.27

Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain. Nat Struct Mol Biol (2008) 1.26

Genetic analysis of sleep. Genes Dev (2010) 1.26

Three methionine residues located within the regulator of conductance for K+ (RCK) domains confer oxidative sensitivity to large-conductance Ca2+-activated K+ channels. J Physiol (2006) 1.22

A Drosophila model for Angelman syndrome. Proc Natl Acad Sci U S A (2008) 1.21

Why a fly? Using Drosophila to understand the genetics of circadian rhythms and sleep. Sleep (2004) 1.21

The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor. J Neurosci (2009) 1.21

Distinct functions of glial and neuronal dystroglycan in the developing and adult mouse brain. J Neurosci (2010) 1.20

Differential trafficking of carboxyl isoforms of Ca2+-gated (Slo1) potassium channels. FEBS Lett (2007) 1.20

Stimulatory action of internal protons on Slo1 BK channels. Biophys J (2003) 1.19

A fly's eye view of circadian entrainment. J Biol Rhythms (2003) 1.18

Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms. J Neurosci (2007) 1.18

Metabolic regulation of potassium channels. Annu Rev Physiol (2004) 1.14

Non-cyclic and developmental stage-specific expression of circadian clock proteins during murine spermatogenesis. Biol Reprod (2003) 1.13

Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations. Aging Cell (2012) 1.13

Novel insights into the regulation of the timeless protein. J Neurosci (2003) 1.11

Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation. Biochim Biophys Acta (2005) 1.10

Quantitative genetic analysis of sleep in Drosophila melanogaster. Genetics (2008) 1.09

The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels. Proc Natl Acad Sci U S A (2008) 1.09

Speed control: cogs and gears that drive the circadian clock. Trends Neurosci (2012) 1.08

Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels. J Physiol (2010) 1.08

Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1. FEBS Lett (2002) 1.06

Molecular mechanism of pharmacological activation of BK channels. Proc Natl Acad Sci U S A (2012) 1.04

A critical period of sleep for development of courtship circuitry and behavior in Drosophila. Science (2014) 1.03

Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila. BMC Neurosci (2004) 1.03

Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Genes Dev (2008) 1.03

An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator. J Neurosci (2009) 1.01

Oxidation of multiple methionine residues impairs rapid sodium channel inactivation. Pflugers Arch (2008) 1.00

Dopamine acts through Cryptochrome to promote acute arousal in Drosophila. Genes Dev (2012) 0.99

Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genet (2013) 0.96

Structure of TatA paralog, TatE, suggests a structurally homogeneous form of Tat protein translocase that transports folded proteins of differing diameter. J Biol Chem (2011) 0.96

C-027 inhibits IgE-mediated passive sensitization bronchoconstriction and acts as a histamine and serotonin antagonist in human airways. Allergy Asthma Proc (2011) 0.95

The thymus is similar to the testis in its pattern of circadian clock gene expression. J Biol Rhythms (2005) 0.95

Interaction between sleep and metabolism in Drosophila with altered octopamine signaling. J Biol Chem (2012) 0.95

The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner. J Biol Chem (2002) 0.94

Functional consequences of methionine oxidation of hERG potassium channels. Biochem Pharmacol (2007) 0.94

The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting. J Neurosci (2009) 0.93

Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount. Elife (2014) 0.93

Reversible binding of heme to proteins in cellular signal transduction. Acc Chem Res (2006) 0.92

A mutually exclusive alternative exon of slo1 codes for a neuronal BK channel with altered function. Channels (Austin) (2008) 0.92