Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly.

PubWeight™: 1.84‹?› | Rank: Top 3%

🔗 View Article (PMC 111839)

Published in J Virol on April 01, 2000

Authors

A G Bost1, R H Carnahan, X T Lu, M R Denison

Author Affiliations

1: Department of Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee 37232, USA.

Articles citing this

Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59. J Virol (2002) 4.29

RNA replication of mouse hepatitis virus takes place at double-membrane vesicles. J Virol (2002) 3.69

A contemporary view of coronavirus transcription. J Virol (2006) 2.47

Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins. J Virol (2004) 2.38

Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase. J Virol (2004) 2.29

The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication. J Virol (2005) 1.71

The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world. Proc Natl Acad Sci U S A (2004) 1.61

A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis. J Virol (2004) 1.53

Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome. PLoS One (2007) 1.42

Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase. J Virol (2003) 1.41

Heterogeneous nuclear ribonucleoprotein A1 regulates RNA synthesis of a cytoplasmic virus. EMBO J (2000) 1.38

Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes. J Virol (2000) 1.38

Identification of mouse hepatitis virus papain-like proteinase 2 activity. J Virol (2000) 1.34

Localization and membrane topology of coronavirus nonstructural protein 4: involvement of the early secretory pathway in replication. J Virol (2007) 1.32

Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs. J Virol (2006) 1.24

Topology and membrane anchoring of the coronavirus replication complex: not all hydrophobic domains of nsp3 and nsp6 are membrane spanning. J Virol (2008) 1.23

Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication. J Virol (2007) 1.22

Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10. J Virol (2006) 1.19

Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication. J Virol (2004) 1.15

Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3. J Virol (2006) 1.13

Mutation in murine coronavirus replication protein nsp4 alters assembly of double membrane vesicles. Virology (2008) 1.13

Genetic analysis of Murine hepatitis virus nsp4 in virus replication. J Virol (2007) 1.12

Genetic interactions between an essential 3' cis-acting RNA pseudoknot, replicase gene products, and the extreme 3' end of the mouse coronavirus genome. J Virol (2007) 1.09

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis. J Virol (2007) 1.06

Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing. J Virol (2007) 1.04

Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7. J Virol (2005) 1.04

Suppression of coronavirus replication by inhibition of the MEK signaling pathway. J Virol (2006) 1.01

Membrane association and dimerization of a cysteine-rich, 16-kilodalton polypeptide released from the C-terminal region of the coronavirus infectious bronchitis virus 1a polyprotein. J Virol (2002) 1.00

Detection of nonstructural protein 6 in murine coronavirus-infected cells and analysis of the transmembrane topology by using bioinformatics and molecular approaches. J Virol (2009) 0.98

Visualizing coronavirus RNA synthesis in time by using click chemistry. J Virol (2012) 0.98

The polypyrimidine tract-binding protein affects coronavirus RNA accumulation levels and relocalizes viral RNAs to novel cytoplasmic domains different from replication-transcription sites. J Virol (2011) 0.96

The coronavirus nucleocapsid protein is dynamically associated with the replication-transcription complexes. J Virol (2010) 0.92

Severe acute respiratory syndrome coronavirus nsp9 dimerization is essential for efficient viral growth. J Virol (2009) 0.89

Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation. J Virol (2014) 0.85

Structures of the N- and C-terminal domains of MHV-A59 nucleocapsid protein corroborate a conserved RNA-protein binding mechanism in coronavirus. Protein Cell (2010) 0.85

Biogenesis and dynamics of the coronavirus replicative structures. Viruses (2012) 0.84

SARS coronavirus replicase proteins in pathogenesis. Virus Res (2007) 0.83

Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity. J Virol (2012) 0.83

Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing. J Virol (2010) 0.81

Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications. J Virol (2014) 0.79

Dissection of amino-terminal functional domains of murine coronavirus nonstructural protein 3. J Virol (2015) 0.77

NMR Structure of the SARS-CoV Nonstructural Protein 7 in Solution at pH 6.5. J Mol Biol (2010) 0.77

Coronaviruses induce entry-independent, continuous macropinocytosis. MBio (2014) 0.75

Expression, crystallization and preliminary crystallographic study of mouse hepatitis virus (MHV) nucleocapsid protein C-terminal domain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.75

In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins. MBio (2017) 0.75

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

Diffusional mobility of Golgi proteins in membranes of living cells. Science (1996) 4.73

