Published in Nucleic Acids Res on August 14, 2015
Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase. Proc Natl Acad Sci U S A (2016) 0.80
Nuclear bodies: Built to boost. J Cell Biol (2016) 0.77
A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression. Mol Cell Biol (2015) 0.76
The spliceosome: design principles of a dynamic RNP machine. Cell (2009) 12.82
Spliceosomal UsnRNP biogenesis, structure and function. Curr Opin Cell Biol (2001) 6.10
The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. Cell (1997) 5.57
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell (2005) 4.95
Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs. EMBO J (2002) 4.48
A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing. Cell (1998) 4.47
Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment. Mol Cell (2000) 4.42
A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP. Cell (2000) 4.33
A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. EMBO J (1999) 3.80
Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay. Methods (2008) 3.16
Isolation of an active step I spliceosome and composition of its RNP core. Nature (2008) 3.10
A human homolog of yeast pre-mRNA splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4 (RP11). Mol Cell (2001) 3.07
Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems. J Cell Biol (1999) 2.93
Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA. EMBO J (1999) 2.90
PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell (2000) 2.88
Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. J Cell Biol (2000) 2.78
Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. Mol Cell (2002) 2.19
Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing. EMBO J (2002) 2.11
HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II. Mol Cell (2010) 2.07
Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins. Proc Natl Acad Sci U S A (2005) 2.00
The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery. J Cell Biol (2008) 1.95
A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs. EMBO J (2003) 1.87
RNA catalyses nuclear pre-mRNA splicing. Nature (2013) 1.86
Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins. EMBO J (2002) 1.82
The SMN complex: an assembly machine for RNPs. Cold Spring Harb Symp Quant Biol (2006) 1.79
Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. J Biol Chem (2001) 1.73
RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies. EMBO J (2004) 1.73
An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Cell (2008) 1.72
Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein. Mol Cell (2004) 1.66
Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. Science (2007) 1.64
A comprehensive interaction map of the human survival of motor neuron (SMN) complex. J Biol Chem (2006) 1.61
Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies. J Cell Biol (2003) 1.61
The spliceosome: a flexible, reversible macromolecular machine. Trends Biochem Sci (2012) 1.56
The Gemin5 protein of the SMN complex identifies snRNAs. Mol Cell (2006) 1.49
A well-connected and conserved nucleoplasmic helicase is required for production of box C/D and H/ACA snoRNAs and localization of snoRNP proteins. Mol Cell Biol (2001) 1.45
Gemins modulate the expression and activity of the SMN complex. Hum Mol Genet (2005) 1.42
CBC-ARS2 stimulates 3'-end maturation of multiple RNA families and favors cap-proximal processing. Nat Struct Mol Biol (2013) 1.38
A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. Hum Mol Genet (1999) 1.38
Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer. J Cell Biol (2004) 1.35
Impaired minor tri-snRNP assembly generates differential splicing defects of U12-type introns in lymphoblasts derived from a type I SMA patient. Hum Mol Genet (2010) 1.34
A conserved Lsm-interaction motif in Prp24 required for efficient U4/U6 di-snRNP formation. RNA (2002) 1.34
Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly. J Biol Chem (2006) 1.34
Structural basis for site-specific ribose methylation by box C/D RNA protein complexes. Nature (2011) 1.32
Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly. Cell (2011) 1.29
Unrip is a component of SMN complexes active in snRNP assembly. FEBS Lett (2005) 1.28
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Mol Cell (2010) 1.27
Enhancement of U4/U6 small nuclear ribonucleoprotein particle association in Cajal bodies predicted by mathematical modeling. Mol Biol Cell (2006) 1.24
Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization. Hum Mol Genet (2005) 1.20
Structural basis of assembly chaperone- mediated snRNP formation. Mol Cell (2013) 1.13
Direct probing of RNA structure and RNA-protein interactions in purified HeLa cell's and yeast spliceosomal U4/U6.U5 tri-snRNP particles. J Mol Biol (2002) 1.12
Disease mechanism for retinitis pigmentosa (RP11) caused by mutations in the splicing factor gene PRPF31. Hum Mol Genet (2002) 1.11
Spliceosomal small nuclear ribonucleoprotein particles repeatedly cycle through Cajal bodies. Mol Biol Cell (2008) 1.11
RNA structural requirements for the association of the spliceosomal hPrp31 protein with the U4 and U4atac small nuclear ribonucleoproteins. J Biol Chem (2006) 1.08
In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein. J Biol Chem (2007) 1.08
Architecture of the spliceosome. Biochemistry (2012) 1.06
Biogenesis of spliceosomal small nuclear ribonucleoproteins. Wiley Interdiscip Rev RNA (2011) 1.05
SMN in spinal muscular atrophy and snRNP biogenesis. Wiley Interdiscip Rev RNA (2011) 0.93
Specific splicing defects in S. pombe carrying a degron allele of the Survival of Motor Neuron gene. EMBO J (2010) 0.93
A mutation linked to retinitis pigmentosa in HPRP31 causes protein instability and impairs its interactions with spliceosomal snRNPs. Hum Mol Genet (2009) 0.93
Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control. J Cell Biol (2014) 0.89
A study of the nuclear trafficking of the splicing factor protein PRPF31 linked to autosomal dominant retinitis pigmentosa (ADRP). Biochim Biophys Acta (2006) 0.89
Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction. Nucleic Acids Res (2014) 0.89
SART3-Dependent Accumulation of Incomplete Spliceosomal snRNPs in Cajal Bodies. Cell Rep (2015) 0.86
Autosomal dominant retinitis pigmentosa secondary to pre-mRNA splicing-factor gene PRPF31 (RP11): review of disease mechanism and report of a family with a novel 3-base pair insertion. Ophthalmic Genet (2013) 0.81
Secondary structure of U6 small nuclear RNA: implications for spliceosome assembly. Biochem Soc Trans (2010) 0.81
The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity. J Cell Sci (2014) 0.79
Immobile survival of motoneuron (SMN) protein stored in Cajal bodies can be mobilized by protein interactions. Cell Mol Life Sci (2013) 0.78