An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.

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🔗 View Article (PMID 10739910)

Published in Acta Crystallogr D Biol Crystallogr on April 01, 2000

Authors

S Munshi1, Z Chen, Y Yan, Y Li, D B Olsen, H B Schock, B B Galvin, B Dorsey, L C Kuo

Author Affiliations

1: Department of Antiviral Research, Merck Research Laboratories, West Point, PA 19486, USA. sanjeev_munshi@merck.com

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