Published in J Cell Biol on March 20, 2000
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev (2002) 19.24
Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43
Numerous microRNPs in neuronal cells containing novel microRNAs. RNA (2003) 6.28
SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing. Cell (2008) 4.54
Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes. J Cell Biol (2008) 3.53
The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins. Mol Cell Biol (2001) 3.27
Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPs. PLoS One (2007) 2.70
SMN interacts with a novel family of hnRNP and spliceosomal proteins. EMBO J (2001) 2.51
Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. J Cell Biol (2001) 2.49
A functional interaction between the survival motor neuron complex and RNA polymerase II. J Cell Biol (2001) 2.44
The survival of motor neurons protein determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy. Mol Cell Biol (2005) 2.23
Self-association of coilin reveals a common theme in nuclear body localization. Mol Biol Cell (2000) 2.15
Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs. EMBO J (2002) 2.04
Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein. Genes Dev (2001) 2.03
The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol (2013) 1.63
Sequence-specific interaction of U1 snRNA with the SMN complex. EMBO J (2002) 1.48
Genetic variants in MicroRNA biosynthesis pathways and binding sites modify ovarian cancer risk, survival, and treatment response. Cancer Res (2010) 1.48
The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway. Mol Cell Biol (2002) 1.39
Naf1 p is a box H/ACA snoRNP assembly factor. RNA (2002) 1.37
SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. Hum Mol Genet (2002) 1.36
snRNAs contain specific SMN-binding domains that are essential for snRNP assembly. Mol Cell Biol (2004) 1.34
Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains. Nat Struct Mol Biol (2009) 1.31
Bioinformatic analysis of the nucleolus. Biochem J (2003) 1.30
Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly. Cell (2011) 1.29
Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein. Nucleic Acids Res (2001) 1.28
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Mol Cell (2010) 1.27
Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death. Proc Natl Acad Sci U S A (2002) 1.23
NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin. Mol Biol Cell (2004) 1.21
Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes. Results Probl Cell Differ (2009) 1.17
A role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy. Mol Cell Biol (2011) 1.16
Dynamics of galectin-3 in the nucleus and cytoplasm. Biochim Biophys Acta (2009) 1.14
ARS2 is a conserved eukaryotic gene essential for early mammalian development. Mol Cell Biol (2007) 1.10
Inhibition of U snRNP assembly by a virus-encoded proteinase. Genes Dev (2007) 1.09
Identification of a novel human immunodeficiency virus type 1 integrase interactor, Gemin2, that facilitates efficient viral cDNA synthesis in vivo. J Virol (2006) 1.08
Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs. Mol Cell Biol (2005) 1.07
Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes. Environ Health Perspect (2010) 1.07
SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain. Hum Mol Genet (2008) 1.07
Functional cooperation of Epstein-Barr virus nuclear antigen 2 and the survival motor neuron protein in transactivation of the viral LMP1 promoter. J Virol (2001) 1.05
Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging Study. Environ Health (2011) 1.00
Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs. Nucleic Acids Res (2011) 0.99
A motor function for the DEAD-box RNA helicase, Gemin3, in Drosophila. PLoS Genet (2008) 0.98
Absence of gemin5 from SMN complexes in nuclear Cajal bodies. BMC Cell Biol (2007) 0.98
Chromosomal aberrations related to metastasis of human solid tumors. World J Gastroenterol (2002) 0.95
Lymphotropic Herpesvirus saimiri uses the SMN complex to assemble Sm cores on its small RNAs. Mol Cell Biol (2005) 0.94
Understanding the biochemical activities of galectin-1 and galectin-3 in the nucleus. Glycoconj J (2004) 0.94
Gemin3 is an essential gene required for larval motor function and pupation in Drosophila. Mol Biol Cell (2008) 0.92
The role of nuclear bodies in gene expression and disease. Biology (Basel) (2013) 0.91
SMN protects cells against mutant SOD1 toxicity by increasing chaperone activity. Biochem Biophys Res Commun (2007) 0.90
SMN deficiency reduces cellular ability to form stress granules, sensitizing cells to stress. Cell Mol Neurobiol (2011) 0.90
SMN regulates axonal local translation via miR-183/mTOR pathway. Hum Mol Genet (2014) 0.87
Transcriptome analysis of newt lens regeneration reveals distinct gradients in gene expression patterns. PLoS One (2013) 0.87
Fibroblast growth factor-2(23) binds directly to the survival of motoneuron protein and is associated with small nuclear RNAs. Biochem J (2004) 0.85
Proteomic analysis of the NOS2 interactome in human airway epithelial cells. Nitric Oxide (2013) 0.83
Expression of microRNA processing machinery genes in rhesus monkey oocytes and embryos of different developmental potentials. Mol Reprod Dev (2009) 0.83
Genetic variants in the microRNA machinery gene GEMIN4 are associated with risk of prostate cancer: a case-control study of the Chinese Han population. DNA Cell Biol (2012) 0.83
Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization. EMBO J (2015) 0.82
NUFIP and the HSP90/R2TP chaperone bind the SMN complex and facilitate assembly of U4-specific proteins. Nucleic Acids Res (2015) 0.81
The Gemin associates of survival motor neuron are required for motor function in Drosophila. PLoS One (2013) 0.81
Expression of Muscle-Specific MiRNA 206 in the Progression of Disease in a Murine SMA Model. PLoS One (2015) 0.81
Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. Nucleic Acids Res (2012) 0.80
Diverse expression of selected SMN complex proteins in humans with sporadic amyotrophic lateral sclerosis and in a transgenic rat model of familial form of the disease. PLoS One (2014) 0.79
Identification and characterization of the porcine (Sus scrofa) survival motor neuron (SMN1) gene: an animal model for therapeutic studies. Dev Dyn (2008) 0.79
Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5. Genes Dev (2016) 0.78
High expression level of Tra2-β1 is responsible for increased SMN2 exon 7 inclusion in the testis of SMA mice. PLoS One (2015) 0.77
Transcriptome analysis of the zebrafish mind bomb mutant. Mol Genet Genomics (2008) 0.77
Long-term exposure to black carbon, cognition and single nucleotide polymorphisms in microRNA processing genes in older men. Environ Int (2015) 0.77
Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract. Hum Genet (2016) 0.77
Identification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4. Biochem Biophys Res Commun (2008) 0.75
Therapeutic strategies for spinal muscular atrophy: SMN and beyond. Dis Model Mech (2017) 0.75
Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem (1996) 45.70
Identification and characterization of a spinal muscular atrophy-determining gene. Cell (1995) 17.41
Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A (1979) 14.61
Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proc Natl Acad Sci U S A (1981) 10.72
Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature (1996) 9.36
A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy. Proc Natl Acad Sci U S A (1999) 7.60
Structure and function in the nucleus. Science (1998) 6.26
The small nucleolar RNAs. Annu Rev Biochem (1995) 6.26
U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus. EMBO J (1989) 6.19
Correlation between severity and SMN protein level in spinal muscular atrophy. Nat Genet (1997) 6.08
Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins. Genes Dev (1988) 5.73
Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding. Cell (1986) 5.59
The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. Cell (1997) 5.57
The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell (1997) 5.28
Structure of spliceosomal snRNPs and their role in pre-mRNA splicing. Biochim Biophys Acta (1990) 5.06
Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins. Cell (1985) 4.98
The survival motor neuron protein in spinal muscular atrophy. Hum Mol Genet (1997) 4.86
A novel nuclear structure containing the survival of motor neurons protein. EMBO J (1996) 4.72
Sno storm in the nucleolus: new roles for myriad small RNPs. Cell (1997) 4.60
A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing. Cell (1998) 4.47
Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells. J Cell Biol (1984) 4.18
Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. J Exp Med (1991) 4.02
Gene for chronic proximal spinal muscular atrophies maps to chromosome 5q. Nature (1990) 3.77
SMN oligomerization defect correlates with spinal muscular atrophy severity. Nat Genet (1998) 3.51
Nuclear bodies: multifaceted subdomains of the interchromatin space. Trends Cell Biol (1999) 3.49
Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q11.2-13.3. Nature (1990) 3.48
Classification of spinal muscular atrophies. Lancet (1980) 3.40
An essential signaling role for the m3G cap in the transport of U1 snRNP to the nucleus. Science (1990) 2.98
Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway. Curr Biol (1999) 2.95
Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems. J Cell Biol (1999) 2.93
De novo and inherited deletions of the 5q13 region in spinal muscular atrophies. Science (1994) 2.87
Cell biology of the snRNP particles. Crit Rev Biochem Mol Biol (1990) 2.59
When is a deletion not a deletion? When it is converted. Am J Hum Genet (1997) 2.38
Association between the nucleolus and the coiled body. J Struct Biol (1991) 2.18
SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins. Proc Natl Acad Sci U S A (1999) 2.18
Is the sphere organelle/coiled body a universal nuclear component? Dev Genet (1995) 2.17
The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body. J Cell Biol (1999) 2.17
Compartmentalization of eukaryotic gene expression: causes and effects. Cell (1997) 2.09
Survival motor neuron gene transcript analysis in muscles from spinal muscular atrophy patients. Biochem Biophys Res Commun (1995) 2.06
Nucleocytoplasmic transport and processing of small nuclear RNA precursors. Mol Cell Biol (1990) 1.96
Differential SMN2 expression associated with SMA severity. Nat Genet (1998) 1.84
Coiled bodies and gems: Janus or gemini? Am J Hum Genet (1998) 1.51
Human autoantibodies: probes for nucleolus structure and function. Virchows Arch B Cell Pathol Incl Mol Pathol (1987) 1.20
Heterogeneity of subcellular localization and electrophoretic mobility of survival motor neuron (SMN) protein in mammalian neural cells and tissues. Proc Natl Acad Sci U S A (1998) 0.92
Detection of fibrillarin in nucleolar remnants and the nucleolar matrix. Exp Cell Res (1991) 0.87
Molecular basis of spinal muscular atrophy: recent advances. J Child Neurol (1999) 0.82
Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem (1996) 45.70
A generic protein purification method for protein complex characterization and proteome exploration. Nat Biotechnol (1999) 25.13
Electrospray ionization for mass spectrometry of large biomolecules. Science (1989) 16.50
Conserved structures and diversity of functions of RNA-binding proteins. Science (1994) 14.75
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell (1996) 12.07
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science (1997) 11.89
Reverse transcriptase motifs in the catalytic subunit of telomerase. Science (1997) 10.10
Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature (1996) 9.36
