Induction of specific immunoglobulin A and Th2 immune responses to P6 outer membrane protein of nontypeable Haemophilus influenzae in middle ear mucosa by intranasal immunization.

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Published in Infect Immun on April 01, 2000

Authors

S Kodama1, S Suenaga, T Hirano, M Suzuki, G Mogi

Author Affiliations

1: Department of Otolaryngology, Oita Medical University, Hazama-machi, Oita 879-5593, Japan.

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Solitary fibrous tumour: significance of p53 and CD34 immunoreactivity in its malignant transformation. Histopathology (1998) 2.00

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DNA binding of PhoB and its interaction with RNA polymerase. J Mol Biol (1996) 1.97

Dual roles of the 11S regulatory subcomplex in condensin functions. Proc Natl Acad Sci U S A (2000) 1.96

Relation between use of health check ups starting in middle age and demand for inpatient care by elderly people in Japan. BMJ (1991) 1.96