Published in Nature on March 21, 1991
A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin) (2012) 20.08
Correlation of two-hybrid affinity data with in vitro measurements. Mol Cell Biol (1995) 4.63
Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J (1996) 3.18
Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators. Proc Natl Acad Sci U S A (1994) 3.18
Fused protein domains inhibit DNA binding by LexA. Mol Cell Biol (1992) 3.01
Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proc Natl Acad Sci U S A (1994) 2.86
A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex. EMBO J (1994) 2.66
The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription. Proc Natl Acad Sci U S A (2004) 2.61
REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J (1995) 2.50
The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex. Mol Cell Biol (1997) 2.42
Transcriptional repression by Drosophila and mammalian Polycomb group proteins in transfected mammalian cells. Mol Cell Biol (1994) 2.35
Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase. Mol Cell Biol (2000) 2.09
Human protein Sam68 relocalization and interaction with poliovirus RNA polymerase in infected cells. Proc Natl Acad Sci U S A (1996) 1.99
Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex. Mol Cell Biol (1995) 1.95
YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix. Mol Cell Biol (2003) 1.92
Coupling of termination, 3' processing, and mRNA export. Mol Cell Biol (2002) 1.92
CCR4 is a glucose-regulated transcription factor whose leucine-rich repeat binds several proteins important for placing CCR4 in its proper promoter context. Mol Cell Biol (1994) 1.90
A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators. Mol Cell Biol (1997) 1.83
The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core. Nucleic Acids Res (1996) 1.83
Transcriptional repression in Saccharomyces cerevisiae by a SIN3-LexA fusion protein. Mol Cell Biol (1993) 1.75
Arrestin-related proteins mediate pH signaling in fungi. Proc Natl Acad Sci U S A (2005) 1.70
CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells. EMBO J (1995) 1.70
A regulatory shortcut between the Snf1 protein kinase and RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A (2000) 1.69
Genetic evidence for transcriptional activation by the yeast IME1 gene product. Genetics (1993) 1.68
The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster. Mol Cell Biol (1999) 1.66
The GLC7 type 1 protein phosphatase is required for glucose repression in Saccharomyces cerevisiae. Mol Cell Biol (1994) 1.63
A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function. Mol Cell Biol (1995) 1.54
Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response. Mol Cell Biol (1996) 1.50
Sip4, a Snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes. EMBO J (1998) 1.43
Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. Genome Res (2002) 1.40
Interaction of the Srb10 kinase with Sip4, a transcriptional activator of gluconeogenic genes in Saccharomyces cerevisiae. Mol Cell Biol (2001) 1.40
Recruitment of the ESCRT machinery to a putative seven-transmembrane-domain receptor is mediated by an arrestin-related protein. Mol Cell Biol (2009) 1.37
GAL4 is regulated by a glucose-responsive functional domain. EMBO J (1993) 1.37
The C terminus of the NF-kappa B p50 precursor and an I kappa B isoform contain transcription activation domains. Nucleic Acids Res (1992) 1.36
Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase. Mol Cell Biol (2004) 1.30
Dissection of the ADR1 protein reveals multiple, functionally redundant activation domains interspersed with inhibitory regions: evidence for a repressor binding to the ADR1c region. Mol Cell Biol (1994) 1.21
Interaction between human tRNA synthetases involves repeated sequence elements. Proc Natl Acad Sci U S A (1996) 1.21
Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor. Proc Natl Acad Sci U S A (1995) 1.21
Transcriptional activators in yeast. Nucleic Acids Res (2006) 1.20
Distinct functions of calmodulin are required for the uptake step of receptor-mediated endocytosis in yeast: the type I myosin Myo5p is one of the calmodulin targets. EMBO J (1998) 1.19
Identification of the C-terminal activator domain in yeast heat shock factor: independent control of transient and sustained transcriptional activity. EMBO J (1993) 1.15
A strategy for constructing large protein interaction maps using the yeast two-hybrid system: regulated expression arrays and two-phase mating. Genome Res (2003) 1.13
The ETS domain transcription factor Elk-1 contains a novel class of repression domain. Mol Cell Biol (2002) 1.12
Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase. Proc Natl Acad Sci U S A (2000) 1.06
Interaction of Proteus mirabilis urease apoenzyme and accessory proteins identified with yeast two-hybrid technology. J Bacteriol (2001) 1.04
Residues in the Swi5 zinc finger protein that mediate cooperative DNA binding with the Pho2 homeodomain protein. Mol Cell Biol (1998) 1.04