The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Cell (1997) 8.94
RNA-binding proteins as developmental regulators. Genes Dev (1989) 8.78
Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature (1992) 8.45
Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. Proc Natl Acad Sci U S A (1996) 8.10
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell (2001) 7.79
Proteomics to study genes and genomes. Nature (2000) 7.48
Analytical properties of the nanoelectrospray ion source. Anal Chem (1996) 7.12
mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence. Mol Cell Biol (1986) 7.07
A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell (1995) 6.19
RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO J (1994) 6.17
Correlation between severity and SMN protein level in spinal muscular atrophy. Nat Genet (1997) 6.08
Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature (1995) 6.08
A novel receptor-mediated nuclear protein import pathway. Cell (1996) 6.04
Transport of proteins and RNAs in and out of the nucleus. Cell (1999) 6.02
Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell (1999) 5.98
Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins. Genes Dev (1988) 5.73
The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. Cell (1997) 5.57
Heterogeneous nuclear ribonucleoproteins: role in RNA splicing. Science (1986) 5.52
The role of cyclooxygenases in inflammation, cancer, and development. Oncogene (1999) 5.50
Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins. Mol Cell (2000) 5.49
Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation. Trends Biochem Sci (1988) 5.47
Physical change in cytoplasmic messenger ribonucleoproteins in cells treated with inhibitors of mRNA transcription. Mol Cell Biol (1984) 5.44
The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J (2001) 5.34
An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell (1998) 5.29
The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell (1997) 5.28
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature (1997) 5.08
A Sm-like protein complex that participates in mRNA degradation. EMBO J (2000) 5.08
The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. Genes Dev (1999) 4.95
Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature (1998) 4.89
Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science (2001) 4.82
Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box. EMBO J (1992) 4.73
Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities. Mol Cell Biol (1988) 4.73
A novel nuclear structure containing the survival of motor neurons protein. EMBO J (1996) 4.72
A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell (1997) 4.68
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J (1997) 4.56
A nuclear localization domain in the hnRNP A1 protein. J Cell Biol (1995) 4.51
The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J (1999) 4.49
A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing. Cell (1998) 4.47
Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells. Cell (1981) 4.34
Structure and function of nuclear and cytoplasmic ribonucleoprotein particles. Annu Rev Cell Biol (1986) 4.33
The pre-mRNA binding K protein contains a novel evolutionarily conserved motif. Nucleic Acids Res (1993) 4.31
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet (2000) 4.30
Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II. Nature (1997) 4.28
RNA binding specificity of hnRNP proteins: a subset bind to the 3' end of introns. EMBO J (1988) 4.26
Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells. J Cell Biol (1984) 4.18
Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. Genes Dev (1999) 4.17
Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. Nat Genet (1998) 4.16
Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci U S A (2000) 4.14
Characterization of heterogeneous nuclear RNA-protein complexes in vivo with monoclonal antibodies. Mol Cell Biol (1984) 4.11
Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion. Nature (2001) 4.10
The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein. Cell (1993) 4.10
Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J Cell Biol (1998) 4.08
Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. Science (2001) 4.06
mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end. Cell (1997) 4.03
Mitotic regulation of the APC activator proteins CDC20 and CDH1. Mol Biol Cell (2000) 4.01
Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature (2001) 3.94
Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins. Mol Cell Biol (1987) 3.91
hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res (1992) 3.89
Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Mol Cell (2000) 3.86
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores. J Cell Biol (1998) 3.77
The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities. Mol Cell Biol (1991) 3.57
Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1. Nature (1997) 3.53
Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly. Proc Natl Acad Sci U S A (1984) 3.51
Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts. Proc Natl Acad Sci U S A (1989) 3.51
A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts. J Cell Biol (1989) 3.47
The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein. EMBO J (1997) 3.46
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell (1999) 3.46
Genomic imprinting--defusing the ovarian time bomb. Trends Genet (1994) 3.38
Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science (1998) 3.38
Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol (1997) 3.36
The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins. Mol Cell Biol (2001) 3.27
Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. Mol Cell Biol (1992) 3.18
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A (2001) 3.11