The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase. Virology (1991) 4.07

Isolation of coronavirus envelope glycoproteins and interaction with the viral nucleocapsid. J Virol (1980) 3.82

Characterization of the budding compartment of mouse hepatitis virus: evidence that transport from the RER to the Golgi complex requires only one vesicular transport step. J Cell Biol (1994) 2.92

The primary structure and expression of the second open reading frame of the polymerase gene of the coronavirus MHV-A59; a highly conserved polymerase is expressed by an efficient ribosomal frameshifting mechanism. Nucleic Acids Res (1990) 2.71

Replication of coronavirus MHV-A59 in sac- cells: determination of the first site of budding of progeny virions. Eur J Cell Biol (1984) 2.61

Site of addition of N-acetyl-galactosamine to the E1 glycoprotein of mouse hepatitis virus-A59. J Cell Biol (1988) 2.49

Localization of mouse hepatitis virus nonstructural proteins and RNA synthesis indicates a role for late endosomes in viral replication. J Virol (1999) 2.49

Coronavirus M proteins accumulate in the Golgi complex beyond the site of virion budding. J Virol (1994) 2.27

The endoplasmic reticulum-Golgi intermediate compartment. Curr Opin Cell Biol (1992) 2.18

Phosphoproteins of murine hepatitis viruses. J Virol (1979) 2.07

Interactions between coronavirus nucleocapsid protein and viral RNAs: implications for viral transcription. J Virol (1988) 2.00

Identification of a domain required for autoproteolytic cleavage of murine coronavirus gene A polyprotein. J Virol (1989) 1.82

The E1 glycoprotein of an avian coronavirus is targeted to the cis Golgi complex. Proc Natl Acad Sci U S A (1990) 1.79

Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59. J Virol (1995) 1.76

Identification of the catalytic sites of a papain-like cysteine proteinase of murine coronavirus. J Virol (1993) 1.74

Mouse hepatitis virus strain A59 RNA polymerase gene ORF 1a: heterogeneity among MHV strains. Virology (1994) 1.73

Cell tropism and expression of mouse hepatitis viruses (MHV) in mouse spinal cord cultures. Virology (1982) 1.72

The transmissible gastroenteritis coronavirus contains a spherical core shell consisting of M and N proteins. J Virol (1996) 1.69

The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis. J Virol (1999) 1.67

Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events. Virology (1992) 1.67

Colocalization and membrane association of murine hepatitis virus gene 1 products and De novo-synthesized viral RNA in infected cells. J Virol (1999) 1.67

Sorting of progeny coronavirus from condensed secretory proteins at the exit from the trans-Golgi network of AtT20 cells. J Cell Biol (1987) 1.66

Processing of the coronavirus MHV-JHM polymerase polyprotein: identification of precursors and proteolytic products spanning 400 kilodaltons of ORF1a. Virology (1998) 1.64

Mouse hepatitis virus 3C-like protease cleaves a 22-kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro. J Virol (1998) 1.61

In vitro replication of mouse hepatitis virus strain A59. J Virol (1987) 1.46

Infection of AtT20 murine pituitary tumour cells by mouse hepatitis virus strain A59: virus budding is restricted to the Golgi region. Eur J Cell Biol (1985) 1.43

Intracellular and in vitro-translated 27-kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59. Virology (1996) 1.43

Two types of virus-related particles are found during transmissible gastroenteritis virus morphogenesis. J Virol (1998) 1.21

The cytoplasmic tail of mouse hepatitis virus M protein is essential but not sufficient for its retention in the Golgi complex. J Biol Chem (1994) 1.16

Structural proteins of human respiratory coronavirus OC43. Virus Res (1986) 1.15

Determinants of mouse hepatitis virus 3C-like proteinase activity. Virology (1997) 1.14

Processing of the human coronavirus 229E replicase polyproteins by the virus-encoded 3C-like proteinase: identification of proteolytic products and cleavage sites common to pp1a and pp1ab. J Virol (1999) 1.11

Identification of an ATPase activity associated with a 71-kilodalton polypeptide encoded in gene 1 of the human coronavirus 229E. J Virol (1997) 1.09

Efficient autoproteolytic processing of the MHV-A59 3C-like proteinase from the flanking hydrophobic domains requires membranes. Virology (1997) 1.07

Proteolytic processing of the coronavirus infectious bronchitis virus 1a polyprotein: identification of a 10-kilodalton polypeptide and determination of its cleavage sites. J Virol (1997) 1.04