Functional interactions between the p35 subunit of the Arp2/3 complex and calmodulin in yeast. Mol Biol Cell (2000) 1.01
STD1 (MSN3) interacts directly with the TATA-binding protein and modulates transcription of the SUC2 gene of Saccharomyces cerevisiae. Nucleic Acids Res (1995) 0.96
The chemistry of regulation of genes and other things. J Biol Chem (2014) 0.96
Inducible, tightly regulated and growth condition-independent transcription factor in Saccharomyces cerevisiae. Nucleic Acids Res (2014) 0.96
The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants. Mol Cell Biol (1996) 0.94
The MYB305 transcription factor regulates expression of nectarin genes in the ornamental tobacco floral nectary. Plant Cell (2009) 0.92
A target essential for the activity of a nonacidic yeast transcriptional activator. Proc Natl Acad Sci U S A (2002) 0.91
Yap1 accumulates in the nucleus in response to carbon stress in Saccharomyces cerevisiae. Eukaryot Cell (2003) 0.90
Activation of simian virus 40 transcription in vitro by T antigen. J Virol (1992) 0.90
Repression and activation domains of RME1p structurally overlap, but differ in genetic requirements. Mol Biol Cell (2002) 0.90
A CUG codon adapted two-hybrid system for the pathogenic fungus Candida albicans. Nucleic Acids Res (2010) 0.89
A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication. J Virol (2011) 0.88
An Abf1p C-terminal region lacking transcriptional activation potential stimulates a yeast origin of replication. Nucleic Acids Res (1997) 0.87
Sip5 interacts with both the Reg1/Glc7 protein phosphatase and the Snf1 protein kinase of Saccharomyces cerevisiae. Genetics (2000) 0.85
A functional screening assay for the isolation of transcription factors. Nucleic Acids Res (2002) 0.85
Assembly of a fragmented ribonucleotide reductase by protein interaction domains derived from a mobile genetic element. Nucleic Acids Res (2010) 0.81
Casein kinase 1 controls the activation threshold of an α-arrestin by multisite phosphorylation of the interdomain hinge. Mol Biol Cell (2015) 0.81
Selection of peptides that functionally replace a zinc finger in the Sp1 transcription factor by using a yeast combinatorial library. Proc Natl Acad Sci U S A (1997) 0.80
Dissecting the function of Atg1 complex in Dictyostelium autophagy reveals a connection with the pentose phosphate pathway enzyme transketolase. Open Biol (2015) 0.79
Epigenetics as an answer to Darwin's "special difficulty," Part 2: natural selection of metastable epialleles in honeybee castes. Front Genet (2015) 0.77
Interaction trap/two-hybrid system to identify interacting proteins. Curr Protoc Cell Biol (2001) 0.76
The 9aaTAD Transactivation Domains: From Gal4 to p53. PLoS One (2016) 0.75
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature (2000) 47.15
CHARMM: the biomolecular simulation program. J Comput Chem (2009) 27.71
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89
A protein interaction map of Drosophila melanogaster. Science (2003) 20.06
An STS-based map of the human genome. Science (1995) 17.72
GAL4-VP16 is an unusually potent transcriptional activator. Nature (1988) 16.53
A gene map of the human genome. Science (1996) 14.32
Deletion analysis of GAL4 defines two transcriptional activating segments. Cell (1987) 14.13
Construction of plasmids carrying the cI gene of bacteriophage lambda. Proc Natl Acad Sci U S A (1976) 13.10
A physical map of 30,000 human genes. Science (1998) 12.43
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet (1997) 10.93
Specific DNA binding of GAL4, a positive regulatory protein of yeast. Cell (1985) 10.25
Gene regulation by proteins acting nearby and at a distance. Nature (1986) 9.71
Highly pathogenic H5N1 influenza virus infection in migratory birds. Science (2005) 9.64
A new class of yeast transcriptional activators. Cell (1987) 9.53
Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1981) 9.45
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 9.19
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli. Gene (1983) 8.85
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell (1994) 8.44
A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor. Cell (1985) 8.30
A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res (1989) 8.06
Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASG. Mol Cell Biol (1984) 7.83
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature (2001) 7.44
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31
Negative effect of the transcriptional activator GAL4. Nature (1988) 7.15
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem (1999) 6.88
Autoregulation and function of a repressor in bacteriophage lambda. Science (1976) 6.83
Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein. Science (1986) 6.79
Structure of the lambda operators. Nature (1973) 6.66
How the lambda repressor and cro work. Cell (1980) 6.65
Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke (2001) 6.61
Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science (1998) 6.50
Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae. Mol Cell Biol (1984) 6.23
Sequence of a repressor-binding site in the DNA of bacteriophage lamda. Nature (1974) 6.22
Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit beta-globin. Cell (1980) 6.20
RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17
Mechanism of action of the lexA gene product. Proc Natl Acad Sci U S A (1981) 6.13
Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science (1997) 6.00
BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science (1999) 5.99
The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87
Cooperative binding of lambda repressors to sites separated by integral turns of the DNA helix. Cell (1986) 5.81
A simple method for clinical assay of superoxide dismutase. Clin Chem (1988) 5.66
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell (1998) 5.60
DNA recognition by GAL4: structure of a protein-DNA complex. Nature (1992) 5.60
Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum (2001) 5.36
Genetic diversity and disease control in rice. Nature (2000) 5.34
Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo. J Virol (1992) 5.19
Spin-torque switching with the giant spin Hall effect of tantalum. Science (2012) 5.18
Multiple repressor binding at the operators in bacteriophage lambda. Proc Natl Acad Sci U S A (1973) 5.15
Interactions between DNA-bound repressors govern regulation by the lambda phage repressor. Proc Natl Acad Sci U S A (1979) 5.02
Extensive variation of human immunodeficiency virus type-1 in vivo. Nature (1988) 5.02
Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization. Proc Natl Acad Sci U S A (1984) 4.90
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78
Novel properties of a restriction endonuclease isolated from Haemophilus parahaemolyticus. Proc Natl Acad Sci U S A (1976) 4.74
Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet (1998) 4.67
Prospective study of sex hormone levels and risk of prostate cancer. J Natl Cancer Inst (1996) 4.66
Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke (2001) 4.64
Recognition of a DNA operator by the repressor of phage 434: a view at high resolution. Science (1988) 4.60
A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives. Nature (1990) 4.57
Purified ryanodine receptor from rabbit skeletal muscle is the calcium-release channel of sarcoplasmic reticulum. J Gen Physiol (1988) 4.56
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci U S A (1995) 4.54
lambda Repressor and cro--components of an efficient molecular switch. Nature (1981) 4.52
The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80. Cell (1987) 4.49
Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell (1999) 4.49
Femtosecond electronic response of atoms to ultra-intense X-rays. Nature (2010) 4.46
Mutants of GAL4 protein altered in an activation function. Cell (1987) 4.44
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene (2008) 4.43
Mechanism of action of the cro protein of bacteriophage lambda. Proc Natl Acad Sci U S A (1978) 4.34
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev (1994) 4.30
Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda. Cell (1975) 4.28
The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F. J Virol (1998) 4.26
Control elements in the DNA of bacteriophage lambda. Cold Spring Harb Symp Quant Biol (1974) 4.23
Specific binding of the lambda phage repressor to lambda DNA. Nature (1967) 4.23
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res (1999) 4.20
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol (2001) 4.16
A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene. Nature (1985) 4.08
Gene regulation at the right operator (OR) of bacteriophage lambda. II. OR1, OR2, and OR3: their roles in mediating the effects of repressor and cro. J Mol Biol (1980) 4.02
A viral phospholipase A2 is required for parvovirus infectivity. Dev Cell (2001) 3.97
Transcription in yeast activated by a putative amphipathic alpha helix linked to a DNA binding unit. Nature (1988) 3.93
Maximizing gene expression on a plasmid using recombination in vitro. Cell (1978) 3.84
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol (2001) 3.82
Repressor structure and the mechanism of positive control. Cell (1983) 3.82
GAL4 activates gene expression in mammalian cells. Cell (1988) 3.81
A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell (1999) 3.80
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest (2001) 3.79
Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature (1997) 3.74
GAL4 activates transcription in Drosophila. Nature (1988) 3.73
Cooperative DNA binding of the yeast transcriptional activator GAL4. Proc Natl Acad Sci U S A (1988) 3.72
Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat Genet (2000) 3.72
A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction. JAMA (1996) 3.69
The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia (2008) 3.69
The lambda repressor contains two domains. Proc Natl Acad Sci U S A (1979) 3.68