Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins.

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Published in J Cell Biol on September 22, 1997

Authors

M C Siomi1, P S Eder, N Kataoka, L Wan, Q Liu, G Dreyfuss

Author Affiliations

1: Howard Hughes Medical Institute, and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6148, USA.

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Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. EMBO J (2001) 2.13

Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review. Clin Pharmacol Ther (2010) 2.13

Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam. J Clin Microbiol (1996) 2.12

Characterization of the major hnRNP proteins from Drosophila melanogaster. J Cell Biol (1992) 2.08

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4. Genes Dev (1995) 2.07