Localization of mouse hepatitis virus open reading frame 1A derived proteins. J Neurovirol (1998) 1.03

Syncytia formation induced by coronavirus infection is associated with fragmentation and rearrangement of the Golgi apparatus. Virology (1996) 1.03

Structural polypeptides of coronavirus IBV. J Gen Virol (1981) 1.02

Morphogenesis of avian infectious bronchitis virus in primary chick kidney cells. Arch Virol (1976) 0.99

Coronavirus JHM: tryptic peptide fingerprinting of virion proteins and intracellular polypeptides. J Gen Virol (1982) 0.92

In vivo and in vitro models of demyelinating diseases. V. Comparison of the assembly of mouse hepatitis virus, strain JHM, in two murine cell lines. Intervirology (1982) 0.89

Intracellular localization of polypeptides encoded in mouse hepatitis virus open reading frame 1A. Adv Exp Med Biol (1995) 0.87

Studies on the structure of a coronavirus-avian infectious bronchitis virus. J Gen Virol (1977) 0.83

Bovine coronavirus nucleocapsid protein processing and assembly. Adv Exp Med Biol (1995) 0.81

Both antisense and sense RNAs against the nucleocapsid protein gene inhibit the multiplication of mouse hepatitis virus. J Vet Med Sci (1994) 0.79

Articles by these authors

Localization of mouse hepatitis virus nonstructural proteins and RNA synthesis indicates a role for late endosomes in viral replication. J Virol (1999) 2.49

Vectors and gene targeting modules for tandem affinity purification in Schizosaccharomyces pombe. Yeast (2001) 2.23

Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d. Virology (1995) 1.80

Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59. J Virol (1995) 1.76

The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis. J Virol (1999) 1.67

Mouse hepatitis virus 3C-like protease cleaves a 22-kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro. J Virol (1998) 1.61

Translation and processing of mouse hepatitis virus virion RNA in a cell-free system. J Virol (1986) 1.51

Intracellular and in vitro-translated 27-kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59. Virology (1996) 1.43

Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes. J Virol (2000) 1.38

Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection. Virology (2001) 1.29

Biochemical characterization of penicillin-resistant and -sensitive penicillin-binding protein 2x transpeptidase activities of Streptococcus pneumoniae and mechanistic implications in bacterial resistance to beta-lactam antibiotics. J Bacteriol (1997) 1.19

Determinants of mouse hepatitis virus 3C-like proteinase activity. Virology (1997) 1.14

Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012. Clin Microbiol Infect (2013) 1.04

Expression and processing of nonstructural proteins of the human astroviruses. Adv Exp Med Biol (1998) 0.92

Processing of the MHV-A59 gene 1 polyprotein by the 3C-like proteinase. Adv Exp Med Biol (1998) 0.90

Coronavirus polyprotein processing. Arch Virol Suppl (1994) 0.88

Veillonella parvula bacteremia without an underlying source. J Clin Microbiol (1996) 0.86

Fatal fat embolism syndrome in a child with undiagnosed hemoglobin S/beta+ thalassemia: a complication of acute parvovirus B19 infection. Pediatr Pathol Lab Med (1996) 0.86

A newly identified MHV-A59 ORF1a polypeptide p65 is temperature sensitive in two RNA negative mutants. Adv Exp Med Biol (1993) 0.79

Effects of mercury released from gold extraction by amalgamation on renal function and environment in Shanxi, China. Bull Environ Contam Toxicol (2009) 0.79

H1N1 infection mimicking the clinical presentation of gastrointestinal GVHD in a patient following allo-SCT. Bone Marrow Transplant (2010) 0.78

Neonatal renal abscess caused by Staphylococcus aureus. Pediatr Infect Dis J (1991) 0.78

The cell biology of coronavirus infection. Adv Exp Med Biol (2001) 0.78

Expression, purification, and activity of recombinant MHV-A59 3CLpro. Adv Exp Med Biol (1998) 0.75

Assessment of future anthropogenic change and associated benthic risk in coastal environments using sedimentary metal indicators. J Environ Manage (2012) 0.75

[Influence of occupational aluminum exposure on cognitive function and glutamate receptor protein expression in workers]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi (2017) 0.75

Dentistry in Texas 2010--fact or fiction? Tex Dent J (2000) 0.75

[Association between H3K4me3/BDNF and the cognitive function of workers occupationally exposed to aluminum]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi (2016) 0.75